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目的在全外显子组水平对比头皮皮脂腺癌（SC）和头皮皮脂腺瘤（SA）的相关致病性基因突变的差异。方法对经过病理诊断的头皮SC和SA样本各1例，利用 Illumina HiSeq 2500平台进行全外显子组测序（WES）。筛选可疑的单核苷酸变异位点，进行突变的保守性和功能分析。利用SciClone软件来追踪亚克隆进化可以得到每例肿瘤样本的克隆性图谱信息。通过MutSigCV软件筛选得到高频显著基因，将体细胞变异与已知驱动基因进行比较，筛选出该肿瘤样本中的已知驱动基因。结果经过对比发现，与头皮SA相比，SC存在两个驱动基因ACVR1B和TFDP1的基因突变。结论头皮SC 驱动基因ACVR1B和TFDP1的基因突变如果能在更大的病例队列中得到证实，对其发生的可能机制以及治疗靶点有重要的意义。

Copyright of Journal of Practical Medicine / Shiyong Yixue Zazhi is the property of Journal of Practical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective]The objective of this study is to identify the genes(TaENO2s)encoding the enolase family member ENO2 in the important crop plant of wheat(Triticum aestivum L.)and to determine the alternative translation feature and protein enolase activity of TaENO2s.[Method]Wheat TaENO2s were identified by bioinformatics. One of the identified TaENO2s was selected as a representative for protoplast-based exogenous expression and characterization of alternative translation products. This selected TaENO2 was also subjected to prokaryotic expression for purification of recombinant protein. The enolase activity of the purified recombinant protein was determined with in vitro assays.[Result]The hexaploid wheat genome had three homeologous TaENO2s which sequences encoded a conserved enolase catalytic center and had a putative alternative translation start site at the internal ATG codon encoding the residue M94(ATGM94) of the enolase sequence. When exogenously expressed in protoplasts, the representative TaENO2 encoded two proteins, one full-length form of cytoplasmic and nuclear enolase protein and one N-terminal truncated form of nuclear transcriptional repressor TaMBP-1, while the variant of the same gene containing mutated ATGM94 only encoded the full-length form of enolase protein. Soluble recombinant GST-TaENO2 protein expressed in Escherichia coli was successfully purified and verified to have an in vitro enzymatic activity to catalyze the conversion from 2-phosphoglycerate (2-PGA)to phosphoenolpyruvate(PEP)[Conclusion]The wheat genome has three TaENO2 genes encoding the enolase protein ENO2. Under the condition of exogenous expression, TaENO2 encodes two protein products via mRNA alternative translation, one enolase protein translated from the first start codon and one TaMBP-1 protein translated from the internal start codon(2-PGA)to phosphoenolpyruvate(PEP).[Conclusion[The wheat genome has three TaENO2 genes encoding the enolase protein ENO2. Under the condition of exogenous expression, TaENO2 encodes two protein products via mRNA alternative translation, one enolase protein translated from the first start codon and one TaMBP-1 protein translated from the internal start codon ATGM94. The prokaryotically expressed recombinant protein GST-TaENO2 possesses in vitro enolase activity.. The prokaryotically expressed recombinant protein GST-TaENO2 possesses in vitro enolase activity. [ABSTRACT FROM AUTHOR]

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Copyright of Applied Chemical Industry is the property of Shaanxi Research Design Insitute of Petroleum & Chemical Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Hebei University of Science & Technology is the property of Hebei University of Science & Technology, Journal of Hebei University of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of China Plastics / Zhongguo Suliao is the property of Journal Office of CHINA PLASTICS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the clinical characteristics and influencing factors of early postoperative vestibular symptoms in patients with acoustic neuroma by collecting preoperative vestibular function examination, clinical data, and early postoperative vestibular symptom data. Methods The study included 64 patients who had undergone surgery for acoustic neuroma between February 2021 and February 2022. Vestibular symptom types were recorded postoperative 1 day, 3 days, 7 days, 30 days respectively, and the severity of vestibular symptoms were assessed using visual analogue scale for vestibular symptoms (VAS-V). Patients were divided into the vestibular symptom relief group (VAS-V≤ 2) and the vestibular symptom persistence group (VAS-V＞2) based on the median VAS-V score at 30 days postoperatively (VAS-V median score=2). Differences in demographic information, Koos grade, and preoperative vestibular examination results were compared between the two groups. A binary logistic regression model was constructed to explore the influencing factors for the persistence of early postoperative vestibular symptoms. Results Vestibular symptoms were most pronounced on postoperative day 3, and there was no significant change in vestibular symptoms from postoperative day 7 to day 30. The most common vestibular symptoms 30 days after the surgery were dizziness and postural symptoms, in 33 cases (51.6%) and 31 cases (48.4%), respectively. Binary logistic regression analysis showed that normal video-head impulse test (vHIT) gain (OR=4.06, P=0.039), cold calorics test unilateral weekness (UW) <75% (OR=12.45, P=0.001), and gender (OR=0.22, P=0.038) were independent risk factors for the persistence of vestibular symptoms at 30 days postoperatively. Conclusions Preoperative vestibular function and gender are important factors in predicting postoperative vestibular symptoms in patients with acoustic neuroma, and the degree of preoperative vestibular function injury is negatively correlated with the duration of postoperative vestibular symptoms, which is helpful to providing references for early postoperative vestibular function recovery in patients with acoustic neuroma. [ABSTRACT FROM AUTHOR]

