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Objective To explore the status and factors influencing the intrinsic capacity of hospitalized elderly patients, in order to provide a reference for further activity to maintain the function of the elderly and improve the outcome. Methods Using a convenience sampling method, 264 elderly patients admitted to the geriatric ward from March 2020 to April 2022 were selected as the study population, and the WHO-recommended intrinsic capacity assessment tool, the Geriatric Index of Comorbidity (GIC) and the General Information Questionnaire were applied to analyze the status and factors influencing the intrinsic capacity of hospitalized elderly patients. Results The intrinsic capacity score of 264 elderly patients was 2. 0 (2. 0, 3. 0), and 94. 32%(249/263) of elderly inpatients had a decrease in at least one dimension of intrinsic capacity. There were differences in age, marital status, residence status, and number of GIC diseases and GIC-disease burden among elderly inpatients with different status of intrinsic capacity in univariate analysis (P < 0. 05). Logistic regression analysis suggested that age (OR=0. 904, 95% CI: 0. 869 to 0. 941) and residence status (OR=0. 254, 95% CI: 0. 092 to 0. 700) were independent influences on the intrinsic capacity of hospitalized elderly patients. Conclusion Intrinsic capacity impairment in hospitalized elderly patients is common. Age and residential status are influential factors in the intrinsic capacity of hospitalized elderly patients. Although multi-morbidity in older adults is correlated to intrinsic capacity to some extent, but it is not an independent influence of intrinsic capacity. (目的 探讨住院老年患者内在能力现状及影响因素, 为进一步采取积极措施维持老年人功能和改善预后提供参考依据。方法 采用便利抽样的方法, 选取2020年3月—2022年4月入住医院老年医学病房的264例老年患者作为研究对象, 应用WHO推荐的内在能力评估工具、老年人共病指数(GIC)及一般资料问卷进行调查, 分析住院老年患者的内在能力现状及影响因素。结果 264例老年患者的内在能力得分为2. 0(2. 0, 3. 0), 有94. 32%(249/263)的老年住院患者存在至少1个维度的内在能力下降。单因素分析中内在能力不同状态的老年住院患者之间年龄、婚姻状况、居住情况及GIC疾病数目与GIC疾病负担存在差异(P＜0. 05)。Logistics回归分析提示年龄(OR=0. 904, 95%CI: 0. 869～0. 941)及居住情况(OR=0. 254, 95%CI: 0. 092～0. 700)是住院老年患者内在能力的独立影响因素。结论 住院老年患者内在能力下降的情况普遍存在。年龄和居住情况是住院老年患者内在能力的影响因素。虽然老年人多病共存在一定程度上与内在能力具有相关性, 但并非内在能力的独立影响因素。)

为推动城市开发与基础设施建设，满足城市新增人口的公共服务需求，地方隐性债务规模快速增长，经济下行加剧了地方政府所面临的债务风险。利用2007—2018年我国285个地级市隐性债务数据，采用固定效应模型，从债务规模与发债主体特征两个视角评估隐性债务对城市空间扩张的驱动机制。主要结论有：（1）隐性债务规模对城市空间扩张有显著正向影响，上期隐性债务规模的增加将推动当期城市建成区扩张。发债规模增加1亿元，城市建成区面积增加0.192 km2，“借债建城”成为地方政府推动城市空间扩张的主要模式。（2）发债企业数和发债企业质量对城市空间扩张有显著正向影响，发债企业数增加，且信用评级为AA+及以上，发债主体的比例提高推动城市建成区面积的增加。信用等级高的发债企业越多，城市扩张能力越强。（3）发债企业数对城市空间扩张的影响存在区域异质性，发债企业数对中西部地区的城市空间扩张具有显著正向影响，对东部地区则无显著影响。

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In order to prepare high-performance and low-cost electrode materials, nickel ion-doped polyANI-coated biomass carbon composite materials (Ni@ PANI/BC) were synthesized by chemical oxidation polymerization using August melon peel biomass carbon (BC) as the matrix, and nickel nitrate and aniline as raw materials. The structures of the Ni@ PANI/BC composites were characterized by SEM, EDS, X-ray photoelectron energy spectrum (XPS), thermal weight analysis (TG) and specific surface area test (BET), and the electrochemical properties of the composites were measured by cyclic voltammetry (CV), constant current charge and discharge (GCD) test and electrochemical impedance spectroscopy (EIS). The effects of nickel ion doping on the structure and electrochemical properties of Ni@ PANI/BC were investigated. It is shown that nickel ion doped BC forms a porous cross-linked mesh porous structure with large specific surface area and good electrical conductivity. When the mass ratio of nickel hydrate nitrate, aniline and BC is 1. 5∶5∶3, the obtained electrode material has the best electrochemical performance. At 1 A/g current density, Ni@ PANI/BC mass capacitance is up to 608. 4 F/g, 5 000 cycles with a capacity retention rate of 85. 4%, which demonstrates Ni@ PANI/BC materials have electrochemical properties comparable to the relevant materials reported in the literature. [ABSTRACT FROM AUTHOR]

