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目的了解接受抗病毒治疗HIV/AIDS患者抑郁状况及其影响因素。方法2022年7月-2022年9月，采用连续抽样法从南京市抗病毒治疗机构招募接受抗病毒治疗HIV/AIDS患者，进行匿名问卷调查，收集患者基本信息，采用患者健康问卷抑郁量表（PHQ-9）、简化的Berger艾滋病感知歧视量表（BHSS）及感知社会支持的多维度量表（MSPSS）调查抑郁状况、HIV耻辱得分以及社会支持水平等。采用多因素Logistic回归分析患者抑郁的影响因素。结果本研究共收集有效问卷1 879份，抑郁检出率为50.1%，多因素logistic回归分析结果显示：相较于初中及以下文化程度的患者，研究生及以上文化程度抑郁的风险更低［OR=0.534，95%CI（0.341，0.835），P=0.006］；相较于抗病毒治疗时长5~10年［OR=0.516，95%CI（0.379，0.702）］、>10年［OR=0.603，95%CI（0.375，0.969）］抑郁的风险更低；相较于中低社会支持水平，高社会支持水平是HIV/AIDS患者抑郁保护性因素［OR=0.430，95%CI（0.349，0.530），P＜0.001］；相较于未存在治疗药物副作用，存在药物副作用发生抑郁的风险更高［OR=2.260，95%CI（1.833，2.786），P＜0.001］；同时在HIV耻辱感量表得分越高，抑郁的可能性越高。结论南京市抗病毒治疗患者抑郁检出率较高，启动抗病毒治疗后应加强患者的药物副作用及心理状态监测，开展心理干预，缓解心理问题出现，提高患者的生命质量。

针对电力公司在开展变压器设备运检过程中存在的非结构化文本数据难以利用、全口径数据难以深度融合、设备知识应用深度较浅等难题，基于语义网、知识图谱、自然语言处理等人工智能技术，对开展设备智能管理的关键技术进行了研究，提出了支撑变压器智能管理的智能技术框架，包括非结构化文本智能识别与提取、以设备为中心的设备知识表示与存储、设备知识服务应用三部分；形成了设备语义提取模型、设备语义相似度计算模型、基于深度神经网络的智能问答模型等三个智能模型；总结了该技术在变压器设备状态评价报告自动化审核、设备信息灵活查询、基于设备故障知识的辅助诊断三个场景的应用成果；提出了基于知识的设备智能技术下一步研究的方向。

目的将声触诊弹性成像（STE）和二维剪切波弹性成像（2D-SWE）检测肝脏硬度进行比较，为STE新技术的临床应用提供循证依据。方法采用 STE和2D-SWE技术，对43例健康志愿者和63例肝硬化患者行肝硬度检测，对比分析两种技术的检测成功率、操作者内重复性、测值相关性和测值差异。结果肝脏STE、2D-SWE检测成功率分别为100%（106/106）、96.2%（102/106）（χ2=2.320，P=0.128），4例2D-SWE检测失败的均为肝硬化患者。在健康组STE测值高于2D-SWE[5.83(5.30~6.37) kPa vs 5.00(4.80~5.20) kPa，Z=4.419，Pvs 18.50(11.95~29.93) kPa，Z=-2.981，P=0.003]。STE和2D-SWE两种技术的测值相关系数为0.896（95%CI：0.849~0.928，P

在应对突发重大传染病时，社区防控是整个社会疫情防控的重要一环。在新型冠状病毒肺炎疫情社区防控实践经验的基础上，提出一个社区疫情排查调度问题的数学模型，根据相关疫情防控信息为社区重点住户估算风险指数，并在此基础上将重点住户分配给各个排查工作小组，为每个小组设定排查路线，从而尽可能高效地完成各项排查任务。为求解该问题，提出一种混合智能优化调度算法，它基于水波优化的启发式策略搜索解空间，并混合了两种局部搜索策略来提高解的精度，形成初步调度方案。在调度方案的实施过程中，如果排查到某个对象有特殊情况需要处置，算法将对方案进行动态调整，以适应变化后的排查任务。在浙江省多个社区排查的实际案例问题上的计算结果验证了方法的有效性。

