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Faced with rapid changes in the external environment, the operation of physical bookstores is facing crises. Metaverse is the product of virtual reality integration and it provides a new idea for the transformation and upgrading of bookstores. Based on the analysis of the current situation of bookstore operation, this paper proposes to build the new scenario, a Metaverse bookstore, from the perspective theory of media scene. The concept of establishing a Metaverse bookstore in this paper explores the dynamics between individuals, individuals and their surroundings, as well as individuals and objects. The Metaverse bookstore is in line with the trend of people's experience consumption and visual consumption. The immersive reading experience brought by Metaverse technology enables the bookstore to transcend time and space boundaries and meet the needs of users for personalized reading scenes. In the final part of the paper, the development strategy is proposed to provide a reference for future application research on Metaverse Bookstore. [ABSTRACT FROM AUTHOR]

BACKGROUND: Interleukin-4 can promote the osteogenic effect of bone substitute materials, but its molecular mechanism is not yet clear. Further elucidating the mechanism of interleukin-4 promoting osteogenic effect can help find safe, economical, and effective methods for the regeneration treatment of alveolar bone defects in patients. OBJECTIVE: To explore the effect of interleukin-4 intervention on polarization transformation of macrophages and osteogenic differentiation of bone marrow mesenchymal stem cells and its possible mechanism. METHODS: RAW264.7 cells in the M1 group were induced with interferon gamma + lipopolysaccharide for 24 hours. RAW264.7 cells in the interleukin-4+M1 group were induced with interferon gamma + lipopolysaccharide for 24 hours and then interleukin-4 was added for 24 hours. RAW264.7 cells in the interleukin4+AG+M1 group were induced with interferon gamma + lipopolysaccharide for 24 hours, and then interleukin-4 and AG-490, a JAK/STAT pathway inhibitor, were added for 24 hours. After intervention, immunofluorescence staining was used to analyze the expression of inducible nitric oxide synthase and CD206, the phenotypic marker protein of macrophages. ELISA kit was used to detect the expression of interleukin-10 and tumor necrosis factor-α in the supernatant of cell culture. The gene expressions of nodular receptor protein-3 (NLRP3), interleukin-1β, and caspase-1 were detected by RT-qPCR. The expression levels of tyrosine protein kinase 1 (JAK1)/ phosphorylated tyrosine protein kinase 1 (p-JAK1), signal transduction and transcription activator 6 (STAT6)/phosphorylated signal transduction and transcription activator 6 (p-STAT6), NLRP3, pro-interleukin-1β and pro-caspase-1 were detected by western blot assay. Then, RAW264.7 cells in the above four groups were indirectly co-cultured with bone marrow mesenchymal stem cells by transwell for 24 hours, followed by alkaline phosphatase staining and alizarin red staining. The mRNA expressions of alkaline phosphatase, collagen type I, and osteocalcin were detected by RT-qPCR. RESULTS AND CONCLUSION: (1) Immunofluorescence and ELISA results showed that interleukin-4 intervention could promote the expression of CD206 and interleukin-10 in M2 macrophages, and inhibit the secretion of inducible nitric oxide synthase and tumor necrosis factor-α. (2) RT-qPCR results showed that interleukin-4 could suppress the expression of NLRP3, interleukin-1β, and caspase-1 mRNAs. (3) Western blot assay showed that interleukin-4 could promote the expression of JAK1/p-JAK1, STAT6/p-STAT6 and NLRP3 proteins. (4) The alkaline phosphatase staining and alizarin red staining of bone marrow mesenchymal stem cells co-cultured with the interleukin-4+M1 group were significantly enhanced, and the mRNA expressions of alkaline phosphatase, collagen type I, and osteocalcin were significantly increased. It is concluded that interleukin-4 may inhibit the activation of NLRP3 by up-regulating JAK1/STAT6 pathway, thus promoting the transformation of macrophages from M1 polarization to M2 polarization, and finally enhancing the osteogenic differentiation ability of bone marrow mesenchymal stem cells. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To systematically review the efficacy and safety of Shuxuening injection combined with nitrates in the treatment of angina pectoris of coronary heart disease. METHODS: Databases of CNKI, Wanfang Data, VIP, CBM, PubMed, Embase, the Cochrane Library and Web of Science were retrieved, with the retrieval time from the establishment of the database to Mar. 2022, the published randomized controlled trials of Shuxuening injection combined with nitrates (observation group) contrasted with nitrates alone (control group) in the treatment of angina pectoris of coronary heart disease were enrolled according to the literature inclusion criteria, so that the data was extracted. The risk bias wvaluation was conducted by using Cochrane system evaluator manual 5. 1. 0, the clinical efficacy and safety were evaluated by using RevMan 5. 3 software. RESULTS: A total of 19 studies were enrolled, including 2 250 patients ( 1 145 cases in the observation group and 1 105 cases in the control group), and the literature quality was general. Results of Meta-analysis showed that compared with using nitrates alone, Shuxuening injection combined with nitrates in the treatment of angina pectoris of coronary heart disease had significantly efficacy for the clinical symptoms of angina pectoris, more significant reduction in the whole blood viscosity, plasma viscosity, fibrinogen and platelet adhesion rate, more significantly improvement in ECG abnormality, with statistically significant differences (P<0. 01). Only three studies reported adverse drug reactions, and the difference in the incidences of adverse drug reactions between two groups was not statistically significant (P = 0. 19). CONCLUSIONS: Shuxuening injection combined with nitrates in the treatment of angina pectoris of coronary heart disease can improve the clinical efficacy and ECG abnormality, reduce the whole blood viscosity, plasma viscosity, fibrinogen level and platelet adhesion rate. [ABSTRACT FROM AUTHOR]

Cytoskeletal networks usually refer to cellular structures that are comprised of microtubules, actin filaments, intermediate filaments, and their associated accessory proteins and motor proteins, facilitating a range of cellular functions such as cell motion, division and growth. In addition to the narrow definition of “cytoskeleton” that provides frame support to an otherwise fluidic cell, cytoskeletal polymers play an important role in many other cellular functions. For example, bacteria flagella and spindle apparatus are essentially microtubules in different forms. In living cells, there are also hundreds of proteins and biochemical factors regulating the structure and dynamics of such networks, which makes it extremely difficult to elucidate the physical mechanisms behind these processes. In recent years, study of in vitro cytoskeletal polymer-motor protein networks built from purified protein components not only helps to understand the fundamental principles of nonequilibrium self-organization and dynamic behavior of cytoskeletal polymers and motor proteins on the subcellular level, but also sheds light on the design of active matter system and active machines that may operate far from equilibrium with life-like behaviors and functions. One notable success is the artificial active nematics built upon microtubules and kinesin motors, in which active stresses are used to generate macroscopic active flow and guide materials assembly. The active stress and order emergence of materials organization can also be tuned by a set of external parameters, such as external magnetic fields and light-activated proteins, in addition to the concentration of protein building blocks, ATP, and crowding agents. In this review, we focus on in vitro cytoskeleton-motor protein networks based on purified components including tubulin, actin, kinesin, and myosin, emphasizing on the non-equilibrium nature of microtubule and F-actin polymerization, generation of active stress and formation of dynamic networks, as well as the self-organization and dynamic behavior of subcellular structures on a larger scale. We conclude with the application of such networks in the study of active matter and artificial cells. [ABSTRACT FROM AUTHOR]

