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Copyright of Engineering Science Research & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: In this study, we aimed to observe the expression of ADAR1 in gastric cancer patients and to determine the role of ADAR1 and underlying the potential clinical significance of ADAR1 in gastric cancer. Methods: Through the GEPIA database,we found differences in the expression of ADAR1 at the m RNA level between gastric cancer and normal gastric tissue samples. In the gastric cancer and paired tissues of 170 gastric cancer patients collected at Xijing Hospital, we verified this difference through immunohistochemistry and analyzed the relationship between the expression of ADAR1 and pathological features. Through the Kaplan-Meier Plotter platform and the TCGA database, we analyzed the impact of ADAR1 expression on the prognosis of gastric cancer patients.Results: ADAR1 was abnormally high expressed in gastric cancer. Moreover, the results showed that the high expression of ADAR1 was related to histological differentiation of gastric cancer(P=0.044) . Gender(HR=2.082 95 % CI=1.160-3.736, P=0.014), and lymph node enlargement(HR=1.582, 95 % CI=1.003-2.496, P=0.049), which were independent risk factors affecting the overall survival of gastric cancer patients. We also found that the expression of ADAR1 was positively correlated with tumor mutation burden(TMB) (P=0.002),indicating potential value in assessing the immunotherapeutic value of gastric cancer patients. In addition, patients with high expression of ADAR1 had a shorter overall survival and poor prognosis. Conclusions: The high expression of ADAR1 in gastric cancer may have the potential to judge prognosis and assess the value of immunotherapy, and is expected to become a new clinical diagnostic and therapeutic target [ABSTRACT FROM AUTHOR]

Copyright of Command Control & Simulation / Zhihui Kongzhi yu Fangzhen is the property of Command Control & Simulation Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Laser Technology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Inorganic Chemicals Industry is the property of Editorial Office of Inorganic Chemicals Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Chinese Institute of Food Science & Technology is the property of Journal of Chinese Institute of Food Science & Technology Periodical Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nonferrous Metals (Mining Section) is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Based on the traditional three degree of freedom (DOF) planar parallel mechanism, a novel reconfigurable 3-DOF planar parallel mechanism is proposed. Firstly, based on the theory and method of topology design of the parallel mechanism position and orientation characteristic (POC). The switch between the 3-revolute-joint, prismatic-joint, revolute-joint (3-RPR) and 3-revolute-joint, revolute-joint, revolute-joint (3-RRR) planar parallel mechanisms is realized through a reconfigurable branch chain. Then, taking 3-RRR configuration as an example, the important topological indexes of the mechanism, such as POC, DOF and coupling degree, are analyzed. Based on the structural characteristics and geometric constraints of the mechanism, the inverse kinematics model is derived by using the closed vector method. Finally, the position workspace of the mechanism is analyzed based on the geometric constraint method of the branched chain and the inverse solution model respectively. This work provides not only a new idea for the analysis of mechanism workspace, but also a new choice for the design of mechanism. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To analysis the correlation of Ki-67, TOPK expression of neoadjuvant chemotherapy(NACT) in triple-negative breast cancer (TNBC) with prognosis. Methods: 90 TNBC patients admitted in our hospital from March 2014 to June 2016 were collected as research objects, the expression of Ki-67 and TOPK in tumor tissues were detected by immunohistochemistry method, the correlation of Ki-67 and TOPK expression with pathological characteristics were analysed, the survival analysis were analyzed by Cox proportional hazards regression model rognosis, the independent risk factors for prognosis were analysed. Results: In terms of treatment, 91.11 % (82/90) of patients received ≥ 4 cycles of NACT, 84.44 % (76/90) of patients received surgery, and post-operative pCR was 22.22 % (20/90) and ORR was 75.56 % (68/90). During the 5-year follow-up, 8 of the 90 patients died (6 died of TNBC and 2 died of other causes), and 2 were lost to follow-up. The positive expression rates of Ki-67 and TOPK were decreased after NACT(P＜0.05). There were significant differences between the positive and negative expression of KI-67 and TOPK in different TNM stages and lymph node metastasis (P＜0.05). The progression-free survival (PFS) and overall survival (OS) of patients with Ki-67 and TOPK positive expression was shorter than negative expression (P＜0.05). The prognosis of TNBC patients were independently associated with TNM stage, lymph node metastasis, positive expression of Ki-67 and TOPK (P＜0.05). Conclusions: The expression of Ki-67 and TOPK in tissues was closely correlated with pathological characteristics and prognosis, which were independent risk fators for prognosis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Functional Materials / Gongneng Cailiao is the property of Chongqing Functional Materials Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mechanical & Electronic Control Engineering is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The contact erosion damage of dam culvert is one of the most common dangerous conditions in dam engineering, which has the characteristics of difficult to detect, sudden damage and great harm. In order to realize the effective detection of the joint part of dam culvert and soil, the time-lapse 3D high density resistivity method was used to detect and judge the contact leakage. Based on the discussion of forward modeling, inversion theory and observation device types of time-lapse 3D high-density resistivity method, combined with the practical application of engineering, the continuous 3D resistivity detection test before and after water injection was carried out, and the resistivity reflection coefficient R was introduced to analyze the development and change law of the resistivity change at the junction in different times before and after water injection. The test results show that there is a good corresponding relationship between the low-resistivity abnormal response and the loose and non-dense area of the joint, which can realize the effective detection of the contact leakage of the joint. [ABSTRACT FROM AUTHOR]

