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In order to effectively manage the groundwater, this paper provided a method of choosing the monitoring wells and determining controlled and assessed water level in over-exploitation areas from the perspective of regional and depression cone areas control. For the whole over-exploitation areas, Thiessen polygon method was used to assign control areas to each observation well, and the ratio of the control area of each well to the total area of the region was used as a weight to calculate the weighted average water level of the areas. Then, according to the proximity to the average water level, one regional water level of the controlled well was selected, regarding the water level of the controlled well at the end of the most recent normal year as the controlled and assessed water level. However, if the assessed year was a dry year, assessed water level should set slackness. For groundwater depression cone areas, it used the water level contour map to judge the distribution of the depression cone, and then chose a controlled well which was located near the center of the cone. Then, it similarly regarded the water level of the controlled well at the end of the most recent normal year as controlled and assessed water level. Applying this method to Guantao County, Hebei Province, the monitoring wells of W16 and W17 were selected as regional and depression cone areas of the controlled wells respectively. When the government had not formulated a plan for the water level recovery, the regional controlled water level was determined as 17.13 m. When the government had formulated a plan for the water level recovery (for example, the water level was recovered by 0.5 m within 5 years), the regional controlled water level was needed to increase by 0.1 m every year on the basis of 17.13 m. The assessed water level was equal to the controlled water level in wet and normal years, but the assessed water level in dry years was equal to the controlled water level minus 0.93 m (slackness). The controlled and assessed water levels in the depression cone areas were all determined to be 12.19 m. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of Life′s Simple 7 (LS7) intervention on chemotherapy-related cardiovascular system damage in HER2 positive patients with breast cancer after radical surgery. Methods A total of 120 HER2 positive patients who received standardized chemotherapy for breast cancer were randomly divided into control group and LS7 group. The control group was addressed with standard chemotherapy scheme, and LS7 group was treated with LS7 intervention for 12 months on the basis of the control group. The improvement effect of cardiovascular system damage in the two groups was evaluated by comparing the degree of cardiovascular system damage, anxiety, depression, and quality of life before and after treatment. Results Compared with the control group, the LS7 group had better overall LS7 score and 7 cardiovascular health indicators (P < 0.05). The LS7 group had higher LVEF (P < 0.05), lower NT-proBNP (P < 0.05), lower anxiety and depression score (P < 0.05), and higher quality of life score (P < 0.05). Conclusion LS7 intervention can significantly reduce chemotherapy-related cardiovascular system damage in HER2 positive breast cancer patients and improve the mental health and quality of life of breast cancer patients, which is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

BACKGROUND: In recent years, there have been many studies on the prevention and treatment of femoral head necrosis with traditional Chinese medicine. A variety of single Chinese medicines, Chinese medicine monomers and Chinese medicine compounds can regulate bone metabolism, lipid metabolism, and oxidative stress by targeting signaling molecules. The prevention and treatment of femoral head necrosis by translation-related signaling pathways has become a research hotspot. OBJECTIVE: To expound the global research progress in hormone-induced femoral head necrosis treated with Chinese medicine, in order to provide some ideas for the treatment of hormone-induced femoral head necrosis. METHODS: CNKI, WanFang, VIP, SinoMed, PubMed, Embase, and Web of Science databases were searched with the search terms “glucocorticoids, avascular necrosis of the femoral head, ANFH, pathogenesis, signal path, Chinese medicine compound, oxidative stress” in Chinese and English. Literature was retrieved on Chinese medicine compounds and active ingredients for intervention of the signaling pathway related to hormone-induced femoral head necrosis. A total of 71 documents were included according to the inclusion and exclusion criteria. RESULTS AND CONCLUSION: Chinese medicine may treat hormone-induced femoral head necrosis through multiple signaling pathways. Total saponins of Panax notoginseng, total flavonoids of Rhizoma Drynariae, and resveratrol glucoside promote osteoblast proliferation and differentiation and inhibit osteoclast formation by regulating the level of β-catenin protein and the formation of β-catenin-TCF/LEF complex via the Wnt/β-catenin signaling pathway. Recipes for invigorating blood and reinforcing marrow, warming yang and tonifying kidney, and relieving bone bi-syndrome maintain osteoblast-osteoclast dynamic balance and bone homeostasis by regulating the OPG/RANK/RANKL pathway. Puerarin, salidroside, allicin, and icariin influence the proliferation and apoptosis of osseous cells and angiogenesis of microvascular endothelial cells in the femoral head via the PI3K/Akt signaling pathway. Ginsenosides can down-regulate the expressions of superoxide dismutase and catalase by interfering with the Keapl-Nrf2-ARE signaling pathway, thereby attenuating oxidative stress damage. Gastrodin, lutein, and astragaloside IV can promote the proliferation and differentiation of osteoblasts by intervening Nrf2/HO-1 signaling, thereby improving the level of oxidative substances. Naringin and polygonin balance the osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells via the Nrf2/ARE signaling pathway. Traditional Chinese medicine can regulate oxidative stress response of osteocytes, which is another important way to treat hormone-induced necrosis of the femoral head. [ABSTRACT FROM AUTHOR]

Objective In the gathering and transportation of natural gas mines with high hydrogen sulfide content, in order to effectively reduce the corrosion hazard of hydrogen sulfide to the system, dehydration is often used to control the water dew point. Methods Based on the research of dehydration technology of high sulfur natural gas at home and abroad, triethylene glycol solvent absorption method was selected as the dehydration treatment process of high sulfur natural gas in Shunbei No. 2 area. Considering the characteristics of high sulfur natural gas in Shunbei No. 2 area, the traditional triethylene glycol dehydration process was optimized and improved locally, and the separation process before the raw gas inlet adsorption tower and the flash-vapor recovery process were added at the same time. Based on the influence of the pre-heating location, regeneration purity and hydrogen sulfide, the paper adopted a two-stage low-liquid/high-liquid heat exchange pre-heating process and LNG gasification gas extraction process to form a dehydration process which is suitable for high-sulfur natural gas in Shunbei No. 2 area. Results After transformation, the dehydration process realized zero discharge of sulfur-containing tail gas from dehydration system by pressurized recovery, and the combination of efficient desulfurization and purification of triethylene glycol (TEG) realized by LNG gasification and gas stripping, the problem of corrosion and maintenance of regeneration device in acid environment was solved. Conclusions This dehydration process effectively promoted the realization of the overall development plan of Shunbei No. 2 area, and formed a high-pressure gathering and transportation dehydration process suitable for natural gas with high hydrogen sulfide content in Shunbei No. 2 area, which provides technical support for the further development of Shunbei natural gas blocks. [ABSTRACT FROM AUTHOR]