Observations across the electromagnetic spectrum of radiative processes involving interstellar dust—emission, absorption, and scattering—are used to constrain the parameters of dust models and more directly to aid in foreground removal of dust for extragalactic and cosmological observations. Dust models can benefit from more independent constraints from complementary observations. Here, we quantify the relationship between scattered light and thermal emission from dust in a diffuse (cirrus) intermediate-latitude cloud, Spider, using data from the Dragonfly Telephoto Array and the Herschel Space Observatory. A challenge for optical observations of faint diffuse cirrus is accurate removal of a contaminating, spatially varying sky. We present a technique to analyze two images of the same cirrus field concurrently, correlating pixel values to capture the relationship and simultaneously fitting the sky-related signal as a complex noncorrelating additive component. For the Spider, we measure a color g − r = 0.644 ± 0.024 and ratios of visible-wavelength to 250 μ m intensity of γ g,250 = (0.855 ± 0.025) × 10−3 and γ r,250 = (1.55 ± 0.08) × 10−3 for the g and r- bands, respectively. We show how to use any dust model that matches the thermal dust emission to predict an upper limit to the amount of scattered light. The actual brightness of the cirrus will be fainter than this limit because of anisotropic scattering by the dust combined with anisotropy of the incident interstellar radiation field (ISRF). Using models of dust and the ISRF in the literature, we illustrate that the predicted brightness is indeed lower, though not as faint as the observations indicate. [ABSTRACT FROM AUTHOR]

A study was conducted to determine the effects of feeding high-protein feed from dehulled Maotaiflavor distiller's grains on growing-finishing pig growth performance and diarrhea indexes. A total of 45 health pigs (Duroc×Landrace×Yorkshire) with an average initial body weight of (43.58±2.50) kg were randomly divided into three groups. Each group had three repeats, each repeat took five pigs. Pigs in the control group were fed the cornsoybean meal diet. In the test groupsⅠand Ⅱ partial soybean meal of the control diet were replaced by the highprotein feed from dehulled Maotai-flavor distiller's grains, which accounting 5.00% and 8.00% of the diet. Lysine and oil were added to balance the diet with nutrient levels. The feeding test lasted for 30 days after a seven- day adaptation period. The results showed that compared with the control group, the daily weight gain of the test groupⅠ and Ⅱ increased 4.03% and 3.09%, respectively (P>0.05); the feed weight ratio decreased 4.14% and 3.45%, respectively (P>0.05); the diarrhea index decreased 1.07 and 1.29 percentage points (P<0.05), there was no significant difference between test groupⅠand test group Ⅱ (P>0.05). Preliminary confirmation showed that the replacement of partial soybean meal in the basic diet by high protein feed from dehulled Maotai-flavor distiller's grain did not affect the growth performance of growing-finishing pigs, but could reduce the diarrhea indexes of the pigs and had certain control effects on diarrhea. Based on the growth performance and diarrhea indexes, the addition ratio of high-protein feed from dehulled Maotai-flavor distiller's grains in the growing-finishing pig diet should be 5.00%. [ABSTRACT FROM AUTHOR]

目 的 以 打 造 三 位 一 体 专 业 “金 课”为 目 标,对 来 华 留 学 生 课 堂 教 学 进 行 持 续 性 改 革。 方法 以2013—2017级南京医科大学国际教育学院留学生467人为研究对象,将改革前(2015—2016年)和改 革后(2017—2019年)留学生平时成绩和笔试成绩分别汇总,运用统计学方法比较分析,以调查问卷方式获得改 革后学生课堂参与度信息。结果 教学方法改革后3年间学生综合成绩显著提高,尤其是课堂参与度。小班 教学能快速提高学生实验操作技能,结合教师讲解和小组讨论,学生能够更好地掌握理论知识,完善课后作业。 结论 在来华留学生课堂教学改革过程中,应增强先进教学理念、技术与课堂教学的密切联系,逐步达成精益 求精、与时俱进的“金课”建设目标,实现知行合一,学以致用。 [ABSTRACT FROM AUTHOR]

Fly ash, slag powder, and metakaolin were used as the main raw materials to prepare the binary alkali-activated cementitious materials, and the compound alkali-activated cementitious materials with different proportions were corroded in 5%(NH4)2SO4 solution for 120 days by different immersion methods. The preparation scheme was optimized by measuring its mechanical properties. Then scanning electron microscopy (SEM) was used to analyze the erosion mechanism of different ratios. Results show that the optimal ratio of fly ash-slag powder (FA-SP) is 2:3, and the strength loss is serious under semi-immersion with a large number of cracks and salt crystal. The optimal ratio of metakaolin-slag powder (MK-SP) is 1:1, which has stable structure, unapparent difference in appearance between the semi-immersed group and the full-immersed group. It has good resistance to sulfate corrosion and less erosive by NH+4. [ABSTRACT FROM AUTHOR]

BACKGROUND: Studying the molecular mechanisms of M2 macrophage-induced bone regeneration and collating and analyzing the comprehensive gene regulatory network of multiple signaling pathways are important for targeting and regulating the immune response mediated by bone replacement materials to promote alveolar bone defect repair OBJECTIVE: To review relevant literature and summarize the research progress in relevant signaling pathways of M2 macrophages in bone regeneration, in order to find accurate and proactive immunomodulatory strategies for the regenerative treatment of alveolar bone defects in clinical settings. METHODS: Relevant literature in CNKI, Web of Science and PubMed were searched. Search terms were “macrophages, polarization, bone regeneration, osteogenesis, signaling pathway” in Chinese and English. According to the inclusion criteria, 55 articles were included for review. RESULTS AND CONCLUSION: The role of macrophages in bone healing is complex, and switching M0/M1 macrophages to the M2 phenotype through a finetuned and precise strategy leads to the formation of an appropriate M2 dominance, which is more conducive to bone regeneration. Once the M2 macrophage phenotype is altered, their cell surface markers, secreted cytokines and chemokines, as well as transcriptional and epigenetic pathways (signaling pathways) are changed accordingly. The article summarizes the molecular mechanisms involved in the polarization of M2 macrophages and thus inducing bone defect repair or osteogenic differentiation by various signaling pathways over the past 7 years. Each signaling pathway plays an important role in participating in or regulating the inflammatory response, osteogenesis and chondrogenic differentiation during bone metabolism. Numerous in vivo and ex vivo studies have shown that targeting and modulating signaling pathways may be an effective way to promote bone regeneration by targeting macrophage polarization. Further clinical studies are needed to elucidate whether modulating signaling pathways in favor of reducing the M1/M2 macrophage ratio may be an effective way to promote alveolar bone defect repair. Once this mechanism is clearly elucidated, pharmacology and novel biomaterials targeting the macrophage polarization state may be used as a strategy to promote bone regeneration. [ABSTRACT FROM AUTHOR]

The test study on temperature characteristic of an engine anti-icing sensor is carried out in the icing wind tunnel. The results of temperature characteristic changing with air total temperature，heat air flow， heat temperature as well as the droplet parameters are obtained. The experimental results show that the heat air parameters have great effect on the temperature characteristic of the sensor，and the average measuring deviation of the sensor increases as the heat air temperature and flow increase. Sensor application scenario is affected by the aircraft engine operation. In certain conditions，the average measurement deviation of the sensor fluctuates in a reasonable range. The ice formed on the sensor will affect the air flow into the sensor temperature cavity，and cause the increase of the sensor temperature deviation. This will finally lead to the decrease of the sensor performance and even failure of the sensor if the ice amount is too much. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the molecular mechanism of anti-inflammatory effects of Ruyi Jinhuang powder based on network pharmacology and data mining. METHODS: The inflammatory targets were obtained from GeneCards database, the active components and relative targets of Ruyi Jinhuang powder were obtained from BATMAN-TCM database. After the intersection of disease target and drug target, the regulation network and proteinprotein interaction ( PPI ) network were constructed. R software was used for gene ontology ( GO) functional enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis, AutoDock Vina was used for molecular docking to verify the reliability of the results. RESULTS: A total of 217 active components and 159 intersection genes of inflammation-Ruyi Jinhuang powder were obtained after screening. Totally 2 051 GO items and 149 signal pathways were obtained through GO and KEGG enrichment analysis. Ruyi Jinhuang powder might act on insulin, protein kinase B1, albumin, mitogen-activated protein kinase 1 and tumor necrosis factor ( TNF) through a variety of ketone active components such as carvone, progesterone and curcumin, which were involved in the atherosclerosis signaling pathway, neuroactive ligand-receptor interaction signaling pathway, estrogen signaling pathway and TNF signaling pathway, thereby exerting anti-inflammatory effects. The molecular docking results showed that the results of the network pharmacology study had certain reliability. CONCLUSIONS: This study preliminarily reveals the molecular mechanism of anti-inflammatory effects of Ruyi Jinhuang powder, and provides a new theoretical basis for further basic and clinical research. [ABSTRACT FROM AUTHOR]