【摘要】 基质金属蛋白酶9（matrix metalloproteinases 9，MMP9）被证明在缺血性卒中患者梗死灶及梗死灶周围脑组织，梗死灶血管周围及外周血中性粒细胞中均高表达。聚合酶δ-相互作用蛋白2、白细胞介素17（interleukin17，IL-17）、肿瘤坏死因子α、IL-1β、心血管活性肽、血管内皮生长因子等可通过p38丝裂原活化蛋白激酶（mitogen activated protein kinases，MAPK）、细胞外调节蛋白激酶1/2依赖的核因子κB（nuclear factor κB，NF-κB）和活化蛋白-1、p42/p44MAPK、c-Jun氨基末端激酶、p65-NF-κB等不同途径促进MMP9的表达。MMP9的高表达与缺血性卒中出血转化关系密切，且外周血MMP9水平变化与rt-PA溶栓患者死亡或症状性颅内出血独立相关，与缺血性卒中严重程度及不良功能结局相关。MMP9 rs3918242位点基因多态性与缺血性卒中的风险及疾病严重程度可能相关，但目前研究的结果和结论尚不一致。 【Abstract】 When ischemic stroke occurs, matrix metalloproteinases 9 (MMP9) has been shown to be highly expressed in infarct lesion and surrounding cerebral tissue, and neutrophils will be highly expressed in perivascular around infarct focus and peripheral blood. Polymerase δ-interacting protein 2, interleukin17 (IL-17), tumor necrosis factor alpha, IL-1β, cardiovascular active peptide, vascular endothelial growth factor may promote the expression of MMP9 through p38 mitogen activated protein kinases (MAPK), extracellular regulated protein kinases 1/2-dependent nuclear factor κB (NF-κB) and activated protein 1, p42/p44MAPK, c-Jun N-terminal kinase, p65-NF-κB and other pathways. The high expression of MMP 9 is closely related to hemorrhagic transformation in ischemic stroke. The MMP9 level in peripheral blood is closely correlated with ischemic stroke severity, and is an independent risk factor for death and symptomatic intracranial hemorrhage in patients with rt-PA thrombolysis, and related to poor outcome of ischemic stroke patients. The gene locus polymorphism of MMP9 rs3918242 may be associated with the risk of ischemic stroke and the disease severity, but current research results are still inconsistent.

【目的】探讨长链非编码RNA肝癌高表达转录本（LncRNAHULC）沉默表达对人脑胶质母细胞瘤细胞株SHG44增殖和凋亡的影响。【方法】实时荧光定量PCR（qRT-PCR）验证HULC沉默表达组（HULC-siRNA）及其阴性对照组（NC组）HULC的表达水平。CCK8增殖实验和平板克隆形成实验检测瘤细胞的增殖能力。细胞周期和细胞凋亡实验检测瘤细胞的周期分布及凋亡能力。【结果】qRT-PCR证实HULC-siRNA组较NC组的HULC表达量显著降低（P=0.003）。CCK8增殖实验显示HULC-siRNA组较NC组细胞增殖率显著降低（第2天P=0.003；第3天P=0.005；第4天P=0.009）。平板克隆形成实验显示NC组和HULC-siRNA组的克隆形成率分别为（34.11±1.24）％，（14.44±0.87）％，沉默表达HULC后细胞克隆形成率显著降低（P

在现有大规模分布式环境中，大数据应用的性能与计算效率仍有较大的提升空间。然而，在大规模环境中进行性能分析与优化需要大量领域专家。针对大数据应用中的性能优化问题，提出了一个通用的低效查询语句检测与优化流程，总结了4类显著影响大数据应用性能的低效行为，并针对每一类低效行为，提出了具体的优化策略。最后，通过实验评估验证了提出的优化方案在实际大规模集群中的有效性。

