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According to the characteristics and technical requirements of ammunition transportation, proposes a double-layer vibration isolation system with large load, establishes its dynamic model, solves the transfer function by using Laplace transform, analyzes the influence characteristics of various parameters on the transfer function through MATLAB, establishes the finite element simulation model and compares with the theoretical model, and verifies the accuracy of the model. On this basis, the corresponding optimization rules are set, and the NSGA-II optimization algorithm is used to optimize the system parameters, and the optimal parameters of the double-layer vibration isolator are obtained. Finally, the actual data are used to verify the vibration isolation effect. The results show that the vibration isolation effect of the double-layer vibration isolation system with large load is greatly improved compared with the single-layer linear vibration isolation system.

目的 探讨不同强度有氧踏车训练对不同病程的缺血性卒中患者肢体运动功能、步行能力和心肺适能的影响。 方法 本研究为前瞻性研究，于2019年9月-2020年9月分别连续入组病程＜1个月、1～3个月、4～6个月的缺血性卒中患者各60例，每个病程的患者随机分为试验组和对照组。2组均在常规康复干预的基础上进行有氧踏车训练，试验组为50%～80%最大心率的高强度训练，对照组为3个月的2组在所有评定时间的各项评分差异均无统计学意义。 结论 高强度有氧踏车训练较低强度训练能够有效改善病程≤3个月的缺血性卒中患者的步行能力和心肺适能，并且具有剂量累积效应。 Abstract: Objective To investigate the effects of aerobic cycling training intensity on limb motor function, walking ability and cardiopulmonary fitness in patients with ischemic stroke. Methods This prospective study enrolled the consecutive ischemic stroke patients with disease course 3 months all had no statistical differences. Conclusions Compared to low-intensity aerobic cycling training, high-intensity aerobic cycling training can effectively improve walking ability and cardiopulmonary fitness in patients with ischemic stroke and stroke course ≤3 months, with a dose-cumulative effect.

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Dalian Polytechnic University is the property of Journal of Dalian Polytechnic University Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective:To explore the value of multimodal ultrasound combined assessment of carotid artery plaque vulnerability in patients with coronary heart disease. Methods: From February 2022 to December 2023, 110 patients with coronary artery stenosis caused by coronary atherosclerosis who were diagnosed by coronary angiography in the Neurodiagnostic Department of the Second Affiliated Hospital of Chengde Medical College were selected as the research objects. According to the plaque nature, carotid plaque was divided into vulnerable plaque group (n=35) and stable plaque group (n=75). The properties of carotid plaque were studied by conventional carotid ultrasound, shear wave elastography and contrast-enhanced ultrasound, and the differences of different parameters were compared; Multivariate logistic regression analysis was conducted to identify independent risk factors for the vulnerability of carotid artery plaques in coronary heart disease, and ROC curves were plotted. Results: There was a statistically significant difference in age, history of hypertension, smoking history, LDL-C, Hcy, and hs CRP between the two groups of patients (P<0.05); The difference in echo, extremely low echo, calcification, and calcified nodules between the two groups of patients was statistically significant (P<0.05); The average, minimum, and maximum Young's modulus of the stable plaque group were higher than those of the control group, and the difference was statistically significant (P<0.05); Age, history of hypertension, smoking history, LDL-C, Hcy, hs CRP, degree of contrast-enhanced ultrasound, calcified nodules, plaque echo, and mean shear wave elastic Young's modulushave an impact on the vulnerability of carotid plaques in coronary heart disease. Conclusion: The combined application of multimodal ultrasound can effectively improve the vulnerability of carotid plaques in patients with coronary heart disease, providing important reference for clinical diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agriculturae Zhejiangensis is the property of Acta Agriculturae Zhejiangensis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Natural Gas Industry is the property of Natural Gas Industry Journal Agency and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Explosives & Propellants is the property of Chinese Journal of Explosives & Propellants Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University is the property of Editorial Office of Journal of Xi'an Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Rehabilitation Medicine is the property of China Association of Rehabilitation Medicine, China-Japan Friendship Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Publishing Journal is the property of Wuhan University, School of Information Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Engineering Science Research & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing Institute of Petrochemical Technology