Search

Rock socketed pile is a common foundation in long-span bridge engineering. Due to the drilling tools, a series of undulating rough bodies will be formed on the pile-rock interface, which contributes to the pile bearing capacity. Therefore, it is quite important to accurately quantify the roughness characteristics of actual pile-rock rough interface in calculating the pile bearing capacity considering the interface roughness. For this aim, the sandstone samples containing rough interface were drilled in the rock socketed pile foundation of Maanshan Yangtze River Bridge, and the digital model of the pile-rock interface was reconstructed using three-dimensional laser scanning, aiming to calculate the roughness characteristic, including area expansion rate (S), relative average undulation (Rs) and the average inclination angle (θ) for quantitative analysis. Then, three shear tests and compression tests were performed on pile-rock interface to calculate the JRC 3D (joint roughness coefficient), and the results were compared with three analytical models to check their applicability for actual pile-rock interface. The results show that the actual pile-rock interface has both regular threaded grooves and relatively flat surfaces with low undulation, rather than regular rough bodies or irregular holes in experimental tests. The roughness of the actual pile-rock interface is much greater than that of the rock mass structural plane and the indoor regular rough body, i. e., the area expansion rate, relative average undulation and average inclination angle of the interface of pile-rock interface are obviously larger than those of rock structure surface and regular rough body. The average JRC3D of rock-pile interface (26. 15) is larger than those of rock structural interface (maximum value of 20) and the indoor regular rough body, which can be estimated using JRC = 6. 423 + 2. 329 × (100S) - 0. 187Rs - 2. 676tanθ. The research results can provide scientific basis for establishing design method of deep rock socketed pile based on interface roughness. [ABSTRACT FROM AUTHOR]

Chromatin is the carrier of human genetic information, and the transcriptional regulation of genes located on chromatin under different spatial and temporal conditions is closely linked to DNA accessibility and chromatin-associated complexes. Histone chemical modifications like acetylation, methylation, phosphorylation constitute the histone codes which regulate the chromatin accessibility and the association of transcriptional complexes with chromatin, resulting in the activation or repression of gene transcription in real-time. With significant technical enhancement of high-resolution mass spectrometry and the antibody preparation of protein chemical modifications, a series of novel histone acyl-lysine like crotonyl-, lactyl-, succinyl- etc. are identified, significantly expanding the diversity of the histone codes and increasing the complexity of histone code mediated gene transcription. In this review, we overview the dynamic regulation of crotonyl-lysine, lactyl-lysine, succinyl-lysine, isobutyryl-lysine, methacryl-lysine, and isonicotinyl-lysine of histone through the writers, erasers and readers, and further highlight our current understanding about gene transcription mediated by these novel types of histone lysine acylation in various biological content as well as human diseases linked to histone lysine acylation. Finally, the challenge and future prospective of lysine acylation in biology are further outlined. [ABSTRACT FROM AUTHOR]

Mg-8Al-χZn (χ=0,2,4) alloy ingots with diameter of 30 mm were prepared, which were extruded into bars with diameter of 10 mm at a temperature range of 250 to 350 ℃. Microstructures were observed via Optical Microscope (OM), Scanning Electron Microscope (SEM) and Transmission Electron Microscopy (TEM), and the tensile properties were tested. The results show that as-cast alloys are mainly composed of α-Mg and β-Mg17Al12 phases. With the increase of Zn content, the area fraction of β phase increases slightly, the morphology of lamellar eutectic β phase is unchanged. However, divorced eutectic β phase was changed from discontinuous network to massive. After extrusion at 250 ℃ and 300 ℃,the microstructures were refined due to the occurrence of discontinuous dynamic recrystallization. With the increase of Zn content, the extent of broken of β phase and recrystallization of alloys are increased, the unrecrystallized area and twins decreased, and the homogeneity of the microstructure is improved. However, the comprehensive mechanical properties are decreased slightly due to the increase of brittle β phase. After extrusion at 350 ℃,complete dynamic recrystallization occurred. With the increase of Zn content, the grains are coarsened slightly and the alloys strength decreases and elongation increases obviously [ABSTRACT FROM AUTHOR]

N-6-methyladenosine(m6A) has been well-known to be a type of RNA epigenetic modification over the past decade. The m6A modification enzymes include “Writers” (METTL3/14/WTAP, etc.),“Erasers” (FTO and ALKBH5) and “Readers” (YTHDC1/2,YTHDF1/2/3, etc.), which mediate RNA methylation, demethylation, and recognition binding via a synergistic regulatory system, thereby regulating the fate of RNA after transcription. Spermatogenesis is an essential process of sexual maturation and maintenance of fertility in male mammals, involving the proliferation, and differentiation of Sertoli cells, Leydig cells and spermatogonia, and maintenance of spermatogenic microenvironment. More recently, there are some researches showed that the m6A regulatory system was involved in mammalian spermatogenesis. Abnormal m6A modification and imbalances in the m6A regulatory system can lead to abnormal testicular development, abnormal spermatogenesis and male infertility. This review summarizes the function of m6A modification enzymes in spermatogenesis, and further analyzes the role of m6A differentially modified transcripts in normal spermatogenesis, which has a great significance for understanding mammalian spermatogenesis and decoding the molecular mechanism of clinical spermatogenesis disorders. [ABSTRACT FROM AUTHOR]

Objective To observe the effects of knocking down microchromosome maintenance （MCM）proteins on the proliferation and migration of pancreatic cancer PANC-1 cells. Methods Human pancreatic cancer PANC-1 cells were cultured and divided into the shMCM2 group， shMCM6 group, and control group. The cells in the shMCM2 and shMCM6 groups were transfected with shMCM2 and shMCM6 lentiviral solutions, respectively， to construct MCM2 and MCM6 gene silencing stable cells. The cells in the control group were added with control shRNA-containing lentiviral solution. The CCK-8 method was used to detect the cell proliferation in three groups at 24, 48 and 72 h； the lateral and longitudinal migration ability of cells was observed by cell scratch and Transwell experiments；and the mRNA expression of Cyclin A1, B1, D1, and E1 was detected by RT-qPCR. Results With the extension of the culture time, the cell viability of the three groups increased, and the proliferation rates of the shMCM2 and shMCM6 groups were lower than that of the control group at 72 h. The scratch area ratio and longitudinal migration rate of cells in the shMCM2 group were lower than those in the control group, and the longitudinal migration rate of cells in the shMCM6 group was lower than that in the control group （P<0. 05 or P<0. 01）. Compared with the control group, the mRNA expression levels of Cyclin A1, B1, D1, and E1 were reduced in the shMCM2 group, and the expression levels of Cyclin A1 and B1 mRNAs in the shMCM6 group were reduced （P<0. 05 or P<0. 01）. Conclusion Depletion of MCM2 or MCM6 can inhibit the proliferation and migration of pancreatic cancer PANC-1 cells, and the mechanism may be related to down-regulated expression of cyclins. [ABSTRACT FROM AUTHOR]

During the excavation of deep foundation pit for equipment building of Dalian Bay Subsea Tunnel project, long span steel bracing is used for support. In order to ensure the safety and stability of the whole bracing system, in addition to the influence of the compression of other components on the axial force monitoring, the deformation of the actual steel bracing anchor was monitored during the construction process. The monitoring results show that in addition to the normal axial compression of steel bracing, the compression of filler material has a great interference on the theoretical horizontal stiffness of the whole steel bracing system, and has a great influence on the installation preloading force and axial unloading capacity of steel bracing. According to the analysis, the construction of foundation pit supporting structure should strengthen the compactness of spraying and mixing between piles (including the filling of breast beam), improve the overall stability of supporting structure, and give full play to the bearing capacity of the steel bracing. [ABSTRACT FROM AUTHOR]

