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Objective　To explore the correlation of early serum uric acid fluctuations in patients after the bariatric surgery. Methods　From January 2021 to June 2022，80 patients with the metabolic syndrome who were admitted to Yan'an Hospital of Kunming and completed the follow-up one month after the surgery were selected as the objective of this research experiment.And according to the serum uric acid index one month after the surgery， they were divided into group A with the increase of serum uric acid after the operation and group B with the decrease of serum uric acid after the operation. The BMI value and the changes of various biochemical indexes were compared between the two groups before and after the bariatric surgery. Results　Surgery method， postoperative protein intake，aerobic exercise and water intake were not the reasons for the fluctuation of serum uric acid in patients after weight loss（P > 0.05），and the changes in liver function also could not explain the changes in patients 1 month after weight loss（ P > 0.05） . The changes of blood sugar and triglyceride were the main reasons for the fluctuation of postoperative blood uric acid（P < 0.05）. The greater the decrease in triglycerides after the surgery，the less likely the increase in uric acid will occur.In addition，the increase of blood uric acid at 1 month after operation was greater than the decrease of blood uric acid after the operation，and the change of blood uric acid was correlated with the change of serum creatinine and monocyte/high-density lipoprotein（MHR）（P < 0.05）. The correlation coefficients were 0.204 and 0.511 respectively.respectively. Conclusion　The changes of triglyceride and blood sugar in the early postoperative period are the reasons for the increase or decrease of blood uric acid in patients with weight loss after the surgery，and the changes of blood uric acid are mainly affected by creatinine and monocyte/high density. [ABSTRACT FROM AUTHOR]