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为了快速检测食用植物油中的16种多环芳烃（PAHs)，以氨基化多壁碳纳米管（NH2-MWCNTs）作为样品前处理的吸附剂，采用分散固相萃取（d-SPE）/气相色谱-质谱联用（GC-MS）同时测定食用植物油中的16种PAHs。通过单因素实验对样品前处理条件（吸附剂用量、吸附时间、洗脱剂类型及用量、洗脱时间）进行了优化，对所建立的方法进行了方法学考察，并与已有检测方法进行了对比分析，同时采用所建立的方法对实际样品进行了测定。结果表明：样品前处理最优条件为吸附剂用量15 mg(样品食用植物油质量1.0 g)、吸附时间1 min、洗脱剂甲苯、洗脱剂用量500 μL、洗脱时间5 min；16种PAHs在1～200 μg/kg范围内线性关系良好，方法的检出限在0.05～043 μg/kg之间，定量限在0.17～1.42 μg/kg，加标回收率和相对标准偏差分别为70.67%～10183%和1.34%～9.32%；与已有前处理方法相比，d-SPE高效、简便，且最大程度地减少了有机溶剂的消耗；6种市售食用植物油中苯并\[a\]芘含量均小于2 μg/kg。综上，所建立的方法适用于食用植物油中16种PAHs的测定。To rapidly detect 16 polycyclic aromatic hydrocarbons (PAHs) in edible vegetable oil, the aminated multi-walled carbon nanotubes (NH2-MWCNTs) were used as adsorbents for sample pretreatment, and the dispersion solid phase extraction (d-SPE) with GC-MS method was developed for the simultaneous determination of 16 PAHs in edible vegetable oil samples. The sample pretreatment conditions (the adsorbent dosage, adsorption time, the type and amount of eluent, elution time) were optimized by single factor experiments, and the methodology of the established detection method was investigated and compared with existing methods. Meanwhile, actual samples were detected using the established method. The results showed that the optimal conditions for sample pretreatment were as follows: adsorbent dosage 15 mg (for 1.0 g edible vegetable oil sample), adsorption time 1 min, toluene as the eluent, eluent dosage 500 μL, elution time 5 min. The 16 PAHs showed good linear relationship in the range of 1-200 μg/kg, and the detection limits of the method ranged from 0.05 μg/kg to 0.43 μg/kg, with quantitative limits between 0.17 μg/kg and 1.42 μg/kg. The spiked recovery rate and relative standard deviation were 70.67%-101.83% and 1.34%-9.32%, respectively. Compared to existing pretreament methods, d-SPE is efficient, simple and minimizes the consumption of organic solvents. The content of benzo \[a\] pyrene in 6 commercial edible vegetable oils was less than 2 μg/kg. In summary, the established method is suitable for the determination of 16 PAHs in edible vegetable oil.

目的本研究旨在改进生殖男科领域现有的精液处理方法，特别是针对双层密度梯度法中的300 ×g 20 min处理条件，以提高受精结局。方法收集2020年7月和9月以及2022年3月和5月在中山大学附属第六医院生殖医学中心进行辅助生殖助孕的1 623例患者的精液标本进行实验。预实验中，比较四种不同的双层密度梯度方法（200 ×g 10 min、200 ×g 20 min、300 ×g 10 min和300 ×g 20 min）处理后标本的精子DNA碎片率和回收率。然后，筛选出一种最优的方法作为新方法，并与目前在用的旧方法（300 ×g 20 min双层梯度法）进行对比，检验受精率是否有统计学差异。在新方法的基础上，进一步优化为单层密度梯度法，并与双层密度梯度法进行对比，检验是否存在统计学差异。实验过程中严格控制温度、离心速度和离心时间，同时记录每组样本的数量和处理条件。结果在保证足够的精子回收率的基础上，发现四种双层密度梯度法中300 ×g 10 min的精子DNA碎片率低于300 ×g 20 min。因此，选择300 ×g 10 min作为新方法进行试验。结果表明，新方法300 ×g 10 min的总受精率、二核体（2pn）受精率均高于300 ×g 20 min，且差异有统计学意义（Pg 10 min的卵裂率也略高于300 ×g 20 min，但差异没有统计学意义（P>0.05）。单层密度梯度法的总受精率、2pn受精率均高于双层密度梯度法，但差异没有统计学意义（P>0.05）；单层密度梯度法的卵裂率高于双层密度梯度法，囊胚形成率低于双层密度梯度法，且差异均有统计学意义（Pg 20 min双层梯度法，300 ×g 10 min双层梯度法成功提高了总受精率、2pn受精率、卵裂率，缩短了精液优化处理的时间；而单层密度梯度法虽提高了卵裂率、节约了试剂成本和操作时间，但其囊胚形成率却出现了下降的情况。这些发现为生殖男科领域的精液处理方法提供了有益的指导和启示。

针对电动汽车这一新型储能资源大规模接入后电力市场多主体竞争格局，提出一种计及需求响应潜力的电动汽车聚合商多主体日前投标策略。以实现削峰填谷、保障电网安全稳定运行等为目标，促使电网与聚合商等多方市场主体可持续发展，探索其未来商业模式。首先，根据电动汽车用户出行特性进行电动汽车集群分类，考虑出行时间、到达时间及荷电状态等因素，模拟集群内用户随机充放电选择。结合聚合商整体充电功率上限值与电能波动区间值等主要因素，基于历史数据评估聚合商需求响应潜力。然后，考虑多个聚合商投标问题，建立日前市场投标模型，以测算电动汽车聚合商日前市场效益。为探寻多元竞争格局下最优日前市场投标策略，以日前投标净利润最大为目标函数，考虑电量、功率上限及电池容量等约束条件，利用Gurobi对优化问题进行求解。最后，通过湖北省武汉市某区实际负荷算例验证了所提策略的先进性及可行性。

Diabetic gastroparesis is a common complication in diabetic patients. It is manifested as recurrent nausea, vomiting, early saturation and abdominal fullness. The main pathophysiology is a condition that slows down the emptying of the stomach. In recent years, the external treatment of Traditional Chinese Medicine in the treatment of diabetic gastroparesis has been widely used in clinical practice, which can improve the clinical symptoms of patients. By searching the relevant literature, this paper briefly listed external treatment of Traditional Chinese Medicine, and looked forward to the future development direction of new nursing technology. (糖尿病胃轻瘫是糖尿病常见并发症之一, 表现为反复发作恶心、呕吐、早饱和上腹饱胀, 主要病理生理是胃排空延缓。近年来中医外治法治疗糖尿病胃轻瘫在临床实践中得到广泛应用, 可有效改善患者临床症状。本文通过检索相关文献, 简要列举糖尿病胃轻瘫中医外治疗法, 旨在为今后糖尿病并发症护理研究提供参考。)