A sparrow search algorithm optimized support vector machine(SSA-SVM) based aviation arc fault detection method was proposed to address the issues of high concealment and difficulty in detecting arc fault in aviation line systems. Firstly, wavelet decomposition was used to decompose the arc fault current data, which can effectively overcome the problem of modal aliasing during empirical mode decomposition. From the perspective of signal disorder, energy entropy, fuzzy entropy, and approximate entropy were extracted from the current component, and feature vectors were constructed. Then, the sparrow search algorithm was used to optimize the weights of the support vector machine to obtain the optimal weights. Finally, the trained support vector machine was used to classify the test samples. In order to verify the effectiveness of the proposed method, an arc experimental platform was established to simulate the generation of arc faults in aviation line systems. AC series normal and arc fault current data were collected, and the SSA-SVM algorithm proposed was applied for arc fault detection. The results show that the proposed method can effectively identify arc fault, with a detection accuracy of 99. 5% . Compared to particle swarm optimization or genetic algorithm optimized support vector machines, the detection accuracy of arc fault is 2. 5% and 2% higher, respectively. [ABSTRACT FROM AUTHOR]

BACKGROUND: Recent studies have shown that the occurrence and prevention of osteoporosis often focus on the cellular molecular level, and the mechanism of related signaling pathways is an important way to further understand osteoporosis. At present, traditional Chinese medicine has been proved to play a significant role in alleviating osteoporosis. Kaempferol as an emerging Chinese herbal extract has become the focus of clinical and basic research due to its antiosteoporosis effectiveness and mechanism of action. OBJECTIVE: To further understand the mechanism underlying the anti-osteoporosis effect of kaempferol active monomer through regulation of related signaling pathways by analyzing and collating domestic and foreign literature. METHODS: “Kaempferol, osteoporosis, osteoblasts, osteoclasts, bone marrow mesenchymal stem cells, signaling pathways” were used as Chinese and English search terms to search CNKI, WanFang, VIP, PubMed, Web of Science and Embase databases for relevant literature published from database inception to February 2023. RESULTS AND CONCLUSION: Kaempferol affects the occurrence and progression of osteoporosis to varying degrees by participating in the regulation of differentiation, proliferation and apoptosis of bone marrow mesenchymal stem cells, osteoblasts and osteoclasts. Kaempferol can prevent and treat osteoporosis by regulating various signaling pathways. Kaempferol can promote the proliferation and differentiation of osteoblasts and inhibit the formation of osteoclasts by interfering with the Wnt/β-catenin signaling pathway to regulate β-catenin protein counting and the formation of β-catenin-TCf/LEF complex. Kaempferol interferes with the RANK/RANKL pathway to maintain the dynamic balance of osteoclasts and bone homeostasis. Kaempferol can promote bone formation by intervening with the PI3K/Akt signaling pathway to upregulate the levels of related osteogenic factors Runx2 and Osterix and promote bone cell calcification. Kaempferol interferes with osteoclast differentiation and inhibits reactive oxygen species activity by regulating the ER/ERK pathway. Kaempferol inhibits the expression of ERK, JNK, p38/MAPK and decreases reactive oxygen species production by interfering with the MAPK pathway, thus protecting osteogenesis. Kaempferol enhances the expression of osteogenic factors, bone morphogenetic protein-2, p-Smad1/5/8, β-catenin and Runx2, inhibits the expression of Peroxisome proliferation-activated receptor, and promotes the differentiation and proliferation of osteoblasts through the BMP/Smad pathway. [ABSTRACT FROM AUTHOR]

groundwater level near the river is a key to accurately assessing the effect of recharge. Based on unstructured grid refinement method，four different grid generation methods (two structural grids and two locally refined unstructured grids) were set，and different boundary conditions and subdivision of two unstructured grids were used to numerically simulate the process of groundwater recharge by river. Through a comparison of the final flow field, water levelvariations before and after recharge under different distances with river, groundwater balance and operation eficiency of model, the advantages and disadvantages of different grid refinementmethods in the linear recharge simulation were demonstrated. The results show that two locally refined unstructured grid models and fine structured grid model are more accurate than coarse structured grid model, resulting in more accurately description of the changes in groundwater levels caused by river recharge； two locally refined unstructured grid models have a shorter running tme than fine structured grid model, and run more efficiently without significantly reducing the accuracy of the simulation; Q-tree grid model has some advantages over nested grid model in long-term simulation, and the simulation accuracy is slightly higher than nested grid model in the later period of river recharge； moreover, Q-tree grid model has the advantage of multilevel refinement with fewer grids and shorter running tme than nested grid model. In conclusion, the Q-tree grid refinement method not only guarantees emulation accuracy, but also reduces running tme to a large extent, which indicates that the Q-tree grid refinement method should be recommended ｏｒ ｓｉｍｕｌａｔｉｏｎｓｏｆｇｒｏｕｎｄｗａｔｅｒｒｅｃｈａｒｇｅｂｙｒｉｖｅｒ． [ABSTRACT FROM AUTHOR]

目的 对河南省中医药科研现状进行调查"探讨影响中医药科技工作者的科研能力的因素"对其进行分析以便更 好进行科研工作. 方法 随机抽取河南省中医药科技工作者 410 例, 采用问卷调查方式对科研人员基本情况, 研究立项, 科技项 目评价体系及经费问题进行调查, 并对调查结果进行分析. 结果 科研工作人员中高级职称较少, 承担的项目级别较低 科研人 的事前评价与成果评价指标不完善 经费预算编制复杂 经费未能落实等方面对科研结果有一定的影响. 结论 培养科研人才, 完善科研经费管理制度, 客观量化指标等方面是目前需要解决的主要问题. [ABSTRACT FROM AUTHOR]

Approach slab installed at bridgehead of road-bridge transition section can effectively reduce the damage caused by vehicle bumping. However, there may also be some problems such as the rupture and disengaging of the approach slab. To avoid the abovementioned problems, theoretical and numerical simulation methods were used to study the layout scheme of approach slab at bridgehead of expressway road-bridge transition section. The present results show that there is an optimal scheme between the thickness and length of the approach slab, e. g., the optimal length of approach slab with the thickness of 0. 35 m should be larger than 8 m. The service life of the deeply buried approach slab is longer than that of the conventional layout of the approach slab, because the shear force of the deeply buried approach slab is obviously reduced. It also can be concluded that the pavement settlement will be significantly reduced when cement stabilized graded crushed stone is placed above the approach slab. [ABSTRACT FROM AUTHOR]