A rapid fluorometric method was established to detect glyphosate by using cerium ion and pyrophosphate ion (Ce-PPi) coordination polymer networks (CPNs). Based on coordination of cerium ion (Ce3+) and pyrophosphate ion (PPi), fluorescent Ce-PPi CPNs were synthesized by simple selfassemble process, and the structure and properties were characterized. Upon introducing glyphosate, the ligand field effect of PPi with Ce3+ was weakened resulting in a decrease in fluorescence of Ce-PPi CPNs. Based on this principle, the quantitative detection of glyphosate was achieved by optimizing the conditions, with R² of 0.997 2 and the detection limit of 0.014 μmol/L. The established method based on Ce-PPi CPNs possessed outstanding sensitivity and exclusive selectivity for rapid detction of glyphosate, and could be used for the detection of glyphosate in tap water and apple samples. The limit of quantitation (LOQ) was 0.05 mg/kg and the recoveries were between 77% and 87%. The method provided a potential choice for the rapid, on-site and real-time, detection of glyphosate. [ABSTRACT FROM AUTHOR]

[Objective] To establish a reasonable farming system and find suitable rotation crops for Polygala tenuifolia. [Method] This study selected eight common crops to study the effects of soil water extracts of different crops on seed germination and seedling growth of Polygala tenuifolia. [Result] The soil water extracts of different crops had inhibitory effects on the germination of Polygala tenuifolia seeds. The higher the concentration of the extract, the stronger the inhibitory effect. The average total inhibition rate from small to large was soybean, millet, corn, wheat, sorghum, castor, oil sunflower and sesame. The soil water extracts of different crops had a promoting effect on the growth of Polygala tenuifolia seedlings. The growth of seedlings and roots was gradually inhibited as the concentration increased compared to other treatments. The overall growth of seedlings and roots of Polygala tenuifolia in each treatment showed a negative correlation; castor, sesame treatment, Polygala tenuifolia had tall seedlings and short roots; soybeans, corn and millet treatment, Polygala tenuifolia had long roots, low seedlings and poor growth. The root length and root weight of soybean, corn, wheat, sorghum and millet treatments were higher than those of CK. The POD activity of Polygala tenuifolia seedlings, except for sesame and castor, increased with the increase of concentration. The overall MDA content showed an increasing trend with the increase of concentration, while the SOD activity first increased and then decreased with the increase of extract concentration. [Conclusion] Based on the comprehensive growth index and physiological index, soybean, corn, wheat and millet are more suitable rotation crops for Polygala tenuifolia. [ABSTRACT FROM AUTHOR]

In order to select high-quality rice varieties and to promote the efficient development of the rice industry, we comprehensively measured and analyzed the growth period, yield, rice quality and other indicators of the 40 Indica rice varieties currently popularized in south- ern Henan rice area. We selected the high-yielding and high-quality rice varieties suitable for the ecological climate of the rice area. Results showed that Jingliangyou 1468 and Huanghuazhan accounted for level 2 of the ministerial standard. Tsuen Liangyou Efeng Silk Seedling, Pingliangyou 3648, Changliangyou No. 8, Nongjing Silk Seedling and Chunfengyou 6377 reached level 3. The average unit yield of the above seven varieties reached more than 7.8 t/hm², which could achieve high quality and high yield, which was suitable for popular cultivation in southern Henan rice area. [ABSTRACT FROM AUTHOR]

In Lhis paper, human embryonic sLcm cell line and iLs diffcrcnLiaLcd neural sLcm cell line nrc sclccLcd as Lhc objccLs Lo sLiidv Lhc rcgulaLorv cilccL of his Lone modificaLions on Lhc diffcrcnLiaLion of embryonic sLcm colls ・ The disLribuLion paLLcrns of 8 his Lone modificaLions and funcLional clusLcrs of his Lone modificaLions nrc obLaincd in Lhc flanking regions of LranscripLional iniLiaLion si Les of Lhc diffcrcnLially expressed genes in Lhc Lwo cell lines ・ The resnlLs show LhaL in Lhc Lwo cell lines, Lhc disLribuLion paLLerns of 8 hisLonc modificaLion profiles arc consisLcnL and show Lwo disLribuLion Lypcs; The fLincLional clusLei's compose of 113K27ac, 113K4mc3 and 113K9ac arc conscrvaLivc, while Lhc funcLional ckisLcrs compose of 1131<27mc3, 113K36mc3 and 113K79mcl and Lhc funcLional cl us Lei's composed of 113K9mc3 and 113K27mc3 disappear during Lhc diffcrcnLiaLion of embryonic sLcm cells inLo neural sLcm cells・ This paper reveals Lhc pailial rcgulaLory mechanism of hisLonc modificaLions on Lhc dillcrcnLiaLion of embryonic sLcm cell lines inLo neural sLcm cell lines and pro vids some imporLanL LhcorcLical basis for Lhc sLudv of molecular rcgulaLorv mechanism of Lhis diffcrcnLiaLion process. [ABSTRACT FROM AUTHOR]

Taking the Chaohu Lake region as the research object, this paper studies the structural characteristics and influencing factors of the rural tourism's source market in the Chaohu Lake region based on the travel notes data of rural tourism from travel websites from 2016 to 2021, employing the combination of statistical analysis and ArcGIS spatial analysis. The results show that: the rural tourism's source market is seasonal with prominent holiday season and weekend effects. April to October is the high season, and November to March is the low season; the geographical concentration index of rural tourism's source market is generally high. The tourist source is characterized by concentrated distribution, with Hefei as the main tourist source, and the average attraction radius of tourists is 219.59km, which belongs to the short-range source market. There are other important influencing factors including leisure time, climate comfort, transportation, and economic development level of tourist source destinations. [ABSTRACT FROM AUTHOR]

目的探讨退变腰椎椎间盘髓核组织腱糖蛋白C（TNC）、β连环蛋白（β-catenin）、Yes相关蛋白1（YAP1） 表达变化及其临床意义。方法选择腰椎椎间盘退行性变患者46例（观察组），因外伤所致腰椎骨折患者16例（对 照组），取腰椎椎间盘髓核组织，免疫组化染色，采用Image-Pro Plus 6. 0软件分析TNC、β-catenin、YAP1表达。比较 两组腰椎椎间盘髓核组织TNC、β-catenin、YAP1表达，分析退变腰椎椎间盘髓核组织TNC、β-catenin、YAP1表达的 关系及其与Oswestry功能障碍指数问卷表（ODI）评分、日本骨科协会下腰痛（JOA）评分的关系。结果观察组腰椎 椎间盘髓核组织TNC、β-catenin、YAP1相对表达量均高于对照组（P 均<0. 05）。退变腰椎椎间盘髓核组织TNC表达 与β-catenin、YAP1表达均呈正相关关系，β-catenin表达与YAP1表达亦呈正相关关系（P 均<0. 05）。腰椎椎间盘退行 性变患者ODI评分为（38. 39 ± 5. 13）分、JOA评分为（13. 30 ± 2. 80）分，其退变腰椎椎间盘髓核组织TNC、β-catenin、 YAP1表达与ODI评分均呈正相关关系，与JOA评分均呈负相关关系（P 均<0. 05）。结论退变腰椎椎间盘髓核组 织TNC、β-catenin、YAP1表达升高，三者可能共同参与腰椎椎间盘退行性变过程。 [ABSTRACT FROM AUTHOR]