The ecological footprint model of water resources was used to study the environmental carrying capacity of water resources in 115 cities in nine provinces and regions of the Yellow River Basin from 2010 to 2018 and the spatial and temporal characteristics of water resources in nine provinces and regions of the Yellow River Basin were discussed. The results show that the per capita ecological footprint of water resources in the nine provinces and regions of the Yellow River Basin is generally higher in the west and lower in the south. Only 28.7% of the cities in nine provinces and regions of the Yellow River Basin are in the state of ecological surplus of water resources. The water resources carrying capacity in the south of nine provinces and regions of the Yellow River Basin is high and the water resources carrying capacity in the east of Hu Huanyong line is similar to that in the west of Hu Huanyong line. The utilization rate of water resources in each city in nine provinces and regions of the Yellow River Basin has been increasing over the years. The average water resources pressure in the nine provinces and regions of the Yellow River Basin is increasing year by year. In general, the serious shortage of water resources and the uneven spatial and temporal distribution of water resources are the important factors restricting the high-quality development of the nine provinces and regions of the Yellow River Basin. [ABSTRACT FROM AUTHOR]

Copyright of Ordnance Industry Automation is the property of Editorial Board for Ordnance Industry Automation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: In addition to intraoperative bleeding and postoperative drainage after posterior approach for lumbar spinal stenosis, there is a large amount of hidden blood loss. Patients combined with rheumatoid arthritis may affect perioperative bleeding, especially hidden blood loss, which has not been reported before. OBJECTIVE: To compare intraoperative blood loss, postoperative drainage and hidden blood loss of posterior lumbar interbody fusion on lumbar spinal stenosis in patients with rheumatoid arthritis and non-rheumatoid arthritis and identify the risk factors of hidden blood loss in patients with rheumatoid arthritis. METHODS: Totally 65 patients diagnosed as lumbar spinal stenosis with rheumatoid arthritis (rheumatoid arthritis group) and 87 patients without rheumatoid arthritis (non-rheumatoid arthritis group) were retrospectively enrolled. All patients were treated with posterior decompression fusion and posterolateral fusion with internal fixation system of pedicle screw + titanium rod + interbody fusion cage. Posterolateral autogenous bone grafting was performed during the operation. The extracted measures included demographic characteristics, rheumatoid arthritis-related parameters such as rheumatoid arthritis duration, Steinbrocker classification and anti-rheumatoid arthritis drugs as well as information on operation and blood loss. Intraoperative blood loss, postoperative drainage and hidden blood loss were the primary outcomes. The secondary measures included operation time, preoperative and postoperative hematocrit and hemoglobin, the number of anemia pre- and post-operatively, autologous blood and allogeneic blood transfusion. RESULTS AND CONCLUSION: (1) The mean age and bone mass index were (65.97±8.02) years and (25.76±3.68) kg/m2 of patients in rheumatoid arthritis group. The gender ratio, age and number of surgical segments were all matched between the rheumatoid arthritis and non-rheumatoid arthritis groups. (2) The mean duration was (16.78±12.73) years in the rheumatoid arthritis group, of which the most common anti-rheumatoid arthritis drug was single or combined disease-modifying anti-rheumatic drugs. There was no statistical difference in the number of pedicle screws and interbody cages between the two groups, so was the incidence of perioperative complications. (3) The primary outcomes showed that there was no statistical difference in total blood loss, intraoperative blood loss and postoperative drainage between the two groups. Hidden blood loss and the proportion of hidden blood loss were lower in non-rheumatoid arthritis group than in the rheumatoid arthritis group (P < 0.001, 0.012). Stratified analysis based on the number of surgical levels suggested hidden blood loss and the proportion of hidden blood loss in non-rheumatoid arthritis group was superior to those of rheumatoid arthritis group in long-segment surgery (≥ 3 segments). (4) The secondary outcomes showed the change of hematocrit was lower in the non-rheumatoid arthritis group (P=0.021) than in rheumatoid arthritis group, but the reduction of hemoglobin was not significantly different between the two groups. In addition, there was no significant difference in neoformative and grade-aggravated anemia, as well as the number of allogeneic blood transfusion and operation time. (5) Multiple linear regression analysis of hidden blood loss in the rheumatoid arthritis group showed high Steinbrocker classification, non-taking disease-modifying anti-rheumatic drugs, large change of hemoglobin and allogeneic blood transfusion were independent risk factors. (6) It is concluded that there were no differences in total blood loss, intraoperative blood loss, postoperative drainage and operation time between rheumatoid arthritis group and non-rheumatoid arthritis group. Hidden blood loss and the proportion of hidden blood loss in total blood loss were higher in the rheumatoid arthritis group than in the non-rheumatoid arthritis group, especially in long-segment surgery. The high Steinbrocker classification, non-taking disease-modifying anti-rheumatic drugs, large change of hemoglobin and allogeneic blood transfusion were independent risk factors for hidden blood loss in the rheumatoid arthritis group. [ABSTRACT FROM AUTHOR]