Approach slab installed at bridgehead of road-bridge transition section can effectively reduce the damage caused by vehicle bumping. However, there may also be some problems such as the rupture and disengaging of the approach slab. To avoid the above-mentioned problems, theoretical and numerical simulation methods were used to study the layout scheme of approach slab at bridgehead of expressway road-bridge transition section. The present results show that there is an optimal scheme between the thickness and length of the approach slab, e. g., the optimal length of approach slab with the thickness of 0. 35 m should be larger than 8 m. The service life of the deeply buried approach slab is longer than that of the conventional layout of the approach slab, because the shear force of the deeply buried approach slab is obviously reduced. It also can be concluded that the pavement settlement will be significantly reduced when cement stabilized graded crushed stone is placed above the approach slab. [ABSTRACT FROM AUTHOR]

Ｏｂjｅｃｔｉｖｅ　Ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ｔｈｅ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｅｃｔ ｏｆ ｅｎｔｅｃａｖｉｒ ｏｒ ａｄｅｆｏｖｉｒ ｄｉｐｉｖｏｘｉｌ ａｓ ｔｈｅ ａｎｔｉｖｉｒａｌ ｔｈｅｒａｐｙ ｆｏｒ ｈｅｐａｔｉｔｉｓ Ｂ ｃｉｒｒｈｏｓｉｓ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｈｅｐａｔｏｇｅｎｏｕｓ ｄｉａｂｅｔｅｓ. Ｍｅｔｈｏｄｓ　Ａ ｔｏｔａｌ ｏｆ 80 ｈｅｐａｔｉｔｉｓ Ｂ ｃｉｒｒｈｏｓｉｓ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｈｅｐａｔｏｇｅｎｏｕｓ ｄｉａｂｅｔｅｓ ｗｈｏ ｖｉｓｉｔｅｄ Ｑｉｎｇｄａｏ Ｈｏｓｐｉｔａｌ ｏｆ Ｉｎｆｅｃｔｉｏｕｓ Ｄｉｓｅａｓｅｓ ｗｅｒｅ ｅｎｒｏｌｌｅｄ，ａｎｄ ａｃｃｏｒｄｉｎｇ ｔｏ ｔｈｅ ａｎｔｉｖｉｒａｌ ｄｒｕｇ ｔｈｅｙ ｃｈｏｓｅ，ｔｈｅｙ ｗｅｒｅ ｄｉｖｉｄｅｄ ｉｎｔｏ ｇｒｏｕｐ Ａ ａｎｄ ｇｒｏｕｐ Ｂ， ｗｉｔｈ 40 ｐａｔｉｅｎｔｓ ｉｎ ｅａｃｈ ｇｒｏｕｐ. Ｔｈｅ ｐａｔｉｅｎｔｓ ｉｎ ｇｒｏｕｐ Ａ ｗｅｒｅ ｔｒｅａｔｅｄ ｗｉｔｈ ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ｅｎｔｅｃａｖｉｒ 0. 5 ｍｇ ｑｄ，ａｎｄ ｔｈｏｓｅ ｉｎ ｇｒｏｕｐ Ｂ ｗｅｒｅ ｔｒｅａｔｅｄ ｗｉｔｈ ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ａｄｅｆｏｖｉｒ ｄｉｐｉｖｏｘｉｌ 10 ｍｇ ｑｄ. Ｔｈｅ ａｎｔｉｖｉｒａｌ ｔｈｅｒａｐｙ ｌａｓｔｅｄ ｆｏｒ 48 ｗｅｅｋｓ. Ｔｈｅ ｐａｔｉｅｎｔｓ ｉｎ ｂｏｔｈ ｇｒｏｕｐｓ ｗｅｒｅ ｇｉｖｅｎ ｄｉａｂｅｔｉｃ ｄｉｅｔｓ ａｎｄ ｉｎｓｕｌｉｎ ｔｏ ｃｏｎｔｒｏｌ ｂｌｏｏｄ ｇｌｕｃｏｓｅ，ａｓ ｗｅｌｌ ａｓ ｌｉｖｅｒ - ｐｒｏｔｅｃｔｉｎｇ ａｎｄ ｔｒａｎｓａｍｉｎａｓｅ - ｌｏｗｅｒｉｎｇ ｔｒｅａｔｍｅｎｔｓ. Ｔｈｅ ｃｈａｎｇｅｓ ｉｎ ｂｉｏｃｈｅｍｉｃａｌ ｐａｒａｍｅｔｅｒｓ，ｖｉｒａｌ ｒｅｓｐｏｎｓｅ，ｄｉａｂｅｔｅｓ ｃｏｎｔｒｏｌ，ａｎｄ ｔｈｅ ｉｍｐｒｏｖｅｍｅｎｔ ｉｎ ｌｉｖｅｒ ｓｔｉｆｆｎｅｓｓ ａｆｔｅｒ ｔｒｅａｔｍｅｎｔ ｗｅｒｅ ｏｂｓｅｒｖｅｄ ｉｎ ｂｏｔｈ ｇｒｏｕｐｓ. Ｔｈｅ ｔ - ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｃｏｍｐａｒｉｓｏｎ ｏｆ ｃｏｎｔｉｎｕｏｕｓ ｄａｔａ ｂｅｔｗｅｅｎ ｇｒｏｕｐｓ，ａｎｄ ｔｈｅ ｃｈｉ - ｓｑｕａｒｅ ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｃｏｍｐａｒｉｓｏｎ ｏｆ ｃａｔｅｇｏｒｉｃａｌ ｄａｔａ ｂｅｔｗｅｅｎ ｇｒｏｕｐｓ. Ｒｅｓｕｌｔｓ　Ｔｈｅ ｖｉｒａｌ ｒｅｓｐｏｎｓｅ ｓｈｏｗｅｄ ａ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ ｂｅｔｗｅｅｎ ｇｒｏｕｐ Ａ （85％ ，34 /40）ａｎｄ ｇｒｏｕｐ Ｂ （65％ ， 26 / 40）（χ2 ＝4. 27，Ｐ ＜0. 05）. Ｃｏｍｐａｒｅｄ ｗｉｔｈ ｇｒｏｕｐ Ｂ，ｇｒｏｕｐ Ａ ｓｈｏｗｅｄ ｓｉｇｎｉｆｉｃａｎｔ ｉｍｐｒｏｖｅｍｅｎｔｓ ｉｎ ｂｉｏｃｈｅｍｉｃａｌ ｐａｒａｍｅｔｅｒｓ （Ｐ ＜0. 05）. Ａｆｔｅｒ 48 ｗｅｅｋｓ ｏｆ ｔｒｅａｔｍｅｎｔ，ｇｒｏｕｐ Ａ ｈａｄ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｌｏｗｅｒ ｌｅｖｅｌｓ ｏｆ ｂｌｏｏｄ ｇｌｕｃｏｓｅ ａｎｄ ｇｌｙｃｏｓｙｌａｔｅｄ ｈｅｍｏｇｌｏｂｉｎ ｔｈａｎ ｇｒｏｕｐ Ｂ （ｂｌｏｏｄ ｇｌｕｃｏｓｅ:7. 53 ±1. 13 ｍｍｏｌ/ Ｌ ｖｓ 8. 34 ± 1. 12 ｍｍｏｌ/ Ｌ，ｔ ＝ 3. 220，Ｐ ＜ 0. 05；ｇｌｙｃｏｓｙｌａｔｅｄ ｈｅｍｏｇｌｏｂｉｎ:7. 23％ ± 0. 64％ ｖｓ 7. 79％ ± 0.84％ ，ｔ ＝3. 354；Ｐ ＜0. 05）. Ａｆｔｅｒ ｔｈｅ ｔｒｅａｔｍｅｎｔ，ｌｉｖｅｒ ｓｔｉｆｆｎｅｓｓ ｓｈｏｗｅｄ ａ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ ｂｅｔｗｅｅｎ ｇｒｏｕｐ Ａ ａｎｄ ｇｒｏｕｐ Ｂ （16. 86 ± 5. 67 ｋＰａ ｖｓ 19. 47 ±5. 32 ｋＰａ，ｔ ＝2. 123，Ｐ ＜0. 05）. Ｃｏｎｃｌｕｓｉｏｎ　Ｃｏｍｐａｒｅｄ ｗｉｔｈ ａｄｅｆｏｖｉｒ ｄｉｐｉｖｏｘｉｌ，ｅｎｔｅｃａｖｉｒ ｃａｎ ｉｍｐｒｏｖｅ ｇｌｙｃｏｇｅｎ ｍｅｔａｂｏｌｉｓｍ ａｎｄ ｂｌｏｏｄ ｇｌｕｃｏｓｅ ｒｅｇｕｌａｔｉｏｎ ｔｈｒｏｕｇｈ ｉｍｐｒｏｖｉｎｇ ｌｉｖｅｒ ｆｕｎｃｔｉｏｎ ａｎｄ ｐｒｏｍｏｔｉｎｇ ｈｅｐａｔｏｃｙｔｅ ｒｅｐａｉｒ，ａｎｄ ｆｉｎａｌｌｙ ａｃｈｉｅｖｅ ａ ｂｅｔｔｅｒ ｂｌｏｏｄ ｇｌｕｃｏｓｅ ｃｏｎｔｒｏｌ. [ABSTRACT FROM AUTHOR]

