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Objective To explore the intervention effect of case management model in lung cancer patients with chemotherapy and the improvement of their hope level and quality of life. Methods A total of 81 patients who received chemotherapy in this hospital from April 2020 to April 2022 were selected and divided into two groups according to random number table method. Forty patients in the control group received routine nursing, and 41 patients in the observation group received case management model nursing based on routine nursing. The improvement of discomfort symptoms, the level of hope, the degree of cancer fatigue, the incidence of chemotherapy adverse reactions and the quality of life of the two groups were compared. Results After nursing, the scores of Chinese version of Anderson symptom assessment scale(MDASI-C) and Cancer-related Fatigue Scale (CFS) in the observation group were lower than those in the control group, while the scores of Herth Hope Inventory (HHI) and Function Assessment of Cancer Therapy-Lung (FACT-L) were higher in the observation group and the differences were statistically significant (P<0,05). The incidence of chemotherapy-related adverse reactions (7.32%) in observation group was lower than that in control group (25.00%) and the difference was statistically significant (P<0.05). Conclusion The application of case management model in patients with lung cancer chemotherapy can effectively relieve their discomfort symptoms improve their hope level and cancer-related fatigue, reduce the incidence of adverse reactions, and further improve their quality of life. [ABSTRACT FROM AUTHOR]

Copyright of Hazard Control in Tunnelling & Underground Engineering is the property of Shandong University Scientific Journals Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This investigation was under taken to explore probable mechanisms and signal pathways involved in diaphragm dysfunction induced by Sepsis. The rat sepsis model was constructed by injecting 8 mg/kg LPS into the abdominal cavity. Male SD rats were divided into 3 groups (n=6/group): comparing control group (Con group), LPS group (Sepsis group) and calcium Protease inhibitor pretreatment group (Calpeptin group). Each group of rats was sacrificed, and then their diaphragm tissues were quickly separated. The pathological changes of the diaphragm tissue were observed by using the hematoxylin-eosin (HE) staining method. Additionally, the mRNA expression levels ofμ-Calpain, caspase-3, Beclin-1, TNF-αand IL-6 in diaphragm tissue were detected by real-time fluorescence quantitative PCR (qRT-PCR). Under the light microscope, we could see that the diaphragm cross-section in the Con group was regular, with full and orderly muscle fibers, closely spaced muscle fibers, and nuclei distributed along the edge of the lens. In the diaphragm muscle cells of the Con group, there were intact capillary endothelium and no interstitial hyperplasia. Compared with the Con group, HE staining of the sepsis group rats with LPS for 24 h showed no obvious changes in diaphragm atrophy, but the contractiity of the diaphragm decreased, which was consistent with our previous research results. The mRNA expression levels of the above genes in sepsis group were significantly increased (P<0.05), and were significantly decreased after Calpeptin pretreatment(P<0.05) by qRT-PCR. Diaphragm muscles are prone to dysfunction during sepsis. Calpeptin, a calpain inhibitor, can significantly reduce the activation of inflammation, apoptosis and autophagy pathways induced by LPS. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

For the seizure failure of piston pin bearing in the preliminary structural design, the heat transfer of piston is simulated and its temperature field is calibrated, and the thermo-mechanical deformation of piston at state is analyzed. The analytic results show that the non-compatible deformation of piston pin bearing is main reason leading to wear. Accordingly, the profile matching of piston pin boss bearing under thermo-mechanical condition is presented. On this basis, the profile of piston pin boss bearing is optimized, and the optimized profile is validated by simulation and engine test. The barrel-shaped, exponential and hyperelliptic profiles of the connecting rod small end bearing are compared to investigate the influences of those profiles on the load distribution of the bush. Results show that exponential and hyperelliptic profiles are more suitable for improving the load distribution of the connecting rod small end bearing. [ABSTRACT FROM AUTHOR]

Principles for Formulating Prescriptions Based on Zang-Fu Organs, Origin and Superficiality, Deficiency and Excess, Cold and Heat Syndrome is one of ZHANG Yuansu’ s famous masterpieces. With decades of clinical experience, ZHANG Yuansu summarized his own pathogenesis theory corresponding to Zang-Fu organs, cold and heat syndrome, deficiency and excess syndrome. In his efforts, the theory of differentiation based on Zang-Fu organs was appreciated by doctors of later ages. Conciseness of the prescription and the medication rules on treatment of TCM liver diseases recorded in this book was the fruit of the combination of inheritance of the Classic and his own theoretical innovation. The clinical thought of diagnosis and treatment, including grasping physiological function of zang-fu organs, understanding progression of diseases, tactfully using medicines of guiding action and leading to improving the curative effects, is still of great clinical significance up to now. [ABSTRACT FROM AUTHOR]

Objective To observe the stability of esomeprazole sodium fro injection in different solvent and different drug compatibility. Methods Forty mg esomeprazole sodium for injection was respectively dissolved in 100 mL of 0.9% sodium chloride, xylitol, 10% glucose, 5% glucose, 5% fructose and glucose and sodium chloride injection. The concentrations of esomeprazole sodium in different solvents at 0, 0.5 h, 1 h, 2 h, 3 h, 4 h, 6 h, 8 h and 12 h were detected by HPLC, and we also observed the changes in appearance and measured pH value. The best solvent with stable drug compatibility was used to mix with esomeprazole sodium solution. The esomeprazole sodium solution of 100 mL was repsectively mixed with 10 mL vitamin C, levofloxacin lactate, compound amino acid, vitamin B6, hydrochloric acid methoxy metoclopramide, ondansetron hydrochloride our Joan, glucose acid calcium, Tanreqing injection Reduning injection and mannitol injection.The color change of compatibility was observed at 0, 0.5 h, 1 h, 2 h, 3 h, 4 h, 6 h, 8 h and 12 h . Results When the esomeprazole sodium for injection was dissolved in 0.9% sodium chloride and xylitol within 12 h, the PH value and drug concentration were in a stable state; when dissolved in other solutions within 12 h, the PH value and drug concentration were decreased. The 0.9% sodium chloride injection was selected as esomeprazole sodium solvent, When we mixed esomeprazole sodium with vitamin C, the color changed after 8 h; when we mixed esomeprazole sodium with levofloxacin lactate, compound amino acid, vitamin B6, hydrochloric acid methoxy metoclopramide, ondansetron hydrochloride our Joan and gluconic acid, the color changed after 6 h; and when we mixed esomeprazole sodium with Tanreqing injection and Reduning injection, the color changed after 4 h and when we mixed with mannitol injection, the color changed after 1 h. Conclusion The PH value and drug concentration were in a stable state when the esomeprazole sodium for injection was dissolved in 0.9% sodium chloride, and the color changed in a short time when the esomeprazole sodium was compatible with Tanreqing injection, Reduning injection and mannitol injection, thus the clinical medication should be paid attention to. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)