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目的探讨10q24.3缺失导致全面性发育迟缓患儿的诊断方法。方法通过回顾性分析1例全面性发育迟缓患儿的临床资料以及患儿和患儿父母家系低深度全基因组拷贝数变异测序（CNVseq）和家系全外显子组测序（WES）的检测结果。结果患儿为10月龄男性，四大能区均有发育落后，并伴有特殊面容（眼距增宽、斜视、鼻梁低平、前额凸出、腭裂、高腭弓等），四肢肌张力低下等表现，CNVseq和WES基因检测发现患儿存在10q24.3新发杂合缺失，该区间包含基底细胞痣综合征基因SUFU和低镁血症、癫痫及智力发育迟滞关联基因CNNM2，局灶性节段性肾小球硬化伴神经发育综合征TRIM8基因，推测患儿发病的原因与SUFU基因和CNNM2基因以及TRIM8基因缺失高度相关。结论对全面性发育迟缓、特殊面容表现的患儿应尽早完善基因检测，以明确诊断，有利于判断预后。

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Control Theory & Applications / Kongzhi Lilun Yu Yinyong is the property of Editorial Department of Control Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aiming at the problem that speech enhancement networks have difficulty in extracting global speech-related features and are ineffective in capturing local contextual information of speech. This paper proposed a two-branch attention and U-Net-based time-domain speech enhancement method, which used a U-Net encoder-decoder structure and took the high-dimensional time-domain features obtained from a single-channel noisy speech after one-dimensional convolution as input. Firstly, this paper designed Conformer-based residual convolution to enhance the noise reduction ability of network by utilizing residual connection. Secondly, this paper designed a two-branch attention mechanism structure, which utilized global and local attention to obtain richer contextual information in the noisy speech, and at the same time, to effectively represent the long sequence features and extract more diverse feature information. Finally, this paper constructed a weighted loss function by combining the loss function in the time domain and frequency domain to train the network and improve the performance in speech enhancement. This paper used several metrics to evaluate the quality and intelligibility of the enhanced speech, the enhanced speech perceptual evaluation of speech quality(PESQ) on the public datasets Voice Bank+DEMAND is 3.11, the short-time objective intelligibility(STOI) is 95%, the composite measure for predicting signal rating(CSIG) is 4.44, the composite measure for predicting background noise(CBAK) is 3.60, and the composite measure for predicting overall processed speech quality(COVL) is 3.81, in which the PESQ is improved by 7.6% compared to SE-Conformer, and improved by 5.1% compared to TSTNN improved by 5.1%. Experimental results show that the proposed method achieves better results in various metrics of speech denoising and meets the requirements for speech enhancement tasks. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The U-turn task is one of the contents of autonomous driving research, and most of the solutions under the standard roads in cities cannot be implemented on non-standard roads. Aiming at solving this problem, this paper establishes a vehicle U-turn dynamical model and designs a multi-scale convolutional neural network to extract feature maps as the input of the agent. In addition, for the sparse reward problem in the U-turn task, this paper proposes a hierarchical proximal policy optimization algorithm that combines hierarchical reinforcement learning and proximal policy optimization algorithm. In experiments with simple and complex scenarios, this algorithm learns policies faster and has a higher success rate of U-turn compared to other algorithms. [ABSTRACT FROM AUTHOR]