Objective To explore the clinical value of serum progesterone (P) and human chorionicgonadotropin (β-HCG) combined with color Doppler ultrasound for detecting endometrial thickness in the early diagnosis of ectopic pregnancy (EP). Methods Fifty-six cases of EP (EP group), 52 cases of normal pregnancy(normal pregnancy group) and 52 cases of spontaneous abortions (abortion group) in our hospital from March 2015 to June 2016 were selected as the research subjects. The levels of serum P and β-HCG, and endometrial thickness were measured. Then the results were analyzed. Results The serum P and β-HCG levels, and endometrial thickness in the normal pregnancy group were significantly higher than those in the EP group and spontaneous abortion group, the difference was statistically significant (P<0.05), but which had no statistical difference between the EP group and spontaneous abortion group (P>0.05); the EP detection rate of serum P and β-HCG combined with color doppler ultrasound for detecting endometrial thickness was obviously higher than that of single item detection, the difference was statistically significant (P<0.05). Conclusion Serum P and β-HCG combined with color Doppler ultrasound for detecting endometrial thickness can increase early diagnostic rate of EP and has an important clinical significance for the diagnosis and treatment of EP. [ABSTRACT FROM AUTHOR]

目的 观察老年帕金森病(PD)患者认知功能的变化情况,并探讨其相关影响因素. 方法 选取老年(年龄≥60岁) PD患者80例. 门诊随访2年,由专职人员详细记录患者一般资料与量表结果. 量表评估包括统一帕金森病评定量表(UPDRS)、简易智能精神状态量表(MMSE)、中国版韦氏成人智力量表(WAIS-RC)、中国版韦氏记忆量表(WMS)、汉密尔顿抑郁量表(HAMD)和蒙特利尔认知评估量表(MoCA). 结果 随访结束时,认知功能正常老年PD患者比例显著降低(P<0.05),轻度认知功能障碍老年PD患者比例显著升高(P<0.05),认知功能障碍率显著升高(P<0.05);MMSE评分和MoCA评分均显著降低(P均<0.05);MoCA指标中,除视空间、执行功能和定向外,余各项指标均显著降低(P均<0.05);MMSE指标中,除阅读理解、书写能力和图形描画外,余各项指标均显著降低(P均<0.05). Logistic回归分析结果显示,病程和运动亚型对老年PD患者认知功能影响显著(P均<0.05). 结论 老年PD患者认知功能下降明显,病程和运动亚型对老年PD患者认知功能影响较大. [ABSTRACT FROM AUTHOR]