Objective To explore the status quo of ICU nurses' knowledge, attitude and practice of physical restraints use in general hospitals in Guangxi, and to provide a theoretical basis for clinical training and quality control. Methods A simple random sampling method was used to select ICU nurses from Grade III and Grade II hospitals in Guangxi, including 2 Grade III hospitals and 3 Grade II hospitals, with a total of 201 ICU nurses. The knowledge, attitude and practice status of nurses on physical restraints use were investigated by using a physical restraints knowledge, attitude and behavior questionnaire, and the influencing factors were analyzed. Results The total score and scores of knowledge dimension, attitude dimension, and behavior dimension were (135. 08±18. 07), (68. 70±9. 49), (20. 73±4. 82), (45. 66±8. 95), respectively, indicating a low-to-medium level awareness of physical restraints among ICU nurses in general hospitals in Guangxi. There were statistically significant differences in the level of knowledge, attitude and practice of ICU nurses with different hospital levels, ICU working years, and ICU specialist qualifications (P＜0. 05). Conclusion ICU nurses in Guangxi have a more positive attitude towards physical restraint, and their knowledge and behavior level need to be strengthened urgently. ICU managers should improve the physical restraint training mechanism, types and teams of ICU nurses, strengthen relevant knowledge and skills training according to the different characteristics of nurses, build positive attitudes and emotions through enhanced knowledge, promote behavioral changes, and improve the development of physical restraint specialization. (目的 探讨广西壮族自治区ICU护士身体约束知信行现状, 为临床开展相关的培训及质控提供理论依据。方法 采用简单随机抽样法, 选取广西壮族自治区三级甲等、二级甲等共5所医院的ICU护士共201名作为研究对象, 采用“ICU护士实施身体约束知信行评估量表”调查护士对患者实施身体约束的知识、态度和行为现状, 并分析影响因素。结果 广西壮族自治区ICU护士身体约束知信行总分、知识维度、态度维度、行为维度得分分别为(135. 08±18. 07)分、(68. 70±4. 82)分、(45. 66±8. 95)分, 整体上为中等偏低水平。不同医院等级、ICU工作年限、有无ICU专科资质的ICU护士身体约束知信行水平差异有统计学意义(P＜0. 05)。结论 广西壮族自治区ICU护士身体约束态度较为积极, 知识及行为水平亟待加强。ICU管理者应健全ICU护士身体约束培训机制、种类和队伍, 根据护士的不同特征强化相关知识与技能培训, 通过增强知识建立积极态度和情感, 促使行为改变, 促进身体约束专科化发展。)

Oculomotor nerve palsy is a nerve condition that affects patient’s vision and quality of life. This article summarizes the nursing experience of a patient with mild oculomotor nerve paralysis treated with plum-blossom needle tapping therapy. Based on the differentiation of symptoms and signs in Traditional Chinese Medicine, plum-blossom needle technique therapy, as well as daily life support, dietary care, medication, and emotional nursing interventions, can effectively improve symptoms such as ptosis, strabismus, and limited eye movement in the patient. (动眼神经麻痹严重影响患者视觉及生活质量。本文总结采用梅花针叩刺法治疗1例轻度动眼神经麻痹患者的护理经验。根据护理评估及中医辨证分型, 在生活起居、饮食护理、情志护理基础上, 采用梅花针中医护理技术, 有效改善了患者上睑下垂、斜视、眼球活动受限等症状。)

数据中台将一个机构（企业、事业或政府部门）的数据作为战略资产进行管理，是从数据收集到处理应用的一套管理机制，以期提高数据质量，实现广泛的数据共享，最终实现数据价值最大化。给出数据中台的定义，提出数据中台参考技术框架，并分别对物理管理、逻辑管理、数据资产管理、数据服务和信息安全管理的组成和技术进行了展开讨论。最后以华谱系统建设为例，介绍面向家谱大数据、结合HAO智能模型的数据中台实现——华谱数据中台。

Objective To investigate the effect of quality control circle (QCC) activities in improving the blood pressure control rate in young and middle-aged hypertensive patients in nursing clinics. Methods From July 1, 2020 to January 31, 2021, a total of 316 cases of young and middle-aged hypertensive patients were collected. According to the random number table method, they were randomly divided into control group and QCC group. Patients in the control group were given routine health education, and patients in the QCC group were given QCC activities on the basis of routine health education. A checklist for monitoring blood pressure was developed and factors influencing the successful blood pressure were analyzed. Countermeasures were carried out to improve quality of nursing interventions on hypertension. The two groups were intervened for 6 months, and the blood pressure control rate of the two groups was observed. Results Unreasonable lifestyle and lack of health education from nurses were the main risk factors for the blood pressure failure among young and middle-aged hypertension patients. The blood pressure control rate in the QCC group was higher than that in the control group(68. 35%, vs. 32. 91%, P＜0. 01). Conclusion QCC activities could improve the blood pressure control rate in young and middle-aged hypertensive patients. (目的 探讨高血压护理门诊中运用品管圈活动改善中青年高血压患者血压达标率的效果。方法 选取2020年7月—2021年1月高血压护理门诊中青年高血压患者316例, 根据随机数字表法随机分为常规组(n=158)和品管圈组(n=158)。常规组给予常规健康宣教, 品管圈组在常规组的基础上开展品管圈活动, 制定高血压患者血压达标情况督查表, 对影响达标的因素进行分析, 进而针对性制定对策以改进相关护理措施。两组分别干预6个月, 比较患者血压达标率情况。结果 生活方式不合理和护士健康宣教缺乏是中青年高血压患者血压不达标的主要危险因素。品管圈组患者血压达标率优于常规组(68. 35%vs. 32. 91%, P＜0. 01)。结论 开展品管圈活动能有效提高中青年高血压患者的血压达标率。)

针对脑血管病的危险因素积极进行早期干预管理是减少脑血管病危害最有效的方法。本章节介绍脑血管病高危人群管理的推荐意见，包括对不可干预和可干预血管危险因素的控制，阿司匹林在缺血性卒中一级预防中的应用以及首次卒中风险评估等方面。 Abstract: Early intervention to manage the risk factors of cerebrovascular disease is the most effective way to reduce the harm of cerebrovascular diseases. This chapter presents recommendations for the management of populations at high risk for cerebrovascular disease, including control of non-interventionable and interventionable vascular risk factors, the use of aspirin in the primary prevention of ischaemic stroke, and the risk assessment of first-time stroke.

