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BACKGROUND: Sepsis-induced systemic inflammation leads to rapid bone mass loss; however, there is a lack of effective treatments. Ulinastatin is an antiinflammatory drug, but its protective effect and mechanism on bone under sepsis-induced systemic inflammation are still unclear. OBJECTIVE: To explore whether ulinastatin can relieve acute bone loss caused by lipopolysaccharide. METHODS: (1) Animal experiment. Thirty male C57BL/6 mice were randomly divided into three groups (n=10 per group): control group, model group and experimental group. The control group was injected intraperitoneally with normal saline, the model group was injected intraperitoneally with lipopolysaccharide, and the experimental group was injected intraperitoneally with lipopolysaccharide and ulinastatin. In the experimental group, ulinastatin was injected continuously for 3 days. After intraperitoneal injection of ulinastatin for 14 days, femoral tissues were taken for CT scanning and pathological observation. (2) Cell experiment. C57BL/6 mouse primary osteoblasts were isolated and divided into three groups: the control group was routinely cultured, lipopolysaccharide was added to the model group, and lipopolysaccharide with ulinastatin was added to the experimental group. Cell proliferation and osteogenic differentiation were detected. C57BL/6 mouse bone marrow mononuclear cells were isolated and divided into three groups: the control group was routinely cultured, lipopolysaccharide was added to the model group, and lipopolysaccharide and ulinastatin were added to the experimental group. Osteoclast differentiation was detected. RESULTS AND CONCLUSION: (1) Animal experiment. CT scanning and hematoxylin-eosin staining showed that bone mass in lipopolysaccharide-treated mice was reduced but increased after treatment with ulinastatin. Tartrate resistant acid phosphatase staining showed that the number of osteoclasts in bone tissue increased in the model group, but significantly decreased in the experimental group compared with the model group. (2) Cell experiment. Cell counting kit-8 assay showed that lipopolysaccharide treatment inhibited the proliferation of osteoblasts, and ulinastatin elevated the proliferation of osteoblasts after lipopolysaccharide treatment. Alkaline phosphatase staining, alizarin red staining and osteogenesis-related gene (alkaline phosphatase, Runx2, osteocalcin, osteoblastin, nuclear factor κB receptor-activating factor ligand, osteoprotegerin) detection showed that lipopolysaccharide treatment inhibited osteogenic differentiation of osteoblasts and elevated the nuclear factor κB receptor-activating factor ligand/osteoprotegerin ratio; ulinastatin did not have any significant effect on the reduction of osteoblast function induced by lipopolysaccharide but decreased the nuclear factor κB receptor-activating factor ligand/osteoprotegerin ratio. Tartrate resistant acid phosphatase staining and osteoclast-related gene (tartrate resistant acid phosphatase and matrix metalloproteinase 9) detection showed that lipopolysaccharide treatment could promote osteoclast differentiation of bone marrow monocytes, while ulinastatin could inhibit lipopolysaccharide-induced osteoclast differentiation of bone marrow monocytes. (3) Overall, ulinastatin can significantly inhibit lipopolysaccharide-induced bone loss, mainly through promoting osteoblast proliferation and directly or indirectly inhibiting osteoclast differentiation to alleviate bone loss and achieve osteoprotective effects. [ABSTRACT FROM AUTHOR]

In order to explore the enhancement effect of palm fiber on the mechanical property of quartz sand, the reduced triaxial extension test was carried out to test the shear property of palm fiber reinforced quartz sand under saturated condition. The stress-strain curves, initial elastic modulus and secant modulus of saturated quartz sand reinforced with different fiber lengths and contents were calculated. The varying law of the shear strength of palm fiber reinforced quartz sand with the fiber content was analyzed based on the Mohr-Coulomb criterion. Furthermore, the strengthening effect of palm fiber on the mechanical properties of quartz sand was obtained through comparing the volume strain and porosity of contrast plain sand and reinforced sand during shear process. The results show as followed. Palm fibers can enhance the stress-strain strength of quartz sand during tensile failure, while the optimal fiber content and length for improving the peak stress and residual stress of quartz sand are 0. 