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Objective To investigate the efficacy and safety of sacubitril valsartan in the treatment of heart failure (HF) of midrange ejection fraction（HFmrEF）in patients after acute myocardial infarction (AMI). Methods A total of 102 patients with HFmrEF after AMI were divided into the control group and the experimental group, with 51 cases in each group. The control group was given conventional treatment for AMI and anti-HF treatment, and the angiotensin-converting enzyme inhibitor (ACEI)/ angiotensin Ⅱ receptor blocker (ARB) was used without contraindications. The experimental group was replaced by ACEI/ARB with sacubitril valsartan on the basis of the control group. After 6 months of treatment, the total effective rates of the two groups after treatment were analyzed, and the cardiac function, N-terminal pro-brain natriuretic peptide (NT-proBNP) and serum inflammatory factor C-reactive protein (CRP) were compared before and after treatment. The occurrence of adverse reactions after treatment was recorded. Kaplan-Meier method was used to analyze the cumulative cardiovascular mortality, HF rehospitalization rate and end-event-free survival after 6 months of treatment in two groups. Results After treatment, there was no significant difference in the occurrence of adverse reactions between the two groups (P＞0.05). The total effective rate was higher in the experimental group than that of the control group (P＜0.05). Compared with before treatment, left ventricular ejection fraction (LVEF), stroke volume (SV), mitral diastolic blood flow velocity E peak and A peak ratio (E/A) and 6 min walking distance (6MWD) were increased in the two groups, and left ventricular enddiastolic diameter (LVEDD) and left atrial diameter (LAD) were decreased in the two groups after treatment (all P＜0.05). After treatment, LVEF, SV, E/A and 6MWD were higher in the experimental group than those in the control group (P＜0.05). LVEDD and LAD were lower than those in the control group (all P＜0.05). Compared with results before treatment, NT proBNP and CRP were decreased after treatment in the experiment group than those in the control group (P＜0.05). There was no significant difference in the cumulative cardiovascular mortality between the experiment group and the control group (3.9% vs. 5.9%，P=0.524). The cumulative HF rehospitalization rate was lower in the experimental group than that of the control group (9.8% vs. 23.5%，P=0.042). The cumulative end-point-free survival rate was higher in the experiment group than that of the control group (86.3% vs. 70.6%, P=0.037). Conclusion Sacubitril valsartan is safer and more effective than ACEI/ARB in the treatment of AMI patients with HFmrEF, and it is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ecology & Rural Environment is the property of Journal of Ecology & Rural Environment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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The Huang-Huai-Hai plain is the main production area of summer maize in China, which is also one of the worst-hit drought areas. The loss of summer maize yield caused by drought has seriously affected China's grain production. Therefore, it is of great significance to clarify the law of drought in this area for the formulation of anti-disaster measures and the guarantee of grain production. Base on the meteorological data of 76 stations from 1981 to 2015 in Huang-Huai-Hai plain was used in this study, the crop water deficit index(CWDI) as the drought index was used to analyze the spatial-temporal evolution characteristics of drought for summer maize in this area. The results showed that the overall changing trend of CWDI in the whole summer maize growth period increased first, and then decreased with the highest drought frequency occurring in sowing-seedling stage and tasseling-milk ripe stage. Drought was getting worse in the summer maize growth period during the period of 2011 to 2015, and southern Hebei, northern Henan and Shandong province exhibited the highest CWDI value. The slight drought was the main drought type in this area in the whole summer maize growth period, the moderate light drought ranked second and the severe and extra severe drought was barely. The frequency of drought in the northern area was higher than that in the southern area, as well as the western area was higher than that in the eastern. The ratio of extra severe drought occurring station was the highest in the sowing-seedling stage, and the ratio of slight drought occurring stations was the highest in the other growth periods. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Engineering for Thermal Energy & Power / Reneng Dongli Gongcheng is the property of Journal of Engineering for Thermal Energy & Power and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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In this paper, we calculated the impact on Hong Kong's economy due to the establishment of Hong Kong-Zhuhai-Macao bridge. First, the amount of exports/imports between the pearl river delta cities and Hong Kong, the GDP and per capita GDP of the pearl river delta cities, the GDP and per capita GDP of Hong Kong, the distance of the pearl river delta cities to Hong Kong are chosen as indexes. The change of imports and exports amount due to the change of the distance between Hong Kong and the pearl river delta cities in 2017, 2020, 2025 and 2030, are measured by using the gravity model. And then, based on Cobb Douglas model, import/export trade indicators are introduced and scientific research level is added to the index of technological change, we measured the influence of import and export trade on Hong Kong's economy with the ridge regression estimation method. So we obtain the economic effect due to the establishment of Hong Kong-Zhuhai-Macao bridge. At last, we put forward some suggestions. [ABSTRACT FROM AUTHOR]

In this paper, the bibliometric method is used to sort out and analyze the development of business model study by statistical analysis and citation networks. Empirical results show the latest hot topics in the business model study focus on business model diagnosis, innovation and design. Three future trends are proposed including the quantification of theoretical research, the extension of the research range and the informatization of market research. The perspective and conclusion of business model in this paper will be particularly illuminating for both academic research and enterprises1 practice application. [ABSTRACT FROM AUTHOR]