Objective To search and evaluate the evidence of postoperative pain management in spinal surgery so as to promote the standardized management of postoperative pain in patients with spinal surgery. Methods According to the "6S" evidence model, evidence of management of postoperative pain in spinal surgery were systematically searched from BMJ Best Practice, UpToDate, Cochrane library, Joanna Briggs Institute (JBI), National Guideline Clearinghouse(NGC), National Institute for Health and Clinical Excellence(NICE), Scottish Intercollegiate Guidelines Network(SIGN), Guidelines International Network(GIN), Registered Nurses’ Association of Ontario(RNAO), China Medical Network, PubMed, Web of science, Embase, EBSCO, Chinese Biomedical Medicine(CBM), China National Knowledge Infrastructure(CNKI), WanFang Data. Results A total of 10 articles were selected, including 1 clinical decisions, 2 evidence summary, 5 guidelines, 1expert opinion, 1 expert consensus, best evidences were summarized from the 5 aspects of pain evaluation, intervention, monitoring, education and organization. Conclusion This study summarized the best evidence of postoperative pain management in spinal surgery, which provided evidence for clinical application. In the process of evidence transformation, standards should be formulated to regulate the pain management behavior of medical staff in combination with clinical practice, so as to reduce postoperative pain in patients with spinal surgery and improve the quality of nursing (目的 检索并评价脊柱外科术后疼痛管理的相关证据, 以促进脊柱外科术后患者疼痛的规范化管理。方法 按照“6S”证据模型, 系统检索BMJ Best Practice、UpToDate、Cochrane library、Joanna Briggs Institute(JBI)、美国指南网、英国国家临床医学研究所指南网、苏格兰院际间指南网、国际网络指南网、加拿大安大略省注册护士协会网站、中国医脉通指南网、PubMed、Web of science、Embase、Ebsco、中国生物医学文献数据库、中国知网、万方数据库中关于脊柱外科术后疼痛评估管理的相关证据。结果 共纳入文献10篇, 包括临床决策1篇, 证据总结2篇, 指南5篇, 专家意见1篇, 专家共识1篇, 从疼痛评估、干预、监测、教育以及组织5个方面汇总最佳证据。结论 脊柱外科术后疼痛管理的证据总结可为临床应用提供循证依据, 在证据转化过程中应结合临床实际制定标准规范医护人员的疼痛管理行为, 降低脊柱外科术后患者疼痛, 提高护理质量。)

摘要：旨在为提高油莎豆的贮藏稳定性，采用微波对油莎豆进行预处理，研究了冷藏（4 ℃）和常温（20~31 ℃）贮藏条件下油莎豆水分含量、脂肪酶活性及其油脂酸值和过氧化值的变化规律，同时测定了油莎豆油的脂肪酸组成和脂质伴随物含量。结果表明：在常温贮藏或冷藏过程中，油莎豆的水分含量、脂肪酶活性及油莎豆油的酸值、过氧化值均呈一定增长趋势，微波预处理显著降低了油莎豆的水分含量、脂肪酶活性和油莎豆油的酸值；常温贮藏和冷藏120 d后，704 W 处理270 s制备的油莎豆油的酸值（KOH）小于4 mg/100 g，显著低于未经微波预处理的油莎豆油，满足国标（GB 2716—2018）的要求；微波预处理对油莎豆油脂肪酸组成无显著影响，但能提高油莎豆油中生育酚和总酚的含量，其分别在400 W处理270 s、704 W处理210 s时达到最高，为41.70 mg/100 g和10.21 mg/100 g；经微波预处理后，油莎豆油植物甾醇含量总体较空白组有所降低，但保留率在73.05%以上。综上，微波预处理对油莎豆的安全贮藏及其油脂中脂质伴随物的溶出有积极作用。In order to improve the storage stability of tiger nut, the tiger nut was pretreated by microwave and stored at low temperature (4 ℃) and room temperature (20-31 ℃), and the indicators′ change including moisture content and lipase activity of tiger nut, and acid value and peroxide value of its oil were studied. Meanwhile, the fatty acid composition and lipid concomitant content of tiger nut oil were investigated. The results showed that during the storage at room temperature or low temperature, the moisture content, lipase activity of tiger nut and acid value, peroxide value of its oil showed an increasing trend, and microwave pretreatment could significantly reduce the moisture content and lipase activity of tiger nut, and acid value of tiger nut oil. After storage for 120 d at low or room temperature, the acid value of oil from tiger nut treated with the microwave power of 704 W for 270 s was less than 4 mgKOH/100 g, which was significantly lower than the control group, still met the requirements of the national standard (GB 2716-2018). The microwave pretreatment couldn′t affect the fatty acid composition of tiger nut oil, however, rendered the content of tocopherol and total phenol of tiger nut oil to a higher level, reaching their highest at 400 W for 270 s and 704 W for 210 s, respectively, which were 41.70 mg/100 g and 10.21 mg/100 g. After microwave pretreatment, the sterol content of the tiger nut oil was lower than the control group, but the sterol retention rate was above 73.05%. In a word, microwave pretreatment positively impacts the storage safety and the dissolution of lipid concomitant of tiger nut oil.

利用理论模式GCITEM，在国际地磁参考场（IGRF）下，模拟了地磁平静条件下的电离层发电机主导的中低纬电离层电势分布，研究了太阳活动、季节、世界时和低层大气潮汐对电离层电势的调节作用。结果表明，各种条件下中低纬电势全局分布基本一致，都具有两个正电势峰值（源）和一个负电荷峰值（汇）；电势分布存在明显的季节和世界时差异；中低纬电离层电势峰值差随着太阳活动的增强明显增加，并在一定太阳活动高值后趋于饱和；周日迁移潮主要影响赤道地区，导致电势峰值差增加，而半周日迁移潮主要影响中纬度地区，导致电势峰值差减小。

This paper summarized the nursing management of the nasogastric enteral nutrition for a patient with endotracheal intubation for acute respiratory failure complicated with severe pneumonia. Nursing interventions such as endotracheal intubation, nursing of enteral nutrition and prevention of aspiration and other issues were carried out to control infection, improve the patient’s pneumonia situation and reduce the occurrence of complications. (本文总结1例急性呼吸衰竭气管插管合并重症肺炎患者鼻饲肠内营养液的护理干预措施, 主要从气管插管、肠内营养的护理以及预防误吸等方面进行干预, 旨在控制感染, 改善患者肺炎症状, 减少并发症的发生。)