A typical shale gas production platform was selected, and a self-designed two-phase flowmeter experimental device prizing was used to evaluate the field performance of the wet gas flowmeter under different production conditions. Methods The characteristics of wet flow measurement in shale gas wellhead are analyzed, and the performance characteristics of wet flowmeter in shale gas wellhead under different gas-liquid flow rates are investigated. Results Within the tested flow range, the deviation of gas flow metering result is between - 6. 07 % and 0. 82 %, and the deviation of liquid flow metering result is between - 24. 91 % and 96. 49 % . As the flow rate of gas-liquid two phase flow deceases, the measurement error of wet gas flowmeter increases gradually. Conclusions The measurement performance of wet gas flowmeter is closely related to gas-liquid flow and other working conditions, so it is necessary to further expand the scale and scope of the experiment, and formulate clear technical requirements indicators of wet gas flowmeter as soon as possible to ensure that the applied wet gas flowmeter can meet the demand of shale gas exploitation. [ABSTRACT FROM AUTHOR]

Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) has been developed rapidly in recent years and has been widely used in many fields. Although MALDI MSI can obtain multiple imaging data of different compounds in one experiment, the imaging analysis of small molecules with low abundance, low ionization efficiency, and matrix interference is still very challenging. In order to improve the signal response of target molecules in MALDI MSI, it is necessary to apply the on-tissue derivatization to MALDI MSI. In recent years, the combination of derivatization and mass spectrometry imaging has shown excellent results for the analysis of target molecules containing reactive groups such as carboxyl, amino, and aldehyde groups. This review aims to introduce the application of on-tissue derivatization on MALDI MSI, including developed derivatization reagents and pretreatment methods for derivatization, the selection of matrix and the reagent coating device. Finally, the perspectives for derivatization in mass spectrometry imaging are outlooked. [ABSTRACT FROM AUTHOR]

Under the background of carbon peak carbon neutrality, energy sharing among multiple entities in active distribution network (ADN) helps to absorb wind and light. However, the growing wind and photovoltaic capacity within microgrids has resulted in more pronounced daily fluctuations in net load. This has rendered traditional time-of-use electricity pricing less effective in mitigating peak demand and filling valleys in microgrids. To address this issue, a scheduling strategy considering the shared energy among multiple entities in the context of an active distribution network was proposed in this paper. The objective was to maximize the net income by deducting the electricity purchase cost from the electricity sales revenue generated within the ADN and distributed to sublevel microgrids. Furthermore, the strategy takes into consideration the scheduling autonomy of the sub-level microgrids, which aim to minimize their own operating costs under the pricing policies of the electricity grid. To achieve this optimization, the sub-levels' goal of minimizing operating costs was transformed into a constraint on the super-level objective function by employing Karush-KuhnTucker (KKT) multipliers, as done in the study. The KKT multipliers were employed along with the big M method to linearize the nonlinear constraints, thereby improving the computational efficiency of the model. Additionally, the continuous coupled variables between the upper and lower levels were discretized in the MATLAB Gurobi environment. The effectiveness of the proposed scheduling strategy was evaluated through a case study carried out on an active distribution network implemented in the IEEE 33-node system. This analysis demonstrates the practical feasibility and benefits of the model for optimizing energy distribution within the ADN framework. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between Helicobacter pylori (Hp） infection and serum gastrointestinal hormones and monoamine neurotransmitter levels in patients with ulcerative colitis. Methods 145 patients newly diagnosed with ulcerative colitis were selected into the study group, and 140 patients without abnormal results by gastrointestinal endoscopy were assigned into the control group. In two groups, Hp infection was diagnosed by using 13C urea breath test (13C-UBT). The levels of gastrointestinal hormones(substance P (SP), endothelin (ET), vasoactive intestinal peptide (VIP) and monoamine neurotransmitters(norepinephrine (NE), 5-hydroxytryptamine (5-HT) were detected. Serum levels of gastrointestinal hormones and monoamine neurotransmitters were compared between active and remission phase patients in the study group. Serum levels of gastrointestinal hormones and monoamine neurotransmitters were compared between Hp-positive and -negative patients. The relationship between Hp infection and gastrointestinal hormone- and monoamine neurotransmitter-related indexes in patients with ulcerative colitis was assessed by Logistic regression analysis. Results Hp infection rate and VIP level in the study group were lower, whereas the levels of SP, ET, NE, and 5-HT were higher than those in the control group (all P < 0.05). Hp infection rate and VIP level in the active phase group were lower, while the levels of SP, ET, NE, and 5-HT were higher than those in the remission phase group (all P < 0.05). In the study group, the levels of SP, ET,NE and 5-HT in Hp-positive patients were lower, whereas the level of VIP was higher compared with those in Hp-negative counterparts (all P < 0.05). Logistic regression analysis showed that SP, ET, NE and 5-HT were the protective factors for Hp infection in patients with ulcerative colitis (all P < 0.05), while elevated level of VIP was the risk factor (P < 0.05). Conclusions In ulcerative colitis patients, there are differences in the levels of gastrointestinal hormones and monoamine neurotransmitters between patients with and without Hp infection. Hp infection may be correlated with the changes in the levels of gastrointestinal hormones and monoamine neurotransmitters. [ABSTRACT FROM AUTHOR]

In order to study the cutting performance of shearer drum, the discrete element method was used to analyze the influence of pick installation angle, pick tip angle and rotating speed on productivity, lump coal rate, three-way resistance, three-way torque, cutting specific energy consumption and cutting power. The results of study show that with the increase of pick installation angle, lump coal rate, productivity, cutting specific energy consumption and cutting power first increase and then decrease, and the three-way torque increases. With the increase of the sharp angle of the pick, the three-way resistance, three-way torque, cutting specific energy consumption and cutting power increase first and then decrease, and the lump coal rate and productivity decrease; with the increase of the speed, the three-way resistance and three-way torque decrease first and then increase; with the increase of the cutting specific energy consumption and cutting power, the lump coal rate decreases, and the production first increases and then decreases. The three-way resistance is: cutting resistance > traction resistance > lateral resistance, and the three-way torque is: lateral torque > cutting torque > traction torque. The research conclusion lays a theoretical foundation for improving the cutting performance of shearer drum. [ABSTRACT FROM AUTHOR]

A method for rapid analysis of stamp seals using hydrogen flame desorption ionization mass spectrometry (HFDI-MS) was developed. HFDI-MS combined with multivariate statistical analysis provides an analysis strategy for the identification and traceability of stamp seals. First, HFDI-MS was used to quickly analyze different types of stamp ink (mud) samples, and it was found that the captured mass spectra were significantly different. The characteristic ion signals on the mass spectra of different types of stamp inks were different, indicating that HFDI-MS has the potential of analyzing stamp seals. It was also found that the reproducibility of HFDI-MS was good. Subsequently, the mass spectra of two different types of probes (smooth surface probe and sand surface probe) for HFDI-MS analysis were compared after sampling. The experimental results showed that more abundant mass spectrometry information could be captured with the combination of sand probe sampling and HFDI-MS analysis. Therefore, the sand surface probe was used for sampling in HFDI-MS analysis of the stamp seals. At last, the feasibility of HFDI-MS to directly analyze the stamp seals was examined. Photosensitive ink, atomic ink and ink pad (for engraving seal) were used to make stamp seals. The seal stamp was placed in the air for 4 h before being analyzed by HFDI-MS. A sand surface probe was used to collect samples of the simulated stamp seal. Then, HFDI-MS was used to quickly analyze the stamp seals. The mass spectra captured by HFDI-MS were significantly different in the number and intensity of ion signals. So cluster analysis was used to identify stamp seals. The results showed that the three types of stamp seals from different sources were clearly distinguished. Finally, the signals of 26 characteristic ions of the three types of stamp seals were screened out by combining the mass spectra. According to the reference, the characteristic ion signals of pigment 21 and polyacrylic alcohol compounds have been found. HFDI-MS has the advantages of no voltage, easy operation, and the method is rapid and direct. The combustion product of hydrogen will not introduce impurity interference and cause pollution to the mass spectrometer. In addition, there is no memory effect for HFDI-MS. HFDI-MS can provide a new analysis strategy for the rapid identification and traceability of stamp seals in forensic science, cultural relic identification or other fields. It was worth noting that HFDI-MS cannot be considered as an absolute non-destructive analysis, and it was not suitable for scenarios that require non-destructive analysis of materials. However, it could be considered as minimally invasive sampling to ensure that the original file was not damaged. [ABSTRACT FROM AUTHOR]

