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卒中是中国居民致死和长期致残的主要原因，传统的治疗药物受限于血脑屏障阻碍、稳定性差、缺乏靶向性、低载药量，治疗效果可能欠理想。纳米材料作为一种新兴的、非侵入性、可实时控制的药物，已被广泛用于卒中的诊疗。纳米药物能够有效提高药物的生物相容性、稳定性、靶向性，并延长药物的半衰期，从而有效改善传统药物的疗效。近年来纳米材料在缺血性卒中诊疗领域取得了一定进展，但仍面临临床转化等挑战。本文主要综述纳米材料在缺血性卒中诊疗中的研究进展和挑战，旨在继续推动纳米材料在卒中诊疗中的研究与应用。 Abstract: Stroke is a major cause of death and long-term disability among residents in China. Traditional therapeutic drugs are limited by the obstruction of the blood-brain barrier, poor stability, lack of targeting, and low drug loading, which may result in suboptimal treatment outcomes. Nanomaterials, as an emerging, non-invasive, and real-time controllable drug delivery system, have been widely used in the diagnosis and treatment of stroke. Nanomedicines can effectively enhance the biocompatibility, stability, and targeting of drugs, as well as prolong their half-life, thereby significantly improving the efficacy of traditional medications. In recent years, there has been some progress in the application of nanomaterials in the field of ischemic stroke diagnosis and treatment, although challenges in clinical translation remain. This article primarily reviews the research progress and challenges of nanomaterials in the diagnosis and treatment of ischemic stroke, aiming to further promote the research and application of nanomaterials in stroke therapy.

依托输电线路实际工程，选取输电铁塔主材与横担连接处钢管角钢组合节点为研究对象，采用数值软件ABAQUS建立了钢管角钢组合节点精细化有限元模型，基于静力加载试验验证了有限元模型的合理性；随后模拟分析了组合节点的传力机理和应力分布，明确了不同参数对组合节点受力特性的影响规律。结果表明，钢管、中环板与竖向板相交区域的应力集中且最大应力达到屈服强度，并向四周扩散且逐渐减小，中环板厚度和竖向板厚度是影响组合节点极限承载力的关键因素。基于有效宽度法计算了中环板和竖向板的承载能力，建立了不同板件内力占比计算公式，基于此，提出了组合节点承载力计算方法。所提出的极限承载力计算方法与数值模拟结果的误差在13%以内，验证了计算方法的合理性，为钢管角钢组合节点的结构设计与分析提供指导。

目的总结原因不明矮身材儿童的临床特征并探讨其致病基因，为临床精准诊疗提供依据。方法收集我院儿科内分泌专科2018年1月至2022年8月就诊的未能明确诊断的矮身材儿童临床表现、实验室检查及全外显子组测序（WES）结果进行回顾性分析，根据不同作用机制对致病基因进行归纳总结。结果纳入患儿48例（男性30例，女性18例），年龄（7.73±3.97）岁，身高标准差分值为-3.63±1.67；临床表现：特殊面容33例（68.8%），体型或骨骼系统异常31例（64.6%），围产期异常26例（54.2%，其中61.5%为小于胎龄儿），内分泌系统异常24例（50.0%，其中87.5%生长激素（GH）峰值低于正常），矮身材家族史21例（43.8%）；实验室检查：GH激发试验峰值（9.72±7.25）ng/mL，IGF-1 标准差分值为-0.82±1.42，骨龄与年龄差值（-0.93±1.39）岁；WES共发现相关基因变异者25例，其中14例（56.0%）为致病变异，6例（24.0%）为可能致病变异，5例（20.0%）为意义未明变异；评价为致病及可能致病变异的基因共14个，其中影响细胞内信号通路10个（PTPN11、RAF1、RIT1、ARID1B、ANKRD11、CSNK2A1、SRCAP、CUL7、SMAD4和FAM111A），影响细胞外基质（ECM）4个（ACAN、FBN1、COL10A1和COMP）。结论临床上表现为严重矮身材伴特殊面容、非匀称体型、骨骼系统异常、小于胎龄儿、GH峰值低于正常和矮身材家族史等特征的儿童，其病因需考虑罕见单基因疾病的可能，WES是提高单基因性矮小症诊断效能的重要手段。本组患儿致病基因中，主要致病机制是影响细胞内信号通路和ECM组分或功能，进一步研究有助于发现和研究新的矮小症致病变异和基因功能。