BACKGROUND: Many clinical research observations have indicated a close association between rheumatoid arthritis and osteoporosis as well as bone mineral density (BMD). However, it remains unclear whether there is a causal genetic relationship between rheumatoid arthritis and the development of osteoporosis and alterations of BMD. OBJECTIVE: To assess the potential causal relationship between rheumatoid arthritis and osteoporosis as well as BMD using a two-sample Mendelian randomization approach, provide meaningful insights from a genetic perspective into the underlying mechanisms and offer a reference for early prevention of osteoporosis and improvement in the progression of the disease. METHODS: We conducted a study using data from publicly available genome-wide association studies databases to identify single nucleotide polymorphisms associated with rheumatoid arthritis as instrumental variables (P < 5×10-8). The main outcomes of the study included osteoporosis and BMD at five different sites, including total body BMD, lumbar spine BMD, femoral neck BMD, heel BMD, and forearm BMD. The inverse variance-weighted method was used as the primary analysis method to evaluate causal effects. Weighted median, simple median, weighted mode and MR-Egger regression were used as supplementary analyses. Causal relationships between rheumatoid arthritis and the risk of osteoporosis and BMD were assessed using odds ratios (OR) and 95% confidence intervals (CI). Heterogeneity was assessed using Cochran’s Q test and horizontal pleiotropy was evaluated using MR-Egger intercept tests. RESULTS AND CONCLUSION: The inverse variance-weighted analysis demonstrated a positive association between genetically predicted rheumatoid arthritis and osteoporosis (OR=1.123, 95% CI: 1.077-1.171; P=4.02×10-8). Heterogeneity test (P=0.388) indicated no significant heterogeneity among the single nucleotide polymorphisms. MR-Egger intercept (P=0.571) tests did not detect horizontal pleiotropy, and sensitivity analysis showed no evidence of bias in the study results. There was no causal relationship between rheumatoid arthritis and BMD at the five different sites. The total body BMD (OR=1.000, 95% CI: 0.988-1.012; P=0.925), lumbar spine BMD (OR=0.999, 95% CI: 0.982-1.016; P=0.937), femoral neck BMD (OR=1.001, 95% CI: 0.986-1.016; P=0.866), heel BMD (OR=0.996, 95% CI: 0.989-1.004; P=0.419), and forearm BMD (OR=1.063, 95% CI: 0.970-1.031; P=0.996) indicated no significant association. MREgger intercept analysis did not detect potential horizontal pleiotropy (total body BMD: P=0.253; lumbar spine BMD: P=0.638; femoral neck BMD: P=0.553; heel BMD: P=0.444; forearm BMD: P=0.079). Rheumatoid arthritis may contribute to the development of osteoporosis through the interaction between chronic inflammation and bone formation, resorption, and absorption. Additionally, the use of glucocorticoids and the presence of autoantibodies (such as anti-citrullinated protein antibody) in patients with rheumatoid arthritis showed associations with osteoporosis. Future research should focus on monitoring systemic inflammatory markers, standardized use of glucocorticoids, and regular screening for osteoporosis risk in patients with rheumatoid arthritis. [ABSTRACT FROM AUTHOR]

In the Northwest oilfield, there were some problems for high sulfur-containing associated gas during the desulfurization and purification of dimethylethanolamine ( MDEA) solution, such as frequent liquid blocking and flushing tower and the hydrogen sulfide concentration in the purified gas over-standard, etc. The analysis results showed that the high heavy hydrocarbon content in the associated gas system was one of the causes which led to the amine solution foaming and lo>v tray efficiency. A new- counter current low back mixing spray state tray structure ( SDST) based on the principle of spray state was proposed and designed. The hydraulic test results showed that compared to the Fl float valve tray, the SDST pressure drop could be reduced by 10 %, the flux could be increased by 30 %, and the operation flexibility was basically unchanged. The industrial application results of SDST trays in associated gas desulfurization process showed that SDST tray has a good foaming suppression performance, which can effectively solve the problem of liquid blocking and flushing tower in associated gas desulfurization process, and at the same time increase the plate efficiency by more than 1 Cl%, and also effectively solve the problem of hydrogen sulfide concentration over-standard in the purified gas caused by the low tray efficiency during the associated gas desulfurization process. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of strengths-based cognitive behavioral therapy (SBCBT) model on hope in adolescents with depression. Methods: Totally 89 adolescents with depression meeting the diagnostic criteria for mild and moderate depressive episodes of the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) were randomly divided into the combined treatment group (n=44) and the sertraline group (n=45). The combined treatment group received 8 times of SBCBT intervention on the basis of the sertraline group. The Adult Dispositional Hope Scale (ADHS), Hamilton Depression Scale-17 (HAMD-17) and Hamilton Anxiety Scale (HAMA) were measured at base-line and 6 weeks after intervention. Results: After 6-week intervention, the ADHS total scores in both groups were higher than the baseline (P <0.001), and the total scores of HAM D-17 and HAMA in both groups were lower than the baseline (P <0.001). The ADHS total scores were higher and the total scores of HAMD-17 and HAMA were lower in the combined treatment group than in the sertraline group (P<0.001). Correlation analysis showed that the total score difference of ADHS was positively correlated with the total score difference of HAMD-17 (r=0. 46, P <0.001) and the total score difference of HAMA (r = 0.29, P <0.01). Conclusion: It suggests that SBCBT is beneficial to improve depression, and enhance the hope of adolescent patients with depression. [ABSTRACT FROM AUTHOR]

aboratory tests were carried out on the silt solidified by the granulated blast furnace slag (GGBS) alkali-activated by hydrated lime and MgO powder. The optimal mixing amount of hydrated lime and MgO powder used as the alkali activator of GGBS was determined. The bearing capacity of the silt solidified by the GGBS alkali-activated by hydrated lime was studied by using field test. The research shows that the silt solidified by the GGBS alkali-activated by 15% MgO powder and 6% hydrated lime can be used as bridge abutment backfill materials. Considering the economy and reinforcement effect, the silt solidified by the GGBS alkali-activated by 6% hydrated lime can be used as the backfill material of abutment of road-bridge transition section in practice. The present research can be used for controlling differential settlement of road-bridge transition section of expressway. [ABSTRACT FROM AUTHOR]

In order to explore the assimilation application of cloud-affected satellite microwave observations, the inversion model of atmospheric temperature and humidity profile in cloudy condition based on the artificial neural network algorithm was developed by using Fengyun-3D(FY-3D) microwave temperature sounder-2(MWTS2) and microwave humidity sounder-2(MWHS2) data and the indirect assimilation scheme of cloudy data was established. One-month continuous experiments and real-case study about clear-sky and cloudy assimilation were performed in June 2019 to illustrate the influence of MWTS2 and MWHS2 cloudy observations on regional numerical weather prediction model. The results show that the assimilation of MWTS2 and MWHS2 data improves the predicted temperature and humidity field, which is mainly reflected in the reduction of bias and root mean square error in the high layer of the model. The improvement rate of cloudy assimilation is higher than that of clear-sky assimilation. Assimilating MWTS2 and MWHS2 data has a positive effect on improving precipitation prediction skills. The improvement of cloudy assimilation on precipitation prediction is mainly reflected in 12 ~24 h after assimilation, which is more obvious than that of clear-sky assimilation. The real-case study of heavy precipitation shows that the adjustment of temperature, humidity and moisture flux divergence field by MWTS2 and MWHS2 data is conducive to improve precipitation forecast skill, while cloudy assimilation can adjust the initial field of weather system directly, having better prediction effect of precipitation position and intensity. [ABSTRACT FROM AUTHOR]