Objective To explore the method of predicting high lymph node load in patients with early breast cancer to avoid unnecessary sentinel lymph node biopsy. Methods The clinicopathological and thoracic multi-slice spiral CT (MSCT) data of 2620 patients with early (cT1~2N0M0) breast cancer treated in the Affiliated Cancer Hospital of Zhengzhou University from January 1, 2014 to August 1, 2018 were collected. According to the postoperative pathological results, the patients were divided into the group with axillaryhigh lymph node burden (HNB) and the non-HNB group. The influencing factors of axillary lymph node burden in patients with early breast cancer were determined by univariate and multivariate analysis, and the diagnostic model of MSCT to HNB was established. The best cutoff value for the diagnosis of HNB was determined through analyzing the receiver operative characteristic ( ROC) curve, and the consistency between MSCT diagnosis and pathological diagnosis was evaluated by Kappa test. Results Among the 2 620 patients, 168 were diagnosed of HNB. Univariate analysis showed that the tumor size, the status of human epidermal growth factor receptor 2 (HER-2), the number of abnormal lymph nodes showed in MSCT, the ratio of the length to the diameter of the maximum abnormal lymph node as shown in MSCT, the condition of the maximum abnormal lymph node door, and the parenchyma of the maximum abnormal lymph node were related to axillary lymph node burden in patients with early breast cancer (P<0.05). Multivariate analysis showed that the number of abnormal lymph nodes showed in MSCT was an independent influencing factor of axillary HNB in patients with early breast cancer. Compared with patients without abnormal lymph nodes, the OR values of patients with 1, 2, 3 or more abnormal lymph nodes displayed by MSCT and in axillary HNB status were 3.305, 9.379, 126.163 and 780.953, respectively. Using 3 or more abnormal lymph nodes detected by MSCT to predict the area under the ROC curve of axillary HNB in patients with early breast cancer, the area was 0.928, the sensitivity was 82.1%, the specificity was 95.4%, and the accuracy was 94.5%. Kappa test showed that the consistency between MSCT diagnosis and pathological diagnosis was relatively high (Kappa =0.629, P<0.001). Conclusions The number of abnormal lymph nodes showed in MSCT is an independent influencing factor of axillary HNB in patients with early breast cancer. Taking 3 or more abnormal lymph nodes showed in MSCT as the threshold can help to predict the axillary HNB status of early breast cancer patients and exempt some of them from unnecessary sentinel lymph node biopsy. [ABSTRACT FROM AUTHOR]

The unique and extreme ecological environment of cryosphere acts as a gigantic reservoir of microorganisms, which preserves precious records of the diversity and evolutionary history of ancient microbes. Climate change and human activities have made significant impacts on the ecological system. Global warming causes melting of the cryosphere that remained frozen for thousands of years and releases microorganisms, some of them are recovered to life and constitute a potential threat to the ecological environment and human health. It is urgent to combine multidisciplinary research forces to investigate the microbial ecology of cryosphere, analyze the microbe pathogenesis and transmission mechanisms, as well as evaluate the biosecurity risks caused by the reboot of dormant microorganisms. [ABSTRACT FROM AUTHOR]

In view of the defects of high error rate and low efficiency of dense correspondence of remote sensing imagery, an dense corresponding approach for remote sensing imagery based on tilt correction and parallax estimation was proposed. First, the epipolar imagery was generated by tilt correction based on the sparse corresponding points. Afterwards, the initial disparity of the epipolar image couple was interpolated from the sparse correspondence, and the best correspondence was searched around the nearby area of initial parallax along the epipolar. In order to improve the search efficiency, the average gray value of the matching window was computed incrementally, and the search step was set to 2 during the search process. Experimental result illustrates the matching density of pixel by pixel can be achieved, and the accuracy rate and precision of the matching result are high. The realistic 3D scene reconstructed from the dense corresponding points demonstrates the effectiveness and practicability of the proposed approach. [ABSTRACT FROM AUTHOR]

Horn is a unique organizational structure of the cloven-hoofed ruminant suborder, which is a tool for animals to fight and resist foreign enemies, but it is easy to cause damage to livestock houses and casualties to staff in modern intensive breeding. The horns of cattle and sheep are different from deer, which are non-value-added animal products, and will reduce feed remuneration, reduce feed con‐ version rate, and do not adapt to the development trend of modern and efficient breeding. Man-made corner removal, while violating animal welfare, will waste huge manpower and material resources, which is easy to cause animal stress. The cultivation of hornless cattle and sheep breeds through genetic improvement is an important task in the development of efficient animal husbandry. The hole horns of cattle and sheep are relatively special, hollow and externally keratinized, which is difficult to directly carry out the regulation of tissue development, but mostly explore its genetic mechanism from the genome level. This paper reviews the research progress of the main gene of hornless traits in cattle and sheep at home and abroad, which provides a scientific reference for further research on the presence or absence of horns and horn development, and the development of molecular breeding of cattle and sheep, and provides a reference for the subsequent use of molecular biology technology to carry out the cultivation of hornless cattle and sheep breeds. [ABSTRACT FROM AUTHOR]

Nonalcoholic fatty liver disease( NAFLD) is defined as hepatic steatosis without heavy drinking( the amount of alcohol intake is limited within the safe threshold),and the difference between NAFLD and alcoholic liver disease is largely dependent on the amount of alcohol intake. Alcohol intake and NAFLD coexist in a considerable proportion of the population, and this proportion is increasing continuously. There are still controversies over the definition of “safe threshold” and whether moderate drinking within the “safe threshold” has a protective effect against NAFLD, so as to improve the adverse outcome and survival prognosis of chronic liver diseases. This article elaborates on the above ideas, and it is believed that we should pay attention to individualized risk assessment when evaluating the influence of drinking on NAFLD and follow the principle of individualization when judging the benefits and harms of drinking and giving suggestions for drinking. [ABSTRACT FROM AUTHOR]

【Objective】To explore the effect of application of Zn,B,Mn fertilizers on yield, sugar content and sugar yield in sugar beet.【Methods】The “3414” optimal regression design test plan was applied. Three factors of Zn,B,Mn with 4 fertilizer levels (no fertilizer (CK), low dosage, middle dosage and high dosage) were set up.【Results】Compared with CK, the yield was increased by 20.64%-25.53%, the sugar content was increased by 0.02-0.83 degree (except treatment 8), and the sugar yield was increased by 21.86%-30.85%. By establishing the effect function equation of fertilizer response and sugar yield, the optimum fertilizers amount were ZnSO4·7H2O 20.50 kg/hm², Na2B4O7·10H2O 27.01 kg/hm², MnSO4·7H2O 42.35 kg/hm².【Conclusion】Applying the appropriate amount of Zn,B,Mn fertilizer could improve the sugar beet yield and sugar content, and would be helpful to improve the sugar yield. [ABSTRACT FROM AUTHOR]