BACKGROUND: There is limited anterior cervical spine space. Incomplete hemostasis or drainage during artificial cervical total disc replacement can incur a series of complications. Preoperative factors can directly affect the amount of bleeding during spine surgery, while there are no publications aiming at cervical artificial disc replacement. OBJECTIVE: To analyze influencing factors on operation time and hemorrhage in patients undergoing single cervical total disc replacement. METHODS: Fifty-six patients with cervical spondylosis who underwent cervical total disc replacement from October 2012 to December 2017 in Department of Spine Surgery, Peking University People’s Hospital, were retrospectively enrolled. Pre- and intra-operative related parameters were measured. Primary outcomes included operation time, intraoperative blood loss and postoperative drainage. The secondary outcomes included demographic data such as sex, male and hypertension; surgery-related information such as operated segment, types of cervical spondylosis and artificial prosthesis; parameters in X-ray plain films such as the motion range and cervical lordosis of C2-C7 and index segment, the height of intervertebral disc, MRI classification (Modic classification and Pfirrmann classification) and preoperative functional score. The analysis was performed between primary and secondary outcomes as well as among primary outcomes. RESULTS AND CONCLUSION: (1) The average age of 56 patients (30 males and 26 females) was 48.2±9.8 years; operation time, intraoperative bleeding and postoperative drainage were 73.2±13.4 minutes, 51.8±41.2 mL and 7.8±5.3 mL, respectively. (2) There were no differences both in operation time and intraoperative blood loss in terms of demographics, while the drainage was statistically different in various ages (P=0.030). (3) The operation time of Prestige-LP implantation was statistically shorter than that of Mobi-C and Prodisc-C (P < 0.05). There was a positive correlation between the intermittent on taking (nonsteroidal antiinflammatory drugs) and intraoperative blood loss (r=0.310, P=0.020). The higher intervertebral disc of the operation segment was, the longer operation time was (P=0.028). (4) There was a significant difference in more intraoperative blood loss with osteoporosis compared to the normal ones (P=0.039); while the rest radiological parameters in X-ray were in no relation to primary outcomes, neither were in MRI degree, Modic change and Pfirrmann classification. (5) There was a positive correlation between operation time and intraoperative blood loss (P=0.010) and postoperative drainage (P=0.001). (6) These indicate that the height of intervertebral space can prolong operation time. Osteoporosis is a risk factor for intraoperative blood loss. The longer the operation time is, the more intraoperative blood loss and postoperative drainage will be. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Hebei University of Science & Technology is the property of Hebei University of Science & Technology, Journal of Hebei University of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Northeastern University (Natural Science) is the property of Dongbei Daxue Xuebao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The liver is an important metabolic and immune organ in human body. Exosomes are extracellular vesicles released by cells and carry a variety of molecules such as proteins, lipids, DNA, and RNA. Studies have found that exosomes play an important role in various liver diseases. This article elaborates on the role of exosomes in the pathogenesis of non-neoplastic liver diseases and related research advances in their role as biomarkers for disease diagnosis and therapeutic methods. It is pointed out that in-depth studies are needed to explore the biogenesis and release of exosomes and the exact mechanism of exosomes in liver diseases,in order to provide a basis for the prevention and treatment of non-neoplastic liver diseases. [ABSTRACT FROM AUTHOR]

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Capital Institute of Physical Education is the property of Shoudu Tiyu Xueyuan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Northeastern University (Natural Science) is the property of Dongbei Daxue Xuebao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)