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目的　观察低剂量硼替佐米联合环磷酰胺（ＣＴＸ）治疗多发性骨髓瘤（ＭＭ）的疗效。方法　将６８例初治 ＭＭ患者随机分为Ａ组３５例和Ｂ组３３例，均予低剂量硼替佐米及地塞米松，Ａ组联合ＣＴＸ，Ｂ组联合沙利度胺。化 疗４～１０个疗程，观察两组疗效，并随访平均３６个月。结果　化疗结束后，Ａ组完全缓解率２８．５７％、深度反应率 ８２．８６％，Ｂ组分别为９．０９％、４５．４５％，Ｐ均＜０．０５。两组疾病进展时间、总生存时间及主要不良反应比较，Ｐ均＞ ０．０５。结论　低剂量硼替佐米联合ＣＴＸ治疗ＭＭ可提高近期疗效，且不增加不良反应，但远期疗效未提高。 [ABSTRACT FROM AUTHOR]