轻断食在近些年来越来越受到关注,逐渐成为大众比较推崇的一种减重饮食方式。不少研究 表明,轻断食在超重或肥胖人群中的短期减重中有较为显著的效果,为超重或肥胖人群带来了福音。同时,相 关研究表明其在延缓衰老、延长寿命、改善血脂水平、调节血糖水平、改善胰岛素抵抗等方面也有成效。该文将 引用各个试验来说明轻断食在该些方面的成效,为进一步开展长期轻断食试验提供参考。 [ABSTRACT FROM AUTHOR]

Objective To evaluate the predictive value of neutrophil to lymphocyte ratio(NLR) and B-type natriuretic peptide (BNP) in elderly patients with heart failure complicated with pulmonary infection. Methods 178 heart failure patients in our hospital from June 2018 to May 2020 were selected as the research objects, and they were divided into pulmonary infection group (n=92) and non-pulmonary infection group (n=86) according to whether they were complicated with pulmonary infection. The differences of NLR and BNP levels and other clinical indicators between the two groups were compared. Univariate and multivariate Cox regression were used to analyze the influence of NLR and BNP levels on heart failure complicated with pulmonary infection. The predictive value of NLR combined with BNP on heart failure complicated with pulmonary infection was analyzed by receiver operating characteristic (ROC) curve. Results Multivariate logistic regression analysis showed that NLR (OR=7.606, 95% CI: 3.123-18.526) and BNP (OR=4.264, 95% CI: 1.682-10.811) were independent risk factors of elderly heart failure complicated with pulmonary infection after adjusting for other related variables. Pearson correlation analysis showed that BNP level was positively correlated with NLR level (r=0.400, P<0.001). The area under ROC curve of NLR, BNP and NLR+BNP in predicting pulmonary infection in elderly patients with heart failure was 0.810, 0.756 and 0.838, respectively. Conclusion BNP and NLR are independent risk factors of elderly patients of heart failure with pulmonary infection .The combined detection of BNP and NLR has predictive value for those patients. [ABSTRACT FROM AUTHOR]

Objective To estimate the correlation between head injury and risk of Alzheimer's disease (AD) by using meta-analysis, and to provide scientific basis for the prevention decision of AD. Methods The relevant cohort studies on the correlation between head injury and risk of AD were searched by computer in the Cochrane Library, PubMed, Medline, Embase, China National Knowledge Infrastructure databases. The search period was from January 1990 to December 2021. According to the inclusion criteria, literatures were screened and relevant data were extracted. STATA software was used to check the heterogeneity of the results and perform the meta-analysis. Results A total of 17 studies were included in the study, with a total of 5 176 850 subjects. The results of heterogeneity test showed that there was heterogeneity among the results (12=48. 3 %,P =0. 014), so the random effect model was adopted to combine effect size. The combined results showed that subjects with head injury had significant higher incidence of AD than those without head in-jury (RR =1. 12, 95 %CI :1. 03 —1. 21). According to the severity of head injury, subgroup analysis showed that the relative risk of AD in patients with moderate and severe head injury was 1.30 (95 %CI :1. 01-1. 59) [ABSTRACT FROM AUTHOR]

On the basis of a generalized third-order Rucklidge system, a fourth-order hyperchaotic circuit system based on an quadratic nonlinear active magnetron memristor is proposed. The dynamics characteristics of the system, such as system phase diagram, Lyapunov exponential spectrum, bifurcation diagram, and coexisting attractor are studied by numerical simulation. The analysis results show that the system has rich dynamics characteristics and new topological structure. The system's circuit is designed and implemented by using Multisim circuit simulation software and FPGA digital hardware circuit. The experimental consequences are very consistent with the numerical simulation results. Finally, an image encryption algorithm is designed by combining scrambling-diffusion algorithm with DNA encryption. The new system chaotic sequence is used to encrypt image, and the encryption histogram, correlation between adjacent pixels, sensitivity, robustness and information entropy are analyzed. The results show that the new system is very sensitive to both chaotic key and plaintext, and the key space is large. The proposed chaotic system has high security performance when applied to image encryption. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of microRNA (miR) -451 on the expression levels of estrogen receptor (ER),cell cycle protein D1 (Cyclin D1) and B lymphocytoma-2 gene (Bcl-2) in proliferative mammary epithelial cells, elucidate the pathogenesis of cyclomastopathy and lay the foundation find for discovering new therapeutic target. Methods In June 2020,a total of 20 rats were randomly divided into control group and cyclomastopathy group by the random number table method, with 10 rats per group. Rats in cyclomastopathy group were conducted with estrogen and progestogen by using sequential method, rats control group were injected with normal saline. The expression levels of miR-451 were detected by using quantitative reverse transcription PCR, western blotting test was used to detect the expression levels of ER, Cyclin D1 and Bcl-2 protein in two groups of rats.The correlations of miR-451 with the expression of ER, Cyclin D1,and Bcl 2 protein were also analyzed. Results The expression of miR-451 in control group was 1.75 times higher than that in cyclomastopathy group, and the relative expression levels of ER,Bcl-2 protein were significantly higher than those of control group. There was a negative correlation between the expression levels of miR-451 and the relative expression levels of ER and Bcl-2 protein (r=-0.87,-0.79,P <0.05).Conclusion The expression levels of miR-451 in cyclomastopathy group is down-regulated, and may influence the occurrence and development of cyclomastopathy through increasing the relative expression levels of ER,Bcl-2 protein. [ABSTRACT FROM AUTHOR]

As one of the iron-based superconducting thin films, Fe(Se, Te) thin films have the simplest crystal structure, fewer elements and easy to be synthesized, which is conducive to the study of superconductivity mechanism and has potential technical applications. In this paper, Fe(Se, Te) thin films were prepared by magnetron sputtering on CaF2 single crystal substrates at 320 ℃ and annealed in argon atmosphere. The effects of annealing time on the crystal structure, surface morphology, composition and electrical transport characteristics of Fe(Se, Te) thin films were investigated. The results show that the crystallinity of Fe(Se, Te) thin films is good, annealing is helpful to eliminate FeSe phase in the thin films, lattice constant c is not sensitive to annealing, and the grain size of the thin films increases after annealing. The composition of Fe (Se,Te) thin films is different from the nominal composition of target material, and the longer the annealing time, the denser the particles on the Fe (Se, Te) films surface. The resistance of Fe (Se, Te) thin films decreases with the increase of temperature, showing semiconductor characteristics, and the resistance increases obviously after 3 h annealing. [ABSTRACT FROM AUTHOR]

Various processes including oil extraction, transportation and storage release crude oil and its products into soil with pollution, the most serious environmental problems today. Biochar with the characteristics of high adsorption capacity, high specific surface area, and high microporosity and ion exchange capacity, can adsorb pollutants chemically or physically while promoting the biodegradation of petroleum hydrocarbons and polycyclic aromatic hydrocarbons in soil by affecting soil microbial community structure and abundance. This paper summarizes the production and property of biochar and its environmental application for removing petroleum hydrocarbons and polycyclic aromatic hydrocarbons pollutants in soil and focuses on associated mechanisms of petroleum hydrocarbon adsorption kinetics and biodegradation. In addition, the future biochar remediation of oilcontaminated soil is prospected. [ABSTRACT FROM AUTHOR]

