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育龄期女性是自身免疫性疾病的高发人群，其发病率在1.5~10例/万人。生物制剂作为该类疾病的新兴治疗手段，由于其疗效确切、不良反应小，亦在育龄期妇女广泛使用。研究显示，不同生物制剂在穿透胎盘屏障方面差异显著。目前，世界卫生组织（WHO）及美国儿科学会（AAP）尚未对妊娠期生物制剂暴露婴儿提出统一的疫苗接种方案。本文拟对育龄期女性在妊娠期选择不同的生物制剂、对胎儿及疫苗免疫应答的影响进行综述，旨在为临床决策提供更明确的指导，促进母婴健康高质量发展。

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The current fishery aquaculture monitoring equipment is low in endurance, high in cost and difficult to be widely used. An autonomous underwater vehicle AUV for fishery moving and fixed-point monitoring is proposed and designed. The AUV adopts a three-body modular structure design, with three Myring shaped cabins distributed in a balanced three-cabin shape to facilitate bottom stabilityand connected by T-brackets to reduce resistance. Considering the resistance interference between the three cabins of the three-body structure, the resistance calculation and design of different cabin spacing are carried out based on the computational fluid dynamics method. With the optimization objective of minimizing the direct navigation resistance, the parametric models of three cabins and the T-shaped bracket are established. The control of the AUV shape is realized by changing the parameters of the bow and stern curve equations of the cabin and the cross-section curve equation of the T-shaped bracket, which in turn leads to the shape optimization design of the AUV. The results show that the T-shaped bracket reduces the direct navigation resistance value by 26. 28% compared to the traditional triangular bracket, and the AUV shape optimization reduces the direct navigation resistance value by 24. 05%, which improves the endurance. The results of the study provide a new equipment in the field of fishery aquaculture monitoring, as well as a reference for the optimized design of other three-body structure AUVs. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Physical Education / Tiyu Xuekan is the property of Journal of Physical Education Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Xinjiang Agricultural Sciences is the property of Xinjiang Agricultural Sciences Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Detergent & Cosmetics is the property of Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Piezoelectrics & Acoustooptics is the property of Piezoelectric & Acoustooptic and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To address the low segmentation accuracy of multifidus muscle lesion sites in MRI images of patients with lumbar disc herniation, this paper proposes a new model to improve the U2-Net network with the goal that the encoding and decoding subnetworks are interconnected by a series of nested jump paths. To reduce the semantic missing of feature maps in the encoding and decoding subnetworks, the jump connections in the middle of RSU-7,RSU-6,RSU-5,and RSU-4 in the U2-Net model are redesigned, while the RSU-4F part remains unchanged. In addition, the channel attention module is added to enable the net to focus on channels of higher contribution to task, thus extract high quality multifractal muscle features. The experiments on the multifidus muscle MRI image dataset show that the improved U2-Net outperforms U-Net,U2-Net and U-Net++ network in indicators of Dice, HD and MIoU. It can be concluded that the proposed approach has good performance on MRI image segmentation of multifidus muscle, which can assist doctors to make diagnosis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Gastroesophageal reflux disease (GERD) is a common recurrent disease and the treatment of GERD is challenging. Chronic heartburn and/or reflux symptoms seriously affect the quality of daily life of patients. Studies have shown that GERD is closely associated with the impairment of anti-reflux barrier of the esophagus, of which mucin (MUC) is the main component. The role of MUC in the pathogenesis of GERD and influencing factors were reviewed in this article. [ABSTRACT FROM AUTHOR]

Copyright of Computer Engineering & Science / Jisuanji Gongcheng yu Kexue is the property of Computer Engineering & Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Surfactant Detergent & Cosmetics (2097-2806) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Surfactant Detergent & Cosmetics (2097-2806) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: With the in-depth research and rapid development of tissue engineering, tissue-engineered scaffolds provide a new opportunity for bone tissue repair. OBJECTIVE: To explore the cell proliferation of bone marrow mesenchymal stem cells after co-culture with the magnesium-based alloy scaffolds, to provide a new idea for the construction of tissue-engineered bone scaffolds and provide a basis for the clinical application of tissue-engineered scaffolds. METHODS: The bone marrow fluid of rabbits was extracted under sterile conditions. Bone marrow mesenchymal stem cells were cultured and isolated by the whole bone marrow adherent method. Bone marrow mesenchymal stem cells were identified by flow cytometry and osteogenic differentiation ability was tested. Bone marrow mesenchymal stem cells at passage 3 were seeded on magnesium-based alloy scaffolds and chitosan polycaprolactone tricalcium phosphate scaffolds respectively. The cell growth was observed by laser confocal scanning on days 3 and 10, and cell proliferation was detected using an MTT assay on days 1, 4, 7, 10 and 14, respectively. RESULTS AND CONCLUSION: (1) The cultured cells highly expressed CD44 and CD90, but hardly CD34. (2) The morphology gradually changed to polygonal after osteogenesis induction. Von Kossa staining showed that the calcium nodules between the cells were stained black, and the alkaline phosphatase activity was significantly higher than that of the control group (P < 0.05). (3) After co-culture of magnesium-based alloy and bone marrow mesenchymal stem cells, confocal scanning showed that the cells could adhere to the scaffold and grow in clusters. With the extension of time, the magnesium-based alloy scaffold was more active in proliferation than the seed cells loaded on the chitosan polycaprolactone tricalcium phosphate scaffold, and the number of cells was significantly increased. MTT assay showed that when the two materials were co-cultured with bone marrow mesenchymal stem cells for 10 days, the cell growth reached its peak. (4) These results indicate that rabbit-derived bone marrow mesenchymal stem cells have a good osteogenic potential. After co-cultured with magnesium based alloy scaffolds, the cells adhered and grew well on the surface of the scaffolds, indicating that the tissue-engineered magnesium-based implants were successfully constructed. [ABSTRACT FROM AUTHOR]