Introns after splicing play an important role in expression and regulation. Therefore, it is found that there is interaction between mature mRNA and its corresponding intron, and the relation is coevolution. In order to verify this theory, the genome sequences of 13 species were taken as research objects, and the optimal matched segments between mature mRNA and its intron sequences were obtained by using the local matching method named Smith- Waterman. Meanwhile, the distribution of the optimal matched segments on mRNA was obtained. Analysis results show that the average length and matching rate distribution of the optimal matched segments were similar to the combined characteristics of siRNA and miRNA. The UTR regions on mRNA had strong interaction with introns. Segments with low GC content were more likely to interact with 3'UTR region, while those with high GC content were prone to interact with 5' UTR region. Hence, the sequence characteristics of the optimal matched segments are coincident with the general regulation of RNA-RNA interaction, and introns can be regarded as functional segments of regulating gene expression. The conclusion is of constructive significance for further study the function and evolution of introns. [ABSTRACT FROM AUTHOR]

BACKGROUND: Osteoporosis has always been a hotspot in medical research. Visual analysis of English literature regarding osteoporosis can intuitively understand the research status, hotspots and frontiers in this field, and help researchers to hold on the research topic and direction. OBJECTIVE: To perform bibliometric, co-presence, co-citation, and visual analyses of English literature regarding osteoporosis, and to explore the relevant research status, research hotspots and dynamic frontiers in this field in the past 5 years. METHODS: The CiteSpace software was used for co-presence analysis of the authors, institutions, countries, and keywords and for co-citation analysis of cited authors, references, and journals in the 2015-2019 related literature included in the Science Citation Index Expanded (SCI-E) of Web of Science (WOS). RESULTS AND CONCLUSION: A total of 2 980 articles were included. High-yielding countries include China, the United States, Japan, South Korea, and the United Kingdom. The main research institutions are Pittsburgh University, Harvard University, McMaster University, Oxford University, and other world-renowned universities. Shanghai Jiao Tong University wins a place in the orthopedics research. As high-yielding authors, Hong-Wen Deng focuses on genetic and osteoporosis mechanisms; Hiroyuki Kato, Yukio Nakamura, and Takako Suzuki jointly focus on the development of anti-osteoporosis drugs such as denosumab and ibandronate; Jonathan D Adachi focuses on vitamin D and osteoporosis and bone metabolism research; William D Leslie focuses on dual-energy bone mineral density assessment of osteoporosis; JA Kanis focuses on the appropriate population and timing for anti-osteoporosis. Osteoporosis International and Journal of Bone and Mineral Research published the most of research regarding osteoarthritis. New England Journal of Medicine, LanceT, JAMA-J and other top publications are also very concerned about osteoporosis research. The research discipline involves clinical and basic disciplines, with a focus on basic subjects. Advances in the development of anti-osteoporosis drugs are an important entry point for basic medical research. Lack of osteoporosis, zoledronic acid, glucocorticoid-induced osteoporosis, fat mass, oophorectomy, osteoporosis, mineral density, ovarian cancer, anti-osteoporosis, and bone metabolism is the frontier of osteoporosis research. In 2015-2016, animal research and senile osteoporosis were hotspots. In 2016-2017, the design of randomized trials, adult bone metabolism, and physical activity interventions were emerging areas of osteoporosis research. In 2017-2019, glucocorticoid-induced osteoporosis, mesenchymal stem cells and activation of cellular pathways were emerging areas of osteoporosis research. To conclude, CiteSpace can be used to bibliometrically analyze the English literature of osteoporosis and intuitively reveal the overall development trend of osteoporosis research in the past 5 years. Therefore, it can provide references for osteoporosis scholars in the reference content and development direction of the topic, and the results have certain significance. [ABSTRACT FROM AUTHOR]

目的 分析 108 例中耳炎患者患耳分泌物病原菌培养鉴定及药敏试验结果,为抗菌药物的合理使用提供参考。方法 收集108例中耳炎患者[慢性化脓性中耳炎 (CSOM) 患者 62 例,中耳胆脂瘤46例]患耳分泌物标本,利用梅里埃的质谱仪对标本进行菌株培养鉴定,利用梅里埃的vitek II对菌株进行药敏试验。结果 108 例中耳炎患者中80例检出病原菌,培养出病原菌 86 株; 44 例 CSOM 患者检出病原菌,其中革兰阳性菌19株(金黄色葡萄球菌12株、凝固酶阴性葡萄球菌7株、其他革兰阳性菌0株),革兰阴性菌 21 株(铜绿假单胞菌14株、其他革兰阴性菌7株),真菌7株; 36例中耳胆脂瘤患者检出病原菌,其中革兰阳性菌22株(金黄色葡萄球菌15株、凝固酶阴性葡萄球菌4株、其他革兰阳性菌3株),革兰阴性菌15株(铜绿假单胞菌7株、其他革兰阴性菌8株),真菌2株。金黄色葡萄球菌药敏结果显示庆大霉素、利福平、奎奴普丁/达福普汀、苯唑西林、万古霉素、复方新诺明、利奈唑胺等药物敏感性高,红霉素、青霉素G敏感性较低。铜绿假单胞菌药敏结果显示哌拉西林/他唑巴坦、阿米卡星、哌拉西林、亚胺培南、头孢吡肟、头孢他啶等药物敏感性高,庆大霉素、左旋氧氟沙星、环丙沙星药物敏感性略低;其他革兰阴性菌药敏结果显示哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、美罗培南、头孢吡肟、头孢他啶等药物敏感性高,复方新诺明、左旋氧氟沙星、环丙沙星等药物敏感性相对较低。结论 CSOM 和中耳胆脂瘤患耳内分泌物病原菌均以金黄色葡萄球菌和铜绿假单胞菌最多见,不同病原菌对常用抗菌药物敏感性不同。 [ABSTRACT FROM AUTHOR]

With the continuous evolution of equipment support system of systems from traditional hierarchical tree structure to complex network structure, the original research methods and evolution laws can not solve the multi-network evolution problems encountered well. Based on the interdependence among different sub-network nodes, the theory of interdependent network is applied to the evolutionary analysis of equipment support network. The network characteristics of equipment support system of systems are analyzed, and the measures of network robustness are defined based on the maximal connected subgraph and network support efficiency. In the network evolution model, the evolution rules and steps of the model are determined according to the equipment support mechanism, the network interdependency proportional parameter F, which represents the proportion of maintenance, storage and supply nodes with interaction, and the interdependence redundancy parameter K, which represents the average number between some maintenance node and its neighbors in storage and supply network, are defined, and their effects on network robustness are analyzed through simulation. The simulated results of evolution model show that the robustness and overall support efficiency of interdependent network can be improved by controlling the parameters K and F. [ABSTRACT FROM AUTHOR]

Based on the analysis of currently mainstream trusted storage system (TSS), we design and implement a trusted execution environment (TEE)-based TSS, which conforms to Global Platform (GP) standard. Our TSS provides not only authorized encryption, the integrity and consistency of data, but also many security storage operation properties such as atomicity operations of persistent object. In order to improve the read/write performance of big data, a newmethod is proposed for dynamically allocating continuous memory in REE’s kernel memory space and mapping the address to the TEE through communication pipe. This method can reduce switching times, allocating memory times and copy memory overloads between two worlds. The experiments showthat our system has an 8% to 10% performance improvement compared with related trusted storage systems. [ABSTRACT FROM AUTHOR]

