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将浮式网架结构应用于深海工程可为人类开发深海提供所需要的空间。选取正放四角锥网架为结构单元,利用Morison方程计算波浪力、海流力,通过函数关系找出作用于结构自身荷载的最大值,平均施加到水面以下球节点上,并施加重力、浮力、上部荷载,模拟结构在海洋环境荷载作用下的力学响应,用百年一遇的海况进行校核,得出该网架结构单元相对承载力较高、安全可靠的结论。由于承载力出现较大的富余,为进一步优化结构,可通过网架结构布局上的改进来实现,包括整体上采用抽空四角锥网架等杆件较为简单的网架体系,局部抽除某些内力较小的杆件,或者将抽掉的杆件替换成与钢结构有较好融合且适应海洋环境的其他材料,使得浮式网架结构更经济安全地应用于实际工程。

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Inorganic Chemicals Industry is the property of Editorial Office of Inorganic Chemicals Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To compare the transdermal absorption of Bulleyaconitine A on normal rabbit intact skin，normal rabbit damaged skin，pathological damaged normal skin，and pathological damaged injured skin barrier models in vivo. Methods The rabbit model of pathological injury was obtained by intramuscular injection of 50% glycerol. The damaged skin was prepared by gently rubbing the skin surface with a wooden stick wrapped in No. 1 sandpaper until it turned light red. Four skin barrier models were topically treated with Bulleyaconitine A gel. Blood samples were collected at various time points after drug administration for normal skin （1 h，2 h，3 h，4 h，5 h，6 h， 8 h，10 h） and damaged skin （1 h，2 h，3 h，4 h，5 h，6 h，8 h，10 h，12 h，24 h，36 h）. HPLC-MS/MS was used to detect drug concentrations in rabbit models at different time points after Carbenoxolone administration. Drug pharmacokinetic parameters were calculated using DAS 3.2.0，and inter-group pharmacokinetic parameters were statistically analyzed using SPSS 23.0. Results The trends of three pharmacokinetic parameters，AUC（0-t）， AUC（0-∞），and Cmax，in four skin barrier models of rabbits are consistent. They are as follows in size order: intact skin of normal rabbits > damaged skin from pathological injury > intact skin from pathological injury > intact skin of normal rabbits. Different external skin environments have a significant impact on the permeability of Bulleyaconitine A absorption. The permeability of damaged skin is significantly higher than that of normal skin （P < 0.05）. Pure pathological damage （internal injury），with consistent skin conditions，shows no significant impact on the absorption and elimination of Chuanwu （P > 0.05）. Compared to intact skin of normal rabbits，damaged skin from simulated external trauma， and damaged skin from internal and external trauma， the absorption of Bulleyaconitine A significantly increases and the elimination capacity significantly decreases （ P < 0.05） . Conclusion The barrier function of the stratum corneum is the main limiting factor for Bulleyaconitine A transdermal absorption. Bulleconitine A may accumulate in the body under the condition of trauma or internal or external injuries， which may affect drug safety. When conducting experiments on transdermal drug delivery formulations，it is advisable to simultaneously compare normal skin with damaged skin caused by simulated trauma or pathological damage from internal and external injuries. Studying the transdermal absorption under conditions simulating clinical muscle and skin injuries from internal and external trauma will help in a more comprehensive and accurate evaluation of the efficacy，pharmacokinetics，and toxicological properties of transdermal drug delivery formulations. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin University of Science & Technology is the property of Journal of Harbin University of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of International Architecture is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To develop a UPLC-Q Exactive-MS method for the rapid determination of palmatine in cynomolgus monkey plasma. Method It was detected by using an UltiMate 3000 high-performance liquid chromatography-tandem mass spectrometry system with Q Exactive quadrupole-electrostatic field orbitrap. The monkey plasma was precipitated and diluted with acetonitrile containing berberine to act as an IS.The analytical column was packed with accucore Hypersil GOLD Dim C18 （100 mm×2.1 mm，1.9 μm） . The mobile phase was acetonitrile and water （0.1% formic acid） at gradient elution and a flow rate of 0.3 mL/min. The column temperature was 30℃. The ESI sources were operated in the positive ion mode （ESI+） . The scan type for MS detection was set to slective ion scan mode （t-SIM） The details of parameters was shown below： palmatine， [M-Cl]+， m/z 352.15433； berberine， [M-Cl]+， m/z 336.12303， resolution 70 000， automatic gain control （AGC） And ion implantation time （IT） was set to 5e4 and 200 ms respectively. The spray gas and collision gas was nitrogen and high purity nitrogen. Results Excellent liner relationship was obtained from the range of 105.0 ~ 8200 μg/L （concentration of injection solution 0.2625 ~ 20.50 μg/L，linear equation is Y= 0.001 188 51C-0.000 042 206 6， = 0.999 6，weight 1/C2），and the limit determination of PMH was 105.0 μg/L. The inter- and intra-day RSD was less than 4.06%. The matrix effector of inter- and intra-day was 91.71 ~ 97.74% （n = 5） . Dosing plasma was stable under the follwing conditions：room temperature for about 1 day，-20 ℃ for 1 day / 10 days / 35 days， and -20 ℃for 35 days，the room temperature freeze-thaw twice. Conclusion The method with wide linear range proved accurate， simple and rapid with high sensitivity and specificity applied to the analysis of the palmitine in pharmacokinetics and toxicokinetics. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Henan Agricultural Sciences is the property of Editorial Board of Journal of Henan Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Wuhan University Journal (Philosophy & Social Sciences) / Wuhan Daxue Xuebao (Zhexue Shehui Kexue Ban) is the property of Wuhan University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin University of Science & Technology is the property of Journal of Harbin University of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Wuhan University Journal (Philosophy & Social Sciences) / Wuhan Daxue Xuebao (Zhexue Shehui Kexue Ban) is the property of Wuhan University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electric Machines & Control / Dianji Yu Kongzhi Xuebao is the property of Electric Machines & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)