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Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Hainan Medical University is the property of Journal of Hainan Medical College Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the internal molecular mechanism of Bushen Huoxue Decoction " from deficiency to stasis" in the treatment of osteoporosis ( OP ) by network pharmacology and molecular docking technology. Methods The related chemical components and targets of Bushenhuoxue Decoction were collected from tcmsp, Batman TCM, chemical database, tcmid database and How Net, and then the target was annotated with gene; the disease-related targets were retrieved from geencards and OMIM databases to obtain the corresponding targets; and then, used Cytoscape 3. 7. 2 software to visualize the corresponding relationship between drug components, diseases and targets to construct a " traditional Chinese medicine component target disease" network, and obtained the intersection target data from string database to construct protein interaction network; useed R language software to analyze gene enrichment of go and KEGG; finally, molecular docking was carried out for core compounds and targets. Results A total of 171 active compounds of Bushen Huoxue Decoction were obtained, 11 core components were screened out, 166 corresponding targets were predicted; 1335 OP related targets, 54 genes were intersected; 13 core target proteins were screened by PP! protein network; 279 and 63 enrichment result were obtained by go and KEGG enrichment analysis; molecular docking result showed that the core compounds stigmasterol and mapkl, PPARG and !3-sitosterol had good binding properties with PPARG in the treatment of osteoporosis. Conclusion Bushen Huoxue Decoction plays an important role in nutritional support, immune regulation, anti-inflammatory, damage repair and other aspects. Through network pharmacology and molecular docking, it explains the internal molecular mechanism of "from deficiency to blood stasis" in the treatment of osteoporosis [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Angiogenesis and osteogenesis are essential parts of bone development. The regeneration and angiogenic-osteogenic coupling exist through the whole process of bone formation and remodeling, which play important roles in the mechanisms such as new bone formation, fracture healing, bone defect repair, and osteoporosis. Vascular endothelial cells, vascular endothelial growth factors, and other factors are key parts in angiogenic-osteogenic coupling. Especially in recent years, the discovery of specific H-type blood vessel enriches the content of vascular-osteogenesis coupling and deepens the understanding of the coupling. Blood vessels and bones are closely related and interacted with each other. The significances of blood vessels to bones are not only the transmission of bone-transferring substances, but also the secretion of factors, signal transmission, function regulation, and so on. Bone related cells can secrete or promote the secretion of vascular endothelial growth factor and other angiogenic factors, which regulate angiogenesis. Therefore, this present paper summarizes the role of angiogenic-osteogenic coupling-related factors, cells, and their mechanisms in the bone. [ABSTRACT FROM AUTHOR]

Objective To investigate biomechanics of proximal femoral nail anti-rotation (PFNA) with different entry points in the treatment of lateral wall fracture of femoral intertrochanteric fracture by finite element method. Methods Based on CT data of the hip of volunteers, three-dimensional model of right femur was extracted and optimized by Mimics and Geomagic software. Then, three A models (crushed lateral femoral wall and completed medial femoral wall) and three B models (crushed lateral femoral wall and medial femoral wall) were obtained by assembling different entry points with PFNA model in SolidWorks software and simulating different fracture lines of lateral wall. All the six models were imported into Abaqus software to set material properties and boundary conditions for transportation. The Von Mises cloud pictures of the model were calculated and viewed. Results In model A, the upper entry of the lateral wall formed stress concentration, the middle showed largest displacement and the bottom showed uniform stress distribution and smaller displacement. In model B, the upper entry of the lateral wall showed larger displacement, the middle showed largest stress concentration and the bottom showed smaller stress dispersion and displacement. Conclusion PFNA, which is selected the bottom entry of lateral femoral wall, has the best biomechanical effect in the treatment of lateral wall fracture of femoral intertrochanteric fracture. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the dynamic biomechanical properties of unstable intertrochanteric fracture fixed with proximal femoral nail antirotation II(PFNA-II)through finite element analysis, and therefore to provide theoretical foundation for clinic application. Methods Finite element model of Evans IV intertrochanteric fracture fixed by PFNA-IIwas developed. We simulated the conditions of fracture union and internal fixation removal by adjusting the contact relation-ship of fractures and taking out of PFNA-II. Stress peak and biomechanical stability of models were compared with normal femur model through finite element analysis. Results The highest stress concentration area of fixation models was located in the caudal passage of the blade through the nail. After fracture union, the stress of internal fixation increased. After internal fixation was removed, the stress of femoral neck increased significantly and the stability decreased. Conclusions In order to avoid internal fixation rupture after fracture union, PFNA-II should be removed, meanwhile the risk of femoral neck fracture requires attention. [ABSTRACT FROM AUTHOR]

目的探讨三角固定髓内钉(TPFNA)对A2.2型股骨转子间骨折稳定性及抗扭转性的影响。方法选取6对新鲜成人股骨标本制作A2.2型股骨转子间骨折模型。将骨折模型随机分为TPFNA组和股骨近端防旋髓内钉(PFNA)组,每组同侧6肢,分别给予TPFNA、PFNA固定。记录100、200、300、400、500、600 N垂直压缩状态下位移情况及扭转角为1°、2°、3°、4°、5°时的扭矩。结果 TPFNA组在200、300、400、500、600 N垂直压缩状态下的位移均小于PFNA组(P均<0.05)。TPFNA组扭转角为2°、3°、4°、5°时的扭矩均大于PFNA组(P均<0.05)。结论A2.2型股骨转子间骨折行TPFNA固定的稳定性及抗扭转能力均较好,均优于PFNA。 [ABSTRACT FROM AUTHOR]