目的睡眠相关痛性勃起（SRPE）是一种以夜间睡眠中反复被伴有疼痛的阴茎勃起中断而觉醒为临床特征的罕见睡眠障碍，目前病因尚不明确。本研究目的在于探讨可能相关的危险因素对SRPE的发病的影响。方法通过问卷调查的方式，我们对前来泌尿男科就诊的SRPE患者或非SRPE患者进行信息采集。通过Logistic回归分析评估年龄、职业、每晚睡眠开始时间、每周性交频率、心理状态、勃起功能障碍、慢性前列腺炎病史、前列腺增生病史、腰椎疾病史、中枢神经系统疾病史、 高血压病史、糖尿病病史及家族史等是否为SRPE发病的影响因素。结果290名受试者完成了研究，其中对照组145名，病例组145名。单因素Logistic回归分析发现，慢性前列腺炎病史、脑力劳动、职业、中枢神经系统疾病史、晚睡、性生活频率、焦虑状态可能与SRPE发病相关。将上述因素纳入到多因素回归分析模型中后发现，性生活≥2次/周（OR 95%CI = 0.326（0.179，0.592）及晚睡（24时后入睡）（OR 95%CI = 0.494（0.265，0.918）可能是SRPE的保护因素；慢性前列腺炎史（OR 95%CI = 3.779（2.082，6.859）可能是SRPE的危险因素。然而，中枢神经疾病史、职业影响在多因素分析中的统计学差异不显著。结论：慢性前列腺炎、 焦虑状态可能是SRPE的独立危险因素；性生活≥2次/周及适当地推迟睡眠时间可能是独立保护因素。

目的探讨中医禁食疗法对超重/肥胖2型糖尿病患者的临床疗效。方法本研究以超重/肥胖2型糖尿病患者为研究对象，使用中医禁食疗法治疗1周，对所有患者的临床疗效进行评估并随访6月。在禁食结束、禁食后3月、6月分别对糖化血红蛋白、空腹血糖、空腹胰岛素、HOMA-IR、体质量、BMI等指标进行检测。结果完成中医禁食疗法后随访3月和随访6月时，患者糖化血红蛋白均显著低于基线值水平（PPPP

采用氟盐反应法制备TiB2/Al复合材料铸锭，并以此为原料利用高压气体雾化制粉技术制备TiB2/Al复合材料粉末。利用金相显微镜、扫描电子显微镜、X射线衍射仪、粒度分布仪等手段对所制备铸锭和粉末的组织及性能进行了表征。结果表明：Al熔体中TiB2的溶度积远小于TiAl3和AlB2的溶度积，TiB2自Al熔体中沉淀析出导致的体系Gibbs自由能变化量比TiAl3或AlB2自Al熔体中沉淀析出导致的体系Gibbs自由能变化量的值更小。TiB2/Al复合材料铸锭及粉末均主要由α-Al相和TiB2相组成。气体雾化制备TiB2/Al复合材料粉末中TiB2颗粒具有纳米尺度，且均匀弥散地分布于Al基体之中，不存在明显的偏聚现象。TiB2/Al复合材料粉末的粒度主要分布在10～100 μm之间，呈正态分布，粒径介于10～70 μm粉末占比（质量分数）约为81.1%，粒径大于70 μm粉末收得率为12.6%，粒径小于10 μm粉末收得率为6.3%。

以花生仁为原料，先红外辐射预处理，再采用酶解法提取浓香花生油脂体。在单因素试验的基础上，通过响应面法优化浓香花生油脂体的提取工艺并对其品质进行分析。结果表明：浓香花生油脂体最佳提取工艺条件为液料比6∶ 1、复合酶（纤维素酶、果胶酶与木聚糖酶比例63∶ 24∶ 13）加酶量460 U/g、pH 5.5、酶解时间110 min、酶解温度51 ℃，在此条件下浓香花生油脂体得率为50.89%。所得浓香花生油脂体呈半流动态乳液状，淡黄色，具有浓郁的烘烤花生香，平均粒径为（3.49±0.61）μm，必需氨基酸含量为5.39 mg/100 g，氨基酸总量为13.50 mg/100 g，冻融稳定性良好。 The peanuts were pretreated by infrared radiation, and then flavored peanut oil bodies were extracted by enzymolysis method. Based on single factor experiment, the extraction technology of flavored peanut oil bodies was optimized by response surface methodology, and the quality of flavored peanut oil bodies was analyzed. The results showed that the optimal extraction conditions of flavored peanut oil bodies were obtained as follows: liquid-solid ratio 6∶ 1, complex enzyme(ratio of cellulase to pectinase to xylanase 63∶ 24∶ 13) dosage 460 U/g, pH 5.5, enzymolysis time 110 min and enzymolysis temperature 51 ℃. Under the optimal conditions, the yield of flavored peanut oil bodies was 50.89%. The flavored peanut oil bodies extracted was semi-fluid emulsion, light yellow, with strong roasted peanut aroma. The average particle, content of essential amino acids and total amino acids of flavored peanut oil bodies were (3.49±0.61）μm, 5.39 mg/100 g and 13.50 mg/100 g,respectively. Also the flavored peanut oil bodies had good freeze-thaw stability.

