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Objective: To explore the predictive value of intracranial pressure parameters combined with serum caveolin-1 and aquaporin-4（AQP-4） on the poor prognosis of patients with hypertensive intracerebral hemorrhage （HICH） after operation. Methods: 106patients with HICH who were admitted to Hebei Provincial Chest Hospital from January 2020 to January 2022 were selected, and the patients were followed up for 3 months after operation. The patients were divided into good prognosis group（55 cases） and poor prognosis group（51 cases） according to Glasgow Outcome Scale （GOS） score. Intracranial pressure parameters [pressure response index （PRx）, mean wave amplitude （MWA） and intracranial pressure dose under the threshold of 20 mm Hg（Dicp20） ]were monitored after operation, and serum caveolin-1 and AQP-4 levels were detected. Multivariate logistic regression was used to analyze the factors of poor prognosis in patients with HICH after operation. The value of intracranial pressure parameters combined with serum caveolin-1 and AQP-4 in predicting postoperative poor prognosis of patients with HICH was analyzed by receiver operating characteristic curve （ROC）.Results: The PRx, MWA, Dicp20 and serum caveolin-1, AQP-4 levels in the poor prognosis group were higher than those in the good prognosis group （P ＜0.05）. Low preoperative Glasgow coma score （GCS） score, high PRx, high Dicp20, high caveolin-1 and high AQP-4 were risk factors for poor prognosis of HICH（P＜0.05）. The area under the curve of combining PRx, Dicp20, caveolin-1 and AQP-4 to predict poor prognosis of HICH patients at 3 months after operation was 0.823, which was larger than that predicted by PRx,Dicp20, caveolin-1 and AQP-4 alone. Conclusion: High PRx, Dicp20, caveolin-1 and AQP4 are risk factors for postoperative poor prognosis in patients with HICH, and the combination of intracranial pressure parameters PRx, Dicp20 and serum caveolin-1, AQP4 has a high value in predicting postoperative poor prognosis in patients with HICH. [ABSTRACT FROM AUTHOR]