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Chinese Mass Spectrometry Society is the property of Journal of Chinese Mass Spectrometry Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effectiveness and safety of endovascular treatment of basilar artery acute occlusion with stenosis. Methods The clinical data of 28 patients with basilar artery stenosis in situ and acute occlusion were retrospectively analyzed. They were treated with one or more endovascular treatment techniques within 6-8 h after onset. The National Institute of Health Stroke Scale（ NIHSS） and Glasgow coma scale（ GCS） were used to assess the patient’s neurological function during admission. The degree of vascular recanalization was evaluated by modified Thrombolysis In Cerebral Infarction（ m TICI）. Patient’s intracranial situation were assessed by MRI or CT 72 hours after surgery. The prognosis of patients were assessed at 90-day with Modified Rankin Scale. Results 25 patients（ 89. 3%） had good vascular recanalization and 3（ 10.7%） had poor vascular recanalization by intraoperative angiography. On 90 days follow-up,16 patients（ 57.1%） had better curative effect,12（ 42.9%） had poor curative effect and the mortality was 25%. There were no complications of endovascular therapy. Conclusion Endovascular treatment of basilar artery acute occlusion with stenosis is effective and safe. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Combining multiple observational data and ERA5 time-by-time reanalysis data, combined with a limited area wind field analysis method, the process of controlling the next fast-developing bow-shaped squall line of Hainan Island's subtropical high on April 22, 2020 was analyzed. The results show that under the background of the weaker environmental wind shear in Hainan Island, the interaction of gust fronts, ground β-mesoscale convergence lines, and small-scale thunderstorms quickly developed into a highly organized bow-shaped squall line, and a strong cold pool near the ground. Drive the storm to deviate from the average guided airflow and move quickly to the southeast. The divergent wind field obtained by the decomposition of the wind field more intuitively reflects the diagnostic information of the weather system than the original wind field. The high-altitude divergent wind field more clearly shows the convective development and the dissipated early high-altitude divergence on the original wind field. The ground mesoscale convergence line reflects the characteristics of strong ground convergence at the bow-shaped echo bulge and rapid advancement of the cold pool. The next 1h precipitation will be on the warm and wet inflow side near the convergence line. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

1岁以内起病良性癫痫综合征分类以发病年龄及有无家族史为主要标准,其临床特征及致病基因谱各具特点,但 又存在部分重叠。良性家族性新生儿惊厥主要致病基因是KCNQ2、KCNQ3;良性家族性新生儿-婴儿癫痫主要致病基因是 SCN2A、KCNQ2;良性家族性婴儿癫痫主要致病基因为PRRT2,其中KCNQ2基因突变是1岁以内良性癫痫综合征的共患病基 因。对癫痫患儿的早期识别仍具有重要意义,可避免过度诊疗及缓解家属心理压力。 [ABSTRACT FROM AUTHOR]

吉兰-巴雷综合征(GBS)是一种与感染有关的免疫介导的自身免疫性周围神经炎性疾病,其临床特征为四肢对称性、弛缓性、上行性麻痹,可伴颅神经受累、脑脊液蛋白细胞分离及周围神经电生理改变。近年来,有研究发现GBS是一组具有相似的临床表现和转归的临床综合征,各型临床表现复杂,容易漏诊、误诊。目前,该病的确切病因尚不明确。该病具有自限性,但部分患者会遗留较严重的后遗症。该文旨在对儿童GBS的发病诱因、发病机制、临床特点等进行综述,以提高临床医生对GBS的认识. [ABSTRACT FROM AUTHOR]

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

At present, the energy consumption of conventional natural gas deep decarbonization process is high, which are shown as follows: high temperature of the regenerator, large heat load of reboiler, simple heat exchange flow, small heat exchange network integration, and the high heat loss. A split desorption process was studied. In this process, two materials entered the regenerator to recover the heat of the top gas in the regenerator, and reduce the cooling water flow of overhead cooler, thereby reducing the heat load of reboiler and achieving a certain energy saving effect. The results showed that the split desorption process could save more energy than the conventional process. When the CO2 molar fraction in the feed gas was 3. 63%, the optimum split ratio was 0. 3, and then the purification effect was best. When the CO2 molar fraction in the feed gas was 20 %, the optimum split ratio was 0.4, and then the purification effect was best. When the second stock was selected for the feed position, it was recommended that the eighth plate should be selected as the optimum feed position. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to solve the problem of low accuracy of multi-target tracking, particles in particle filter are easy to disperse in the process of multi-speaker tracking. This paper presented a parallel particle filter algorithm and GPU-based K-means clustering multi-source localization method. The method first analyzed the particle filter to achieve multi-target tracking, data association process had a large amount of computation, and the particles gradually diverged with the emergence of multiple targets. In order to solve the problem of large amount of computation and particle divergence, this paper proposed a method of parallel particle filter and K-means clustering. Experiments show that, as the number of particles and the number of targets increases, the amount of computation increases exponentially and the particles scatter seriously. By using the GPU-based K-means clustering method, the particle filter multi-speaker tracking method has more convergent particle sets and higher tracking accuracy than the traditional particle filter tracking method. [ABSTRACT FROM AUTHOR]