9% and 12 mm. The initial elastic modulus and peak secant modulus of palm fiber reinforced quartz sand increase with the rise of effective confining pressure, and the overall stiffness is positively correlated with the effective confining pressure. The strengthening effect of palm fibers on the shear strength of quartz sand only appears in the low confining pressure state. The critical porosity and shear dilating of quartz sand are reduced by the addition of palm fibers. The research results are helpful to promote the applications of palm fiber reinforced sand and provide the corresponding theoretical basis. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To study effect of STIL gene on proliferation and apoptosis of cervical cancer cells and its mechanism. Methods: Expressions of STIL mRNA and STIL protein in cervical cancer tissues, adjacent tissues, cervical cancer cell lines HeLa, SiHa, caski and human normal cervical epithelial cells HUCEC were calculated by RT-qPCR and Western blot. HeLa cells were divided into control （NC） group, si-NC group, si-STIL group, si-STIL+IL-6 group. CCK-8 and plate cloning assay were utilized to detect cell proliferation and cloning ability, and flow cytometry was used to analyze cell apoptosis rate. Western blot was used to detect IL-6, IL-6R and p-STAT3 proteins levels. sh-STIL stably transfected HeLa cells were subcutaneously inoculated into back of nude mice to investigate effect of inhibiting STIL expression on tumor formation. Results: STIL mRNA and protein expressions in cervical cancer tissues were significantly higher than adjacent tissues （P<0.05）. STIL mRNA and protein expressions in HeLa, SiHa, and caski cells were significantly higher than HUCEC cells （P<0.05）. Compared with si-NC group, cell absorbance, number of clones, and protein levels of IL-6, IL-6R and p-STAT3 in si-STIL group were significantly reduced （P<0.05）, and apoptosis rate was significantly increased （P<0.05）. Compared with si-STIL group, cell absorbance, number of clones and protein levels of IL-6, IL-6R and p-STAT3 in si-STIL+IL-6 group were significantly increased （P<0.05）, and apoptotic rate was significantly reduced （P<0.05）. Inhibiting STIL significantly inhibited tumor growth in vivo （P<0.05）. Conclusion: STIL gene expression is up-regulated in cervical cancer, and inhibiting STIL can inhibit proliferation and induce apoptosis of cervical cancer cells by inhibiting IL-6/STAT3 pathway. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Based on the structural characteristics of zeolite and the kinetic mechanism of iron and manganese removal using zeolite, this article summarizes the factors of the material itself in affecting 让s iron and manganese removal performance, including manually controlling and adjusting the factors that affect zeolite synthesis, such as silicon aluminum ratio, impurity removal, alkalinity, crystallization temperature, crystallization time, and directing agent, while ensuring the basic framework of zeolite during the synthesis process, as well as pre-treatment modifications such as microwave, high temperature, coating, and chemical agent soaking ・ This article provides reference and research recommendations for future research on modified zeolites. [ABSTRACT FROM AUTHOR]

Copyright of Applied Chemical Industry is the property of Shaanxi Research Design Insitute of Petroleum & Chemical Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Synthetic Crystals is the property of Journal of Synthetic Crystals Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Pesticide Science / Nongyaoxue Xuebao is the property of Chinese Journal of Pesticide Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the status of heavy metal pollution in lotus root samples in Shandong Province and to assess the health risk. Methods A total of 1 927 lotus root samples were collected by stratified random sampling method in 16 cities of Shandong Province. According to GB 5009.2682016, r Determination of Multi 一 elements in Food, r and GB 5009. 172014 H Determination of Total Mercury and Organic Mercury in Food, r, the contents of lead, cadmium, mercury, and arsenic in lotus root were determined and analyzed. The pollution index method was used to assess the pollution status of heavy metals in lotus roots, and the target hazard coefficient method and total target hazard coefficient method were used to quantitatively assess the health risks of heavy metals in lotus root to human health. Results The four heavy metals in lotus root in Shandong Province were detected to varying degrees. The average values of lead, cadmium, mercury, and arsenic were 0. 017 4, 0. 004 6, 0. 001 8, and 0. 029 9 mg/kg, respectively. A total of 42 samples exceeding the standard were collected from 1 927 samples in this study, with an overall eligibility rate of 97. 82%. The pollution index and comprehensive pollution index of the four heavy metals in lotus root were all lower than 0. 7. The THQ and TTHQ values of the four heavy metals in adults and children were all less than 1. Conclusion The overall level of heavy metals in lotus roots in Shandong Province is relatively low. The health risks caused by heavy metals exposed by residents consuming lotus root are at an acceptable level, so it is suggested to continuously monitor the level of heavy metals in lotus root and evaluate its health risk. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Hubei Open Vocational College is the property of Journal of Hubei Open Vocational College Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Previous studies have shown that shikonin has the potential to treat hypertrophic scar and that microRNAs are involved in the regulation of the pathological mechanism of hypertrophic scar. It is speculated that shikonin may regulate the occurrence and development of hypertrophic scar through microRNAs regulation. OBJECTIVE: To investigate the mechanism of shikonin on the fibrosis of human hypertrophic scar fibroblasts via MicroRNA-382-5p. METHODS: Hypertrophic scar tissue and normal skin tissue adjacent to the scar (within 3 cm around the scar) were provided by the Department of Burn and Plastic Surgery, General Hospital of Ningxia Medical University to extract human hypertrophic scar fibroblasts and human normal skin fibroblasts, respectively. Hematoxylin-eosin staining was used to identify normal skin and hypertrophic scar and immunofluorescence was used to identify fibroblasts. The relative expression level of MicroRNA-382-5p was detected by quantitative real-time PCR at the tissue level. Hypertrophic scar fibroblasts were randomly divided into shikonin group (shikonin was dissolved in dimethyl sulfone to make drug solution at a concentration of 13.46 μmol/L, which was used for cell culture for 24 hours), dimethyl sulfone group, MicroRNA-382-5p negative control group, MicroRNA-382-5p inhibitor group, shikonin+MicroRNA-382-5p negative control group and shikonin+MicroRNA-382-5p overexpression group. Real-time fluorescence quantitative PCR and western blot were used to detect the expression of Collagen Type I α1, Collagen Type III α1 and α-smooth muscle actin at mRNA and protein levels, respectively. Cell counting kit-8 was used to detect cell viability. Cell scratch test was used to detect the migration ability of cells. RESULTS AND CONCLUSION: Compared with normal skin fibroblasts, hypertrophic scar fibroblasts had stronger proliferative activity (P < 0.01). Compared with the dimethyl sulfone group, shikonin down-regulated the expression levels of Collagen Type I α1, Collagen Type III α1 and α-smooth muscle actin in human hypertrophic scar fibroblasts (mRNA: P < 0.01, protein: P < 0.01), and inhibited the migration of hypertrophic scar fibroblasts (P < 0.05). Compared with normal skin, MicroRNA-382-5p was highly expressed in hypertrophic scar (P < 0.01), and shikonin could down-regulate the expression of MicroRNA-382-5p (P < 0.01). Inhibition of MicroRNA-382-5p down-regulated the expression level of Collagen Type I α1, Collagen Type III α1 and α-smooth muscle actin in hypertrophic scar fibroblasts (mRNA: P < 0.01, protein: P < 0.01), and inhibited the migration of hypertrophic scar fibroblasts (P < 0.05). Under the influence of shikonin, overexpression of MicroRNA-382-5p upregulated the expression levels of Collagen Type I α1, Collagen Type III α1 and α-smooth muscle actin in hypertrophic scar fibroblasts (mRNA: P < 0.01, protein: P < 0.01), and promoted the migration of hypertrophic scar fibroblasts (P < 0.01). To conclude, shikonin can inhibit the fibrosis and migration of hypertrophic scar fibroblasts by down-regulating the expression of MicroRNA-382-5p. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective] The present paper aimed to further study the causes of calf blindness aud provide theoretical support for reducing the incidence of congenital blindness of calves aud reducing the economic losses of the breeding industry. [ Method] A cattle farm was selected in Ningxia, whose birth date was close to that of blind calves aud their mothers, aud normal calves. Blood and plasma samples were collected. Through metabonomic aualysis, the differential metabolites and pathway changes between blind calves and their mothers, aud normal calves were studied. [Result] The VIP value of OPLS-DA > 1 and the univariate statistical aualysis P < 0. 05 were used as the criteria for significautly different metabolites. A total of 256 different metabolites were screened from the comparison group of blind calves and normal calves ( V aS. vs. VaL), including 144 in the positive ion mode and 112 in the negative ion mode. A total of 177 different metabolites were screened from the comparison group between the blind calf aud its mother ( VaS. vs. CS), including 108 in the positive ion mode aud 69 in the negative ion mode. The content of rhodopsin in the blind calf was significantly lower than that of its mother, with log2 FC reaching - 2. 87. Compared with its mother, there were 30 differential metabolic pathways with P < 0. 