Aiming at the current situation of low endurance and high cost of mobile monitoring equipment for aquaculture, which limits the widespread application of such equipment, a small portable AUV for mobile and fixed-point monitoring of fishery aquaculture is proposed and developed. A seal-like operation mode is proposed, replacing expensive underwater inertial navigation systems with conventional GNSS. The three main hulls are arranged in a pin pattern with a modular structure to increase smoothness. The unpowered diving and floating are controlled by the motor-controlled piston altering the volume of the external oil bladder. With the low-power STM32F407 chip as the control core, FreeRTOS embedded real-time operating system and LabVIEW development environment are employed to develop the AUV water surface autonomous cruise and dynamic obstacle avoidance system, data image acquisition and communication system, and shore-based intelligent fisheries big data interaction interface. The results of energy consumption analysis and simulation experiments show that the AUV has low energy consumption, and the endurance time is about 77 h when carrying a lithium battery of 5.184 kWh, which can perform autonomous cruising. Tests show that the prototype can effectively communicate with the shore-based host computer, collect water quality information and underwater video images. The AUV for aquaculture monitoring has flexibility in carrying sensors, long endurance, low power consumption, low cost, easy maintenance and upgrading, and is able to meet the demand for three-dimensional movement and long-term fixed-point monitoring of various aquaculture. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Mechanical Strength / Jixie Qiangdu is the property of Zhengzhou Research Institute of Mechanical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To study the role and mechanism of mir-199-3p in the pathogenesis of diabetic retinopathy (DR). Methods The diabetic model of rats was established by injection of streptozotocin. The expression of miR-199-3p and vascular endothelial growth factor A (VEGFA) in the retina of rats was detected by RT-qPCR. The targeting relationship between miR-199-3p and VegfA in retinal cells was studied by dual luciferase assays. Apoptosis of retinal cells was evaluated by TUNEL staining. Protein of VEGFA and transforming growth factor-β(TGF-β), Hepatocyte growth factor (HGF), pigment epithelium derived factor (PEDF) were detected by Western blot. Results The retinal staining showed that the pathological changes such as retinal capillary dilation and vascular curvature in diabetic rats. The results of reverse transcription showed that the expression of miR-199-3p decreased and VEGFA increased in the retina of diabetic rats significantly. The targeting relationship between miR-199-3p and VegfA was confirmed by dual luciferase assays. The low-expression of miR-199-3p significantly reduced the number of retinal ganglion cells and enhance the apoptosis of retinal cells, while the low expression-miR-199-3p and VEGFA significantly reversed the effects of miR-199-3p on retinal cells(P<0.01). Western blot results showed that the expression of TGF-β and HGF decreased significantly after over-expression of miR-199-3p with the increased expression of PEDF(P<0.001). However, over-expression of miR-199-3p combined with VEGFA expression significantly reversed the expression of these proteins. Conclusions miR-199-3p inhibits diabetic retinopathy by targeting at VegfA. [ABSTRACT FROM AUTHOR]

Copyright of Tunnel Construction / Suidao Jianshe (Zhong-Yingwen Ban) is the property of Tunnel Construction Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of South Architecture / Nanfang Jianzhu is the property of South Architecture Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective High-throughput sequencing was used to study on the changes of structural characteristics of gut microbiota in patients with non-puerperal mastitis （NPM). Methods A total of 40 NPM patients and 30 healthy controls （HC) were enrolled from Aug 2020 to Mar 2022. Stool samples were collected and then subjected to high-throughput sequencing. Bioinformatics analyses were performed based on the sequencing results. Results Analysis of Alpha diversity showed that the index of sobs, ace, chao and shannon of gut microbiota in NPM group were significantly lower than those in the healthy controls （HC) group （P<0.05).The difference analysis between groups showed that there were significant differences in the relative abundance of 1 class, 5 orders, 14 families and 28 genera between NPM group and HC group. Linear discriminant analysis （LDA) showed that among different species, 1 class, 2 orders, 5 families and 10 genera had a significant impact on the difference between the groups （LDA>3, P<0.5), of which 10 genera including Faecalibacterium, Escherichia Shigella were enriched in the NPM group, and Anaerostipes, Streptococcus, Christensenellacea_R-7_group, Alistipes, UCG-002, Ruminococcus_torques_group, Corynebacterium and Neisseria were enriched in HC group. The area under the ROC curve （AUC) of the above 10 genera as a group of microbiota was 0.73. The AUC of Anaerostipes and Ruminococcus_torques_group as a single genus was 0.72 and 0.70, respectively, which indicated diagnostic significance. Conclusion The richness and diversity of gut microbiota in NPM patients was significantly lower than that in healthy control subjects. There are certain differences in the structure of the gut microbiota between the two groups. The microbiota group or single genus can be used as a potential biomarker to distinguish NPM patients from healthy people. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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