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目的罕见的原发性腰椎间隙感染肺炎克雷伯菌合并阴沟肠杆菌的临床诊疗初探，为此类罕见脊柱感染诊疗提供临床经验。方法腰痛伴左下肢麻痛7月余、加重1周余的老年男性患者，经实验室、影像学检查，诊断为腰椎间盘突出症，入院后症状急性加重，复查腰椎增强MRI示L3/4椎间隙后部局部强化信号，VAS评分9分，腰部JOA评分6分。实施腰椎后路L3/4、L4/5椎间盘摘除＋cage植骨融合＋L3-L5椎弓根钉棒内固定术，并留取术中L3/4椎间盘标本备细菌培养。结果细菌培养结果回示肺炎克雷伯杆菌及阴沟肠杆菌感染，术后敏感抗生素治疗6周，患者在术后半年的随访中获得痊愈。结论对临床表现为急性剧烈腰痛或下肢疼痛的中老年患者，在常规实验室、影像学检查提示腰椎退行性疾病的同时应考虑脊柱感染可能。

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Copyright of Journal of Xinyang Normal University Natural Science Edition is the property of Journal of Xinyang Normal University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To compare PC-12 cells’apoptosis caused by the serotonin herbicides atrazine (ATR), simazine (SIM) and cyanazine (CYA). Methods The rat adrenal medullary pheochromoma PC-12 cell line was selected for routine culture. At the cell logarithmic growth phase, ATR, SIM and CYA were used at a concentration of 200 μmol/L for 24 h, respectively, and the same solvent was added in the control group. The CCK-8 method was used to detect the cell survival rate; the content of reactive oxygen species (ROS) in PC-12 cells was detected; the Real-time PCR and Western blotting methods were used to detect the mRNA and protein expressions of Bax, p53, Bcl-2 and Caspase-3. Results Compared with that in the control group， the survival rate of the cells in ATR group， SIM group and CYA group was significantly decreased. The intracellular ROS activity of the three groups was significantly increased, and the mRNA and protein expressions of Bax，p53 and Caspase-3 were increased. mRNA and protein expressions of Bcl-2 were significantly reduced （P<0. 01) . Compared with that in ATR group， the cell survival rate of SIM group and CYA group was significantly increased, the intracellular ROS activity of the two groups was significantly decreased， the expressions of Bax, p53 and Caspase-3 mRNA and protein were significantly reduced, and the expressions of Bcl-2 mRNA and protein were significantly increased (P<0. 01). Compared with that of SIM group， the cell survival rate of CYA group was significantly increased， while the intracellular ROS activity was significantly decreased; the Bax， p53 and Caspase-3 mRNA and protein expressions were significantly reduced， and Bcl-2 mRNA and protein expressions were significantly increased (P<0. 01）. Conclusion ATR，SIM and CYA can all promote PC-12 cells’apoptosis; ATR has the strongest effect while CYA has the weakest effect. [ABSTRACT FROM AUTHOR]