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Objective To investigate the efficacy and possible mechanism of Guanxining combined with amlodipine in the treatment of hypertension complicating heart failure (HF). Methods Eighty-three patients with hypertension complicating HF were selected as the study subjects. They were divided into control group (41 cases, treated by amlodipine) and observation group (42 cases, treated by Guanxinning combined with amlodipine) by random number table method. We compared the clinical efficacy between the two groups as well as changes of cardiac function (LVEF, LVESd, LVEDd, IVST and NT-proBNP), blood pressure, blood coagulation indexes, vascular endothelial function [endothelin-1, NO, angiotensin Ⅱ (AngⅡ)], and serological indexes [microRNA196a-2 ( miR-196a-2) and soluble factor associated suicide ( sFas )] levels before and after the treatment. Results The total effective rate of the observation group was higher than that of the control group (P<0. 05). After treatment, LVEF and IVST in the observation group were higher than those in the control group while LVESd, LVEDd, systolic blood pressure, diastolic blood pressure, low-shear whole blood viscosity, plasma viscosity and red blood cell aggregation index were lower than those in the control group (P<0. 05). After treatment, the levels of serum NT-proBNP, endothelin-1, AngⅡ, miR-196a-2 and sFas in the observation group were lower than those in the control group while the level of NO was higher than that in the control group (P<0. 05). Conclusion Guanxinning combined with amlodipine is effective in the treatment of hypertension complicated with HF. It could promote the recovery of cardiac function, and improve blood pressure, coagulation function and vascular endothelial function. Its mechanism may be related to the regulation of expression of miR-196a-2 and sFas. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Practical Medicine / Shiyong Yixue Zazhi is the property of Journal of Practical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of South China Fisheries Science is the property of South China Fisheries Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oil Crop Sciences is the property of Oil Crops Research Institute of Chinese Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effects of pregabalin combined with serratus anterior plane block (SAPB) on sleep quality and serum inflammatory factors in patients after thoracoscopic radical resection of lung cancer. Methods: The collection period of cases was from March 2019 to July 2020. 60 patients who met the requirements after thoracoscopic radical resection of lung cancer were screened and divided into the control group (n=30) and the study group (n= 30). Both groups were given SAPB, followed by intravenous patient-controlled analgesia. The control group was given a placebo. The study group was given pregabalin 150 mg 2 hours before surgery and 75 mg pregabalin on the second day after surgery. The sedative and analgesic effects, sleep quality, serum inflammatory factors, anxiety, vital signs and adverse reactions were compared between the two groups. Results: The visual pain analogue scale (VAS) of the study group was lower than that of the control group at 12 h, 24 h, and 48 h after the operation, and the Ramsay score was higher than that of the control group (P<0.05). The 48h postoperative state-trait anxiety scale (STAI) and Pittsburgh Sleep Quality Index (PSQI) scores of the study group were lower than those of the control group (P<0.05). Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) in the study group were lower than those in the control group at 24 h and 48 h after surgery (P<0.05). The heart rate (HR) of the study group was lower than that of the control group at 4 h, 24 h, and 48 h after the operation, and the systolic blood pressure (SBP) and diastolic blood pressure (DBP) were higher than those of the control group (P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Pregabalin combined with SAPB in patients after thoracoscopic radical resection of lung cancer can maintain the patient's vital signs, obtain good analgesic and sedative effects, improve the patient's sleep quality, reduce their anxiety, and reduce serum inflammation. The level of sex factors is safe. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Oil Crop Sciences is the property of Oil Crops Research Institute of Chinese Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of high mobility group protein 1 (HMGB1) antagonist BoxA via tail vein injection on the improvement of clinical signs and anti-inflammatory effects in a rat model of bacterial meningitis (BM). Methods: Male Sprague-Dawley (SD) rats were used and the normal rats were set as the control group (n=20). Another sixty rats were injected with Es- cherichia coli (DH5α1× 107 CFU/mL) to establish BM rat model and then were randomly divided into two groups (n=30): after anesthesia one group received intravenous BoxA (BoxA group), the other one received PBS injection as placebo (Vehicle group). Three days after model establishment, the clinical index of each group and pathophysiological parameters (intracranial pressure and CSF white blood cells (WBC) count) were evaluated, Enzyme-linked immunosorbent assay (ELISA) method were used to detect the relative serum HMGB1 content, Evans blue staining were used to observe the blood-brain barrier (BBB) permeability, immunofluorescence staining were used to detect the expression level of cerebral inflammation cytokines (IL-1β and TNF-α). Results: Compared with Control group, clinical indicators, intracranial pressure, WBC count and serum HMGB1 content in Vehicle group has significantly increased (P<0.05). These changes were partially reduced in the BoxA group compared to the Vehicle group (P<0.05). In addition, Vehicle group showed increased EB leakage and increased expression of inflammatory factors (IL-1β and TNF-α) than Control group (P<0.05). These changes were also partially adjusted in the BoxA group compared to the Vehicle group (P<0.05). Conclusion: Tail vein injection of HMGB1's inhibitor BoxA can down-regulate HMGB1 expression and alleviate the clinical symptoms and inflammatory responses in BM rats. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Despite of the harsh environmental conditions, alpine regions have very specialized and diverse plants. Abiotic factors play important roles in the formation and evolution of floral traits of these alpine plants. In this paper, the hairy corona of alpine plant Comastoma pulmonarium was studied to explore the evolutionary and adaptive significance of this distinctive floral structure in the extreme alpine environment and its effects on plant reproductive fitness. The results showed that in artificially corona removed flowers, pollen grains in anthers (t = 2.61, P<0.05) and fertilization rate (t=2.05, P<0.05) decreased greatly after rain-wash. However, there were no significant differences of the seed weight and seed germination rate between artificially corona removed flowers and control flowers. Additionally, pollen germination rate reduced significantly due to water immersion (t = 30.67, P<0.001) and direct exposure to sunligh t(t = 9.89,P<0.001), indicating that hairy corona could maintain viability of pollen grains in front of rain immersion and intense solar radiation. This study indicates that the hairy corona of C. pulmonarium has adaptive significance for both male and female reproductive success in the harsh environment of alpine regions, and further confirms selection on the flower morphology of alpine plants by abiotic factors. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)