In the experiment, different concentrations of N-carbamylglutamic (NCG) were added to the diet to determine the production performance, egg quality, plasma nitric oxide (NO) and nitric oxide synthase ( NOS) level changes, to explore the effect of NCG-NO pathway on egg production and egg quality functions of Dagu chicken hens. A total of 12-week-old 192 Dagu chicken hens were randomly divided into four groups with four replicates in each group and 12 replicates in each group. The control group Dagu chicken hens were fed with basic diet, and the experimental groups Dagu chicken hens were fed with 0.08% and 0.12%, 0.16% level of NCG diet. The pre-test period was 1 w, and the experiment lasted for 25 w. The results showed that the egg production rate of 0.08% NCG group and 0.12% NCG group was significantly higher than that of control group (P<0.05). Among all groups, 0.12% NCG group had the lowest feed to egg ratio, and yolk color in NCG groups was significantly higher than that in control group (P<0.05). The egg shape index and the protein height of the 0.12% NCG group were significantly higher than that of control group and other experimental groups (P<0.05). NO content of 0.12% NCG group was significantly higher than other groups (P<0.05). The experiment indicates that dietary supplementation of 0.08% to 0.16% NCG can improve performance and egg quality of broilers during peak laying period, and the effect of NCG at 0.12% NCG level is the best. [ABSTRACT FROM AUTHOR]

Entity alignment aims to discover and link the same entity objects that point to the real word in different knowledge graphs. Entity alignment based on GCN usually acts on undirected graphs of the single relation type, which is easy to result in the problem of inconsistent embedding corresponding results to entity leaning. Therefore, this paper proposed an entity alignment model based on two-way GCN and CVm. It realized the complete representation of the entity by splitting the asymmetric adjacency weight matrix to construct a two-way GCN, so that the model could be learned the forward and backward hidden features of the entity. At the same time, for selecting the most representative entity local semantic information, it used the CVm to weight attributes, which effectively improved the accuracy of entity alignment. By verifying the model on two large real heterogeneous datasets, the Hit@ 1 value of this method was 4% higher than the existing embedding-based entity alignment method on average and maintains a high average reciprocal rank. It proves that this method improves the entity alignment effect to a certain extent. [ABSTRACT FROM AUTHOR]

Objective To explore the active components and potential molecular mechanism of Qigu capsule in the treatment of postmenopausal osteoporosis (postmenopausal osteoporosis, PMOP) by means of network pharmacology. Methods The main active components and corresponding targets of Qigu capsule were obtained from BATMAN-TCM database. The disease targets of PMOP were screened in GeneCards database and GEO database. The drug targets and disease targets were intersected. The drug-component-target network was constructed by using Cytoscape software. At the same time, the intersection targets were introduced into String online software to construct protein interaction network. The core targets were selected for GO (gene ontology) biological process and KEGG (Kyoto encyclopedia of genes and genomes) pathway enrichment analysis. Results 67 active components were obtained, including 24-hydroxy-11-deoxyglycyrrhetinic acid, chrysanthemum oil cyclone, β-sitosterol, γ-sitosterol and so on. A total of 57 intersection targets were obtained, including insulin (INS), interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1) and so on. The results of core target GO biological process and KEGG pathway enrichment analysis show that GO biological process is mainly involved in female pregnancy, multicellular biological process and so on. KEGG pathway is mainly involved in estrogen signal pathway, ovarian steroid production, fluid shear stress and atherosclerosis, interleukin-17 signal pathway and so on. Conclusion The mechanism of Qigu capsule in treating PMOP may be related to the main components of chrysanthemum, astragalus and Cistanche deserticola, such as α-pinene, chrysanthemum oil cyclone, β-sitosterol, etc., and may act on human INS, IL-6, IGF-1 and other targets through estrogen and interleukin signal pathways. [ABSTRACT FROM AUTHOR]

大国关系缓和、各方支持以及保持战略自主性与平衡性为 东盟中心地位的确立提供了重要外部条件。但当下美国推动实施“印太 战略”，中美战略竞争加剧，美日印澳“四边对话”等机制更多参与地 区事务，这些均对东盟中心地位构成挑战。东盟推出《东盟印太展望》， 试图通过概念、规则与合作领域等的重构，维护自身地区主导地位。但 受新冠肺炎疫情暴发、缅甸政局变动和拜登政府继续加大对华战略竞争 的影响，东盟努力的成效有限。中国 - 东盟对话伙伴关系 30 年的发展经 验表明，支持东盟的中心地位对于中国妥处大国关系、推进区域合作以 及构建周边命运共同体都具有重要现实意义。中国应正面回应《东盟印 太展望》，加强与东盟的战略对接，支持东盟在一些具体议题上发挥中 心作用。 [ABSTRACT FROM AUTHOR]

In recent years, the nanostructures of semiconductor materials has attracted wide attention because of its unique and novel size-related characteristics, especially nano-metal oxides. Gallium oxide nanomaterials have excellent photoelectric properties, gas sensing properties, pressure resistance and low loss properties, which bring new opportunities to many research fields such as materials science, electronics and chemistry. In this paper, the preparation methods of nano gallium oxide are reviewed, and its application in photoelectric detection is prospected. [ABSTRACT FROM AUTHOR]

目的总结乳腺癌脉络膜转移的有效诊断及治疗方法。方法对1例乳腺癌脉络膜转移患者的临床资料作回顾性分析。结果患者因"间断干咳伴胸闷、气短1月"就诊,入院后主诉头晕、双眼视物不清,有乳腺癌病史并接受手术治疗。患者视力检查提示视力下降,双眼及附属器超声回报右眼球球壁后上部局部眼球壁增厚,眼部光学相干断层扫描(OCT)回报右眼视盘神经上皮层部分脱离,PET-CT和头颅增强核磁检查回报全身多发转移癌。结合患者病情及影像学检查,诊断为:右乳腺癌改良根治术后右眼脉络膜转移、脑转移、双肺转移、右侧胸膜转移、多发骨转移、纵膈及双肺门淋巴结转移,右眼继发视网膜脱落。患者接受多西他赛单药化疗7周期,并辅以局部化疗,眼部症状有所缓解,目前仍在随访中。结论乳腺癌脉络膜转移患者临床罕见,且较多无症状,确诊时多已晚期。乳腺癌脉络膜转移初筛检查可选择眼部超声明确眼底占位,确诊的金标准为眼转移灶活检,但有严格的适应证。乳腺癌脉络膜转移患者可应用多西他赛等全身化疗或内分泌治疗方案,必要时可联用局部体外放射治疗。 [ABSTRACT FROM AUTHOR]

In order to solve the issue of malicious phonily occupying seats for some ticket agents or passengers in the process of air ticket sales, this paper proposed a blockchain system scheme based on the improved PoA consensus mechanism. The scheme used the alliance blockchain as a communication platform among airlines, adopted credit points and dynamic grading to build a new PoA consensus mechanism, protected passengers ' private information with hash algorithm, and achieved digital storage of ID information, registration of passengers, storage and sharing of passenger booking information for airline corporations relying on smart contracts. The prototype system trial operation shows that the system can timely detect and effectively stop the phonily occupying seats behavior. After analysis and evaluation, the program has the characteristics of privacy protection, decentralization and high security, and provides a new reference to solve the long-standing problem of phonily occupying seats in the civil aviation field. [ABSTRACT FROM AUTHOR]

To understand the current situation of preventive medicine students' knowledge, belief and behavior about new coronavirus pneumonia (new coronary pneumonia), and to provide ideas for the prevention and control strategies of higher vocational colleges in the next stage. Methods Self-designed questionnaires and online surveys were used to investigate preventive medicine students from a vocational college in Guizhou Province. Results The 285 students surveyed had a cognitive score of (60.49±27.03) points for new coronary pneumonia. 37.5% of students said they had varying degrees of anxiety during the face of the epidemic. It performed well in terms of new coronary pneumonia behavior. Conclusion The school’s preventive medicine students’ cognition rate of new coronary pneumonia needs to be improved. The school should carry out targeted publicity work based on the characteristics of the students, change the health communication model, so as to improve the students’ cognitive level and eliminate their anxiety. Make it a true "gatekeeper" of grassroots public health. To understand the current situation of preventive medicine students' knowledge, belief and behavior about new coronavirus pneumonia (new coronary pneumonia), and to provide ideas for the prevention and control strategies of higher vocational colleges in the next stage. Methods Self-designed questionnaires and online surveys were used to investigate preventive medicine students from a vocational college in Guizhou Province. Results The 285 students surveyed had a cognitive score of (60.49±27.03) points for new coronary pneumonia. 37.5% of students said they had varying degrees of anxiety during the face of the epidemic. It performed well in terms of new coronary pneumonia behavior. Conclusion The school’s preventive medicine students’ cognition rate of new coronary pneumonia needs to be improved. The school should carry out targeted publicity work based on the characteristics of the students, change the health communication model, so as to improve the students’ cognitive level and eliminate their anxiety. Make it a true "gatekeeper" of grassroots public health. [ABSTRACT FROM AUTHOR]