05 in total in blind calves, and 10 differential metabolic pathways with corrected P < 0. 05 in total. Among them, bile secretion metabolic pathway had the largest distribution of differential metabolites. Compared with its mother, 4 metabolites in blind calves were significantly up-regulated, and 9 metabolites were significantly down-regulated. Compared with normal calves, there were 12 differential metabolic pathways with P <0. 05 in total in blind calves, and 16 differential metabolic pathways with corrected P < 0. 05 in total. Among them, bile secretion metabolic pathway distributed the most differential metabolites. Compared with normal calves, there were 5 metabolites significantly up-regulated and 4 metabolites significantly down-regulated in blind calves. [ Conclusion] The bile secretion metabolic pathway of blind calves is significantly different from that of their mothers and normal calves. The research suggests that the blindness of calves may be a disease of the body living in the liver, affecting the normal secretion of bile, leading to that the normal intake of fat-soluble vitamin A can not be absorbed and utilized, and thus affecting the vision of calves. In addition, compared with their mothers, the content of rhodopsin, which affects the cascade reaction of light transduction, is significantly down-regulated under the condition that there is no significant difference in vitamin A levels in the body of blind calves. The study suggests that the mutation of rhodopsin gene (RHO) encoding rhodopsin protein and the lack of rhodopsin protein might be another reason for their blindness. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Anhui Agricultural Sciences is the property of Journal of Anhui Agricultural Sciences Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To investigate the effect of shikonin on the collagen deposition of human hypertrophic scar fibroblasts from the perspective of PTEN. Methods Hematoxylin-eosin staining and Masson staining were used to identify hypertrophic scar tissue. Immunofluorescence was used to identify fibroblasts. The relative expression level of PTEN was detected by Western blot at the tissue level. Hypertrophic scar fibroblasts were randomly divided into dimethyl sulfone group, shikonin group, control group, si-NC group, shikonin+ si-NC group and shikonin+si-PTENC group, western blot were used to detect the expression of PTEN and collagen-related proteins (Col1, Col3 and α-SMA）at protein levels, respectively. Results Compared with normal skin, PTEN was lower expressed in hypertrophic scar (P < 0.05). shikonin was dissolved in dimethyl sulfone to make drug solution at IC50 concentration (13.46 μmol/L), which was used for human hypertrophic scar fibroblasts cell culture for 24 hours, shikonin down-regulated the expression levels of Col1, Col3 and α-SMA in human hypertrophic scar fibroblasts, while up-regulated the expression of PTEN (P < 0.05). Transfected with si-PTEN, the expressions of Col1, Col3 and α-SMA in human hypertrophic scar fibroblasts were increased compared with the si-NC group (P < 0.05). After co-transfection with shikonin + si-PTEN, the expressions of Col1, Col3 and α-SMA in human hypertrophic scar fibroblasts were increased compared with shikonin + si-NC group (P < 0.05). Conclusion Shikonin can inhibit collagen deposition in hypertrophic scar fibroblasts by up-regulating PTEN expression. [ABSTRACT FROM AUTHOR]

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We report a case of lupus erythematosus panniculitis misdiagnosed as vasculitis. A 7-year-old boy presented with a 2-year history of erythema and ulceration on the left lower abdomen and depressed skin on the left buttock. He had been diagnosed with vasculitis and skin infection in other hospitals for many times. Dermatological examination showed scattered dark erythema on the left lower abdomen, green bean to nail sized necrosis and ulcers with adhesive black crusts on some areas, and several porcelain-white mild atrophic scars. Non-atrophic band-like depression in normal color was observed on the left hip, ilium, left lower abdomen and the left groin. The skin could be pinched. Histopathological changes in the skin lesions included liquefaction degeneration of basal cells, pigment incontinence, infiltration of lymphocytes and plasma cells around dermal vessels and appendages, mucin deposition between collagen bundles, adipose atrophy, encapsulation of fatty lobules, and positive for Alcian blue staining. The final diagnosis was lupus erythematosus panniculitis. The patient was treated with oral hydroxychloroquine 0.1 g/qd and methylprednisolone 16 mg/qd, and topical mucopolysaccharide polysulfate cream, centella triterpenes cream and crisaborole ointment. Ulcers were healed without new lesion and erythema at one-year follow-up. [ABSTRACT FROM AUTHOR]

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