全光波长转换技术在波分复用网络中有着非常重要的作用,尤其是基于SOA（半导体光放大器）的全光波长转换技术,已有较为成熟的理论研究,但其性能上仍存在很多不足。文章对基于SOA的全光波长转换技术的原理和性能特点进行了分析和比较。由最基础的不同类型的基于SOA的全光波长转换技术扩展到改进的技术方案,对不同结构和类型的全光波长转换技术进行了特性分析和比较,并对它们的应用前景和发展方向进行了展望。结果表明,通过改变SOA的增益特性或者改变系统结构,均能在不同方面改善全光波长转换技术的性能参数。

当前以电子作为信息载体的微电子技术遭遇到发展瓶颈。光传输具有带宽大、速率高的特点,将光子载体与电子载体相结合是未来信息传输发展的必然趋势。波导与光纤的高效耦合是实现光电子集成的关键。文章介绍了国内外几种典型耦合器的最新进展,包括楔形耦合器、GRIN（渐变折射率）透镜耦合器和垂直光栅耦合器,并对它们的性能指标、优缺点进行了比较分析,对进一步提高耦合效率的可行性进行了展望。结果表明,垂直光栅耦合器具有耦合效率高、带宽大、工艺成熟、工艺容差大和耦合步骤简单的优势,在光通信与集成光电子学领域有着广阔的应用前景。

Flight safety in helicopters is a critical aspect of overall aircraft operational safety management, particularly during engine failures requiring autorotative glide, which makes it extremely challenging for the pilot to land the helicopter successfully. In this study, we evaluated the workload and attention allocation of helicopter pilots under such circumstances. In the experiment, a helicopter flight simulator was used to simulate level flight followed by autorotative glide, with the two phases divided into time segments for data collection. First, the data were visualized using heat maps and saccade sequence diagrams, while changes in eye movement metrics (such as peak value and standard deviation) were statistically analyzed. Finally, the criteria through the inter-criteria correlation (CRITIC) method was used to calculate the weight coefficient for each area of interest. This evaluation system was further applied to analyze and compare the changes in eye-movement data and attention to areas of interest during the two phases. The results revealed a shorter fixation duration, but a greater fixation number during the autorotative glide phase. Further, the mean pupil diameter changed over a larger range than during level flight (in level flight, the mean was 5.229 mm, while the standard deviation was 0.059 mm; in autorotative glide the corresponding values were 5.326 mm and 0.126 mm, respectively). For the tachometer, the weight coefficient matched the color of the heat map (2.7 % and colorless during level flight, but 23.8 % and red during autorotative glide), while those for the airspeed indicator and forward view differed significantly between the two phases. This discrepancy stemmed from the fact that during autorotative glide, the pilots prioritized monitoring aircraft rotation speed and attitude, with a particular focus on the forward view, rotor speed, and airspeed, resulting in a more concentrated attention distribution compared to that achieved during level flight. These results confirmed a significant increase in pilot workload during autorotative glide landing, while a shift was observed from low-frequency long gaze time during level flight to high-frequency short gaze time during autorotative glide. Furthermore, the pilots allocated 81 % of their attention to the tachometer, airspeed indicator, and forward views. Adopting this strategy can improve pilots’ landing success and provide flight students with valuable training advice to prevent landing failures when helicopters lose power.

