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Objective To explore the clinical efficacy and safety of Changlong Kaixuan Xingqiao powder in treating tinnitus of spleen deficiency and blood stasis. Methods A total of 90 patients with tinnitus of spleen deficiency and blood stasis who visited the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University from February 1 to December 31, 2022 were selected and randomly divided into the treatment group(45 cases) and the control group (45 cases) by the random number table method. The scores of tinnitus evaluation questionnaire (TEQ), tinnitus handicap inventory (THI), visual analogue scale (VAS).as well as Traditional Chinese Medicine (TCM) syndrome integral, clinical total effective rate, and incidence of adverse reactions were compared between the two groups. Results There were no statistically significant differences in the TEQ, THI, VAS scores, and TCM syndrome integral between the two groups before treatment (P>0.05). After treatment, the TEQ, THI, VAS scores, and TCM syndrome integral of the two groups were lower than those before treatment. with statistically significant differences (P<0.05). After treatment, the TEQ, THI, VAS scores, and TCM syndrome integral of the treatment group were lower than those of the control group, with statistically significant differences (P<0.05). The clinical total effective rate of the treatment group was higher than that of the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The clinical efficacy of Changlong Kaixuan Xingqiao powder in treating tinnitus is accurate and safe. [ABSTRACT FROM AUTHOR]

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目的分析川、滇、黔、渝结合部地区变应性鼻炎(AR)过敏原检测数据分布特点。方法选取2015年7月至2019年11月就诊于西南医科大学附属中医医院耳鼻喉科门诊,且临床诊断为AR的患者共747例作为研究对象,对患者的外周血进行过敏原特异性免疫球蛋白E(IgE)抗体检测并记录各项数据。结果患者血清特异性IgE总阳性率为88.09%;在658例阳性患者中,屋尘螨/粉尘螨过敏原血清特异性IgE阳性率最高为61.71%,其次为屋尘(32.66%)、柏树/榆树/梧桐/柳树/杨树(28.78%);男性患者的检出阳性率为87.60%,女性患者为88.59%,男女患者阳性率比较,差异有统计学意义(χ2=0.174,P>0.05)。各季度屋尘螨/粉尘螨阳性率比较,差异无统计学意义(χ2=7.867P<0.05),其中以第三、四季度阳性检出率最高。结论屋尘螨/粉尘螨为川、滇、黔、渝结合部地区AR患者最主要的过敏原,第二、三季度为疾病高发期,利用此检测方式对于AR诊断,具有可行性,且能提供确切的过敏原,找到病因,临床根据检测结果进行相应治疗方法。 [ABSTRACT FROM AUTHOR]

Objective T o explore the part mechanism of Buzhong Yiqi Recipe in interfering with laryngeal squamous cell carcinoma (LSCC) cell lines. Methods Using literature review and bio information analysis methods, the main taget gene proteins were screened out: miRNA 138 5p, S0X9, YAPl, FOX Cl, combined wit h LSCC cell line culture in vitro and normal saline (control group ), Chinese medicine compound ( Buzhong Yiqifang granule freeze dried powder, traditional Chinese medicine compound group ) control intervention experiment, using Real time fluorescent quantitative polymerase chain reaction and Western blotting [Glyceral dehyde3 phosphate dehydrogenase (GAPDH) as standard internal reference control], the ex pression differences of the above mentioned screening indicators were tested and verified respectively. Results Compared with t he control group, the expression level of miRNA 138 5p in the Chinese medicine compound group was higher, and the difference was statistically significant (P < O. OS). T he expression levels of SOX9 and FOXC1 protein in the traditional Chinese medicine compound group were lower than t hose in the control group, and t he differences we re statistically significant (PO. OS) . Conclusion Buzhong Yiqi Recipe (Traditional Chinese Medicine Classics) can down regulate t he expression of SOX9 and FOXC1 protein thro ugh miRNA 138 5p, and inhibit LSCC cell line. [ABSTRACT FROM AUTHOR]