Objective To investigate knowledge attitude and behavior of preventive medicine students for COVID 19.and to provide ideas for the prevention and control strategies of epidemic diseases in vocational colleges, Methods A self-designed ques questionnaire and online survey were used to investigate the preventive medicine students in a vocational college in Guizhou province. Results The cognitive score for COVID 19 was (60. 49±27. 03) scores, 37, 5% of the students said they had different levels of anxiety in the face of the epidemic. The students were better at COVID 19 behavior. Conclusions The COVID 19 awareness rate of the respondents needs to be improved. Schools should conduct publicity work in combination with the characteristics of students, change the mode of health communication so as to improve students cognitive level and eliminate anxiety.and become a real gate keeper of public health at the grassroots level. [ABSTRACT FROM AUTHOR]

In order to study the evolution law of oil shale meso-structure at different temperatures, the oil shale samples from Fushun were scanned by micro-CT test and analysis system. The results show that with the increase of temperature, the crack structure in the specimen undergoes three stages of "generation-closure-redevelopment" but the porosity of whole oil shale specimen increases. To select a small area with a crack as the research object, from 100 to 300°C, the gradual closure of crack leads to an increase in the pore number, but a decrease in the pore volume. From 300 to 600°C, crack re-expansion and extension, most of the voids in the region are connected, and pore number decreases but pore volume increases. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical effect of sodium tanshinone IIA sulfonate(STS) combined with simvastatin(SV) on coronary heart disease with angina pectoris(CHD-AP) and its effects on the hemorheology, serum tumor necrosis factor(TNF)-α, C-reactive protein(CRP), endothelin(ET)-1 and nitric oxide(NO) levels. Methods: 210 cases with CHD-AP in our hospital from April 2016 to April 2017 were selected as research objectives and randomly divided into two groups. SV was provided to the control group and SV combined with STS was provided to the observation group. The clinical effect, changes of hemorheology, serum TNF-α, CRP, ET-1 and NO levels before and after treatment as well as adverse reaction were compared between two groups. Results: At 1 month after treatment,the overall effective rate was 91.4% in the observation group, which was significantly higher than that of the control group(78.1%, P<0.01).The plasma viscosity(PV), whole blood viscosity(WBV), platelet adhesion rate(PadT), serum TNF-α, CRP and ET-1 of both groups at 1 month after treatment were significantly lower than those before treatment(P<0.01), which decreased more significantly in the observation group(P<0.01). The serum NO level at 1 month after treatment was significantly higher than those before treatment(P<0.01), which was significantly higher in the observation group than that in control group(P<0.01). No statistical difference was found in the adverse reaction rate between two groups(1.9% vs. 2.9%, P>0.05). Conclusion: STS combined with SV showed better clinical effect on CHD-AP with high safety, which may attribute to improve the hemorheology, serum TNF-α, CRP, ET-1 and NO levels. [ABSTRACT FROM AUTHOR]

Hepatitis B cirrhosis is a chronic progressive disease caused by hepatitis B virus ( HBV) infection and has various complications such as upper gastrointestinal bleeding, hepatic encephalopathy, and hepatorenal syndrome, and it may progress to liver cancer and even cause death in severe cases. In addition, HBV infection is also a high risk factor for renal injury, and patients with HBV infection had a higher incidence rate of renal injury than those without HBV infection. Renal injury does great harm to patients with hepatitis B cirrhosis, and some patients even have renal failure, with poor prognosis and high mortality. In recent years, hepatitis B cirrhosis with renal injury has become a research hotspot. This article briefly describes the research advances in the indices for hepatitis B cirrhosis with renal injury, compares the influence of different nucleotide analogues on renal function during antiviral therapy, and summarizes how to adjust the medication for patients with renal injury. It is pointed out that early identification and reasonable evaluation of renal function in patients has important clinical significance. [ABSTRACT FROM AUTHOR]

2017 年以来，美日印澳“四边对话”重新活跃。“四边对话” 以“印太”为合作地域，以推进海上安全合作与加强基础设施建设为主要合作内容，旨在通过四国间的协调行动，应对地区形势的显著变化， 构建与维护符合自身利益的地区秩序。“四边对话”的重新活跃反映了各国围绕地区秩序在外交、经济与安全领域展开合纵连横与力量博弈的新动向。中国既要警惕其战略意图，同时秉承合作、包容和互利共赢的理念，寻求与拓展各地区机制间的对话、对接，共同维护本地区的稳定与发展。 [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical characteristics and prognosis between patients underwent percutaneous coronary intervention(PCI) with or without cardiac surgery support. Methods: The clinical data of 2308 cases of patients underwent PCI were retrospectively analyzed, they were divided into the backup group(n=2031) and the non-backup group(n=277) according to the cardiac surgery support. The baseline information, PCI related indicators, and occurrence of major adverse cardiac events(MACE) in two groups were compared. Results: Compared with the backup group, there were significant increase in the medical costs and LVEF, decrease in the percentage of emergency PCI, history of AMI and PCI, STEMI in the non-backup group(P0.05). Backup group was given priority to triple-vessel disease and over, complex lesions of type B and C, numbers of stent placement and the proportion of left main lesion were significantly increased, and the proportion of target vessel intravascular ultrasound(IVUS), the success rate of PCI, total incidence of intraoperative complications were significantly lower than those in the non-backup group(P0.05). There was no significant difference in the incidence of MACE after PCI between two groups(P0.05). Conclusions: There is remarkable difference in the clinical characteristics in PCI between with or without cardiac surgery, PCI without cardiac surgery is given priority to emergency PCI with relatively milder lession of target vessel. PCI is safe and feasible for low risk cases, and has high success rate and fair prognosis. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical efficacy of Xinkeshu Tablets in the treatment of coronary heart disease(CAD) patients with depression after percutaneous coronary intervention(PCI) and effect on the quality of life(QOL). Methods: 68 cases of patients with CAD and depression after PCI were randomly divided into the treatment group(n=34) and the control group(n=34). The control group was given routine drug treatment, while the treatment group was given Xinkeshu tablets for 4 tablets each time,3 times a day on the basis of control group. The treatment course was 3 months. The changes of hemorheology indexes, anxiety symptoms, QOL after PCI were compared between two groups. Results: After treatment, the blood viscosity, plasma viscosity, hematokrit and platelet aggregation rate were significantly lower than those before treatment. At 1 month after treatment, the HAMA score in both groups were all remarkably reduced(P<0.05), and there was no significant difference on the the HAMD score between two groups(P>0.05). At 3 months after treatment, the HAMA score in treatment group was significantly reduced than that in the control group(P<0.05). At 1, 3 months after treatment, the WHOQOL-BREF score of each dimension were significantly increased than those before treatment(P<0.05),and the psychological, social relations dimension scores in treatment group were significantly higher than those in the control group(P<0.05). Conclusions: Xinkeshu tablets can improve the hemorheology, reduce the anxiety symptoms, improve the QOL in the treatment of CAD patients with depression after PCI. [ABSTRACT FROM AUTHOR]