为了解决风味（原香和烤香）油茶籽油掺伪浸出油茶籽油的定性判别问题，设计高、低两个掺伪梯度，基于挥发性成分构建并对比分析了定性判别风味油茶籽油掺伪浸出油茶籽油的主成分分析（PCA）模型和逻辑回归模型。结果表明：逻辑回归模型定性判别风味油茶籽油掺伪浸出油茶籽油的能力较强，优于PCA模型；高掺伪梯度下定性判别原香和烤香油茶籽油掺伪浸出油茶籽油，PCA模型的最低检出限分别为20%和60%，而逻辑回归模型的最低检出限均为10%；低掺伪梯度下定性判别原香和烤香油茶籽油掺伪浸出油茶籽油，PCA模型的判别不准确，而逻辑回归模型的最低检出限均为4%。逻辑回归模型能很好地定性判别风味油茶籽油掺伪浸出油茶籽油。 Based on volatile components, principal component analysis (PCA) and logistic regression (LR)models were constructed and compared to solve the problem of qualitative identification of flavor (original/roasted) oil-tea camellia seed oil adulterated with leaching oil-tea camellia seed oil under high and low adulteration gradients.The results showed that LR model had a good ability to qualitatively identify the flavor oil-tea camellia seed oil adulterated with leaching oil-tea camellia seed oil, which was better than that of PCA model. Under the high adulteration gradient, the detection limit of the PCA model for original/roasted oil-tea camellia seed oil adulterated with leaching oil-tea camellia seed oil was 20%/60%, and the detection limit of the LS model was 10%/10%, respectively. Under the low adulteration gradient, the detection limit of LR model for original/roasted oil-tea camellia seed oil adulterated with leaching oil-tea camellia seed oil was 4%/4%, but the discriminative ability of the PCA model was not accurate.The LR model can qualitatively identify flavor oil-tea camellia seed oil adulterated with leaching oil-tea camellia seed oil.

Irrigation of the conjunctival sac is an emergency treatment if there has been chemical injury to the eye, and the ocular drug delivery device is an essential tool for irrigation. This paper introduced the design and application of an adhesive ophthalmic drug delivery device. The adhesive drug delivery device has been design to prevent the leakage of irrigation drugs and improve the patient comfort. (结膜囊冲洗为眼科护理操作的重要操作之一, 受水器是结膜囊冲洗的必备工具。本研究设计一种粘贴式眼科受水器, 可有效阻止冲洗液的外流, 患者使用舒适度高, 有助于提升护理人员工作效率。)

目的比较单精子冷冻和常规冷冻对显微取精患者的胚胎培养及妊娠影响。方法回顾性分析自2018年1月至2021年12月于中山大学附属第六医院生殖医学研究中心行显微镜取精术患者的临床资料，行单精子冷冻共39例307枚成熟卵子为单精子冷冻组，通过SPSS统计软件倾向性评分匹配女方基本助孕信息1：1匹配选择对照组，为常规冷冻组，共410枚成熟卵子，分析单精子冷冻与常规冷冻两组的受精、胚胎培养及移植后妊娠情况。结果单精子冷冻组和常规冷冻组的年龄、体质量指数（BMI）、不孕年限、基础基础卵泡刺激素（FSH）、基础黄体生成素（LH）、基础雌二醇（E2）、抗苗勒管激素（AMH）、窦卵泡计数（AFC）、获卵数、移植胚胎数等一般资料的比较，差异均差异无统计学意义（P>0.05）；两组的受精率、可利用胚胎率、优质胚胎率比较分别为65.8% vs. 60.49%、67.82% vs. 58.87%、70.80% vs. 75.34%，差异均无统计学意义；两组的临床妊娠率为45.45% vs. 70.0%，有统计学差异（P=0.049）。结论显微取精患者若获取精子极少，为增加每颗精子利用机会以及保证后续助孕精子解冻后获取精子，单精子冷冻可为有效选择，但临床妊娠率下降，因例数限制，对后续妊娠的影响还需增加例数再观察分析。

为解决油茶籽油掺伪其他植物油的定性鉴别问题，在油茶籽油中分别掺入大豆油、花生油、葵花籽油、棉籽油、葡萄籽油、菜籽油、棕榈油和米糠油，设置高和低两种不同掺伪梯度，基于14个特征性脂肪酸和甘油三酯指标，运用Python语言构建并对比分析了二分类决策树模型、多分类决策树模型和多层感知机人工神经网络(MLP-ANN)模型用于油茶籽油掺伪定性鉴别的效果。结果表明：高和低掺伪梯度下，二分类决策树模型对油茶籽油掺伪其他植物油的定性鉴别的准确率均达到0.95以上；多分类决策树模型的精确率和准确率在高掺伪梯度下均达到了0.95，但在低掺伪梯度下仅为0.90；在高和低掺伪梯度下，MLP-ANN模型对油茶籽油掺伪定性鉴别的平均精确率均达到0.98，准确率分别达到0.97和0.98。相比于决策树模型，MLP-ANN模型能很好地实现油茶籽油掺伪定性鉴别。 In order to solve the qualitative identification problem of adulterated oil-tea camellia seed oil with other vegetable oils, soybean oil, peanut oil, sunflower seed oil, cottonseed oil, grape seed oil, rapeseed oil, palm oil and rice bran oil were mixed into oil-tea camellia seed oil respectively, two different adulteration gradients of high and low were set up, and based on characteristic fatty acid and triglyceride indicators, the effects of the binary decision tree model, multi-classification decision tree model and multilayer perceptron artificial neural network (MLP-ANN) model for qualitative identification of adulterated oil-tea camellia seed oil were compared and analysed using Python language. The results showed that the accuracy of the binary decision tree model for qualitative identification of oil-tea camellia seed oil adulterated with other vegetable oils under high and low adulteration gradients was above 0.95. The accuracy and precision of the multi-classification decision tree model reached 0.95 at high adulteration gradient, but only 0.90 at low adulteration gradient. Under high and low adulteration gradients, the average precision of MLP-ANN model for qualitative identification of adulterated oil-tea camellia seed oil reached 0.98, and the accuracy reached 0.97 and 0.98 respectively. Compared with the decision tree model, the MLP-ANN model can well realize the qualitative identification of adulterated oil-tea camellia seed oil.