Objective To explore the possible mechanism of Hezhong zhiqiu granules in the treatment of allergic rhinitis (AR) based on the Toll-like receptor(TLR)- nuclear transcription factor-κB(NF-κB) pathway. Methods 12 AR patients (treatment group) admitted to the Department of Otolaryngology of Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University from November 1,2017 to November 30,2018 and 5 healthy volunteers (healthy control group) during the same period were selected as the research objects. Patients with AR were given oral and discontinued treatment with Hezhong zhiqiu granules, and healthy volunteers were not given any intervention. The venous blood and mucosal tissues of the nasal cavity and nasal mound region were collected from patients before and after treatment and healthy volunteers only before treatment, and stored in a refrigerator at -80 ℃. Enzyme-linked immunosorbent assay was used to detect the expression levels of interferon-γ (IFN-γ) and interleukin-4 (IL-4) in venous blood. Fluorescence quantitative polymerase chain reaction and western blotting were used to detect the RNA and protein changes of TLR4 and NF-κB in mucosal tissues in the nasal cavity and nasal collum area. Results Compared with the healthy control group, the expression level of IFN-γ in the serum of patients in the treatment group before treatment was down-regulated, and the expression level of IL-4 was up-regulated, and the differences were statistically significant (P <0.05). TLR4 in the nasal cavity and nasal colloid mucosa of the treatment group and NF-κB mRNA gene protein expression levels were up-regulated at the same time, the differences were statistically significant (P <0.05). After treatment, the above three indicators of patients in the treatment group were negatively correlated with those before treatment (P <0.05). Conclusion Hezhongzhiqiu granules may be able to treat AR by regulating the TLR4-NF-κB pathway. [ABSTRACT FROM AUTHOR]

Objective To explore the influence of Wuhuang decoction lavage on the expression of IT-8 and intercellular cell adhesion molecule-1 (ICAM-1) in sinus secretions of fungal rhinosinusitis (FRS) after operation. Methods A randomized controlled trial was used ,60 FRS patients after nasal endoscopic surgery,who were received in the hospital from January 9th 2013 to September 30th 2016,were divided into the treatment group and the control group according to the random number generated by computer,30 cases in each group. The patients in the treatment group were lavaged with 100 mL Wuhuang decoction through sinuses,once a day for 4 weeks as a period; the patients in the control group were lavaged with fluconazole injection,the frequency and the dosage were the same as the treatment group. The expression of IT-8 and ICAM-1 in sinuses secretion before and 1 month after treatment were determined, moreover the efficacy was evaluated by endoscopic examination 6 months after operation. Simultaneously,5 healthy participants from the school were enrolled as the healthy control group,the expression of IT-8 and ICAM-1 were detected in 1 mC recycling residual in nasal cavity after lavaging with 100 mh normal saline. Results The difference had statistical significance (p

Objective To explore the optimal scheme of Chinese medicine Wuhuang decoction for nasal lavage after operation of chronic rhino-sinusitis. Methods 45 patients with chronic rhino-sinusitis diagnosed by otorhinolaryngology Department of the Affiliated Hospital of Traditional Chinese University from April to December 2017 were selected and randomly divided into treatment group 1, treatment group 2 and treatment group 3, each group of 15 patients, who were treated with Wuhuang decoction for nasal lavage. The scores of conscious symptoms, tolerance to nasal lavage and endoscopic Lund-Kennedy were given at half month, one month and three months after operation respectively. Results At half a month of lavage, one month of lavage and three months after operation, the scores of conscious symptoms and Lund-Kennedy scores of nasal endoscopy in the treatment group 1 and the treatment group 2 were lower than those in the treatment group 3, and the differences were statistically significant (P<0.05). At 1 month of lavage and 3 months after operation, there was no significant difference in the scores of conscious symptoms between the treatment group 1 and the treatment group 2(P>0.05). At 1 month of lavage, the tolerance score of nasal lavage in the treatment group 2 was lower than that in the treatment group 1 and the treatment group 3, and the difference was statistically significant (P<0.05). Conclusion The best treatment for chronic rhino-sinusitis after operation is to lavage once a day in the first half month and once every other day. [ABSTRACT FROM AUTHOR]