基于微环谐振腔FWM（四波混频）效应产生的OFC（光频梳）可实现多波长光源和光孤子传输、存储等,能很好地满足光通信网络的要求。对基于微环谐振腔的OFC已有大量的实验报道,但是理论研究却有些不足。文章介绍了目前两种微环谐振腔OFC的理论分析方法,即NCME（非线性耦合模方程）和非线性LLE（Lugiato-Lefever方程）,对这两种方法的优缺点进行了比较分析。结果表明,LLE由于其计算速度快,更适合用于基于微环谐振腔的超宽带OFC的理论研究。

光交换系统是波长路由、中心数据传输中的核心部分,目前光网络的发展方向是实现高速、多端口数和大容量光交换。采用AWG（阵列波导光栅）的波长路由技术结合高速波长可调激光器,是实现大规模光交换系统中纳秒级开关时间的最有效的技术方案。文章分别从AWGR（阵列波导光栅路由器）的周期性、串联、并联以及串并联等4个方面,对不同的架构方案进行了阐述。

文章提出一种基于全光波长转换（AOWC）的新型波分/时分混合复用无源光网络（HPON）架构,使用掺铒光纤放大器（EDFA）来扩展突发模式全光波长转换模块（BM-AOWCM）的输入动态范围,以满足系统上行2.5 Gbit/s突发信号波长转换应用的要求。分析了动态范围扩展的原理,并通过仿真进行验证。搭建了测试系统,实验结果表明,在误码率为10-9时,动态范围可以由5.5 dB扩展到29.8 dB。

基于少模光纤的模分复用系统能继续提高光纤通信系统的传输容量,目前已成为全球的研究热点。在介绍了少模光纤设计后,文章对3种模式选择性激励技术（偏移注入、长周期光纤光栅和空间光调制）的激励机制、特点及实现进行了研究,并重点介绍了基于空间光调制的模式选择性激励技术。

【目的】建立用全染色体涂抹探针（WCP）对卵子第一极体进行荧光原位杂交（FISH）检测染色体的方法。【方法】收集单精子卵胞浆内注射（ICSI）中不成熟卵母细胞经体外培养成熟和常规试管婴儿（IVF）中未能成功受精的成熟卵母细胞，活检第一极体，固定后行13、14号染色体的全染色体涂抹探针荧光原位杂交。活检后，一部分卵母细胞固定行FISH以分析卵子自身的13、14号染色体，其余行ICSI受精，观察受精和卵裂情况。【结果】共获得成熟母细胞93个，成功活检85个，成功固定78个，共29个第一极体处于分裂中期，均有FISH结果。卵母细胞体外培养成熟后立即取极体进行固定，90．5％（19／21）的极体处于分裂中期，而取卵后30-48h和72h后活检的第一极体处于分裂中期的比例分别为27．3％（6／22）和11．4％（4／35），3组相比有统计学差异（P〈0．01）。11个卵母细胞同时获得了极体和相对应卵细胞的FISH结果，其中10个极体和相对应的卵细胞分别有1条13，14号染色体，剩余1个卵母细胞的极体有2条14号染色体和1条13号染色体，相对应的卵细胞仅有1条13号染色体，二者互补。活检后行ICSI受精的卵母细胞受精率为78．6％（11／14），优质胚胎率45．5％（5／11）。【结论】全染色体涂抹探针对卵子第一极体进行遗传分析可以有效、准确地推测相对应卵母细胞的染色体构成，从而应用于女性染色体易位患者的植入前遗传诊断。

【目的】探讨慢速程序冷冻对透明带显微操作后胚胎冻存率及继续发育的影响。【方法】将96 个Ⅱ 级以上人类 多精受精胚胎随机分为单纯透明带打孔组(n =24), 胚胎活检组(n =40)及对照组(n =32)。为模拟临床种植前诊断活检 后胚胎冷冻过程, 将透明带显微操作后胚胎继续培养6～ 10 h 再进行慢速程序冷冻, 观察各组胚胎冷冻解冻后的冻存率及胚 胎继续发育能力。【结果】活检及透明带打孔后冻融胚胎中发生裂解的卵裂球多位于透明带破口附近。活检组胚胎完整率、 胚胎存活率及卵裂球存活率分别为10%, 25.0 %和29.0%, 较对照组(43.7%, 66.0 %和62.4%)明显降低(P 0.05)。【结论】以丙二醇和蔗糖为冷冻保护剂的 人类分裂期胚胎慢速冷冻程序并不适用于化学法透明带打孔活检胚胎的冷冻保存, 有关人类活检后胚胎的冷冻保存方法值 得进一步探讨。

