By consulting the ancient Chinese medicine classics and analyzing the theoretical connotation of “strengthening vital qi and removing toxicity” and “removing toxicity and recuperating vital qi”, this paper explores the similarities and differences between “strengthening vital qi and removing toxicity” and “removing toxicity and recuperating vital qi” in the treatment of malignant tumors. “Strengthening vital qi and removing toxicity” and “removing toxicity and recuperating vital qi” are both based on “vital qi” and “ toxin”, which are the two bases of tumor growth and prognosis. “ Strengthening vital qi and removing toxicity” emphasizes strengthening vital qi, correcting deviation, and dispersing toxin, and takes “strengthening vital qi” as the priority. The specific method include nourishing yin and warming yang, regulating qi and dispersing depression, and invigorating the spleen and kidney. “ Removing toxicity and recuperating vital qi ” pays attention to removing toxicity, eliminating pathogens, and recuperating health, with the key objective being “ removing toxicity”. The specific method include attacking excessive pathogens, finding the cause and removing toxicity, and using toxic medicines to enhance the effects on tumors. Through the application of clinical events, this paper demonstrates the feasibility and efficacy of the two methods, providing new ideas for clinical tumor treatment, which is of great guiding significance. [ABSTRACT FROM AUTHOR]