BACKGROUND: Fear of falling will aggravate the instability of the knee joint in patients with knee osteoarthritis, leading to the reduction of activities and the decline of the overall body function. Therefore, screening the factors affecting the fear of falling in patients with knee osteoarthritis and constructing a nomogram model can reduce the injury caused by the fear of falling and provide a reference for the formulation of individualized diagnosis and treatment plans. OBJECTIVE: To explore the influencing factors and conditions of fear of falling in patients with knee osteoarthritis, and to establish a predictive model for the risk of fear of falling in patients with knee osteoarthritis. METHODS: A cross-sectional study method was used to enroll 560 patients with knee osteoarthritis who visited Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from September 2019 to February 2021. Among them, 469 were in the falling fear group and 91 were in the nonfalling fear group. The general information of patients, the Western Ontario and McMaster Universities Arthritis Index, and the Hospital Anxiety and Depression Scale scores were analyzed and compared between the two groups to determine the influencing factors of the fear of falling in knee osteoarthritis patients. Receiver operating characteristic curves of the influencing factors were drawn to obtain the Youden’s index with diagnostic value for the fear of falling. The maximum value of the Youden index of each factor was the best diagnostic value (cutoff value) of the knee osteoarthritis fear of falling. A nomogram was drawn to establish the knee predictive model for the fear of falling in patients with knee osteoarthritis. RESULTS AND CONCLUSION: (1) Logistic regression analysis showed that height and male were the protective factors for the fear of falling in patients with knee osteoarthritis, and age, unemployment, Western Ontario and McMaster Universities Arthritis Index stiffness scale score, and anxiety scale score were the risk factors for the fear of falling in patients with knee osteoarthritis. (2) Receiver operating characteristic curve results showed that Western Ontario and McMaster Universities Arthritis Index had a significant diagnostic value for knee osteoarthritis patients (Youden’s index=0.733), followed by age, anxiety, and gender. (3) The results of the nomogram showed that the maximum score of the Western Ontario and McMaster Universities Arthritis Index stiffness scale (8 points) could account for 41.6% of the predictors of knee osteoarthritis fear of falling. (4) It is concluded that there is a high incidence of fear of falling among patients with knee osteoarthritis, and joint stiffness and female gender may be risk factors for fear of falling, while low height may be a protective factor for fear of falling, and there is a need to focus on fear of falling and the management of related factors in clinical treatment interventions. [ABSTRACT FROM AUTHOR]

To perform the bioinformatics analysis of Prohibitin gene of Musca domestica (Housefly)，and aims at providing the basis for its' function research. Internet online procedures and the related software are exploited to analyze the physical and chemical properties of Prohibitin protein and the domains of the protein，and predict the structure and functions of the protein. The Prohibitin protein sequence is composed of 277amino acids with 30.54 kDa of the molecular weight. Theoretical isoelectric point is 5.26. The protein is stable and had structures of transmembrane and helical coils. The protein belongs to the family of PHB，and is located in cytoplasm and dominated by alpha helix in second structure. The phylogenetic tree reveals that the Prohibitin protein in insect has the highest homology. This work provides a systemic sequence analysis of Prohibitin protein of Musca domestica (Housefly). It will provide the useful reference for further investigation of its structure and function. [ABSTRACT FROM AUTHOR]

To analyze the diopter and adjustment function difference before and after the ciliary muscle paralysis of adult patient's myopia. and to provide the evidence whether an adult needs cycloplegic refraction. Method A cross-sectional study: 58 patients (116 eyes) of ametropia (116 eyes)，aged 18~40 years， were first examined by a computerized optometry and an automatic optometry with a purpose to determine the results of the optometry of the maximum positive lens (Corrected Ametropia with Most Plus， CAMP) state of the best corrected visual acuity. On this basis， the adjustment function examinations，including negative regulation (NRA)/positive relative regulation (PRA)， regulatory response(BCC)，were conducted. Then，the Compound Tropicamide Eye Drops mydriasis， 5 min/ times， 3 consecutive times， and 20 min interval of 20 min were used for the diopter and the changes of the diopter of CAMP before and after the pupil were compared．Results Under the different NRA and BCC values， NRA value < +1.75D， NRA value > +2.50D， BCC value < +0. 25D， and the difference of CAMP diopter before and after pupil was statistically significant; NRA value +1.75 ~ +2.25D， the value of the pupil before and after pupil had no significant difference. Conclusion The comprehensive optometry measurement of eye adjustment parameters was of significance in clinic for determining optometry in adult myopia. For adult myopia with NRA value < +1.75D， NRA > +2.50 D and BCC value < +0. 25 D， it is necessary to perform mydriasis optometry. [ABSTRACT FROM AUTHOR]

Objective To observe the changes in levels of serum carcinoembryonic antigen (CEA) in patients before and after gefitinib treatment of non-small-cell lung cancer (NSCLC) and to investigate the clinical significance. Methods Forty patients with NSCLC in clinical stage of Ⅲ~Ⅳwere treated with gefitinib and radiotherapy , and we stopped if the tumor progression or toxicity reaction were found in patients. After treatment, all patients were divided into the control group and non-control group according to RECIST1.1 (Response Evaluation Criteria in Solid Tumors in 2009). The peripheral blood was collected in the morning to detect the serum CEA by electro-chemiluminescence immunoassay (ECLIA). Before treatment, the patients were divided into the high CEA group (CEA>30 μg/L) and low CEA group (CEA ≤30μg/L). Two groups were followed up to December , 2012. The adverse reactions and progression free survival (PFS) were recorded. Results There was no difference in CEA levels before treatment between the control group and non-control group(P>0.05), but the levels of CEA in the control group decreased more after treatment than that of the non-control group (all P<0.01). No difference was found in the adverse reaction between the high CEA group and the low CEA group (P>0.05), but the PFS at 9 months and 12 months was higher in the high CEA group than that in the low CEA group (P<0.01). Conclusion The serum CEA level is decreased in NSCLC patients after treatment of gefitinib, which can become the biological marker in predicting the efficacy and prognosis. [ABSTRACT FROM AUTHOR]

When pedestrian detection is carried out in image and video sequences, there are some problems, such as diverse pedestrian posture and scale as well as pedestrian occlusion, which leads to inaccurate detection of some pedestrians by YOLOv4 algorithm and false detection and missed detection. In order to solve this problem, a complex pedestrian detection model based on improved YOLOv4 algorithm is proposed. Firstly, the ground truth size of pedestrian dataset is analyzed by the improved kmeans clustering algorithm, and the size of anchor box is determined according to the clustering results. Secondly, PANet is used for multi-scale feature fusion to make it more sensitive to multi-attitude and multi-scale pedestrian targets and improve the detection effect. Finally, for pedestrian occlusion problem, the repulsion loss function is proposed to make the predicted box as close to the correct target as possible. The experimental results show that the new de-tection model has better detection effect than YOLOv4 and other pedestrian detection model. [ABSTRACT FROM AUTHOR]

Mindfulness training has shown beneficial effects on cognitive functions in older adults. However, the studies on this topic have used different methods and populations, and their results were inconsistent No systematic review has synthesized and evaluated these findings. This review aims to address this gap by categorizing the studies based on the training methods and cohorts of older adults, and summarizing the effects of mindfulness training on cognitive function. The review finds that mindfulness training had different effects depending on the level of cognitive decline and the training method. Both standardized and unstandardized training methods improved cognitive performance in older adults with normal or subjective cognitive decline. However, the effect of mindfulness training diminished as cognitive decline worsened, being inconsistent in mild cognitive impairment and non-significant in dementia. The review also discusses the possible mechanisms and suggested directions for future research. [ABSTRACT FROM AUTHOR]

The experiment was to study the effect of N-carbamylglutamic (NCG) on intestinal morphology and microflora of the cock in growing period of Zhuanghe big bone chicken. 144 healthy 11-week-old Zhuanghe big bone chickens were randomly divided into four groups (Group C is the control group: Basal diet; Group N1: Basal diet + 0.08% NCG; Group N2: Basal diet + 0.12% level NCG; Group N3: Basic diet + 0.16% level NCG), with three replicates in each group and 12 chickens in each replicate. At the end of 16 w, samples of intestinal tissue and cecal contents were collected for intestinal morphological development and microflora analysis. The results showed that compared with group C, the height of duodenal villi and V/C value in group N1 were significantly increased (P<0.05), and the height of villi of jejunum and ileum was significantly decreased (P<0.05). The V/C of jejunum and ileum of group N2 were significantly increased (P<0.05), the V/C of ileum and the thickness of muscle layer of group N3 were significantly increased (P<0.05). The thickness of cecal muscle layer in group N1, group N2 and group N3 was significantly increased (P<0.05). The height of cecal gland cells in group N1 and group N2 was significantly increased (P<0.05). In the intestines of group N1, the relative abundance of Bacteroidetes, Bacteroides, Alistipes, Faecalibacterium, Clostridia, Rikenellaceae increased. The relative abundance of Actinobacteria, Ruminococcus, Bifidobacterium reduced. The study indicates that adding NCG at a level of 0.08% to 0.12% in diet can effectively promote intestinal morphological development of small intestine and cecum during growing period of big bone chicken roosters. The addition of 0.08% NCG in the diet can affect the structure of caecal flora of big bone chicken. [ABSTRACT FROM AUTHOR]