Heterogeneous graph embedding models based on non-contrastive learning (NCL) do not rely on negative sampling to learn the intrinsic features and patterns, which may cause the model fail to efficiently learn the differences between vertexes. This paper proposed a heterogeneous graph embedding model based on cross-view prototype non-contrastive learning (XPNCL), which learnt better node representations for downstream tasks by finding additional positive samples with more contextual information, and reconsidered the similarity between positive samples. The model firstly designed a tree structure based on random walks in heterogeneous graph. This directed filtering tree (DFT) about positive samples contained rich neighboring and semantic information by filtering out random walk paths that satisfied local structural constraints. Secondly, to achieve the alignment of similar samples in terms of numerical and quantitative from multiple dimensions, XP-NCL defined the cross-view prototype index (ISDR) and peak operator based on the characteristics of heterogeneous graphs. Furthermore, the model trained using stop-gradient updating. Finally, experiments verify the classification and clustering performance of the node on ACM, DBLP and freebase datasets, and the results show that even without the negative samples, the XP-NCL representation can achieve superior performance in many cases compared to other homogeneous and heterogeneous graph baselines. [ABSTRACT FROM AUTHOR]

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[Objective] To obtain high-yield chitinase strains from seawater and optimize culture conditions. [Method] The seawater from Jinsha Bay of Zhanjiang City was collected as samples, chitinase producing strains were isolated using colloidal chitin as the only carbon source, the enzyme activity was measured by DNS method and molecular identification; single factor experiment and orthogonal optimization were used to optimize the optimal conditions for enzyme production.[Result]Six strains of chitinase-degrading bacteria were screened. The strain with the strongest chitinase activity was Z-4. The strain was identified as Stenotrophomonas maltophilia by morphological observation and 16S rDNA sequence analysis.The optimum conditions for producing enzyme of strain Z-4 were obtained as follows: soluble starch addition of 1.5%, peptone addition of 2.5%, KH2PO4 addition of 0.04%; at 30 ℃, pH 7.0, inoculation amount of 2%, 160 r/min and 72 hours of cultivation, the enzyme activity reached 0.452 U/mL, which was 5 times higher than before optimization. [Conclusion] The research results provide an important reference for the effective use of chitin in the ocean to improve the environment. [ABSTRACT FROM AUTHOR]

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The cultivation of rice in China covers a vast area and yields a substantial harvest, making it an important cereal crop and a high-quality energy feed. Rice is rich in nutrients such as carbohydrates, proteins, fats, vitamins, and minerals. Even after aging, rice retains high nutritional value and can be combined with other feed materials to form a balanced feed formula, providing poultry with the necessary nutrients for growth. Rice is relatively inexpensive, and replacing part of the energy feed such as corn with rice in the basic diet can not only improve the production efficiency of poultry but also promote the efficient use of resources and drive the sustainable development of animal husbandry. In recent years, the application of rice and aged rice in poultry production has become more and more extensive. The article reviews the characteristics of high-quality protein, starch, and minerals in rice and aged rice, summarizes their effects on the growth performance, egg-laying performance, slaughter performance, and blood biochemical indicators of poultry, aiming to provide a reference for the application of rice and aged rice in poultry feed. [ABSTRACT FROM AUTHOR]

