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脱发症是皮肤科常见疾病之一，发病率较高但临床治疗手段有限。大部分脱发症与毛囊周期的改变有关，而Omega-3及Omega-6多不饱和脂肪酸被证实通过促进或抑制毛囊细胞释放信号分子，从而促进毛囊生长、改善毛囊周期以及促进毛囊的再生。对多不饱和脂肪酸干预脱发症的研究现状及作用机制的国内外相关研究进行综述，期望能够为多不饱和脂肪酸对各类脱发症的治疗提供新思路及深入探讨脱发症的治疗方法及治疗机制提供借鉴，为利用现代分子生物技术改善脱发症提供理论依据。 Alopecia is one of the common diseases in dermatology, with a high incidence but limited clinical treatment. Most alopecia are associated with changes in hair follicle cycle, and Omega-3 and Omega-6 polyunsaturated fatty acids have been shown to promote or inhibit the release of signaling molecules by hair follicle cells to promote hair follicle growth, improve hair follicle cycle, and promote the regeneration of hair follicles. The research status of polyunsaturated fatty acids in the intervention of alopecia and the intervention mechanism were reviewed. It is expected to provide new ideas for the treatment of various types of alopecia by polyunsaturated fatty acids and to explore the treatment methods and mechanisms of alopecia,and to provide a theoretical basis for the improvement of alopecia by modern molecular biotechnology.

利用p-adic域中的同胚映射，将在超距空间上多孔介质的流体动力学模型推广至分形集，运用苏维宜定义的拟微分算子Tα，研究了一类满足初始条件的液体滴在分形多孔介质上流体动力学的反应扩散拟微分方程，得到了该方程的定解，并进一步讨论了该定解的敛散性。

Copyright of Modern Preventive Medicine is the property of Modern Preventive Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Medical Education Technology is the property of China Medical Education Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Northwest A & F University - Natural Science Edition is the property of Editorial Department of Journal of Northwest A&F University (Natural Science Edition) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

HaCaT keratinocytes in an in vitro atopic dermatitis (AD) model. Methods HaCaT cells were divided into the control group (no treatment) and the model group (0.05, 0.1 and 0.2 mmol/L). HaCaT cells in the model group were stimulated with 10 µg/L tumor necrosis factor-α (TNF-α)/interferon-γ (IFN-γ) for 24 h. Cells in the model group were pretreated with 0.05, 0.1 and 0.2 mmol/L matrine for 1 h and then stimulated with 10 µg/L TNF-α/IFN-γ for 24 h. MTT assay was used to assess the cytotoxicity of matrine. Enzyme-linked immunosorbent (ELISA) assay was performed to determine levels of cytokines (IL-6, IL-8 and IL-1β) and chemokines (TARC, MDC and RANTES). mRNA expression levels of antioxidant genes were detected by real-time quantitative PCR (RT-qPCR). Cell migration was analyzed by scratch closure assay. Immunohistochemistry was commended to analyze the nuclear translocation of NF-κB p65. Western blot assay was used to detect the phosphorylation levels of p38, ERK and p65 proteins. Results Compared with the model group, matrine 0.1 and 0.2 mmol/L significantly decreased the expression levels of IL-6, IL-1β, IL-8 and chemokines, and matrine significantly enhanced the expression levels of superoxide dismutase-1 (SOD1), SOD2, catalase (CAT) and glutathione peroxidase (GPx), and promoted scratch wound healing (P＜0.05). In addition, matrine 0.1 and 0.2 mmol/L inhibited the phosphorylation levels of p38, ERK and p65 proteins and the nuclear translocation of p65. Conclusion Matrine possesses anti-inflammatory and antioxidant properties, and stimulates wound closure in eratinocyte AD model, which may be related to the inhibition of the activation of MAPK and NF-κB pathways. [ABSTRACT FROM AUTHOR]

调和函数在SG3 上的Dirichlet 边值问题是分形分析领域的重要研究内容之一。考虑通过垂直切割自相似图形SG3，得到SG3 上的特定定义域。对于边界值为Cantor 集的新的自相似图形，试图探讨在该定义域上的性质。在研究SG3 左半定义域上的Dirichlet 边值问题的过程中，借助SG3 上的二元有理点的调和函数值和正则导数求解格林函数。进一步，运用调和函数的有限能以及弱公式化等方法，最终得到了SG3左半定义域上的格林函数表达式及其相应的定理。