There has been an increasing incidence of delirium which causing long-term consequences of life. This paper summarized the application status quo of tools for assessing delirium at home and abroad, in order to provide reference for standardized evaluation and precise treatment of delirium. (谵妄在临床发生率高, 远期不良后果严重。本研究就目前国内外谵妄工具的使用情况进行总结和分析, 以期为进一步标准化、精准化谵妄评估到治疗提供依据。)

Objective To investigate the risk factors of cardiac arrest and to establish the logistic regression model. Methods Totally 238 patients with mechanical ventilation in a tertiary hospital were selected from September, 2019 to January, 2020. Multiple indicators of cardiac arrest group (n=72) and non-cardiac arrest group (n=166) were compared. Logistic regression was used to establish a risk prediction model, and the model power and its accuracy were evaluated by receiver operating characteristic. Results The study finally included arrhythmia, hypoxemia, acid-base imbalance, septic shock, history of cardiac arrest, multiple organ dysfunction syndrome to construct the risk prediction model. This model’s area under curve of receiver operating characteristic was 0. 909. When the best predicted probability was 0. 343, the sensitivity and specificity of the logistic model were 0. 819 and 0. 855, respectively. Conclusion The risk prediction model has satisfactory prediction effects and can be used to predict the risk of cardiac arrest in patients with mechanical ventilation, providing the reference for management and preventative treatment for high-risk cardiac arrest patients. (目的 探讨影响心脏骤停风险的因素, 并建立Logistic回归预测模型。方法 选取2019年9月—2020年1月医院收治的行机械通气的238例患者作为研究对象, 将心脏骤停组(n=72)和非心脏骤停组(n=166)的各项因素进行对比, 通过Logistic回归分析建立风险预测模型, 并通过ROC曲线检验模型的预测效果。结果 本研究共纳入心律失常、低氧血症、酸碱失衡、感染性休克、心脏骤停病史、多器官功能障碍综合症6个影响因素构建风险预测模型。本研究的ROC下面积为0. 909, 当最佳界值为0. 343时, 灵敏度为0. 819, 特异度为0. 855。结论 本模型预测效果良好, 适用于临床实践, 在机械通气患者中应用此模型可为临床医护人员及时采取预防性管理措施提供参考。)

Objective To investigate the effect of Traditional Chinese Medicine (TCM) nursing interventions for elderly patients undergoing interventional therapy for arteriosclerosis obliterans of lower extremities. Methods Totally 100 elderly patients undergoing interventional therapy for arteriosclerosis obliterans of lower extremities were randomly divided into control group and observation group, with 50 cases in each group. All patients received routine care during the treatment, and those in the observation group received Traditional Chinese Medicine nursing interventions. The effect of intervention on symptoms and vascular function improvement were measured. The patient satisfaction was evaluated by a self-made questionnaire. Results The Symptom Integral Score in both groups decreased after intervention, and Symptom Integral Score in the observation group was lower than that in the control group, with a significant difference (P＜0. 05). T Ankle-brachial Index and artery blood flow velocity were observed. Improvement in both Ankle-brachial Index and artery blood flow velocity were observed in both groups compared to baseline, and better outcomes were observed in the observation group than those in the control group (P＜0. 05). The patient satisfaction score in the observation group was higher than that in the control group (P＜0. 05). Conclusion Implementation of TCM nursing interventions could effectively relieve the symptoms of numbness and pain, and improve the recovery of vascular function. It is worth promoting in clinical practice. (目的 探讨中医特色护理在老年下肢动脉硬化闭塞症患者介入治疗中的应用效果。方法 100例行介入治疗的老年下肢动脉硬化闭塞症患者随机分为对照组与观察组, 各50例。对照组采用常规护理, 观察组在对照组基础上采用中医特色护理干预。观察两组干预前前后症状和血管功能改善情况, 比较两组护理满意度。结果 干预后, 两组症状积分总分较干预前均下降, 且观察组症状积分低于对照组, 差异有统计学意义(P＜0. 05)。干预后, 2组踝肱指数、动脉血流速度均有提高, 且观察组优于对照组, 差异有统计学意义(P＜0. 05)。观察组护理满意度总分高于对照组, 差异有统计学意义(P＜0. 05)。结论 中医特色护理干预应用于老年下肢动脉硬化闭塞症介入治疗中, 能够有效减轻患者麻木、疼痛等症状, 帮助患者改善血管功能, 值得在临床推广。)

This paper summarized the nursing measures for a patient with chronic obstructive pulmonary disease complicated with type II respiratory failure treated by sequential non-invasive positive pressure ventilation via nasal high-flow oxygen therapy. Nursing interventions were carried out in the following ways: non-invasive positive pressure ventilation, medication nursing, enteral nutrition support, pipeline maintenance, skin care and psychological nursing and other issues. Efforts were made to improve the respiratory failure status and various vital signs, control of carbon dioxide retention and reduce the occurrence of complications. By providing patients with a constant, adjustable, high-speed breathing gas mixture formed from air and oxygen, it was aimed to crush the gas left in the nasal cavity, oral cavity and pharynx, and significantly reduce the amount of carbon dioxide inhaled during the next inhalation. The application of sequential treatment with transnasal high-flow oxygen therapy has achieved positive therapeutic results in patients with hypoxic respiratory failure. (本文总结经鼻高流量氧疗序贯无创正压通气治疗1例慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭患者的护理干预措施, 主要从无创正压通气护理、用药护理、肠内营养支持、管路护理、皮肤护理及心理护理等方面进行干预, 旨在改善患者呼吸衰竭状况和各项生命体征, 控制二氧化碳潴留病情, 减少并发症的发生。通过为患者提供恒定的、可调节的高速空氧混合气体, 冲刷患者呼气末残留在鼻腔、口腔及咽部的解剖无效腔的气体, 可明显减少患者下一次吸气时吸入的二氧化碳的含量。经鼻高流量氧疗序贯治疗的应用, 对低氧性呼吸衰竭患者具有积极的治疗效果。)

This paper summarized the experience of Traditional Chinese Medicine (TCM) enema and emergency care for 8 patients with acute drug poisoning. Based on the routine emergency management, TCM enema was adopted to relieve the symptoms of drug poisoning, prevent the complications, reduce mortality risk and improve the recovery of body function. (本文回顾中药灌肠治疗8例药物中毒患者的急救和护理措施。在常规急救治疗的基础上, 采用中药灌肠及中医特色护理干预可有效控制中毒症状, 对提高急救治疗效果、降低并发症和死亡风险、促进机体功能恢复具有积极意义。)