Xiangshuixi Karst Spring is located in Xiangshuixi Village, Tianquan County, Ya'an City. In order to study the groundwater runoff model and spring origin in this area, 12 groups of water samples were collected on site in February 2022, and the hydrochemical characteristics of this area were analyzed through Piper diagram and ion proportion analysis. Based on the hydrogeological conditions of the study area, the law of groundwater recharge, runoff and discharge was analyzed, and the origin of Xiangshuixi spring was verified by water balance method and isotope characteristics analysis. The results show that the groundwater water chemistry type in Xiangshuixi area is generally HCO3 -Ca·Mg type, its ionic components are mainly weathered and dissolved by dolomite and limestone. The most direct recharging aquifer of Xiangshuixi Karst Spring is the karst aquifer of the Dengying Formation (Z2C1 d). In addition, its replenishment was also affected by the water of the Permian Yangxin Formation (P2 y) and Devonian (D2-3 ) carbonate fracture caves on the north side. [ABSTRACT FROM AUTHOR]

In order to reveal the mapping relationship between internal excitation and vibration characteristics of planetary transmission mechanism, a vibration acceleration measurement system of planetary transmission mechanism was established by designing a vibration test scheme, and the vibration characteristics of typical gearshift 2 500 r/min planetary transmission mechanism were measured and analyzed. The results show that the vibration root mean square (RMS) value of planetary transmission mechanism is correlated with the position of measuring point. The measuring point is in the meshing position of planetary gear, and its vibration amplitude is larger. The vibration RMS value increases with the increase in the torque. The frequency spectrum analysis results show that the vibration energy mainly concentrates on the meshing frequency and multiple frequencies of planetary gears, and the axial frequency spectrum is similar to the radial frequency spectrum. The maximum amplitude of meshing vibration is obtained by measuring the vibration of planetary transmission mechanism and analyzing its frequency spectrum. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical significance of molecular biomarker (eIF4E, survivin, cyclin D1 and P27) expressions in defining the surgical margin in local advanced supraglottic laryngeal squamous cell carcinoma (LSCC) after induction chemotherapy. Methods A total of 95 patients with local advanced (T3-4, N0-2, M0) supraglottic LSCC were enrolled in this study. Clinical response was evaluated after induction chemotherapy with a TPF (docetaxel/ cisplatin/ fluorouracil) regimen. Fifty-nine patients with stable disease (SD) and partial remission (PR) and requiring surgery, were underwent partial laryngectomy. These patients were divided into three groups according to the shortest margin distances: <5 mm (Margin 1) group (n=14), 5-10 mm (Margin 2) group (n=17) and ＞10 mm (Margin 3) group (n=28). Tumors and the adjacent tissues were prepared for tissue microarray (TMA) and were used to identify the expressions of eIF4E, survivin, cyclin D1 and P27. The recurrence rates in three years were also analyzed. Results Primary tumors (T) showed necrosis and tumor retraction after chemotherapy. In Margin 1 group, the retraction zone was found in 10 cases (10/14), necrotic and degenerative tumor cells were occasionally found. No retraction zone was found in Margin 2 and Margin 3 groups. The expressions of eIF4E and survivin proteins were higher in primary tumors. The positive expression rates of eIF4E and survivin proteins decreased sharply with the increase of the margin in three groups. There were no significant differences in positive expressions of cyclin D1 and P27 between three groups. In 59 patients with laryngeal cancer, 12 (20.3%) recurred 3 years after operation, including 11 (78.6%) in Margin 1 group, 1 (5.9%) in Margin 2 group and 0 (5.9%) in Margin 3 group. The recurrence rate was significantly higher in Margin 1 group than that in Margin 2 and Margin 3 groups (P＜0.05). Conclusion The eIF4E and survivin proteins might be used as more sensitive molecular margin markers of partial laryngectomy after induction chemotherapy in patients with local advanced supraglottic LSCC. The margin beyond 10 mm and no expression of markers are relatively safe. [ABSTRACT FROM AUTHOR]

Objective To analyze the expression and significance of kinesin family member 23 (KIF23) in breast cancer based on databases mining. Methods In this study, the differential expression of KIF23 gene in breast cancer and normal tissues was compared using the Oncomine and GCBI databases, and then its expression level was overall analyzed. The relationship between KIF23 expression level and prognosis survival, including relapse-free survival (RFS), overall survival (OS), distant metastases-free survival (DMFS) and post-progression survival (PPS), in breast cancer patients were analyzed by the Kaplan-Meier Plotter database. Results It was discovered that KIF23 was more abundantly expressed in breast cancer and a total of 39 studies in the Oncomine database were involved in the expression level of KIF23 in breast cancer and normal tissues. The median rank of KIF23 gene was 900.0 in all differentially expressed genes of breast cancer (P＜0.05). The expression levels of KIF23 were higher in 23 invasive and 4 non-invasive samples of breast cancer, the median rank of differentially expressed genes was statistically significant (P＜0.05). KIF23 was highly expressed in breast cancer (587.27) compared with that of normal tissues (90.89) after integrated analysis (P＜0.05), which was also proved in the GCBI. In addition, Kaplan-Meier Plotter database analysis indicated that the high expression of KIF23 was closely associated with poor survival. Further analysis showed that the expression levels of survival indicators in ER (+) group were statistically significant. Conclusion KIF23 is highly expressed in breast cancer and is associated with poor prognosis in patients, which may be important for the diagnosis, treatment and prognosis assessment of breast cancer. [ABSTRACT FROM AUTHOR]

Currently more coal resource is buried in deep and more high-quality resource is located in the west of China. It makes a deep mining and a mining in the west become the new normal of coal resources exploitation. Thus a green mine construction, green mining development and green mining propulsion are imperative. This paper puts forward a"mining-dressing-backfilling+X"technical conception of green mining of coal resources. That is an underground integrated production system, which is integrated coal mining, coal-waste separation, and gangue backfilling with "active control of strata movement, gob-side entry retaining, gas extraction, disaster prevention, water-preserved-mining". The system forms a coal mining-dressing-backfilling+X(control, retain, extraction, prevention and preserved) collaborative production mode. The paper defines the"mining-dressing-backfilling+X"technical connotation and framework of greenmining, expounds "mining-dressing-backfilling+X"evolution of four generations, analyzes the specific technical advantages of its practice of green mining and gives the scientific engineering design method. The paper elaborates five aspects of typical "mining-dressing-backfilling + X"technology corresponding technical principle, engineering requirements, design process and methods, key technology and process equipment. Engineering practice of the Tangshan Coal mine, Zhaizhen Coal mine and 12 th Coal mine of Pingdingshan Group has respectively proved that "mining-dressingbackfilling+ control", "mining-dressing-backfilling + retain", "mining-dressing-backfilling + extraction " technologies have a remarkable technical superiority and the engineering demonstration effect. "Mining-dressing-backfilling + X "green mining extension in the future combines "mining-dressing-backfilling+processing", "mining-dressing-backfilling+intelligent", "mining-dressing-backfilling+adjustment"and "mining-dressing-backfilling +coordination". The overall formation of the "mining-dressing-backfilling+X"technology system can provide a strong technical support for the realization of green mining of coal and associated resources. [ABSTRACT FROM AUTHOR]