is the property of Journal of Beijing Institute of Petrochemical Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Arid Zone Research / Ganhanqu Yanjiu is the property of Arid Zone Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanxi Agricultural Sciences is the property of Shanxi Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mechanical & Electronic Control Engineering is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Explosives & Propellants is the property of Chinese Journal of Explosives & Propellants Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai University / Shanghai Daxue Xuebao is the property of Journal of Shanghai University (Natural Sciences) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Pathophysiology is the property of Jinan University, School of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Breast cancer is one of the malignant tumors that seriously affects women’s lives and health. In recent years, the anti-tumor effect of artemisinin (ART), an active ingredient of traditional Chinese medicine, has become more prominent. However, the effectiveness of ART in the treatment of breast cancer metastasis and its mechanism are still unclear. In this paper, we used the mouse breast cancer cell 4T1 and mouse mammary epithelial cell HC11 to explore the role of ART in inhibiting metastasis and inducing apoptosis. The MTS assay showed that ART was able to significantly inhibit the viability of 4T1 cells in a concentration andtime-dependent manner. Analysis of cell colony formation, Transwell and cell scratch results revealed that ART significantly inhibited the metastasis of breast cancer 4T1 cells. Flow cytometry results showed that ART promoted ROS production, loss of mitochondrial membrane potential, cell cycle arrest and thus apoptosis in tumor cells. Bioinformatic analysis methods and studies confirmed that extremely significant high expression of TIGIT (P < 0.001) was closely associated with breast cancer metastasis, and that ART was able to significantly reduce the gene expression level of the TIGIT/CD155 signaling axis (P < 0.001, P < 0.01). In summary, this study reveals the regulatory mechanism by which ART may inhibit breast cancer metastasis by blocking the TIGIT/CD155 signaling axis, which provides a basis for ART as a potential therapeutic agent for breast cancer, and contributes to the exploration of a new way of treating tumors using the active ingredients of Chinese herbal medicine. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Issues of Forestry Economics is the property of Issues of Forestry Economics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Jilin University (Medicine Edition) is the property of Jilin University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Industrial Water Treatment is the property of CNOOC Tianjin Chemical Research & Design Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Immune checkpoint inhibitors ［mainly programmed death-1/programmed death ligand-1 (PD-1/PD-L1) inhibitors］ have emerged as the most promising therapy in lung cancer treatment. However, clinicians still lack sufficient knowledge about immune-related adverse events. Immune-related thyroid dysfunction (irTD), one of the common immune-related adverse events, can be life-threatening in severe cases. This article discussed the thyroid dysfunction induced by PD-1/PD-L1 inhibitors in the treatment of lung cancer from the aspects of the incidence, pathogenesis, predictive biomarkers and treatment of irTD. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Jilin University (Medicine Edition) is the property of Jilin University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Early-onset scoliosis (EOS) is a three-dimensional spinal deformity in children. At present, the main clinical treatment methods include follow-up, surgical treatment and non-surgical treatment, while nonsurgical treatment can delay and control the progression of the disease and buy time for growth and development as well as surgical treatment. Serial casting, traction therapy and targeted exercise for scoliosis are all non-surgical treatments that have been used in clinical practice for many years. With the progress of technology and treatment, new ideas have been provided for the non-surgical treatment of EOS, such as the change of treatment mode and site of action, pharmacological research, mental health monitoring, etc. This article summarizes the nonsurgical treatment methods and new ideas for the development of early onset scoliosis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Fuzhou University is the property of Journal of Fuzhou University, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Edulis Fungi is the property of Acta Edulis Fungi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Bioinformatics is the property of Bioinformatics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Big Data Research (2096-0271) is the property of Beijing Xintong Media Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)