Using 88 counties in Guizhou Province as the research unit, the spatial distribution characteristics of their economical and intensive land use efficiency were analyzed using the entropy value method and the ArcGIS spatial analysis function. The results showed that the regional differences in economical and intensive land use efficiency in the east and west of Guizhou Province were obvious, and the overall distribution trend was high in the west and low in the east. The distribution of economical and intensive land use efficiency in counties of Guizhou Province had a strong positive spatial correlation. The hotspots were located in Guanshanhu, Wudang, and Baiyun districts of Guiyang City and Huichuan, Honghuagang, Bozhou, Renhuai and Suiyang counties of Zunyi City; the cold spots were mainly concentrated and distributed in Shiqian and Jiangkou in the southern part of Tongren, and Shibing and Zhenyuan in the northern part of Qiandongnan Prefecture. [ABSTRACT FROM AUTHOR]

Objective To investigate the application value of serum and aqueous humor insulin-like growth factor 1 (IGF-1) and superoxide dismutase (SOD) levels in predicting postoperative posterior capsular opacification (PCO) in patients with diabetic cataract (DC). Methods Totally 120 patients with DC were selected as the DC group, and 77 patients with simple cataract who underwent surgical treatment were selected as the control group. All DC patients were followed up for at least 6 months after surgery. According to the presence or absence of PCO, DC patients were divided into PCO group (21 cases) and non-PCO group (99 cases). The levels of IGF-1 and SOD in serum and aqueous humor were detected by enzyme-linked immunosorbent assay before operation, and the related data of PCO in DC patients after operation were collected. Multivariate Logistic regression analysis was used to analyze the effects of IGF-1 and SOD in serum and aqueous humor on PCO in patients with DC after operation; the receiver operating characteristic (ROC) curve was drawn, and the area under the curve was used to compare the value of serum and aqueous humor IGF-1 and SOD in predicting PCO in patients with DC. Results The levels of IGF-1 in serum and aqueous humor in the DC group were higher than those in the control group, and the levels of SOD were lower than those in the control group (all P<0. 05). The age, C-reactive protein level and the proportion of hydrophilic intraocular lens in the PCO group were higher than those in the non-PCO group (all P<0. 05). Hydrophilic intraocular lens and high level of IGF-1 in aqueous humor were risk factors for PCO in patients with DC (all P<0. 05), and high level of SOD in aqueous humor was a protective factor (all P<0. 05). The area under the curve of serum and aqueous humor IGF-1 and SOD in predicting postoperative PCO in DC patients was 0. 749, 0. 720, 0. 859, and 0. 884, respectively. The area under the curve of aqueous humor IGF-1 and SOD in predicting postoperative PCO in DC patients was greater than that of serum IGF-1 and SOD (all P<0. 05). The area under the curve of aqueous humor IGF-1 and SOD in predicting postoperative PCO in DC patients was 0. 967, which was greater than that of aqueous humor IGF-1 and SOD alone (both P<0. 05). Conclusions The increase of IGF-1 level and the decrease of SOD level in aqueous humor are related to the occurrence of postoperative PCO in DC patients. IGF-1 and SOD in serum and aqueous humor can be used to predict the occurrence of postoperative PCO in DC patients, and the predictive value of IGF-1 combined with SOD in aqueous humor is higher. [ABSTRACT FROM AUTHOR]

Objective To examine the association between metabolic score of insulin resistance (METS-IR) and bone mineral density (BMD), as well as osteoporosis in patients with type 2 diabetes mellitus (T2DM). Methods A total of 370 patients with type 2 diabetes mellitus were divided into osteoporosis group and non-osteoporosis group. General data and bone mineral density of patients were collected and METS-IR was calculated. The relationship between METS-IR and bone mineral density was analyzed. Results The level of METS-IRin male T2DM patients with osteoporosis was notably lower than that in the non-osteoporosis group P < 0.05 ) Analysis using Spearman correlation revealed a significant positive relationship between METS-IR and total hip bone mineral density (BMD), as well as lumbar spine and femoral neck BMD (all P < 0.001 ) Upon controlling for potential confounders, logistic regression analysis demonstrated that male and female patients with with T2DM, METS-IR levels served as a protective factor against osteoporosis OR = 0.916, 95% CI:0.870-0.964, P = 0.001 ) and ( OR = 0.945, 95% CI: 0.898-0.995, P = 0.033 ), respectively. Conclusion In patients with T2DM, the METS-IR is closely associated with BMD in the femoral neck, hip, and lumbar spine. METS-IR may serve as a protective factor for bone density, indicating potential clinical reference value. [ABSTRACT FROM AUTHOR]

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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Mental Health Journal / Zhongguo Xinli Weisheng Zazhi is the property of Chinese Mental Health Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Scientiarum Naturalium Universitatis Sunyatseni / Zhongshan Daxue Xuebao is the property of Sun-Yat-Sen University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article reports on a 78-year-old male patient with advanced pulmonary sarcomatoid carcinoma with positive PD-L1 expression, who achieved partial remission (PR) and progression-free survival (PFS) of 30 months with sindilizumab and amilorotinib. Grade 2 hypertension and other transient cardiac problems occurred during treatment, but overall quality of life was good. [ABSTRACT FROM AUTHOR]