BACKGROUND: Recent studies have shown that research on naringin anti-osteoporosis mostly stays in in vitro and in vivo experiments. Understanding the mechanism of related signaling pathways and the expression of related proteins and some specific genes is an important way to deeply understand naringin anti-osteoporosis. At present, traditional Chinese medicine has been confirmed to have a significant role in anti-osteoporosis. Naringin is one of the main active ingredients in Rhizoma Drynariae. Its effectiveness and mechanism of action against osteoporosis have been gradually recognized by scholars, and its clinical and basic research has been gradually emphasized. OBJECTIVE: To analyze and summarize the research progress of naringin in anti-osteoporosis in vitro and in vivo, thereby providing some ideas for the next step to study its related mechanism of action. METHODS: The relevant literatures included in CNKI and PubMed database were searched with the Chinese search terms of “naringin, osteoporosis, traditional Chinese medicine compound, pathogenesis, signaling pathway, bone marrow mesenchymal stem cells, osteoblasts, osteoclasts” in Chinese and English, respectively. The corresponding criteria were established according to the research needs, and finally 69 articles were included for review. RESULTS AND CONCLUSION: Naringin blocks the increase in the number of osteoclasts and adipocytes, the decrease in the number of osteocytes and osteocalcin (+) cells induced by fructose-rich diet, and promotes the secretion of Sema3A from osteoblasts and osteocytes, thereby enhancing local bone formation and inhibiting osteoclast production by activating the Wnt/β-catenin pathway. Naringin is an important way to induce autophagy of osteoblasts, but autophagy-related proteins participate in osteoblast differentiation and bone formation. Lack of autophagy in osteoblasts reduces mineralization and leads to an imbalance in the number of osteoblasts and osteoclasts, which results in bone loss and decreased bone density. The composite scaffold loaded with naringin can be used as a necessary carrier for bone defect repair and has excellent bone repair properties. Naringin can also accelerate the growth of new bone tissue by increasing the local contents of bone morphogenetic protein 2 and vascular endothelial growth factor. Naringin can regulate bone metabolism and inhibit oxidative stress via ERK, PI3K/Akt and Wnt signaling pathways to improve osteoporosis, which can play a good role in preventing and controlling the disease. However, the depth and breadth of the relevant research is insufficient. Based on the mechanism of the current study, we should investigate the specific mechanisms by which naringin regulates different pathways and inter-pathway interactions in the future, which will be beneficial to the multifaceted development of naringin used in the treatment of osteoporosis.. [ABSTRACT FROM AUTHOR]

Tahe Oilfield is a high hydrogen sulfide oilfield, the H2S mass fraction in mixed hydrocarbon is 0.68% and the organic sulfur mass fraction is 0.22%. Current desulfurization process adopting the caustic washing process which has high treatment cost and the waste caustic washing water was difficult to treat. A novel idea of mixed hydrocarbon fractionation desulfurization process was put forward by analyzing the on-site process, the sulfur form and the physical properties in mixed hydrocarbon were analyzed. After fractional treatment, the H2S and part mercaptan in mixed hydrocarbon entered into the natural gas processing system followed with the overhead gas. The total sulfur content in light hydrocarbons in the bottom of the tower was reduced from 0.90% to 0.15%. For further caustic washing treatment, the total sulfur content meets the requirement of GB 9053-2013 Stable Light Hydrocarbon. The alkali consumption of fractionation desulfurization process was reduced from 2 t/d to 0.22 t/d compared to caustic washing process, the dosage of alkali(NaOH) were only about one tenth of the present. The processing cost will be reduced by 1.901 million RMB per year. [ABSTRACT FROM AUTHOR]

: The double-skin roof has been applied in the design of modern granary. The inclined upper-plate has the better thermal performance to effectively improve the situation of "hot roof" of granary, compared with the ordinary parallel double-plate. In this study, an experimental and numerical investigation was carried out to determine the thermal performance of double-skin roof with the inclined upper-plate, and the effects of physical parameters on the convective heat transfer. According to the actual size of grain warehouse in application, an experiment setup was established using the similarity theory with a scale of 1:28 to the real one. The double-skin roof consisted of two plates: the lower one was used as the original surface of the warehouse, and another was suspended above. The two flat plates were arranged parallel or inclined for comparison. Changeable parameters included the flow rate through the air gap between the double plates, the thickness of the air gap, and the reducing ratio. Other parameters were the same, such as the air temperature. A systematic investigation was made to clarify the influence of the above factors on the performance of the double-skin roof. The results showed that both the flow rate and the thickness of the air gap dominate the thermal performance of the roof. Under the optimal working condition in the parallel mode (with an air gap of 0.07 m and a flow rate of 60 m³ /h), the temperature increment at the surface of the grain bulk was 1.75 ℃, which was lower than the mode without suspended upper-plate. Moreover, the inclined design of the upper-plate increased the air velocity along the flowing direction. As such, the convection was strengthened at the outlet, and thus improved the average thermal performance of the opened roof. The inclined mode was used to control the temperature at the grain bulk surface within 24 ℃, and only dropped by 1 ℃, compared with the parallel mode under the same working conditions. In addition, a geometric model of the experiment setup was created, where the grid was divided using the software ANSYS ICEM. The convection term in the conservation equation was discretized with the QUICK scheme, and the solution for the flow field was obtained by the SIMPLE algorithm. The experimental data was used as the input profile for the model. The numerical results were compared with the experiment to verify the accuracy of the model. The average and the maximum error were within 3% and 8.9%, respectively. Simulation results demonstrated the effects of the reducing ratio on the roof thermal performance with the analysis of the Ra number and the Nu number. In the inclined mode, the smaller reducing ration was beneficial to the air convection. The outlet velocity of the roof was higher by 30.6% with a reducing ratio of about 0.500, resulting in a larger local Nu number and better thermal performance. More importantly, the Nu number was increasing, when the dimensionless length was in a range of 0.34-0.37. Furthermore, the Nu number increased with the Ra number given a dimensionless length of below 0.15 near the inlet of the double-skin roof. Therefore, the ventilated double-skin roof with an inclined upper plate was recommended for the roof reconstruction design, because of the advanced air convection. : The double-skin roof has been applied in the design of modern granary. The inclined upper-plate has the better thermal performance to effectively improve the situation of "hot roof" of granary, compared with the ordinary parallel double-plate. In this study, an experimental and numerical investigation was carried out to determine the thermal performance of double-skin roof with the inclined upper-plate, and the effects of physical parameters on the convective heat transfer. According to the actual size of grain warehouse in application, an experiment setup was established using the similarity theory with a scale of 1:28 to the real one. The double-skin roof consisted of two plates: the lower one was used as the original surface of the warehouse, and another was suspended above. The two flat plates were arranged parallel or inclined for comparison. Changeable parameters included the flow rate through the air gap between the double plates, the thickness of the air gap, and the reducing ratio. Other parameters were the same, such as the air temperature. A systematic investigation was made to clarify the influence of the above factors on the performance of the double-skin roof. The results showed that both the flow rate and the thickness of the air gap dominate the thermal performance of the roof. Under the optimal working condition in the parallel mode (with an air gap of 0.07 m and a flow rate of 60 m³ /h), the temperature increment at the surface of the grain bulk was 1.75 ℃, which was lower than the mode without suspended upper-plate. Moreover, the inclined design of the upper-plate increased the air velocity along the flowing direction. As such, the convection was strengthened at the outlet, and thus improved the average thermal performance of the opened roof. The inclined mode was used to control the temperature at the grain bulk surface within 24 ℃, and only dropped by 1 ℃, compared with the parallel mode under the same working conditions. In addition, a geometric model of the experiment setup was created, where the grid was divided using the software ANSYS ICEM. The convection term in the conservation equation was discretized with the QUICK scheme, and the solution for the flow field was obtained by the SIMPLE algorithm. The experimental data was used as the input profile for the model. The numerical results were compared with the experiment to verify the accuracy of the model. The average and the maximum error were within 3% and 8.9%, respectively. Simulation results demonstrated the effects of the reducing ratio on the roof thermal performance with the analysis of the Ra number and the Nu number. In the inclined mode, the smaller reducing ration was beneficial to the air convection. The outlet velocity of the roof was higher by 30.6% with a reducing ratio of about 0.500, resulting in a larger local Nu number and better thermal performance. More importantly, the Nu number was increasing, when the dimensionless length was in a range of 0.34-0.37. Furthermore, the Nu number increased with the Ra number given a dimensionless length of below 0.15 near the inlet of the double-skin roof. Therefore, the ventilated double-skin roof with an inclined upper plate was recommended for the roof reconstruction design, because of the advanced air convection. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy of telbivudine combined with adefovir dipivoxil and PEG-IFN-α-2a combined with entecavir as the antiviral therapy for HBeAg-positive patients with chronic hepatitis B (CHB) and a high viral load. Methods A total of 80 previously untreated HBeAg-positive CHB patients with a high viral load who were treated in The Sixth People′s Hospital of Qingdao from November 2012 to November 2015 were enrolled and randomly divided into two groups. The patients in group A were treated with telbivudine combined with adefovir dipivoxil, and those in group B were treated with PEG-IFN-α-2a combined with entecavir. Biochemical and virologic response rates and seroconversion rate were observed at weeks 12, 24, and 48 of administration. The drug resistance rate and incidence rates of adverse events were observed in both groups. The Chi-square test was applied for comparision of categorical data between the two groups, and the t-test was applied for comparision of continuous data between the two groups. Results Biochemical and virologic response rates at weeks 12, 24, and 48 of administration showed no significant differences between the two groups. The seroconversion rates at weeks 12 and 24 of administration showed no significant differences between the two groups, while at week 48 of administration, group B had significantly higher HBeAg clearance rate and seroconversion rate than group A (45.0% vs 67.5%， 22.5% vs 45.0%，χ2=4.114 3 and 4.528 3, both P＜0.05). Group B had significantly higher incidence rates of adverse events than group A. Conclusion Telbivudine combined with adefovir dipivoxil and PEG-IFN-α-2a combined with entecavir can effectively inhibit the replication of high-load HBV DNA, delay disease progression, and realize HBeAg seroconversion. However, the two regimens have their own advantages and disadvantages and should be selected according to clinical situation. [ABSTRACT FROM AUTHOR]