Objective The study aimed to compare the diagnostic efficacy of QuantiFERON-TB Gold （QFT-TB） detection of specific cellular immune IGRAs in tuberculosis diagnostic laboratory for pulmonary tuberculosis, extrapulmonary tuberculosis and special population samples in vitro, which may provide evidence for clinical diagnosis and treatment. Methods A total of 546 patients with tuberculosis （AFB + 146 cases, AFB-247 cases）, 117 patients with molecular biology positive tuberculosis（ Xpert 69 cases, TB-DNA 48 cases） and 36 patients with histopathological positive were collected from January to July 2023. There were 72 cases of extrapulmonary tuberculosis, 276 cases of pleural effusion and 25 cases of ascites. QFT-TB method was used for detection, chi-square test was applied for comparison between groups, and the methodological evaluation of positive rate and coincidence rate were all compared. Results The positive rates of QFT-TB in pulmonary tuberculosis, extrapulmonary tuberculosis and close contacts were 83.69 %, 69.44 %, and 32.41 %, respectively. The coincidence rates of QFT-TB in AFB +, GeneXpert, TB-DNA and pathological confirmed tuberculosis patients were 91.09%, 88.40%, 81.25%, and 72.22%, respectively. The positive rate of pleural effusion in patients with tuberculous pleurisy was 60.50 %, and the uncertainty rate was 29.71%. The positive rate of ascites was 44.00 % and the uncertainty was 36.00%. Conclusion QFT-TB test has good value in the auxiliary diagnosis of pulmonary tuberculosis, and has certain reference significance for the diagnosis of extrapulmonary tuberculosis based on the detection of pleural fluids and ascites. [ABSTRACT FROM AUTHOR]

Pervious concrete was prepared with two industrial solid wastes of granulated blast-furnace slag and Bayer red mud as cementitious materials, sodium silicate solution as alkali activator, and limestone gravel as coarse aggregate. The effects of design porosity, water-binder ratio and aggregate size on the strength and permeability of pervious concrete were studied respectively. The optimal water-binder ratio is influenced by the design porosity and aggregate size. When the design porosity of pervious concrete is 15% and the aggregate size is 4.75-9.50 mm, the optimal water-binder ratio of 0.36 and it has a higher strength and has good water permeability. The mechanics and permeability performance of alkali-activated slag-red mud pervious concrete are better than those of cement pervious concrete, which is in line with the development concept of low carbon and green. [ABSTRACT FROM AUTHOR]

目的 分析并研究不同口服降糖药物对2型糖尿病患者糖化血红蛋白（HbA1c）的影响。 方法 选择2013年5月至2016年1月该院收治的2型糖尿病患者200例作为研究对象，按随机数字表法随机分为观察组和对照组，每组100例。对照组采用二甲双胍联合胰岛素增敏剂治疗，观察组采用二甲双胍联合胰岛素促泌剂治疗，观察并比较两组患者治疗前后踝肱指数（ABI）、空腹血糖（FBG）、餐后2小时血糖（2hPG）、HbA1c、肱动脉-踝动脉脉搏波速率（baPWV）水平等。 结果 两组患者治疗后血糖均得到有效控制，且HbA1c达标率有所提升，但观察组ABI、FBG、2hPG、HbA1c、baPWV水平明显优于对照组，差异均有统计学意义（P<0.05）。 结论 临床对2型糖尿病患者采用二甲双胍联合胰岛素促泌剂治疗能更好地促使患者血糖的控制，有效提升患者HbA1c达标率，值得临床推广应用。 [ABSTRACT FROM AUTHOR]

Objective To explore the molecular mechanism of herba epimedii in the treatment of glucocorticoid-induced osteoporosis ( GIOP) with network pharmacology. Methods The active ingredients and related targets of herba epimedii were screened with Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform ( TCMSP). The disease target of GIOP was obtained with Used GeneCards database and OMIM database. The drug target was intersected with the GIOP disease target through R language. The Cytoscape 3. 7. 0 software was used to construct a network of herha epimedii-active ingredient-GIOP target. Herba epimedii-GIOP protein-protein interaction ( PPI) network was constructed using the String database. The gene ontology (GO) biological function enrichment and Kyoto encyclopedia of genes and genomes (KEGG) pathway were analyzed using R language. Results Twenty-three major active ingredient of herba epimedii were obtained through the screening, and a total of 65 GIOPrelated targets were involved. Quercetin, kaempferol, luteolin, and icariin connected with more than 10 related targets, which were the main components of epimedium in the treatment of GIOP. IL-6, VEG FA, MAPK8, CASP3, and ESRI were the five most frequently linked targets in the interaction of common target protein of epimedium-GIOP, which were the core target genes. Conclusion Herba epimedii may have the treatment effect on GIOP through prostate cancer pathway, cell apoptosis pathway, fluid sheer stress and atherosclerosis pathway, TNF signal pathway, and AGE-RAGE signal pathway in diabetes. This provides a new thought and direction for the study of the mechanism of pharmacodynamics. [ABSTRACT FROM AUTHOR]

Objectives: The seasonal subsidence and uplift of the surface elevation in permafrost area occur due to the annual melting and freezing of active layer, which has an important impact on the safety of engineering construction, the balance of ecological environment, and global climate change. Using global navigation satellite system-interferometric reflectometry (GNSS-IR) to monitor frozen soil deformation is a new technique. Aiming at the terrain influence caused by the non-daily-repeatable orbits of GLONASS and Galileo satellites, this paper proposes a new method to calculate the freeze-thaw deformation of permafrost using these GNSS data. Methods: By introducing the inclination angle of reflector surface, the effects of terrain changes are eliminated, and the seasonal freeze-thaw deformation closer to the actual situation is obtained. The GNSS signal-to-noise ratio data of 2018 and 2019 snow-free days at SG27 site in northern Alaska are used for experiments and compared with the results obtained by existing retrieval methods to verify the effectiveness of this method in monitoring permafrost deformation. Results: The results show that compared with the methods without considering the terrain effect, the surface elevation changes obtained by GLONASS and Galileo have smaller discreteness and smaller uncertainty, and the fitting consistency and determination coefficient R2 of the composite model have been improved. The total average standard deviations are reduced by about 28.9 % and 36.9 %, and the total average R2 are increased by about 0.23 and 0.24, respectively. The total average increases of daily data utilization rate of non-repetitive orbits are about 19.6 % and 22.8 % . Conclusions: This study provides a valuable reference for monitoring permafrost freeze-thaw deformation, and expands the application of GNSS-IR in GNSS system for permafrost freeze-thaw monitoring. [ABSTRACT FROM AUTHOR]