目的探讨泛素特异性蛋白酶44（USP44）在肝细胞癌（HCC）中的表达及其临床病理学意义。方法运用免疫组化方法，检测USP44蛋白在161例肝细胞癌中的表达水平，统计分析其与临床病理参数之间的相关性及其预后价值。结果在161例HCC患者中，98例（60.9%）高表达USP44蛋白，Pearson′s卡方检验结果显示USP44在HCC中的表达水平与临床分期（χ2=14.44，P＜0.001）、肿瘤单灶及多灶性（χ2=8.04，P =0.005）显著相关；Kaplan-Meier分析结果显示，低表达组患者平均生存时间59.6个月，显著低于高表达组患者的平均生存时间185.0个月（Log-rank χ2=20.77，P＜0.001）；多因素Cox比例风险模型揭示USP44是HCC患者的独立预后危险因素。结论USP44蛋白高表达的HCC患者具有良好的生存期，检测其蛋白表达可作为筛选预后良好的肝细胞癌患者的一种手段。

【目的】对比阿尔茨海默病（AD）和血管性痴呆（VaD）的脑区体积及脑白质高信号（WMH）差异，并探究 MRI 对 AD 与 VaD 的鉴别诊断价值。【方法】回顾性分析 35 例 VaD 和 74 例 AD 患者的临床资料和 MRI 影像资料。利用AccuBrainTM 提取不同脑区及WMH 的体积测量值，并利用视觉评分量表评估所有患者WMH；比较AD与VaD 脑区体积及WMH 差异，鉴别诊断采用主成分分析（PCA）和logistic 回归模型两种方法，最后评价各指标的诊断效能。【结果】①AD 组颅内总体积、脑实质、脑灰质、脑白质、海马、杏仁核、下丘脑、额叶（左、右）、枕叶（左、右）、颞叶（左、右）、顶叶（左、右）、海马（左、右）、杏仁核（左、右）、下丘脑（左、右）体积均较VaD 组减小，且差异具有统计学意义（P

【目的】分析中山大学孙逸仙纪念医院的重型β-地中海贫血（β-TM）患者青春发育特点及影响因素。【方法】通过对42 例年龄≥10 岁β-TM 患者进行随访资料回顾、问卷调查、体格检查及实验室检查等评估青春发育状态，分析影响β-TM 患者青春发育的可能因素。【结果】24 例（57.14%）β-TM 患者出现青春发育异常，女性以乳房不发育、原发性闭经及男性以睾丸不增大、阴茎短小为主要表现。其中β0β0 基因型、脾切除后、维生素D 缺乏或者伴有糖尿病的β-TM 患者的青春发育异常发生率均显著增高，差异有统计学意义（χ2 = 3.966，5.196，5.567，4.714，P = 0.046， 0.023，0.018，0.030）。经Logistic 回归分析得出心MRT2* < 20 ms 是β-TM 患者青春发育异常的独立危险因素。【结论】β-TM 患者青春发育异常较常见，起始祛铁年龄大、严重心铁过载、β0β0 基因型、脾切除后以及合并其他内分泌疾病的β-TM 患者青春发育异常发生率更高，低促性腺激素性腺功能减退症可能是青春发育异常的主要发病机制。

围绕下一代光纤通信系统中轨道角动量（OAM）复用技术的关键问题,基于环状光纤中携带OAM的模式基础理论,仿真分析了环状光纤的不圆度对矢量合成OAM模式的本征奇模和偶模的有效折射率、走离长度以及模场强度分布的影响。结果表明,环状光纤不圆度会使得本征模式奇偶模之间的有效折射率差增大,走离长度减小,导致相应OAM模式在环状光纤中传输时稳定性下降。同时,不圆度的存在还会使矢量合成OAM模式的各本征模式的模场强度分布发生畸变,模场泄漏加剧。