Aiming at the influence of underground subway pedestrian tunnel excavation construction on adjacent multi-pipeline disturbance, based on the pedestrian tunnel construction at the entrance and exit of Dengbu Station of Nanchang subway Line 3, the mechanical characteristics of nearby multi-pipeline under the disturbance of tunnel t construction were systematically studied by combining numerical calculation and theoretical analysis, and the influence law of key factors on the mechanical behavior of pipeline was summarized. The calculation method and control measures was proposed for zoning the influence of adjacent dense pipelines dug under an underground subway tunnel. The results show these as follows. Combined with the distribution rule of Peck curve, 60% and 20% of the control value were determined as the threshold of strong, weak and no influence partition. The relationship function between the line vertical displacement and multiple factors obtained by fitting the multiple nonlinear functions has a excellent effect on the division of the affected zones. The established zoning method for the strong and weak impact of the underground excavation of the subway passage on the adjacent dense pipelines can transform the strong impact area of the dense pipelines into the weak impact area and the non-impact area through effective measures to ensure the construction safety. [ABSTRACT FROM AUTHOR]

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of South China University of Technology (Natural Science Edition) is the property of South China University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Arid Land Geography is the property of Chinese Academy of Sciences, Xinjiang Institute of Ecology & Geography and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of South China University of Technology (Natural Science Edition) is the property of South China University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to quantify the influence of the train axle load and base cavity on the dynamic responses of heavy haul railway tunnel, a train-tunnel-surrounding rock numerical model was established by using ABAQUS and Hertz nonlinear wheel-rail contact theory to analyze the dynamic response characteristics of a heavy-haul railway tunnel with base cavity in hard rock, and to determine its potential vulnerable positions. The results suggested that under the action of surrounding rock pressure and 30 t trainaxle load, the maximum principal strain’s amplitude of the bottom structure with cavity was 82.28×10−6, 87.26% higher than that without considering the base cavity. The lower part of the side drain and rail were the two main vulnerable positions in the tunnel bottom structure, because the tunnel’s maximum dynamic responses caused by train load is located below the rail, while the maximum static value caused by surrounding rock pressure is located below the side drain. Hard rock tunnel has a higher dynamic responses and thinner structure under the rail, so the possibility of base disease under the rail may be higher in hard rock tunnel, while the base disease is more likely to occur at the side drain in soft rock tunnel. When the axle load increased by 1 t, with or without cavity, the amplitude of the maximum principal strain in bottom structure increased by 2.56×10−6 and 1.41×10−6, respectively. The dynamic amplitude and static strain of tunnel bottom structures are both greatly increased by the base cavity, which is very unfavorable to the tunnel bottom structure. When the cavity width increased by 10 cm, the amplitude of the maximum principal strain of the bottom structure under the rail increased by about 12.18×10−6, and the static value increased by 3.71×10−6 . However, when the width of the cavity exceeds 50 cm, its growth rate decreases. It is expected to provide a reference for heavy haul railway to improve the axle load and reduce the probability of tunnel’s base disease. [ABSTRACT FROM AUTHOR]

随着诊疗技术水平的提高，缺血性卒中的死亡率逐渐下降，但脑血管事件的复发率仍然 较高。因此，缺血性卒中的二级预防十分重要。社区医生对缺血性卒中患者进行科学规范的管理是 降低脑血管事件复发的关键环节，本文针对基于社区的缺血性卒中患者的二级预防特点及相关问题 做一综述。 Abstract: With the development of diagnosis and management of stroke, the mortality of ischemic stroke is gradually decreased, however, the recurrence rate of cerebral vascular disease remains very high. Therefore, the secondary prevention is particularly important. Community physician play the key role in decreasing cerebral vascular events recurrence through scientific and standard management of patients with ischemic stroke. This paper is to review the characters and relevant problems of secondary prevention medications for ischemic stroke patients in community.

Decades of research using remotely sensed data have extracted evidence for the presence of an ocean in the northern lowlands of Mars in the Hesperian (∼3.3 Ga), but these claims have remained controversial due to the lack of in situ analysis of the associated geologic unit, the Vastitas Borealis Formation (VBF). The Tianwen-1/Zhurong rover was targeted to land within the VBF near its southern margin and has traversed almost 2 km southward toward the interpreted shoreline. We report here on the first in situ analysis of the VBF that reveals sedimentary structures and features in surface rocks that suggest that the VBF was deposited in a marine environment, providing direct support for the existence of an ancient (Hesperian) ocean on Mars. [ABSTRACT FROM AUTHOR]