BACKGROUND: Studies have shown that a certain dose of interleukin-4 intervention can yield the appropriate ratio of M1/M2 macrophage profile to generate a microenvironment conducive to bone healing and promoting bone regeneration. OBJECTIVE: To investigate the effect of interleukin-4 on NLRP3 inflammasome activation and osteoclast differentiation during bone tissue regeneration guided by bone replacement materials. METHODS: Forty-eight 6-8-week-old male SD rats were selected to establish a 5-mm diameter cranial bone defect model on the left and implanted with BioOss bone replacement material at the same time, and the periosteum was sutured. Rat models were randomly divided into control and experimental groups (n=24) at postoperative 3 days. Interleukin-4 and PBS were injected locally into the cranial bone defect area for the experimental and control groups, once a day, for 5 consecutive days. SD rats were executed at 1 and 2 weeks after surgery and skull samples were taken. Immunohistochemical staining was performed to detect the expression of cleaved caspase-1 and interleukin-1β protein. Immunofluorescence staining was performed to observe the expression of inducible nitric oxide synthase (M1 surface marker) and cleaved caspase-1 (NLRP3 indicator). Real-time fluorescence quantitative PCR was performed to detect the expression of related inflammatory factors caspase-1, interleukin-1β and osteoclast factor histone K gene. The differentiation and number of osteoclasts were observed by anti-tartrate acid phosphatase staining. At 6 and 12 weeks after surgery, micro-CT and hematoxylin-eosin staining were performed to observe the osteogenesis of the skull. RESULTS AND CONCLUSION: Immunofluorescence staining showed that the number of inducible nitric oxide synthase and cleaved caspase-1 doublestained cells in the experimental group was significantly lower than that in the control group at 1 and 2 weeks (P < 0.05). Immunohistochemical staining showed that the expression of cleaved caspase-1 and interleukin-1β in the experimental group was significantly lower than that in the control group at 1 week (P < 0.05). RT-qPCR suggested that the expression of caspase-1 mRNA in the experimental group was lower than that in the control group at 1 week (P < 0.05). The expression intensity of interleukin-1β and osteoclast factor histone K mRNA was significantly lower in the experimental group than that in the control group at postoperative 1 and 2 weeks (P < 0.05). Anti-tartrate acid phosphatase staining showed that the number of osteoclasts was significantly lower in the experimental group at 1 and 2 weeks than that in the control group (P < 0.05). Micro-CT results showed that the bone volume fraction and bone mineral density in the bone defect area were significantly higher in the experimental group than those in the control group at 6 and 12 weeks after injection (P < 0.05). Hematoxylin-eosin staining showed that 12 weeks after injection, multiple ossification centers were formed in the center of the defect in the experimental group, with scattered mature bone cells and lacunae, and a large number of osteoblasts around the material arranged into a single layer to participate in the formation of bone matrix. The results suggest that interleukin-4 may be involved in downregulating NLRP3 inflammasome expression, inhibiting the activation of caspase-1 and thus reducing the secretion of interleukin-1β, reducing the inflammatory state of the local microenvironment, as well as inhibiting osteoclast differentiation and playing a role in promoting new bone production during bone tissue regeneration guided by bone replacement materials. [ABSTRACT FROM AUTHOR]

Objective: To explore the influence of early cardiac rehabilitation on cardiac function and mental state after percutaneous coronary intervention (PCI) in elderly patients with acute myocardial infarction (AMI). Methods: 62 elderly patients with AMI who successfully underwent PCI during January 2018 to December 2018 were randomly divided into the study group (n=31) and the control group (n=31). Meanwhile, 30 healthy subjects were selected as the healthy group. The control group was given routine rehabilitation training according to the "rehabilitation procedure after percutaneous coronary intervention", and the study group was given personalized rehabilitation training program was developed according to the 6-min walking test (6MWT) for 6 months, including in-hospital and out-hospital cardiac rehabilitation intervention, psychological intervention and follow-up. The occurrence of cardiac function, mental state and end-point events were compared between the two groups. Results: Six months after rehabilitation, all cardiac function indicators of LVEDD, LVESD and LVEF in the two groups were significantly improved compared with those before rehabilitation, and the study group was significantly better than the control group (P<0.05). There was no significant difference in LVEF between the study group and the healthy group at 6 months after rehabilitation (P>0.05). Six months after rehabilitation, the scores of all items in the SCL-90 scale in the two groups were significantly lower than those in the control group except hostility and paranoia, and somatization, compulsive symptoms, depression, anxiety and psychosis in the study group were significantly lower than those in the control group (P<0.05). During the rehabilitation follow-up, the total incidence of endpoint events in the study group was 9.7%, significantly lower than that in the control group, 25.8%, and 6MWD was also significantly higher than that in the control group (P<0.05). Conclusion: Early cardiac rehabilitation can significantly promote the recovery of cardiac function after PCI in elderly AMI patients, improve their psychological state, and reduce the risk of adverse end-point events after PCI. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of entresto combined with cardiac exercise rehabilitation in heart failure patients with reduced ejection fraction (HFrEF). Methods: 70 patients with HFrEF admitted to the department of cardiology of our hospital From January 2018 to April 2019 were randomly divided into two group. The control group (n=35) was given standard treatment with entresto, and the experimental group (n=35) was formulated personalized cardiac exercise rehabilitation based on the metabolic equivalent measured by cardiopulmonary exercise test (CPET), including in-hospital and out-of-hospital cardiac rehabilitation intervention and regular follow-up for 6 months. Color echocardiography and cardiopulmonary exercise (CPET) were used to analyze the changes of cardiopulmonary function before and after treatment in the two groups, and the prognosis during hospitalization and follow-up was observed. Results: After 6 months of treatment, the levels of left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction, (LVEF) were significantly improved in both groups, and the indicators in the experimental group was significantly better than those in the control group (P<0.05). After 6 months of treatment, the AT of the experimental group was significantly increased, levels of peak VO2/kg and peak VO2 were also significantly increased, and were significantly better than those in the control group (P<0.05). Compared with the control group, the HF rehospitalization rate within 90d (8.6%vs.28.6%) and MACEs incidence (17.1% vs.40.0%) in the experimental group were significantly reduced (P<0.05). Conclusion: Entresto combined with cardiac exercise rehabilitation therapy can be significantly beneficial for HFrEF patients, it has significant efficacy in improving cardiopulmonary function, motor ability and short-term prognosis, which can be used as the first-line treatment for HFrEF patients. [ABSTRACT FROM AUTHOR]

Obective: To analyze the risk factors of postoperative recurrence of cervical cancer, and to investigate the predictive value of serum squamous cell carcinoma antigen (SCC-Ag) level and high-risk human papillomavirus (HR-HPV) infection for postoperative recurrence of cervical cancer. Methods: 300 cases of cervical cancer in our hospital from January 2010 to December 2017 were analyzed retrospectively. Clinical data was collected, and all patients were followed up for 2 years. The expression of SCC-Ag and the infection status of HR-HPV were tested regularly, and patients were divided into the recurrence group and the non-recurrence group according to the recurrence situation. Univariate and multivariate Logistic regression analysis was used to analyze the risk factors of postoperative recurrence of cervical cancer, and taking pathological diagnosis as the gold standard, the predictive value of SCC-Ag and HR-HPV for postoperative recurrence of cervical cancer were analyzed. Results: During the follow-up period, 12 patients were lost to follow-up and 288 of the 300 patients were followed up, 40 cases recurred, 248 cases did not recurred. Univariate analysis showed that postoperative recurrence of cervical cancer was related to tumor diameter, differentiation degree, tumor stromal infiltration, clinical stage, Lymph node metastasis, SCC-Ag positive expression, HR-HPV persistent infection (P<0.05). However, it was not associated with age of onset, Body mass index (BMI), smoking history, sexual behavior start age, family history of cervical cancer, pathological type, postoperative radiotherapy and chemotherapy (P>0.05). Multivariate logistic regression analysis showed that low differentiation, deep myometrial invasion, clinical stage IIA1-IIA2, lymph node metastasis, SCC-Ag positive, HR-HPV positive were the risk factors of postoperative recurrence of cervical cancer (P<0.05). The sensitivity, specificity, positive predictive value and negative predictive value of SCC-Ag combined with HR-HPV were 92.50%, 87.50%, 54.41%, 98.64% respectively. Conclusion: Poor differentiation, deep myometrial invasion, clinical stage IIA1-IIA2, lymph node metastasis, SCC-Ag positive and HR-HPV positive are the risk factors of postoperative recurrence of cervical cancer. The SCC-Ag combined with HR-HPV has a certain value in predicting postoperative recurrence of cervical cancer, which is worthy of clinical attention. [ABSTRACT FROM AUTHOR]