【目的】总结5种亚型儿童RAS通路病的临床特点及基因变异类型，分析Ⅰ型神经纤维腺瘤病（NF1）、努南综合征（NS）、多色素痣型努南综合征（NSML）、科斯特洛综合征（CS）和心-面-皮肤综合征（CFC）的临床共性和特性，提高临床医生对RAS通路病的认识和诊治水平。【方法】回顾性分析我院2015年10月至2018年6月期间确诊的11例RAS通路病患者的临床资料及基因突变类型。【结果】11例RAS通路病患儿的发病年龄为6月~12岁，常见临床表现包括：身材矮小、特殊面容、先天性心脏病、皮肤牛奶咖啡斑、运动发育落后、血小板减少、癫痫、肌张力异常、隐睾等，共检测出5种基因突变类型，包括NF1基因、PTPN11基因、RAF1基因、BRAF基因和HRAS基因。【结论】RAS通路病是丝裂原活化蛋白激酶通路异常引起的一组遗传性生长发育异常综合征。因此，RAS通路病常伴有特殊面容、运动发育落后、心血管、皮肤、骨骼、神经等多系统异常以及肿瘤易感性等共同表现。但因基因突变位点的差异，各类型间亦存在相对特异的表现。另外，因肿瘤易感性是RAS通路病的共性之一，肿瘤监测是随访过程的重要项目。

【目的】探讨程序性死亡受体-1（PD-1）、程序性死亡配体-1（PD-L1）及CD4+CD25+Foxp3+调节性T细胞（Treg）、CD4+/CD8+比值在JAK2V617F突变阳性骨髓增殖性肿瘤（MPN）患者骨髓中的表达及临床意义。【方法】收集45例JAK2V617F阳性的MPN患者，其中原发性血小板增多症（ET）17例、真性红细胞增多症（PV）13例、原发性骨髓纤维化（PMF）15例；包括初治组30例、治疗组15例。15例健康志愿者作为对照组。荧光定量聚合酶链反应（FQ-PCR）检测突变型与野生型JAK2比值。免疫组化检测患者及对照骨髓病理切片p-JAK2、PD-1、PD-L1表达情况，流式细胞术检测Treg和淋巴细胞亚群在MPN患者及对照组外周血中的变化。【结果】初治组p-JAK2、PD-1、PD-L1及Treg表达水平明显高于治疗组及对照组（P均

随着配电自动化的深入应用,数据类业务及网络带宽需求不断增大,针对此问题,文章提出了采用TDM（时分复用）+分组传送技术进行业务传送的方案。建立一种业务传送隔离度的算法,并采用以太网交换机和光电一体化接入设备对各自所传业务的承载隔离度进行了试验比较,验证了隔离度算法的正确性,旨在实现电力传输资源的高效利用。

根据可扩展标记语言（XML）的特性,对XML在北向接口协议制定、北向接口设备建模以及北向接口设备模型数据输出3个方面进行了详细的研究,并给出了具体的示例。研究结果表明,XML技术能方便地作为一个轻量级基于公共对象请求代理体系结构（CORBA）的描述语言,同时能清晰地描述北向接口模型。

综合考虑多种因素,对突发的偏置时间进行改进,提出了一种新的解决资源竞争并能提供服务质量（QoS）保证的机制。结合3种信道调度算法（LRU、FF和PS）,对该机制进行了仿真,并与PPJET机制进行了对比,结果表明,在突发丢失方面该机制的性能明显优于后者。

文章系统地介绍了电信管理网（TMN）管理体系结构和各功能层接口参考点的关系。分析了现有网元管理层-网络管理层（EML-NML）接口Q3标准在面向对象的分布式环境下的不足以及通用对象请求代理体系结构（CORBA）在分布式应用环境下的优势。详尽地阐述了CORBA技术在EML-NML接口中的应用,以及传送网管理平台上基于CORBA的EML北向接口实现体系结构,并提出了一种基于CORBA技术的通用EML-NML接口设计实现方案,最后给出了以ORB IX6.1为CORBA实现平台的TMN总体运行方案。