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目的, 观察依达拉奉右莰醇静脉滴注治疗急性动脉粥样硬化性脑梗死 (ACI)的临床效果, 并探讨其治疗 作用机制。方法, 选取120例ACI患者, 随机均分为实验组和对照组。两组均给予常规治疗, 实验组在常规治疗的 基础上, 加用依达拉奉右莰醇注射用浓溶液 15 mL, 将其溶于生理盐水100 mL中稀释后静脉滴注, 30 min内滴注完 毕, 每天2次；两组疗程均14 d。比较两组总有效率。治疗前和治疗14天, 对患者进行NIHSS评分 (评价神经系统缺 损程度)；治疗90 d, 对患者进行改良Rankin量表评分 (mRS评分, 评价独立生活能力), 计算mRS评分≤1分的患者比 例。治疗前和治疗14天, 采用ELISA方法检测两组的人甲壳质酶蛋白40 (YKL-40)、人可溶性CD40 (sCD40)。统计 两组治疗期间的不良反应发生率。结果, 实验组总有效率高于对照组 (P<0. 05)。与治疗前比较, 治疗后两组 NIHSS评分均降低, 以实验组为著 (P均<0. 05)。实验组治疗后90 d的mRS评分≤1分的患者比例高于对照组 (P均< 0. 05)。与治疗前比较, 治疗后两组YKL-40、sCD40水平均降低, 以实验组为著 (P均<0. 05)。两组治疗期间均未发 生严重不良反应事件。结论, 依达拉奉右莰醇静脉滴注治疗ACI有效、安全, 可有效改善患者神经功能缺损症状、 提高独立生活能力；依达拉奉右莰醇可能通过降低血清YKL-40、sCD40水平起治疗作用的。 [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical efficacy of combined with fascial sheath suspension (CFS) and shortening of levator (LM) in the treatment of bell-negative severe ptosis. Methods The clinical data of 10 patients (17 eyes) with severe blepharoptosis were reviewed. After cutting the skin along the design line, the tarsus were exposed by separating the orbicularis oculi muscle. The levator palpebrae superioris was separated, subconjunctival swelling anesthetized conjunctiva and Müller muscle, and the levator palpebrae superioris and Müller muscle were peeled off. CFS was found along the upward separation of conjunctiva and Müller muscle, and the CFS and levator palpebrae were fixed in the middle and upper part of the tarsus with a 5-0 silk thread. A suture of the double eyelids was formed. Results Ten patients were followed up for 6 months, and there was no obvious regression or adverse reaction, with beautiful effect and high patient satisfaction. Conclusion CFS suspension combined with LM shortening was used to correct severe ptosis with satisfactory clinical effect and safe operation, which can be popularized and applied in clinical practice. [ABSTRACT FROM AUTHOR]

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[Objective] With the proliferation of breeding data brought by new technologies and the new demand for knowledge services in computational breeding, in order to solve the problem of inefficient cross-species subject knowledge acquisition and difficult discovery of elite pleiotropic genes in crop breeding knowledge service. [Method] We constructed trait-regulated-genes ontology model framework, and defined entity hierarchical structure and entity attributes in ontology model. Taking staple crops rice, corn, wheat and model plant Arabidopsis thalliana as data collection objects, a knowledge graph with trait-regulated-genes ontology model as model layer is constructed and experimented. [Result] Finally, the trait-regulated-genes ontology model covering 13 entities, 16 data attributes and 14 object attributes was formed. This model is used as the knowledge graph of ontology layer to realize cross-species subject knowledge association retrieval, mining of elite pleiotropic genes and prediction of gene function across species. [Conclusion] The method of trait-regulated-genes ontology model construction proposed in our study may achieve the correlation discovery of trait regulatory genes across species, improve the efficiency of cross-species subject knowledge acquisition, and support the gene discovery results of multi-dimensional data analysis. This study provides a feasible method path for the mining of pleiotropic genes and gene function prediction, and provides effective data support services for crop breeding scientific research. [ABSTRACT FROM AUTHOR]

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Objective To explore the expression of programmed cell death protein 5 in cervical cancer and its relationship with lymph node metastasis. Methods 98 cases of cervical cancer patients admitted to our hospital were selected as the observation group, and 98 cases of cervical benign lesions were selected as the control group. The expression levels of PDCD5 in serum and lesion tissues of the two groups were compared to analyze the relationship between PDCD5 and pathological features of cervical cancer, and the diagnostic value of PDCD5 in lymph node metastasis of patients with cervical cancer was analyzed by ROC curve. Results The expression levels of PDCD5 in serum and lesion tissue of observation group were lower than those of control group (P < 0.05) . With the increase of clinical stage and pathological grade of cervical cancer, the expression of PDCD5 in serum and lesion tissue was significantly decreased (P < 0.05) . Among the 98 patients with cervical cancer, 32 had lymph node metastasis. The expression levels of PDCD5 in serum and lesion tissue of lymph node metastasis group were lower than those of non-lymph node metastasis group (P < 0.05) . ROC curve results showed that the AUCs of PDCD5 in serum and lesion tissue to predict lymph node metastasis of cervical cancer patients were 0.810 and 0.850, respectively, with no statistical significance (P > 0.05) . Conclusion The Programmed cell death protein 5 is closely related to the pathological features of patients with cervical cancer, and it has a good predictive effect on lymph node metastasis, which is worthy of further study and application. [ABSTRACT FROM AUTHOR]

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