Objective To study the expression of serum caveolin-1 (Cav-1) in patients with pulmonary hypertension (PAH) associated with chronic obstructive pulmonary disease (COPD), and to analyze its clinical significance. Methods According to whether combined with PAH, a total of 65 stable COPD patients were divided into COPD group [pulmonary systolic blood pressure (PASP) ＜40 mmHg, 35 cases] and COPD-PAH group (PASP ≥40 mmHg, 30 cases). Thirty healthy volunteers who received physical examination in our hospital during the same period were selected as normal control group. Baseline data, blood gas analysis, lung function indicators, and expression levels of Cav-1, IL-6, and TNF - α were compared. The receiver operating characteristic curve (ROC curve) was plotted and the optimal cut-off value for Cav-1 diagnosis of COPD combined with PAH was analyzed. Results The first second forced respiratory volume (FEV1)/forced vital capacity (FVC), FEV1 percentage of predicted value (FEV1%), and oxygen partial pressure [p(O2)] were lower in the COPD-PAH group and the COPD group than those in the control group, and the partial pressure of carbon dioxide [p(CO2)] and PASP were higher than those in the control group (P＜0.01). The p(O2) was lower in the COPD-PAH group than that in the COPD group, and the p(CO2) and PASP were higher than those in the COPD group (P＜0.01). The expression levels of Cav-1 were decreased gradually in the control group, COPD group and COPD-PAH group, while the expression levels of IL- 6 and TNF-α were increased gradually (P＜0.01). For predicting the risk of COPD combined with PAH, the area under the ROC curve was 0.902, the optimal cut-off value was 6.66 ng/ml with a sensitivity of 76.7% and a specificity of 85.7%. Cav-1 was consistent with the PASP results measured by Doppler ultrasound (Kappa value = 0.627). Conclusion The serum expression of Cav-1 is down-regulated in the patients with PAH associated with COPD, and Cav-1 can be a novel serum marker for the diagnosis of PAH associated with COPD. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Bioinformatics is the property of Bioinformatics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to solve the problem that the poor tracking accuracy of correlation filter algorithm under occlusion condition, this papre proposed a kernelized correlation filter tracking method using joint multiple blocks estimation. Firstly, it divided the target into several blocks adaptively according to the geometric features of the initial frame tracking box, and each block using the KCF method for tracking independently to get a combined confidence map. Then it took the location and scale of previous frame target as priori information sampling the search area, meanwhile, it used the weight density of the confidence map in the sample box as the observation value, achieved optimal estimation the candidate target using particle filter algorithm.Finally, blocks with lower confidence levels back-project to previous frame for occlusion detection to prevent template update mistakenly. The qualitative and quantitative experiment results show that compared with the original KCF algorithm, the tracking accuracy of the proposed method improves about 10% and it is robust to occlusion and scale change in some degree. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 观察沙库巴曲缬沙坦口服治疗中老年慢性心力衰竭（CHF）患者的治疗效果，并探讨其可能作用机 制。