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肥胖被认为是卒中的危险因素，但肥胖对卒中预后影响的研究却存在矛盾结果，有研究显示肥胖对卒中患者的预后有不利影响，但也有研究显示肥胖和超重的卒中患者可获得更好的预后，卒中患者的BMI和死亡率之间存在反比关系的“肥胖悖论”。了解肥胖与卒中患者的预后有助于帮助临床医师制订个体化的诊疗方案，以及指导疾病预防。因此，本文综述肥胖与卒中预后的相关研究及进展，旨在探讨肥胖界定标准、卒中类型、卒中病情及病程以及预后指标等因素对研究结论的可能影响，为卒中诊治提供参考，指导未来研究方向。 Abstract: Obesity is considered as a risk factor for stroke, but its effect on the prognosis of stroke is still unclear, even there is a “obesity paradox”. That is, there is an inverse relationship between the BMI and mortality of stroke patients. Understanding the effect of obesity on the prognosis of patients with stroke is helpful for clinicians to formulate individualized treatment and guide stroke prevention. Therefore, this article mainly reviewed the progress of the effect of obesity on stroke prognosis, and analyzed the possible factors affecting the conclusions, such as the definition standard of obesity, type of stroke, stroke course and severity, prognosis and other factors, to provide reference for the future research.

Stroke, as a neurological disease characterized by high disability and mortality rates, poses a significant threat to the long-term quality of life for patients. Effective neurofunctional rehabilitation measures can substantially mitigate the long-term disabilities induced by stroke. Motor relearning, a crucial mechanism in post-stroke rehabilitation, is heavily reliant on good sleep quality. However, stroke patients often suffer from sleep disorders, which have a non-negligible negative impact on rehabilitation outcomes. This paper delved into the bidirectional relationship and pathophysiological mechanisms between sleep disorders and stroke rehabilitation. It also reviewed the application and prospect of emerging technologies such as non-invasive/invasive brain stimulation, virtual reality therapy, wearable sleep tracking devices, and gene therapy in stroke patients with sleep disorders, aiming to provide new perspectives and effective methods for optimizing stroke rehabilitation strategies, so as to enhance the rehabilitation effects and quality of life for stroke patients. [ABSTRACT FROM AUTHOR]

In 2013, the Cancer Genome Atlas (TCGA) research center completed the molecular classification endometrial carcinoma (EC), categorizing patients into POLE (DNA polymerase epsilon) mutation type, microsatellite instability-high (MSI-H) type, copy number low (CN-L) type, and copy number high (CN-H) type. Subsequently Western scholars refined this into the ProMisE and Trans-PORTEC classification to better suit clinical applications. Patients with POLE mutation EC have excellent prognosis and lower recurrence rate, allowing for a reduction in surgical scope and a deescalation of treatment. Patients with MSI-H or CN-H are still POLE mutant. MSI-H type patients have a high burden of tumor mutations and significant benefits from immunotherapy. CN-L type patients are the most common, with a prognosis second only to POLE mutant patients. These patients have a higher response rate to hormone therapy to preserve fertility. CN-H type patients have the worst prognosis, with invasive features and a high risk of recurrence. For these patients, postoperative supplementary treatment is necessary to avoid inadequate treatment. However, there are some studies have shown that targeted therapy is more effective for CN-H type patients. The TCGA molecular typing of EC has overcome the limitations of traditional pathological and histological classification for evaluating prognosis, providing new insights into the pathological characteristics, prognosis, clinical diagnosis and treatment decisions of EC. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To comprehensively evaluate the services provided by the BeiDou Navigation Satellite System( BDS-3), a concept of Quality of Service (QoS) in network communication is introduced and then a QoS hierarchical model is proposed. A preliminary classified evaluation index design is given, covering BDS-3 services of Radio Navigation Satellite Service (RNSS), Satellite-Based Augmentation System ( SBAS), Precise Point Positioning (PPP), Regional Short Message Communication ( RSMC), Global Short Message Communication( GSMC),Search and Rescue ( SAR) and Ground Augmentation System( GAS).Then the service guarantee mechanism and parameters mapping relation-ship are analyzed, thus to provide a way to optimize multiple QoS indicators in complex conditions and quickly locate the source of the fault in abnormal conditions. The research results are expected to provide references for the comprehensive evaluation of BDS performance. [ABSTRACT FROM AUTHOR]

In view of the difficulties in data processing and adjustment of coordinate calculation perplexed large-scale GNSS reference station network, this paper proposes a coordinate calculation method. The method is elaborated in four aspects including selection of global framework sites, division of reference station network subnets, single-day data processing of base stations, and global network adjustment calculation. Finally, the internal and external consistence accuracies of the calculation results are evaluated. The analysis results show that the method can solve reference coordinates for network with more than 3 000 stations, and the RMSE of the results is better than 3 mm in both north-south and east-west directions, and better than 6 mm in elevation. The accuracy of the calculation is higher than those of most IGS analysis centers. [ABSTRACT FROM AUTHOR]

Copyright of Art Panorama is the property of Art Panorama Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

细胞自噬是所有真核生物共有的分解代谢途径，其与溶酶体共同完成细胞内代谢废物的降解，从而为生 物大分子的合成提供物质基础。细胞自噬参与肿瘤的发生、发展过程，对肿瘤的生物学作用是一把双刃剑，其活性 降低或增强可导致正常细胞发生恶性转化或促进肿瘤进展。肿瘤微环境是肿瘤细胞赖以生存和发展的环境。自 噬活性改变可影响肿瘤微环境，而肿瘤微环境变化又可影响细胞自噬活性，两者相互影响，互为因果，在肿瘤的发 生、发展及细胞耐药机制中具有重要作用。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)