In order to improve the comprehensive practical ability of students majoring in robot engineering, a teaching robot experimental platform which integrates machinary, electricity, control and image processing is designed and developed in this paper. As a platform integrates robot mechanical structure design, kinematics analysis, motion control and image processing, it is able of joint assembly and demonstration experiments, which avails students to understand robot’s mechanical structure and working principle, and more importantly, it is developed as an open control experimental platform that can complete complex experiments such as robot kinematics analysis, drive control, trajectory planning, image processing, and object recognition & grasp under vision guidance.Strong in integration and manipulability, the designed experimental platform can stimulate students’ learning interest and improve their engineering practical and innovative ability effectively. [ABSTRACT FROM AUTHOR]

To make up for the shortage of experimental devices for the emerging majors such as intelligent manufacturing and robot engineering, as well as the urgent needs in improving students’ innovative and practical ability, we design a dual-arm cooperative teaching robot based on binocular vision.The mechanical part of the two arms is a symmetrical structure mounted on a big stable base to reduce manufacturing cost and coordinated grasping difficulty.In order to increase the accuracy of the robot terminal pose acquisition and thus improve the dual-arm cooperative grasp in both accuracy and stability, we design a teaching motion restoring algorithm and a reprojection error minimization algorithm.The upper computer of the system can drag and control the two arms to do programming teaching and action group experiments; and the robot can not only process images and conduct single-arm grabbing experiments under visual guidance, but also carry out motion analysis experiments, online programming, and open experiments of coordinated grabbing.The proposed system is cost-effective, rich in functions, highly integrative, and able of both drag teaching and open experiments, which is helpful to improve students’ innovative and practical ability, therefore it is very suitable for promotion and application in the experimental teaching courses for intelligent manufacturing, robot engineering and other related majors. [ABSTRACT FROM AUTHOR]

Tahe oilfield produced a large amount of heavy crude oil and associated gas, and the light hydrocarbon was extracted with negative stripping process from heavy crude oil. There were a lot of problems when the light hydrocarbon and associated gas were purified centrally at light hydrocarbon station, such as the total sulfur content in LPG exceeding standard, a lot of alkaline waste produced during the process of light hydrocarbon alkali washing desulfurization, and so on. The application study of UDS desulfurizer during the process of associated gas desulfurization was carried out in order to solve the problem. The results showed that the UDS has good selectivity to both organic sulfur and hydrogen sulfide, and the concentration of total sulfur in LPG could decrease by 86% compared to using MDEA desulfurizer. The application study of light hydrocarbon stripping desulfurization process was carried out, and the results showed that the mass fraction of total sulfur in light hydrocarbon could decrease to less than 0. 03%. Therefore, the stripping process could completely replace the alkaline washing process. A new green and efficient purification process for associated gas with high concentration of sulfur was developed, and it was proved that the process was stable, and could meet the requirement of unit for long cycle operation. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of continuous blood purification and enteral nutrition in the treatment of patients with severe pancreatitis and their influence on the levels of inflammatory factors. Methods: A total of 82 patients with severe pancreatitis who were treated in our hospital from January 2018 to December 2019 were selected as the research objects, and they were divided into a study group (49 cases) and a control group (33 cases) according to different treatment methods. Patients in the control group received only continuous blood purification, and patients in the study group received enteral nutrition support on the basis of patients in the control group. The patients in the two groups were compared with abdominal pain relief time, infection incidence, hospital stay, and blood urea nitrogen before and after treatment. BUN), creatinine (SCr), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), Changes in the scores of acute physiology and chronic health evaluation (APACHE Ⅱ). Results: The time to relieve abdominal pain, the incidence of infection, and the length of stay in the study group were shorter than those in the control group (P<0.05). After treatment, the APACHE Ⅱ score, serum CRP, IL-6, TNF-α, BUN and SCr levels in the study group were lower than those in the control group (P<0.05). Conclusion: Continuous blood purification combined with enteral nutrition support has a good therapeutic effect on patients with severe pancreatitis, which can significantly accelerate the outcome of patients with severe pancreatitis, and improve the renal injury and inflammation of the body. [ABSTRACT FROM AUTHOR]

