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【目的】探讨恶性疟原虫 DNA 疫苗在小鼠体内的免疫反应。【方法】将恶性疟原虫 FCC-1/HN 株重组质粒 pc DNA3-Pfs25 及 pcDNA3-EBA175/HRP Ⅱ经骨骼肌途径分别单独注射或两者混合注射免疫 BALB/c 小鼠, 观察免疫后不同时 间点血清中 IgG 抗体滴度、脾淋巴细胞增殖反应、CD4+/CD8+ T 细胞亚群比值和 NK 细胞杀伤活性的变化。【结果】pcDNA3-EBA175/HRPⅡ与 pcDNA3-Pfs25 分别单独肌肉注射或两者混合肌肉注射免疫小鼠后, 均可见血清 IgG 抗体滴度增高; 针对恶性疟原虫抗原的特异性 T 淋巴细胞增殖反应增强; CD4+/CD8+ T 细胞比率下降以及 NK 细胞杀伤活性增强。【结论】 提示肌肉注射为一有效的 DNA 疫苗免疫途径, 采用编码恶性疟原虫有性期阶段或无性红细胞阶段的重组质粒单独或两者混 合免疫小鼠,均能诱导明显的体液免疫反应、细胞免疫反应和 NK 细胞杀伤活性。

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In accordance with the provisions of the Metrology Law of the People's Republic of China, the product quality inspection institutions tasked with providing societal notarial data must undergo a rigorous assessment of their metro- logical verification, testing capabilities, and reliability by the metrological administrative departments of People's governments at the provincial level or higher. According to the latest version of the "Inspection and Testing Institutions Qualification Accreditation Evaluation Criteria", "Competence assessment for inspection body and laboratory mandatory approval - Genaral requirements for inspection body and laboratory" (RB/T 214-2017), and "Assessment methods and evaluation rules for agricultural product quality and safety inspection institutions", this study summarized the declaration elements, the application procedures, the on-site review and other aspects involved in the qualification recognition of grassroots agricultural product quality inspection institutions. It thereby offers instructive guidance for grassroots agricultural product quality inspection institutions. [ABSTRACT FROM AUTHOR]

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Preventive Medicine is the property of Modern Preventive Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

报道1例在北京大学人民医院内分泌科门诊就诊的初发2型糖尿病患者在使用胰岛素 强化治疗后，逐步转变为二甲双胍联合司美格鲁肽治疗的过程。患者为 38岁男性，因发现血糖高半 年，多饮、多尿、体重下降 1 个月就诊。患者身高 172 cm，体重 98 kg，体重指数 33.13 kg/m2 ，腰围 103 cm。体型肥胖，完善检查考虑 2型糖尿病合并糖尿病酮症，予餐时联合基础胰岛素强化治疗，逐 步调整降糖方案，最终确定为二甲双胍（0.5 g、3次/d）联合司美格鲁肽（0.25 mg、1次/周起始，4周后加 量至0.5 mg、1次/周，8周后加量至1.0 mg、1次/周）降糖治疗，血糖控制达标，体重和腰围下降。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【Objective】 In order to improve the heat resistance of attenuated DHV ( DHV) live vaccine.【Method】 Selection sucrose， pullulan， gelatin，glycerin，phosphates and other ingredients designed heat-protective agent prescriptions，according to the eutectic point formula， the collapse temperature of the scientific design lyophilization process，and compared the potency of the effects of different ways of pre-frozen duck hepatitis vaccine live. 【Result】A better heat protection formulations heat resistance，37 °C 10d，15 d ，respectively，for the viral loss 0. 35Lg，0. 61Lg； For quick freezing，slow freezing and freeze-drying annealing three different ways to compare，find the heat loss duck hepatitis virus descending order: Annealing > slow freezing > Fast freeze; Vaccine trial results showed that long-term storage，can be stored at 2-8 °C 2 years; 10-fold dose of 2 -day-old ducklings were not immune of death，and spiritual diet weight gain were normal， living proof of duck hepatitis heat ducklings safe vaccine，no side effects. 【Conclusion】 The use of A formula and the rapid freeze-drying method of the best heat resistance，extend the shelf life and improve the heat resistance for animal vaccine heat the development of new formulations to provide technical support. [ABSTRACT FROM AUTHOR]

Objective To explore the clinical characteristics of acromegaly patients who had diabetic ketoacidosis (DKA) as their main manifestation. Methods To report the diagnosis and treatment of a patient with pituitary growth hormone and prolactin mixed tumor complicated with DKA from Peking Union Medical College Hospital in February 2017, and the characteristics of these patients in literature were reviewed. Results The patient had DKA and high osmotic status as his first manifestation. His growth hormone (GH) and prolactin (PRL) levels were significantly increased, and imaging results identified a large pituitary mass. The plasma glucose level was high even with insulin treatment at a dose of 90 U/d (0.8 U·kg-1 ·d-1). GH and PRL decreased for more than 50% after bromocriptine treatment. The dose of insulin was reduced to 12 U/d (0.1 U·kg-1 ·d-1), and the blood glucose was controlled. In literature, the prevalence of impaired glucose tolerance and diabetes mellitus was 15%-38%. DKA as the initial clinical condition occurs in 1% acromegaly patients. The main mechanisms are insulin resistance and lipolysis. Plasma glucose level could be controlled with a dose of insulin treatment (50-360 U/d). The dose could be reduced after pituitary adenoma resection and/or somatostatin therapy. Conclusion DKA is a rare clinical manifestation of acromegaly. These patients have severe insulin resistance. To control high plasma glucose levels needs insulin treatment as well as the control of primary disease. [ABSTRACT FROM AUTHOR]

Copyright of Guihaia is the property of Guihaia Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To plan a better program, solicit high quality scientific papers, and enhance the influence of periodicals. Methods: The DOI resolution data of the periodical Pharmaceutical Care and Research from Oct.2010 to Jan.2015 were collected and sorted. The top 50 articles ranking in the DOI resolution number were retrieved and the information of these articles was analyzed and summed up. Results and Conclusion: The popularity of the periodical was rising among the readers abroad. In the past more than 4 years, the number of DOI resolution hit 17 285, and it was still in the rising trend. Statistics revealed the best received authors and their related research fields, the distribution of corporate authors, and so on. To facilitate the publication and technical transfer of scientific research achievements, it is recommended that first priority should be given to the Chinese and English periodicals in China for the publication of those high-quality scientific research achievements. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of Beijing Institute of Technology is the property of Beijing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)