Copyright of Journal of South China University of Technology (Natural Science Edition) is the property of South China University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Atomic & Molecular Physics (1000-0364) is the property of Journal of Atomic & Molecular Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Atomic & Molecular Physics (1000-0364) is the property of Journal of Atomic & Molecular Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of South China University of Technology (Natural Science Edition) is the property of South China University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Forensic Science & Technology is the property of Institute of Forensic Science, Ministry of Public Security and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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In view of the protection of adjacent dense pipelines under the influence of subway tunnel construction, relying on the actual project of Nanchang subway, a three-dimensional finite element model of soil mass dense underground pipelines tunnel excavation was established by using ABAQUS software. Combined with the field measured data and numerical simulation results, the formation deformation law, underground pipeline stress characteristics and underground pipeline deformation law during tunnel CRD ( cross diaphragm) construction were analyzed. The mechanical properties of the pipeline with or without grouting reinforcement were compared. The results show these as follows. The pipeline deformation caused by tunnel excavation is mainly settlement, and the pipe soil stiffness difference has a significant impact on the pipeline deformation and stress. The smaller the stiffness difference between pipe and soil, the closer the deformation trend of pipeline and soil is. The greater the stiffness difference between pipe and soil, the stronger the resistance of pipeline to formation deformation, which will produce greater stress. The pipe section above the left and right pilot tunnels of the tunnel is a dangerous area, which needs to be protected. Dense underground pipelines are mainly manifested in the different materials of pipelines, geometric characteristics of pipelines, and the spatial relationship between pipelines and tunnels. The core of protecting underground pipelines is to control the stratum settlement. The key stage of underground pipeline protection is that the tunnel face is close to the pipeline. At this time, it is necessary to ensure the effect of advance grouting and the rapid closure of initial support, and strengthen the monitoring of pipeline deformation. [ABSTRACT FROM AUTHOR]

Copyright of Systems Engineering & Electronics is the property of Journal of Systems Engineering & Electronics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to improve the accuracy of the risk evaluation level of water-rich soft rock mountain ridge tunnel collapse, a tunnel collapse risk evaluation model based on the game combination assignment-technique for order preference by similarity to an ideal solution (TOPSIS) method was proposed. Firstly, based on the review of relevant literature and the actual engineering situation, a waterrich soft rock mountain ridge tunnel collapse risk evaluation index system including 4 primary indicators and 16 secondary indicators of engineering geology, survey and design, organization and management, and environment and climate was constructed. Then, for the weakness of the traditional hierarchical analysis method in analyzing and processing uncertain information, it was improved by introducing D-number theory. Thus, the subjective weights were determined, which improved the experts􀆳 preference for indicators in the process of determining the weight values and made full use of the experts􀆳 experience. In order to fully consider the correlation and conflict between the selected evaluation indicators and determine the weight coefficients more reasonably, the criteria importance though intercrieria correlation (CRITIC) method was prefered to determine the objective weights, and optimized the combination of the subject and guest weight values by using game theory to derive the optimal integrated solution after weighted normalization. Finally, the evaluation model was applied to five sample tunnel sections in the Yellow Sand Tunnel for example analysis. The results show that the risk level of all the sample tunnel sections is 3, while the risk level of all the other tunnel body sections is 2. The survey shows that there are unfavorable factors such as partial pressure and water surge in the tunnel entrance and exit sections compared with the tunnel body itself, so the evaluation results match the actual situation and verify the applicability of the proposed model. [ABSTRACT FROM AUTHOR]

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aiming at the problems in the bearing fault diagnosis method, such as low efficiency of data storage, transmission and processing, ‘and large number of model parameters leading to waste of resources and low diagnostic accuracy. Based on the improved stage wise weakly ‘orthogonal matching pursuit (SWOMP) algorithm, in view of the problem of low reconstruction accuracy in the SWOMP algorithm, a sigmoid function and a secondary selection process forthe atomic support set were introduced into the SWOMP algorithm. A real-time fault diagnosis ‘method for bearings based on S-shaped quadratic stage wise weak orthogonal matching pursuit (SQSWOMP) algorithm was proposed. Firstly, the intial dictionary was obtained by partitioning the bearing history data into matrices with sliding shift windows, while the overcomplete dictionary was established with the improved K-SVD algorithm. Then, SQSWOMP algorithm was combined with the trained overcomplete dictionary to reconstruct the real-time vibration signals. Finally, the reconstructed signals were sparsely decomposed by using the feature that the dictionary could effectively decompose the specific state signals, but not the other state signals. The results indicate that the reconstruction accuracy and efficiency of SQSWOMP algorithm are better than other matching and tracking algorithms, which can solve the problem of low reconstruction accuracy of SWOMP algorithm. The accuracy of normal, inner ring, outer ring, and rolling body fault diagnosis are improved by 2.17%, 23.46%, 17.30%, and 18.38% without consuming a lot of storage and transmission resources. The accuracy is better than other methods, which can facilitate real-time fault diagnosis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Atomic & Molecular Physics (1000-0364) is the property of Journal of Atomic & Molecular Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Poyang Lake is the property of Journal of Poyang Lake Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)