Objective To explore the mechanisms by which chlorogenic acid combined with forsythoside regulates cytokine storms through network pharmacology and in vitro experiments. Methods The targets of chlorogenic acid and forsythoside were predicted using Swiss Target Prediction, PharmMapper, SEA, and TCMSP databases. Targets related to cytokine storms were retrieved from GeneCards, OMIM, DRUGBANK, and DisGeNET databases. Intersection targets were identified and depicted in a Venn diagram. A protein interaction network was constructed using the STRING database and Cytoscape software. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the DAVID database. A cytokine storm model was established in RAW264.7 macrophages induced by lipopolysaccharide (LPS). Cell viability was assessed using the Cell Counting Kit-8(CCK-8) method. Nitric oxide (NO) levels in the supernatant were measured by the Griess method. Levels of inflammatory cytokines, tumor necrosis factor-alpha(TNF-α), interleukin-6(IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2(COX-2) were determined by enzyme-linked immunosorbent assay (ELISA). The expression of TNF receptor-associated factor 4 (TRAF4), TNF receptor-associated factor 6 (TRAF6), and phosphatidylinositol 3-kinase 3(PIK3C3) proteins were analyzed by Western blot. Results Network pharmacology analysis identified eight core network targets for the treatment of cytokine storms with chlorogenic acid and forsythoside, including serine/ threonine-protein kinase (AKT1), albumin (ALB), hypoxia-inducible factor 1-alpha (HIF1A), IL-6, matrix metalloproteinase-9 (MMP-9), peroxisome proliferator-activated receptor gamma (PPARG), tyrosine kinase (SRC), and Toll-like receptor 4(TLR4). Key pathways included the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) signaling pathway. In vitro experiments showed that compared to the control group, levels of NO, TNF-α, IL-6. iNOS, and COX-2 were significantly higher in the model group (P<0.001). After treatment, levels of NO, TNF-α, IL-6, INOS, and COX-2 significantly decreased compared to the model group(P< 0.001). The combined treatment of chlorogenic acid and forsythoside (11) more effectively reduced inflammatory indicators compared to single treatments (P<0.001). Protein expression of TLR4, TRAF6, PIK3C3, and phosphorylation levels of PIK3C3 significantly decreased in the treatment group compared to the model group. Conclusion Chlorogenic acid combined with forsythoside synergistically suppresses the expression of pro-inflammatory cytokines and regulates cytokine storms, potentially through the TLR4/TRAF6/PIK3C3 signaling pathway. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Practical Medicine / Shiyong Yixue Zazhi is the property of Journal of Practical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Practical Medicine / Shiyong Yixue Zazhi is the property of Journal of Practical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: The researchers noted that upon embedding clinical-grade catgut and polyglycolide-co-lactide threads in the normal human “Zusanli” (ST36) acupoint, the local area displayed temporal and inflammatory stimulatory effects, resulting in thread differentiation. However, the underlying mechanism behind thread involvement remains to be studied. OBJECTIVE: To investigate the expression levels of calcitonin gene-related peptide, 5-hydroxytryptamine, leukotriene B4, and bradykinin at point “Zusanli” (ST 36) in rats after embedding catgut and polyglycolide-co-lactide respectively at different time points. METHODS: 110 male SD rats were divided into a blank group (10 rats), a catgut embedding group (50 rats), and a polyglycolide-co-lactide embedding group (50 rats) according to the random number table method. In the blank group, no thread was embedded. In catgut embedding group and the polyglycolide-colactide embedding group, the thread was embedded in the left side of the ST36 acupoint once. Tissue was collected from the left side of the ST36 acupoint area 8 hours, 3, 7, 14, and 21 days after embedding. The expression levels of calcitonin gene-related peptide and 5-hydroxytryptamine were detected by immunohistochemistry, and the contents of leukotriene B4 and bradykinin were detected by ELISA. RESULTS AND CONCLUSION: (1) Compared with the blank group, the expression of calcitonin gene-related peptide, 5-hydroxytryptamine, bradykinin, and leukotriene B4 was significantly increased in the 8 hours, 3, 7, 14, and 21 days of the catgut embedding group (P < 0.05); calcitonin gene-related peptide expression was significantly increased in 8 hours, 3, 7, and 14 days in the polyglycolide-co-lactide embedding group (P < 0.05); the expression of bradykinin was significantly increased in 8 hours, 3, and 7 days (P < 0.05); the expression of leukotriene B4 was significantly increased at 8 hours, 3, 7, 14, and 21 days (P < 0.05). (2) Compared with the polyglycolide-co-lactide embedding group, the expression of calcitonin gene-related peptide was increased at 7, 14, 21 days after thread embedding (P < 0.05), and the expression of 5-hydroxytryptamine was increased at 8 hours, 3, 7, 14 and 21 days after thread embedding (P < 0.05); contents of leukotriene B4 and bradykinin in tissues were increased at 8 hours, 3, 14 and 21 days after embedding (P < 0.05) in the catgut embedding group. (3) The results show that calcitonin gene-related peptide, 5-hydroxytryptamine, leukotriene B4, and bradykinin in the acupoint region alter after catgut embedding in the ST36 of rats, as well as the alteration of calcitonin gene-related peptide, leukotriene B4, and bradykinin is found in the acupoint region after polyglycolide-colactide embedding in rats, which may be one of the mechanisms involved in the local time sensitive stimulus effects caused by embedding threads at acupoints. Moreover, there is a discernible difference between the two thread types. [ABSTRACT FROM AUTHOR]

该文报道了1例药物临床试验使用双特异性抗体[磷脂酰肌醇蛋白聚糖3(GPC3)和 CD3]发生 药物外渗致局部皮下细胞因子释放综合征患者的护理体会, 双特异性抗体类药物机制虽区别于传统的化疗药 物, 但毒性不容小觑, 静脉输注时仍然首选中心静脉, 同时, 药物应尽可能进行稀释. 对于药物毒性不明的双特 异性抗体类药物, 若发生药物外渗, 应参照发泡性化疗药物进行管理,早期即进行封闭治疗, 做好外渗部位的病 情观察与记录, 指导患者进行手臂功能锻炼,使用中药、西药交替外敷,必要时进行全身治疗, 同时注重患者的 心理护理. 综合上述处理措施,可减轻外渗症状, 避免免疫药物外渗导致的严重不良事件, 确保患者的安全. [ABSTRACT FROM AUTHOR]

Patient safety competence refers to the knowledge, skills and attitudes that medical staff need to reduce unnecessary injuries related to health care to the lowest acceptable level, which is of great significance for improving medical quality and ensuring patient safety. In this paper, the influencing factors and intervention methods of patients safety competence were reviewed by using the scope review method, in order to provide reference for further improving patients safety competence. [ABSTRACT FROM AUTHOR]

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Coastal wetland has many ecological service functions such as shoreline protection, biodiversity conservation, material production, energy exchange, and providing leisure and scientific research space. Vegetation is an important part of coastal wetland, and its distribution, structural changes and other landscape information reflect the health status of coastal wetlands to a large extent. In order to analyze the feasibility of identifying vegetation species under ebb and flow of coastal wetland by remote sensing, two periods of Landsat 8 ebb and flow images were selected to classify vegetation in coastal wetland of Yellow River Delta based on statistical discriminant, decision tree supervised classification and unsupervised classification methods. The results showed that the classification effect of statistical discriminant supervised classification was the best, the classification accuracy was up to 97%, and the vegetation types could be accurately distinguished, and the ebb and flow had little effect on the classification results. The research indicated that remote sensing technology is feasible to extract vegetation information of coastal wetland under different tidal conditions, which can provide technical and data support for vegetation monitoring, ecological restoration and blue carbon storage estimation of coastal wetland. [ABSTRACT FROM AUTHOR]