方法 CHF 患者 124 例（纽约心脏病学会心功能分级为 NYHA Ⅱ～Ⅳ级），随机分为观察组 51 例和对照组 73 例，观察组口服沙库巴曲缬沙坦（起始剂量 25或 50 mg，靶剂量 200 mg或最大耐受计量），2次/天，对照组口服血管 紧张素Ⅱ受体拮抗剂（ARB），两组均治疗6个月。治疗6个月时，判定两组疗效，分别于治疗前、后采集两组静脉血， 检测血清可溶性细胞凋亡因子（sFas）、可溶性细胞凋亡因子配体（sFasL）及N端B型利钠肽原（NT-proBNP）。Spear⁃ man相关分析 CHF患者血清 sFas、 sFasL 水平与血清 NT-proBNP 的相关性。结果 治疗后观察组无效 2例、有效 23 例、显效26例，治疗总有效率96. 08%（49/51），对照组分别为11、39、23例及84. 93%（62/73），两组治疗总有效率比 较，P<0. 05。观察组、对照组治疗前血清sFas水平分别为（2. 09 ± 0. 50）、（2. 00 ± 0. 51）ng/mL，治疗后分别为（1. 56 ± 0. 37）、（1. 83 ± 0. 49）ng/mL。观察组、对照组治疗前血清sFasL水平分别为（0. 36 ± 0. 17）、（0. 34 ± 0. 15）ng/mL， 治疗后分别为（0. 24 ± 0. 14）、（0. 29 ± 0. 10）ng/mL。观察组、对照组治疗前 LgNT-proBNP 水平分别为（2. 92 ± 0. 68）、（3. 02 ± 0. 72）ng/mL，治疗后分别为（2. 00 ± 0. 05）、（2. 18 ± 0. 51）ng/mL。治疗后两组血清 sFas、sFasL 及 LgNT-proBNP 水平与治疗前比较，P 均<0. 05；治疗后观察组血清 sFas、 sFasL 及 LgNT-proBNP 水平与对照组比较，P 均<0. 05。治疗前后患者血清 sFas、 sFasL 水平与血清 NT-proBN P 水平呈正相关（r 分别为 0. 412，0. 336；0. 345， 0. 456；P 均<0. 05）。结论 口服沙库巴曲缬沙坦治疗中老年 CHF 效果较好。沙库巴曲缬沙坦可能通过降低血清 sFas、sFasL水平改善CHF患者的临床症状。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to solve the problems that the existing dynamic hand gesture recognition method in a complex environment has a low recognition rate and poor real-time performance, and would be affected easily by the factors such as irrelevant skin color, illumination change, this paper proposed a dynamic gesture recognition algorithm. Firstly, this paper introduced the K-means clustering algorithm and the YCr'Cb' ellipse skin color model to segment the RGB-D image. Then, it introduced the depth information into the traditional Kalman filtering algorithm, which was regarded as one of the tracking parameters to process the detection range for adding windows in the tracking process. At last, it improved the traditional dynamic time warping algorithm by combining the fast dynamic time warping algorithm and the key feature points, and recognized the gesture with the improved dynamic time warping algorithm. The experimental results show that the proposed method has a relatively high recognition rate (96.8 + 1.5% )in complex background and good real-time performance (the recognition time is 1.86 + 0.02 ms). [ABSTRACT FROM AUTHOR]

This paper proposed a differential evolution particle fdter method based on parallel protocol of zero bank conflict, in order to solve the computational complexity of particle filtering in real-time systems. Firstly it analysed the memory access mode of parallel differential evolution particle filter algorithm in GPU. Then according to the relationship that the root mean square error was proportional to the degree of bank conflicts in memory access, it proposed a differential evolution particle fdter with fdled addressing mode to remove bank conflict,which reduced the computational complexity. It implemented the algorithm in NVIDIA GTX960 GPU, and compared with the serial differential evolution particle filter algorithm. As the number of particles increases, the amount of calculation increases exponentially. Theoretical analysis and simulation results show that the tracking algorithm using GPU acceleration is significandy reduced the execution time. It improves the tracking accuracy and reduces the computation effectively. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Mental Health Journal / Zhongguo Xinli Weisheng Zazhi is the property of Chinese Mental Health Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)