Objective To explore the influence factors of radioiodine therapy in patients with Graves' disease (GD). Methods This study included 203 GD patients who received radiododine therapy in Zhongshan Hospital, Fudan University. The information such as gender, age, the course of hyperthyroidism, the application of antithyroid drug (ATD) and its application time were recorded before the treatment. The thyroid hormone including free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) the thyroid antibody including antithyroglobulin antibody (TGAb), anti-thyroid peroxidase antibody (TPOAb) and thyrotrophin receptor antibody (TRAb) were measured using electrochemical luminescence technique. All patients underwent the examination of thyroid ultrasound to calculate the thyroid volume and had the measurement of the 24 h iodine uptake of the thyroid. All of them were given the corresponding dose of radioactive iodine based on the scintigraphy of thyroid. Results After one-year follow-up, out of the 203 patients, 134 cases (66%) were successfully and 69 cases (34%) were unsuccessfully treated with radioactive iodine. Non-conditional Logistic regression analyses showed that the radioiodine dose per thyroid volume unit was independently associated with the outcome of radioiodine therapy in GD patients (P＝0.013, OR＝4.225, 95%CI:1.362-13.016), while no significance was found between theraputic effect and gender, age, body mass index (BMI), course of disease, ATD treatment and its application time, FT3, TPOAb and 24 h iodine uptake. ConclusionsThe radioiodine dose per thyroid volume unit significantly affects the GD patients’ outcome of radioiodine therapy. A higher therapeutic dose is recommended when the thyroid volume is large. [ABSTRACT FROM AUTHOR]

Objective To analyze the personal health status and related lifestyle and behaviors of chronic diseases in Nu Ethnic Minority；To understand the knowledge and control situation of overweight or obesity， hypertension，diabetes mellitus and dyslipidemia among residents of Nu Ethnic Minority aged over 15 years old；To provide basis for health education on chronic disease prevention and treatment. Methods A total of 267 residents aged 15 and above from 209 families in 10 natural villages in Gongshan County in Yunnan Province were selected with stratified multistage cluster sampling method. Cross-sectional survey was applied to obtain the condition of individual health and behavioral lifestyle among Nu minority. The software of SPSS statistical was applied to analyze. Counting data is described by frequency. Results Only 4.3% of Nu Ethnic Minority residents aged 15 years or older considered themselves overweight or obese in Yunnan Province. 75.0% of Nu Ethnic Minority residents controlled weight by diet. Only 10.9%of people knew they had high blood pressure. 87.0% people controlled blood pressure with drugs. Only 5.2% knew themselves had diabetes. 75.0% of Nu Ethnic Minority residents controlled blood sugar with increasing physical activity and receiving medication. Only 6.4% of people knew they had dyslipidemia．66.7% treated with drugs to control blood lipids. Only 28.9% of the population surveyed had undergone a medical examination. Conclusion Among the residents of Nu Ethnic Minority aged 15 and above in Yunnan Province，the awareness rate of chronic diseases，such as overweight or obesity，hypertension，diabetes mellitus and dyslipidemia is lower than that in other regions，which should be paid more attention to. [ABSTRACT FROM AUTHOR]

In order to study the impact characteristics of the ring chain effected by temperature and corrosion area,a chain model was built to simulate the heavy load launching process of different regions on corroded chain under diverse conditions including different temperatures,different corrosion areas,and temperature-corrosion areas coupling via ABAQUS,and extract the stable values of the impact characteristics.The coherence functions between impact characteristics and temperature,impact characteristic and corrosion density were fitted by MATLAB,and also proved by experimental verifications simultaneously. The results showed that the yield strength of the 23MnNiCrMo54 steel decreased with the temperature increase.In the process of heavy load launching,the maximum stable stress in the corrosion area No.III was higher than that in other areas,and reached a yield state from a larger area.The model fitting by diverse impact characteristics(stable stress,stable friction dissipative energy,plastic dissipative energy,stable intrinsic energy) and temperature and corrosion area coupling was obtained.This method provide a significant parameter-basis for forecasting the service life and optimizing the design of the ring chain. [ABSTRACT FROM AUTHOR]

The Yellow River is important water source in Northwest and North China. It is of great significance to understand the characteristics and causes of its streamflow changes. In this paper, impacts of climate changes and human activities such as cropland changes and water reservoirs on streamflow variations at seasonal scale were thoroughly quantified using daily streamflow data, daily precipitation data, cropland data, and information of water reservoirs in the Yellow River Basin. Firstly, multi-year trends of streamflow and change points at seasonal scale during 1960- 2005 were evaluated, and then the streamflow changes during the growth period of wheat and growth period of maize and soybean were estimated by Generalized Additive Models for Location, Scale and Shape (GAMLSS) model. Besides, two different precipitation scenarios were proposed to elucidate the impacts of changes in precipitation and cropland at seasonal scale on different streamflow components defined by different percentiles. The results indicated that: 1) The change points of streamflow during the growth period of wheat and growth period of maize and soybean at the five hydrological stations in the Yellow River Basin occurred during the mid- and late-1980s and early 1990s. Except at Huayuankou Station, the streamflow in the Yellow River Basin was generally in decreasing tendency and the decreasing tendency at most hydrological stations was significant at 95% confidence level. 2) Based on two precipitation scenarios set in this study, the streamflow during years with high precipitation was always higher than that during years with low precipitation, implying that precipitation still plays the critical role in streamflow changes. The impacts of cropland changes on streamflow were related with both changes in precipitation and the percentiles of streamflow components. At Tangnaihai Station, the increasing cropland increased the lower quantile of streamflow and decreased the upper quantile of streamflow during the growth period of wheat of high precipitation years while did the opposite during the growth period of wheat of low precipitation years. Results of this study can provide theoretical and practical grounds for water resources management and allocation across the Yellow River Basin. [ABSTRACT FROM AUTHOR]

Wet gas wildly exists in natural gas industry. The online metering of wet gas flow is of great significance to reduce the investment and operation cost of oil and gas field, and improve the production efficiency and the level of scientific management. In the last decade, the wet gas online metering technologies have advanced considerably, and many wet gas flow meters with diverse metering principles have appeared. This paper briefly introduces the current situation and technical needs of wet gas measurement in PetroChina, and analyzes the metering principles of current wet gas flow meters. The laboratory test results and filed application of wet gas flow meters are analyzed in detail, and the technical difficulties in the field application of wet gas flow meters are summarized. In order to improve the popularization and application of wet gas flow meters, it is recommended that the further wet gas flow meter testing and field application to be conducted to study the operating range of wet gas flow meters and its adaptability for long-term use, to establish the standard test method and access criteria to regulate the use and maintenance of wet gas flow meter. [ABSTRACT FROM AUTHOR]

Objective To investigate the transcranial doppler ultrasonography in monitoring blood stream of cerebral vessels after endovascular treatments for acute ischemic stroke and the relationship between the prognosis and blood stream on basis of TCD.Methods 150 acute ischemic stroke patients who underwent endovascular treatments from May 2011 to June 2016 were studied retrospectively.All patients were monitored by TCD before operation,24 hours and 72 hours after operation on the basis of the score thrombolysis in brain ischemia(TIBI) of TCD.According to modified Rankin score（mRS,≤2 or＞2）,all patients were divided into 2 groups,i.e.favourable and unfavourable outcome.The clinical data of different groups were analyzed.The multivariable Logistic regression analysis were performed to analyze the related prognosis factors.Results In this study,the patients of recanalization of 24 hours was 115(77.0%).The recanalization of 72 hours was 97(65.0%).The favourable outcome was 95(63.3%) and unfavourable outcome was 55(36.7%).The mean age,the heart disease history,the baseline admission NIHSS score,the mean time getting treatment,the rate of recanalization 72 hours after operation were significantly different between 2 groups.In multivariable Logistic regression analysis,the baseline admission NIHSS score,the mean time getting treatment and the rate of recanalization 72 hours after operation were related with prognosis.Conclusions The monitoring of TCD is efficient tool after endovascular treatments in acute ischemic stroke.The recanalization rate of 72 hours on basis of TCD is predictor for favourable outcome. [ABSTRACT FROM AUTHOR]