In order to study the effect of polyethylene glycol phase change material on the snow melting and ice melting ability of asphalt mixture, phase change material was added in the asphalt mixture mixing process, and the applicability of polyethylene glycol phase change material was considered, two gradations of AC-10 and AC-13 were adopted, and three methods were designed for evaluation: sponge freezing test, ice adhesion test and ice melting test. The results show that the PEM will accelerate the thawing of the sponge, and the higher the content of the PCM, the greater the light intensity, and the shorter the freezing time of the sponge and asphalt mixture・ Polyethylene glycol phase change material can greatly reduce the adhesion between ice and asphalt pavement; the cumulative ice melting quality and ice melting rate of phase change asphalt mixture are greater than those of ordinary asphalt mixture, and the increase of phase change material content and the decrease of ambient temperature will improve its relative snow melting and ice melting capacity・ Polyethylene glycol phase change material has a good effect of melting snow and ice in different gradations, and can be applied to winter pavement de-icing. [ABSTRACT FROM AUTHOR]

Objective To evaluate the factors influencing poor visual outcomes in patients with retinal vein occlusion (RVO) after receiving anti-vascular endothelial growth factor (VEGF) therapy. Methods This study included patients diagnosed with RVO and treated with anti-VEGF therapy at Qingyuan Hospital affiliated with Guangzhou Medical University from June 2018 to June 2023. Clinical and ocular data were collected. Patients were divided into two groups based on their final best-corrected visual acuity (BCVA) in logMAR: a poor vision group (final logMAR BCVA＞1) and a control group (final logMAR BCVA≤1). Characteristics of the two groups were compared, and risk factors for poor visual outcomes were analyzed. Results Among 177 patients meeting the inclusion criteria, 70 were in the poor vision group and 107 were in the control group. The poor vision group had significantly higher rates of older age, central RVO, inner retinal layer disorganization, and external limiting membrane disruption (P＜0.05). Baseline vision and hematocrit were significantly lower in the poor vision group (P＜0.05). Multivariate logistic regression analysis showed that carotid artery disease (OR=3.40, 95% CI: 1.22-12.44; P＜0.05), baseline vision (OR=0.01, 95% CI: 0.00-0.005; P＜0.001), inner retinal layer disorganization (OR=7.80, 95% CI: 2.33-26.15; P＜0.05), external limiting membrane disruption (OR=6.87, 95% CI: 2.05-23.00; P＜0.05), and hematocrit (OR=1 415 526, 95% CI: 21.69-9.24×1010; P＜0.05) were significantly associated with poor visual outcomes after anti-VEGF therapy in RVO patients. Conclusion Carotid artery disease, poor baseline vision, inner retinal layer disorganization, external limiting membrane disruption, and lower hematocrit are risk factors for poor visual outcomes in RVO patients after anti-VEGF therapy. [ABSTRACT FROM AUTHOR]

Objective To investigate the mechanism of Zuogui Pills (ZGP) on improving the stemness of ovarian germline stem cells (OSCs) in ovarian aging rats through the gap junction protein connexin 43 (Cx43) phosphorylation based on the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway. Methods Eight week-old female SD rats were randomly divided into control (CON), model (cyclophosphamide, CTX), ZGP and dehydroepiandrosterone (DHEA) groups, six rats in each group. CTX was injected intraperitoneally for 15 days to establish a model for ovarian aging, and then ZGP (1.85 g·kg-1) or DHEA (8.1 mg·kg-1) was administered by gavage once daily for 30 days. Follicle count at different stages and pathological changes of ovarian tissues were observed by HE staining. ELISA was used to detect serum levels of anti-mullerian hormone (AMH), follicle- stimulating hormone (FSH), and estradiol (E2) . The expression levels of related proteins (PCNA, MVH, Oct4, Cx43, p-Cx43, EGFR, AKT、p-AKT) in ovarian tissue were detected by Western Blot. Results Compared with the CON group, rats in CTX group had significantly reduced body mass (P＜0.05) and ovarian mass (P＜0.05). The number of primordial follicles decreased significantly (P＜0.01). Serum FSH level increased remarkably (P＜ 0.01), while AMH and E2 levels showed a downward trend (P＞0.05). The protein expressions of Oct4, MVH, PCNA, EGFR, p-AKT/AKT, p-Cx43 (Ser368) /Cx43 and Cx43 in ovarian tissue were obviously decreased (P＜ 0.05, P＜0.01). Compared with the model group, the body mass of rats in ZGP group was significantly increased (P＜0.05), as well as ovarian mass and ovarian coefficient were remarkably increased (P＜0.01). The number of primordial follicles were increased significantly (P＜0.01), and E2 level increased significantly (P＜0.05). The protein expressions of Oct4, MVH, PCNA, EGFR, p-AKT/AKT, p-Cx43 (Ser368) /Cx43 and Cx43 in ovarian tissue were all increased significantly (P＜0.05, P＜0.01). Conclusion ZGP may ameliorate ovarian aging by maintaining the stemness of OSCs. Its mechanism of actions is related to the PI3K/AKT signaling pathway and gap junction protein phosphorylation. [ABSTRACT FROM AUTHOR]

The synthesis of a novel complex [Ni3 (L3 -)2 (1,4-bib)4 (H2 O)2]·5H2 O (1) with three-dimensional framework structure was achieved through a hydrothermal reaction, employing 5-((4-carboxylphenoxy)-methyl) isophthalic acid (H3 L) as the main oxygen-containing ligand, complemented by the N-donor ligand 1,4-bis(1H-imidazol-1-yl)benzene (1,4-bib), and Ni(II) ions. The structure of complex 1 was characterized by single crystal X-ray diffraction, powder X-ray diffraction, and elemental analysis. Complex 1 is crystallized in the triclinic crystal system of P-1 space group, and its crystallographic parameters are a =1. 260 5(7) nm, b = 1. 349 1(7) nm, c = 1. 364 8(7) nm, α = 111. 913(8)°, β = 117. 251(7)°, γ =90. 732(8)°, V =1. 866 2(18) nm3, Z =1, Mr =1 769. 66, F(000) =916, μ = 0. 84 mm-1, Dc = 1. 575 mg·m-3, S =1. 06, R1 =0. 056, wR2 =0. 159. The joint contribution of semi-rigid tricarboxylic acid ligand L3 -, rigid 1,4-bib and also with Ni(II) ion to form a predictable high-dimensional structure. Complex 1 is a three-dimensional network constructed through the coordination of N and O atoms with Ni ion and the structural extension of the ligand. In addition, the magnetic properties of Ni(II) compound containing single d electron center were studied: the carboxyl group in mononuclear complex 1 only binds to one cation, resulting in magnetism in the solid being determined by the behavior of single metal ions. Variable temperature magnetic susceptibility of　χmT in complex 1 can be described by zero field splitting. [ABSTRACT FROM AUTHOR]