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Hepatic alveolar echinococcosis (HAE) is a common zoonotic endemic parasitic disease in western China. It lacks of typical clinical manifestations in the early stage, and symptoms become prominent during the end stage, with an alarmingly high mortality rate. Among the treatment of end-stage HAE (es-HAE), orthotopic liver transplantation is almost the only radical treatment due to insufficient remnant liver volume, uncontrollable bleeding and difficulty in vascular reconstruction in vivo. However, the shortage of donor liver and long-term postoperative use of immunosuppressants limit its application. The introduction of ex vivo liver resection and autotransplantation (ELRA) resolves this dilemma and significantly broadens the indications of es-HAE. In addition, multiple centers in China have optimized and modified ELRA to further improve the treatment system of es-HAE. At present, liver transplantation (including ELRA) of es-HAE remains a hot topic for clinicians. In this article, orthotopic liver transplantation, ELRA, auxiliary ELRA and other surgical treatment of es-HAE were reviewed, aiming to further enhance the diagnosis and treatment of es-HAE and improve clinical prognosis of the patients. [ABSTRACT FROM AUTHOR]

Copyright of China Forestry Economy is the property of China Forestry Economy Magazine Agency and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Northern Agriculture / Beifang Nongye Xuebao is the property of Journal of Northern Agriculture Editorial and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Science & Biotechnology is the property of Journal of Food Science & Biotechnology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electric Machines & Control / Dianji Yu Kongzhi Xuebao is the property of Electric Machines & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

前降支起源异常伴钙化在临床上较为罕见, 本文分析了 1 例前降支开口于右冠状窦 伴重度钙化病变的急性心肌梗死患者的诊疗过程, 通过讨论其介入手术策略的选择及血管内 超声对钙化病变的诊断价值, 旨在提高介入医师对此类冠状动脉畸形的认识, 强调在重度钙 化冠状动脉病变中, 血管内超声对介入方案选择的指导价值及棘突球囊对改善不良预后的重 要意义。 [ABSTRACT FROM AUTHOR]

目的　分析 2020 年 6 月—2023 年 4 月临沂地区儿童流感流行病学及甲型流感临床特征。方法　收集 2020年6月—2023年4月临沂市妇幼保健院儿科急诊及发热门诊就诊的流感样症状儿童鼻咽拭子标本6 651份，采 用多重实时荧光PCR方法进行流感病毒检测与分型鉴定；同时记录患儿性别、年龄、发病时间、症状，并后续于电子 病历系统中调取患儿实验室与影像学检查等临床资料。结果 6 651 份儿童咽拭子标本中，流感阳性 1 298 例 （19. 52%），其中甲型流感 1 015例（78. 20%）、乙型流感 283例（21. 80%）。2020年 6月—2021年 5月、2021年 6月— 2022年5月、2022年6月—2023年4月流感阳性例数分别为24例（2. 96%）、275例（10. 50%）、999例（31. 03%），各年 度比较，P均<0. 05。男性及女性流感阳性例数分别为785例（19. 91%）、513例（18. 94%），两性别比较，P>0. 05。≥1 岁者、1～3岁者、4～6岁者、7～14岁者流感阳性例数分别为172例（7. 08%）、469例（22. 04%）、466例（31. 96%）、191 例（30. 08%），4～6岁、7～14岁者与其他年龄段比较，P均<0. 05。2020年6月—2023年4月临沂地区儿童流感出现 了3次流行高发季节，其中2次甲型流感高发［2022年7月—10月（夏季）、2023年2月—4月（春季）］，1次乙型流感 高发（2021年 12月—2022年 3月）。高发季节 2022年夏季甲型流感阳性率低于 2023年春季，2022年 8月最高峰甲 型流感阳性率低于 2023年 3月最高峰，2022夏季 H1N1型、未分型甲型流感病毒低于 2023年春季，H3N2型甲型流 感病毒高于 2023 年春季，P 均<0. 05。2022 年夏季 1～3 岁者甲型流感发生例数高于 2023 年春季，7～14 岁者低于 2023年春季，P均<0. 05；2022年夏季高热、咳嗽发生例数低于 2023年春季，呕吐、腹泻、肌痛发生例数高于 2023年 春季；2022年夏季支气管炎发生例数低于2023年春季，肌炎发生例数高于2023年春季，P均<0. 05。2022年夏季甲 型流感患儿白细胞计数4～12×109 /L者高于2023年春季，≤4×109 /L者低于2023年春季，P均<0. 05。结论 2020年 6月—2023年 4月临沂地区儿童流感出现逐年增高趋势，2021年冬季到 2022年春季为乙型流感流行，而 2022年流 感高发季节为2022年7月—10月（夏季），高峰期为8月份，均为甲型流感H3N2亚型，2023年流感高发季节为2023 年 2月—4月（春季），高峰期为 3月份，以甲型流感 H1N1亚型为主；4～6岁、7～14岁流感阳性率高于其他年龄段。 高发季节夏季甲型流感儿童呕吐、腹泻等胃肠道症状较春季高发，更易引起肌炎、惊厥等并发症，而高发季节春季甲 型流感儿童易出现高热、咳嗽，更易引起支气管炎，且易发展为重症。 [ABSTRACT FROM AUTHOR]

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