【目的】研究成人骨髓间质干细胞(MSC)基本生物学特性。【方法】采用Ficoll-Paque 淋巴细胞分离液分离成人 MSC , 体外扩增, 比较不同培养基和血清含量对MSC 生长的影响, 流式细胞仪检测MSC 表面抗原表达。【结果】成人骨髓间 质干细胞在体外扩增原代可获得(5 ～ 6)×105 个细胞, 15 代可获得(3～ 4)×1012个细胞, 随着传代次数的增加, 细胞的增殖能 力下降。L-DMEM 培养基有利于细胞的培养扩增。细胞流式细胞仪检测结果显示CD29、CD44 、CD59 、CD105 、CD166 表达阳 性, CD11a 、CD14、CD33、CD34、CD45、CD38 、CD80 、CD86 、CD117 表达为阴性。【结论】MSC 有很强的自我更新能力, 在组织工 程中具有广阔的应用前景。

Incontinence-associated dermatitis (IAD) is a local skin inflammation caused by fecal impregnation. By analyzing and summarizing the Traditional Chinese Medicine (TCM) cognition, epidemiology, the concept of TCM external treatment and its application in IAD, this paper aims to broaden the thinking of IAD nursing, provide a basis for the exploration of more TCM external treatment methods applied to IAD, and provide a reference for the construction of systematic TCM external treatment methods applied to the nursing scheme of IAD patients. (失禁相关性皮炎(IAD)是由于大小便浸渍引起的局部皮肤炎症。本文通过对IAD的中医认知、流行病学、中医外治疗法的概念及在IAD中的应用等方面进行分析与归纳, 旨在为IAD的护理拓宽思路, 为更多的中医外治方法应用于IAD的探索提供依据, 为构建系统化的IAD中医外治法护理方案提供参考。)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Uranium Mining & Metallurgy is the property of Uranium Mining & Metallurgy Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Uranium Mining & Metallurgy is the property of Uranium Mining & Metallurgy Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The World Health Organization estimates that 50% of the global population will be affected by myopia by 2050, of which 10% will have high myopia. Regular medical check-ups and follow-ups are essential to prevent abnormal axial elongation, which leads to high myopia in children. Additionally, the prevalence of aging and widespread use of digital devices (3C products) are expected to exacerbate ocular diseases, impacting ophthalmic medical resources and capacity. Childhood myopia is a major public health concern. Asian countries, such as Singapore and China, have implemented more comprehensive national programs for myopia prevention and control, including prevention, screening, and treatment. In Taiwan, along with the national myopia prevention efforts, some municipalities have introduced cycloplegic refraction examinations for young children, which have shown sustained success in controlling myopia. This article re-evaluates Taiwan’s vision care programs in light of myopia policies from other Asian countries and proposes a new blueprint for visual healthcare plans. The proposed plan recommends that educational institutions should encourage health promotion models in schools; develop knowledge-driven myopia prevention education; enhance collaboration with eye care professionals; ensure strong support from health authorities; and implement strategies for vision monitoring, surveying, and feedback to ensure the visual health of school children. [ABSTRACT FROM AUTHOR]

Copyright of China Surfactant Detergent & Cosmetics (2097-2806) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Science & Technology & Economy is the property of Grain Science & Technology & Economy Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Frontiers of Computer Science & Technology is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

高尿酸血症指血尿酸水平升高 (血尿酸>420 mmol/L) 超过正常范围的病理状态, 是痛风, 慢性肾脏病等 其他相关疾病的潜在危险因素. 高尿酸血症患者存在肠道菌群失调, 其肠道菌群与健康人相比有较大差异, 具有菌 群多样性下降, 有益菌群减少, 潜在致病菌增加, 短链脂肪酸生成减少的特点. 肠道菌群在嘌呤代谢中发挥重要作 用, 某些潜在致病菌群可参与嘌呤代谢过程, 导致体内嘌呤负荷增加, 促进血尿酸水平升高. 肠道内尿酸分解代谢 的失调也会影响尿酸排泄, 部分菌群失调可能减少肠道对尿酸的分解, 进一步加重高尿酸血症. 肠道菌群失调也可 影响宿主的抗氧化防御体系影响尿酸水平. 肠道菌群代谢产物 (如短链脂肪酸等) 失调也可能改变肠道环境, 影响 尿酸的生成和排泄过程. 最后, 肠道菌群失调可能破坏肠道屏障的完整性, 增加肠道通透性, 导致血尿酸水平的进 一步升高. 上述这些机制共同作用, 影响高尿酸血症的发生发展. 通过调整饮食, 服用益生菌, 益生元及粪菌移植 等方法增加有益菌, 抑制有害菌, 可能对高尿酸血症起防治作用. [ABSTRACT FROM AUTHOR]