With the popularization and application of wind power generation technology, in order to meet the needs of enterprises for professional and technical personnel, the related majors in colleges and universities need to strengthen the training and exercise of the students’ engineering ability. A practical teaching platform for doubly fed wind power generation, which adopts modular and open design, can enable students to master and practice a variety of technologies, such as excitation system of doubly fed wind generator, operation control of VSCF, wind turbine simulation, DSP development, data communication, digital filtering. It can provide strong support for the senior engineering and technical personnel training. [ABSTRACT FROM AUTHOR]

Objective To observe the morphological changes of adipocytes after subcutaneous injection of botulinum toxin type A (BTX-A) in the inguinal region of rabbits. Methods Twenty healthy male rabbits were divided into four groups: A, B, C, and D. Normal saline was used in group A (control group), and different concentrations of BTX-A (50, 100, 200 U/ml) were injected into the adipose of the inguinal region of the rabbits in group B, C, and D (experimental groups). Four weeks after injection, the adipose was taken out for paraffin section and hematoxylin-eosin (HE) staining. The basic structure of rabbit adipocytes was observed under light microscope. The superficial area and quantity of adipocytes was measured and statistically analyzed. Results Four weeks after BTX-A injection, the superficial area and quantity of adipocytes was significantly decreased in each experimental group compared with the control group. The difference was statistically significant (P<0.05). The difference in the superficial area and quantity of adipocytes was statistically significant among the 3 experimental groups (P<0.05). Conclusion Four weeks after injection of BTX-A into rabbit adipose, it was found that BTX-A can reduce the superficial area and quantity of adipocytes and has a decomposition effect on adipose tissue. [ABSTRACT FROM AUTHOR]

Objective To study the characteristics of colorectal cancer patients in Yunnan Tumor Hospital， and to provide the basis for the prevention and treatment of colorectal cancer. Methods Retrospective analysis was used to review colorectal cancer patients who were diagnosed first and received the main treatment in Yunnan Cancer Hospital fromMarch 2005 to December 2014．According to the sampling principle，there were 100 cases each year ， with a total of 1000 cases. The clinical and pathological data were analyzed， including age， gender， pathogenesis， pathological type， and TNM stage. Results The average age of the 1000 patients enrolled in the survey was（63.4 ± 12.8） years old， the male and female age group (60-69) accounted for the highest proportion．both men and women aged between 60 and 69 had a high occurance rate， and male patients were more than the female with a fraction of 1.42:1. Rectum is the most common primary site， accounting for 57%， followed by ascending colon， sigmoid colon， straight B junction， transverse colon， descending colon， and cecum. Adenocarcinoma was the main pathological type， accounting for 89.4%．Stage III was the most common in TNM staging， accounting for 35.9%， followed by stage II， I， and stage IV. Most rectal cancers were found at stage III， and colon cancer at stage II . Conclusion The proportion of colorectal cancer in the age group (60-69 years) was the highest; the proportion of middle-aged and male was significant．The high incidence of colorectal cancer was 60 ~ 69 years old， especially males．The main part of colorectal cancer was located in the rectum.Adenocarcinoma was the most common pathological type. Most patients were later stage when diagnosed. [ABSTRACT FROM AUTHOR]

The desulfurization device of a natural gas purification plant in Sichuan-Chongqing gas field has the characteristics of high acid gas load, large processing capacity and amine circulation. The complete overhaul results showed that the corrosion thickness of the bottom of regenerator, reboiler, and the return line of semi-lean liquid were seriously decreased. The corrosion conditions in the field were analyzed and evaluated by macroscopic observation, corrosion coupon test and hydrogen probes, and the corresponding corrosion control measures and supervision/inspection schemes were developed. The results showed that the high cyclic volume and acid gas load were the main factors leading to the serious corrosion of the bottom of the regenerator, and the carbon steel inner lined 316L stainless steel could preferable inhibit the corrosion in the bottom of the regenerator. [ABSTRACT FROM AUTHOR]

Biostimulants are becoming widely applied and extended in the fertilizer industry, because of their effects on soil improvement, anti-stress ability enhancement and root growth promotion, which can increase efficient uptake and utilization of soil nutrients, crop yield and quality.This review introduced the concepts of biostimulants, and summarized the functions and related mechanisms of commonly-applied biostimulants in the market, i.e.humic acid, amino acid, seaweed extracts and plant-growth-promoting bacteria(PGPR). The properties and applied characteristics of different organic wastes containing some biostimulating compounds as the main material of functional water soluble fertilizers (WSF)in the industry were presented. The technical keys to compound these organic wastes with some bio-active substances to produce the functional WSF were explored, with the aims to support the value -added utilization of organic wastes, reduce the use of fertilizers, and promote crops忆 quality and quantity. [ABSTRACT FROM AUTHOR]

Deep resource exploitation is imperative,but it is facing with more complicated mining environment and dangerous mining disturbances to induce the potential catastrophe process.Combined with the challenge of “four high and one disturbance” in deep coal mining and the technical advantages of backfilling mining in ground control,this paper summarizes five major technical problems faced by deep backfilling mining,thus the conception of green mining integrating mining,separating and backfilling in deep coal resources is put forward.The theoretical research and technical system of the conception have been basically formed which has been carried out in typical mines such as the 12th Coal Mine of Pingdingshan Group and Tangshan Coal Mine of Kailuan Group.In order to build integral theories and technology system of the green mining integrating mining,separating and backfilling in deep coal resource,backfilling and ground control theory in deep coal mine and five other basic theories need further researches and beyond that,seven key technologies such as the layout of mining-dressing-backfilling green mining system,automatic backfilling,mass flow material transportation and intelligent coal-waste separation need to be developed.These theories and techniques provide a reliable basis for realizing the safe,efficient and green mining of deep resources. [ABSTRACT FROM AUTHOR]

Computation-intensive tasks in the data processing for global ionosphere mapping are analyzed. A parallel algorithm with OpenMP technique is proposed for data preprocessing incorporating normal equation matrix stacking, parameter pre-elimination, and normal equation matrix inversion. A validation experiment was executed on a single server. Results indicate that the computing time for rapid global ionosphere mapping is only about 10~13 minutes with a speedup of about six, the time for final global ionosphere mapping is only about 39-47 minutes and the speedup is about five. The precision for global ionosphere products are about 2.8~3.8 TECUs compared with IGS final products, and the final solutions are at higher precision, about 0.2 TECUs in contrast to rapid solutions. The parallel algorithm proposed in this paper is very useful for the optimal testing of global ionosphere mapping, when reprocessing long time span data extending over periods such as 10 years, as well as for the real-time ionosphere mapping. [ABSTRACT FROM AUTHOR]

This paper analyzes the weighted Shapley value for cooperative games in which paxtial cooperation is based on a set system, which is the set of feasible coalitions that can be formed by players in a game, and the structure of feasible coalitions is completely free. In this context, we define the weighted Shapley value which distributes the Harsanyi dividends proportional to the weights of players. We provide two axiomatic characterizations of the weighted Shapley value: one by means of component efficiency and proportional fairness, and the other with efficiency and weighted balanced contributions. Moreover, the stability of feasible coalitions is analyzed, and some properties of the weighted Shapley value are obtained. Finally, we give two examples about assignment games showing that our method is feasible and effective. [ABSTRACT FROM AUTHOR]