[Objectives] This experiment aimed to investigate the yield and quality of high erucic acid rape under different nitrogen and phosphorus fertilizer interactions, in order to identify nitrogen and phosphorus fertilizer application treatments that were suitable for stable yield and quality improvement of high erucic acid rape varieties. [Methods] This experiment using high erucic acid rape‘Mianyou 309'as the material, set up 4 nitrogen fertilizer levels (N0:0 kg·hm-2, N1:60 kg·hm-2, N2:120 kg·hm-2, N3:180 kg·hm-2) and 4 phosphorus fertilizer levels (P0:0 kg·hm-2, P1:45 kg·hm-2, P2:90 kg·hm-2, P3:120 kg·hm-2), totaling 16 treatments. This experiment was conducted to compare the effects of different nitrogen and phosphorus interactions on the yield and quality of high erucic acid rape. [Results] The application amount of nitrogen and phosphorus fertilizer affected the number of pods, seeds per pod and thousand seed weight per plant, thereby affecting the yield of rape. The yield reached its maximum value under N3P2 treatment in 2020 and 2021, with a maximum value of 2 848.7 kg·hm-2 in 2020, an increase of 206.5% compared with the minimum value of 929.4 kg·hm-2. The maximum value in 2021 was 2 908.3 kg·hm-2, which was 213.6% higher than the minimum value of 927.4 kg·hm-2. Under N3P2 treatment, the measured yield of rape oil in 2020 and 2021 reached the maximum of 1 144.0 and 1 353.1 kg·hm-2, and the maximum erucic acid yield was 582.5 and 685.8 kg·hm-2, respectively. Nitrogen fertilizer significantly affected the oil content of high erucic acid rape, with the highest oil content (41%-42%) under N2 conditions for two years. Nitrogen and phosphorus fertilizers significantly affected the content of erucic acid, reaching the maximum value under N2P2 treatment for two years, with a maximum value of 55.0%. [Conclusions] Reasonable application of nitrogen and phosphorus fertilizers could significantly improve the yield and quality of rape, achieving the goal of increasing yield and income.‘Mianyou 309', as a rape processed with erucic acid, could achieve higher yield and better quality by applying nitrogen 180 kg·hm-2 and phosphorus 90 kg·hm-2. [ABSTRACT FROM AUTHOR]

Most traditional drone cross-domain authentication schemes rely on PKI, which are highly dependent on trusted third parties and prone to single points of failure and low authentication efficiency. Accordingly, this paper proposed a block-chain-based UAV network cross-domain identity authentication protocol scheme, which not only effectively realized the cross-domain authentication of UAVs, but also improved many security problems faced by the traditional PKI-based model. At the same time, to discover the privacy protection of UAV network cross-domain authentication, this paper proposed a method to anonymize the UAV cross-domain identity authentication identity. The results of security analysis and simulation experiments show that the scheme can not only resist common network attacks, but also significantly improve authentication efficiency and reduce time overhead. [ABSTRACT FROM AUTHOR]

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了解医生职业倦怠患病率、 危险因素及预防缓解策略。 方法 使用与职业倦怠相关的检索词在 PubMed、中国知网、万方、维普中文科技期刊数据库进行文献检索, 筛选 2013 年 11 月—2023 年 11 月的系统性综述 研究为研究资料, 对这些文献再次进行系统性综述, 分析、总结医生职业倦怠患病率及其危险因素, 提出相应的预 防缓解策略。 结果 共检索到 90 篇文献, 最终有 33 篇文献纳入研究。 有 28 篇文献报道了研究人群职业倦怠和/或 不同维度的患病率, 总体职业倦怠患病率估计范围为 0 ~ 95.2%。 12 篇文献所报道的情绪衰竭、人格解体、个人成就 感降低患病率估计范围分别为 0 ~ 86.2%、0 ~ 91.0%、0 ~ 87.1%。 医生职业倦怠危险因素包括个体因素、工作组织、 患者安全与医疗质量、团队合作与领导支持、与医患关系相关的因素、培训因素。 结论 医生职业倦怠普遍存在, 全 球医生职业倦怠程度很高。 应当倡导采取系统性的职业健康防护措施, 将针对个人的干预和组织层面上的干预相 结合, 为医生提供更好的职业健康环境, 预防和控制职业倦怠。 [ABSTRACT FROM AUTHOR]

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