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the regulation of DIRAS2 gene expression by acetylated STAT3 and its involvement in the proliferation of triple-negative breast cancer(TNBC)cells. Methods The expression levels of DIRAS2 and acetylated STAT3 in TNBC tissues and cells were analyzed by database query, Western blotting, and qRT-PCR. TNBC cell lines MDA-MB-231 and SUM159 were selected, and lentivirus or plasmid was used to construct DIRAS2 overexpression and STAT3 wild or Lys685 mutation cell lines. The CCK-8 assay was used to evaluate the effect of DIRAS2 and STAT3 acetylation on the proliferation of TNBC cells. Western blotting, pyrosequencing, ChIP and IP were employed to investigate the regulatory effect and mechanism of acetylated STAT3 on DIRAS2 expression. Results The expression of DIRAS2 was decreased in TNBC tissues and cells. Pyrosequencing analysis found that the methylation level of CpG islands in the DIRAS2 promoter was increased in TNBC cells compared with normal breast epithelial cells, which promoted the growth of cancer cells. Furthermore, TNBC cells showed an increase in STAT3 acetylation, which was accompanied by a shift in the methylation status of the DIRAS2 promoter. ChIP and IP experiments showed that acetylated STAT3 could bind to the DIRAS2 promoter, and the STAT3 Lys685 mutation disrupted the interaction between STAT3 and DNMT1. Conclusion Acetylated STAT3 induces DIRAS2 promoter methylation by recruiting DNMT1, leading to loss of DIRAS2 expression and cancer cell proliferation in TNBC. [ABSTRACT FROM AUTHOR]

Establishing a differentiated green mine evaluation system for different types of mines is of significant practical importance. This study constructs a green mine evaluation system for the gold industry based on the analytic nierarchy process (AIP). The evaluation system sets the green mine evaluation index system for the gold industry as the target level, with 6 indicators as the criteria level such as mining area environment, resource development methods, and comprehensive resource utilization, 22 indicators as the index level such as functional zoning, mine landscape, and mining area greening. The AIP method was employed to determine the weight ranking of different indicators, identifying important criteria levels such as resource development methods, energy conservation and emission reduction, and comprehensive resource utilization. As for the index level, key indicators include associated mineral resource utilization, green development, energy conservation and consumption reduction, mining recovery rate, Deneficiation (metallurgy) recovery rate, and simultaneous mining and reclamation. The evaluation results provide a reference for the construction of green mines in the gold industry. [ABSTRACT FROM AUTHOR]

This study aims to explore the effects of different types of trace element raw materials and their addition levels on the storage quality of 5‰ premixed feed for piglets. There are a total of 5 groups in the experiment, namely group 1: inorganic trace element group; groups 2: trace element coating group; groups 3: glycine trace element group (trace element addition level is 70% of unorganized); groups 4 and groups 5: complex amino acid chelated trace element group (trace element addition level is 70% and 50% of unorganized), with 3 replicates for each group. The premix is stored in a normal warehouse for 90 days, and the loss rates of several vitamins and enzyme activity are measured and calculated on the 1st, 21st, 42nd, 63rd and 90th days. The results showed that from day 1 to 63, the activity of yeast xylanase and β-glucanase has increased to varying degrees. At 90 days, the activity of yeast xylanase in each group began to decrease, with group 5 having the highest loss rate. Compared with groups 1, 2, and 3, the loss rate of warm amylase activity and acidic protease activity in groups 4 and 5 were significantly reduced (P<0.05). The loss rate of vitamins in different groups increases with the prolongation of storage time. At 90 days, compared with other groups, the loss rate of vitamin B2 in groups 4 and 5 were significantly reduced (P<0.05). At day 42, the loss rate of vitamin B6 in group 5 was significantly lower than that in other groups (P<0.01). Throughout the entire experiment, the phytase activity and vitamin E loss rate in group 1 were significantly higher than those in other groups (P<0.05), with group 5 having the lowest phytase activity and vitamin E loss rate. In summary, replacing inorganic trace elements with organic trace elements has less impact on enzyme preparations and vitamins in the premix, and low concentrations of organic trace elements are more conducive to the preservation of the premix. [ABSTRACT FROM AUTHOR]

Copyright of e-Education Research is the property of Northwest Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Stroke is the property of Chinese Journal of Stroke Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Geodesy & Geodynamics (1671-5942) is the property of Editorial Board Journal of Geodesy & Geodynamics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)