Objective : To investigate the effect of sitagliptin on renal function and the expression of suppressors of cytockine signaling (SOCS 1) and podocalyxin in diabetic nephropathy rats. Method : The rats were randomly divided into four groups: control group, model group, cigliptin group and benazepril group. The model group, siggliptin group and benazepril group were injected intraperitoneally with streptozotocin to establish the model, while the control group was injected intraperitoneally with the same volume of normal saline. After the model was established successfully, 7 mg / kg / d of cigliptin and benazepril were given by gavage respectively in the cigliptin group (n=8) and benazepril group (n=8). Model group (n=8) and control group (n=10) were given the same amount of distilled water by gavage for 8 weeks. The metabolism related indexes, renal fibrosis index, the level of inflammatory factors in renal tissue and the expression levels of podocalyxin, SOCS1 and Desmin protein were detected and compared. Result : After 8 weeks of intervention, compared with the control group, fasting blood glucose, glycosylated hemoglobin, triglyceride, total cholesterol, 24 h urinary protein excretion rate, creatinine, body weight, transforming growth factor- β1(TGF - β1), interleukin(IL)-6, IL-1β, SOCS 1 and Desmin were significantly increased, while collagen-Ⅳ (C-Ⅳ), fibronectin (FN), laminin (LN) and podocalyxin were significantly decreased (P<0.05). Compared with the model group, the fasting blood glucose, glycosylated hemoglobin, triglyceride, total cholesterol, 24-h urinary protein excretion rate, creatinine, body weight, TGF - β1, IL-6, IL-1β and desmin levels were significantly decreased, while the expression of podocalyxin and SOCS 1 protein was significantly increased (P<0.05). However, there was no significant difference between irbesartan group and sitagliptin group (P>0.05). Conclusion : Sitagliptin can improve the renal fibrosis and renal function in diabetic nephropathy rats by increasing the expression of podocalyxin and SOCS1 protein, reducing the expression of inflammatory factors and Desmin protein in renal tissue. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of neutralizing interleukin-17 (IL-17) on the expressions of collagen and apoptosis-related factors in model mice with idiopathic pulmonary fibrosis induced by bleomycin. Methods Thirtytwo male C57BL/6 mice were randomly divided into normal control group, model group, neutralizing antibody group and antibody control group. The mouse model of idiopathic pulmonary fibrosis was induced by intratracheal infusion of bleomycin (BLM, 5 U/kg). Mice in the neutralizing antibody group and the antibody control group were injected with IL-17 monoclonal antibody or isotype control antibody through the caudal vein every 4 days from the day 3 after BLM instillation, and the model group and the normal control group were given the same amount of normal saline. At the day 28, all mice were euthanized, the lung fibrosis degree was assessed by Masson staining. The mRNA contents of collagen typeⅠand type Ⅲ in lung tissues were determined by real-time fluorescent quantitative PCR, and the expression levels of Cleaved-cysteinasparate protease (Cleaved-caspase)-3 and Cleaved-caspase-9 were detected by Western blot assay. Results Compared with the model group, the degree of pulmonary fibrosis was significantly declined in the neutralizing antibody group (P＜ 0.01), the mRNA expressions of collagen typeⅠand type Ⅲ were obviously decreased (P＜0.01), and the protein expressions of Cleaved-caspase-3 and Cleaved-caspase-9 were markedly reduced (P＜0.01), but there were no significant differences in these data between model group and the antibody control group. Conclusion Neutralizing endogenous IL-17 may improve pulmonary fibrosis by regulating the expressions of Cleaved-caspase-3 and Cleaved-caspase-9 proteins. [ABSTRACT FROM AUTHOR]

目的 评价臌胀片对代偿期丙型肝炎肝硬化抗病毒疗效的影响。方法 将80例代偿期丙型肝炎肝硬化患者随机分为观察组和对照组各 40 例,均予聚乙二醇干扰素 α-2a、利巴韦林抗病毒治疗,观察组另服臌胀片,治疗 24 周,随访 24 周,比较两组病毒学应答率、Child-Pugh评分、肝功能、血常规。结果治疗 48 周后,观察组持续应答率高于对照组(P<0.05); 两组治疗后各时点 Child-Pugh 评分较治疗前明显降低(P均<0.05),且观察组较对照组降低更明显(P均<0.05);治疗第24、48周,观察组肝功能指标低于对照组(P均<0.05)。治疗第12、24周,观察组白细胞高于对照组(P均<0.05);治疗第24周,观察组血小板高于对照组(P<0.05)。结论臌胀片可提高聚乙二醇干扰素α-2a联合利巴韦林治疗代偿期丙型肝炎肝硬化抗病毒疗效,且能减轻其不良反应。 [ABSTRACT FROM AUTHOR]

A transfer method of near infrared (NIR) spectra analysis model is studied in order to enable one instrument (reference instrument) and the other one (target instrument) to share the model. The transfer set samples are selected with Mahalanobis distances by taking an analysis model of mixed-amine fuel for example, and the algorithm of piecewise direct standardization (PDS) combined partial least squares (PLS) is used to set the spectral correction matrix between the reference and target instruments. The number of transfer samples, the number of prime factors of PLS regression and the window width of PDS are confirmed based on the average of root mean square (ARMS) of corrected spectra of transfer samples. The corrected rate of spectra of transfer samples reachs 96.5% with transfer sample number of 12 and prime factor number of 1 and window width of 39. Standard deviation of prediction set (SEP) of every analysis item on target instrument is near SEP on reference instrument after the analysis model of mixed-amine is transferred, the transferred model can predicate triethylamine content, xylidine content, water content and density accurately. The results indicate that the sample selection based on Mahalanobis distances and PDS-PLS algorithms can deduct the difference of NIR spectra among instruments and improve the analytical accuracy of NIR model. [ABSTRACT FROM AUTHOR]