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为了促进黄丝藻胞内储能物质的高效积累，研究了不同氮形态（NO-3、Urea和NH+4）及初始氮浓度（1、3、6、9、18 mmol/L）对黄丝藻生长、碳水化合物和总脂积累的影响，在此基础上建立了基于氮调控促进黄丝藻生物量和储能物质同步高效积累的“低氮（初始氮浓度3 mmol/L）转高氮（初始氮浓度18 mmol/L）”两步法培养策略，并对两步法培养策略的培养时间进行优化。结果表明：与Urea和NH+4比较，黄丝藻更倾向于利用NO-3，分别在3 mmol/L和18 mmol/L条件下获得最高生物量（3.69 g/L）和总脂含量（57.3%）；在“低氮转高氮”两步法培养中，低氮培养时间6 d转高氮培养12 d可显著提高黄丝藻胞内储能物质的积累，储能物质产率最高，达到274.26 mg/(L·d)，其中生物量、总脂产率和碳水化合物产率分别为6.37 g/L、152.92 mg/(L·d)和121.35 mg/(L·d)。基于“低氮转高氮”的氮调控两步法是一种极具前景的培养模式，可在保证总脂产率相当的情况下显著提高生物量和碳水化合物产率。In order to promote efficient enrichment of energy storage compounds in Tribonema sp. , the effects of different nitrogen forms (NO-3, Urea and NH+4) and initial nitrogen concentration (1, 3, 6, 9, 18 mmol/L) on the growth, carbohydrate and lipid accumulation of Tribonema sp. were investigated. Then a two-step culture strategy from low nitrogen (initial nitrogen concentration 3 mmol/L) to high nitrogen (initial nitrogen concentration 18 mmol/L) based on nitrogen regulation was established to promote the simultaneous and efficient accumulation of biomass and energy storage compounds in the alga, and the culture time of the two-step culture strategy was optimized. The results indicated that the highest biomass concentration (3.69 g/L) and total lipid content (57.3%) were obtained at 3 mmol/L and 18 mmol/L of NO-3 in Tribonema sp. , respectively, compared with Urea and NH+4. In the two-step culture strategy of "low nitrogen to high nitrogen", 6 d of low nitrogen culture to 12 d of high nitrogen culture could significantly increase the accumulation of energy storage compounds in Tribonema sp. , and the highest energy storage compounds yield was 274.26 mg/(L·d), of which the biomass and yields of total lipid and carbohydrate were 6.37 g/L, 152.92 mg/(L·d), 121.35 mg/(L·d), respectively.The two-step nitrogen regulation based on "low nitrogen to high nitrogen" is a promising culture model that can significantly increase biomass and carbohydrate yield while ensuring comparable total lipid yield.

【Objective】The study was conducted to investigate the effect of acarbose on high-carbohydrate diet-induced liver injury in largemouth bass and to detect similar functional therapeutic drugs in the initial screening.【Method】 The largemouth bass (Micropterus salmoides) with an initial body weight of 7.25 (±1.67) g was taken as research object. First, a normal-level carbohydrate group (1.3% α-starch, CK) and a high carbohydrate group (22.0% α-starch, high carbohydrate group) were set up to induce high carbohydrate diet-induced liver injury. Then, largemouth bass with an initial body weight of 7.5 mg/kg was fed with acarbose to explore the therapeutic effects of acarbose on high carbohydrate diet-induced liver injury by using gross pathology, histopathology, enzymology, and flow cytometry. In addition, six candidate Chinese herbal medicines were screened by simulating the sugar control principle of acarbose, and their therapeutic effects on high carbohydrate diet-induced liver injury were preliminarily analyzed.【Result】Continuous feeding of high carbohydrates for 45 days could cause liver enlargement, whitening, and a significant increase in liver to body ratio in largemouth bass (P<0.05). After 15 days of treatment with acarbose, compared with the high carbohydrate group, the blood glucose level of largemouth bass decreased by 1.77 mol/L, ALT and AST activities decreased to 42.00 U/L and 157.67 U/L, respectively, while ALKP activity increased and showed a trend of returning to normal values, effectively slowing down hepatocyte vacuolization and reducing hepatic glycogen accumulation. The results of flow cytometry showed that the total apoptosis rate of liver cells in the high carbohydrate group was the highest at 4.64% among the three groups, while that of the acarbose group significantly decreased to 1.24% (P<0.05). In addition, compared with the control group, the ROS content in the liver tissue of largemouth bass in the high carbohydrate group increased to 30.94%, while that decreased to 22.35% in the acarbose group, showing a trend of returning to normal levels. After 15 days of treatment with 6 types of Chinese herbal medicine, the liver morphology was maintained and the liver to body ratio was reduced, however, there was no significant difference among different treatments (P>0.05). Among them, cinnamon treatment had a more significant effect, reaching the lowest liver to body ratio at 3.35%.【Conclusion】Acarbose can effectively alleviate liver enlargement in largemouth bass caused by high carbohydrate diets, reduce liver to body ratio, alleviate liver cell apoptosis and vacuolization, reduce liver glycogen accumulation, alleviate oxidative stress damage in the body, thus protect the health of largemouth bass. Among the six traditional Chinese medicines, cinnamon has a better therapeutic effect and has a similar effect to acarbose. It can be used as a candidate herbal medicine for further development and utilization to treat high carbohydrate diet-induced liver injury in largemouth bass. [ABSTRACT FROM AUTHOR]

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This paper reviewed the clinical data of a typical elderly paranoid schizophrenia (SP) patient, and experience of narrative nursing combined with nostalgia therapy was summarized. The multi-disciplinary team (MDT) made an assessment and diagnosis at the patient first, and then according to evidence-based search to develop intervention plans, which included drug therapy, physical therapy and rehabilitation and nursing intervention. Specifically, the nursing intervention was mainly about narrative nursing combined with nostalgia therapy. After the intervention, the patient's mental symptoms were effectively controlled, sleep quality and medication compliance were improved. The implementation of narrative nursing combined with nostalgia therapy is potentially effective to improve the mental rehabilitation the SP patient (本文回顾1例典型老年期偏执型精神分裂症(SP)患者的临床资料, 总结叙事护理联合怀旧疗法护理干预措施。通过多学科团队(MDT)评估、诊断, 再根据循证检索制定干预计划, 包括药物治疗, 物理治疗与康复, 护理干预等。老年科特色护理干预包括叙事护理、怀旧疗法和引导式认知训练等。经干预后患者精神症状得到有效控制, 睡眠质量和服药依从性得到改善。叙事护理联合怀旧疗法能够有效促进老年SP患者康复。)

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OBJECTIVE: To explore the ruxolitinib-associated infectious adverse events based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) database, so as to evaluate the safety of clinical use. METHODS: Reports of rucotinib-associated infectious adverse events were collected from the FAERS database from the fourth quarter of 2011 to the third quarter of 2023 by using the preferred system organ classification ( SOC) and preferred terminology (PT) in the Medical Dictionary for Regulatory Activities ( version 26. 1). The risk signal was detected and analyzed by reporting odds ratio (ROR) in ratio imbalance method. RESULTS: A total of 6 406 reports of ruxolitinib-associated infectious adverse events were collected. Ruxolitinib was detected as a risk signal for infection and infectious diseases at SOC level, ROR = 1. 52 (95%CI = 1. 48-1. 56). A total of 103 PT with risk signals were detected in the SOC for infection and infectious diseases, among which the most common PT were infectious pneumonia, infection, sepsis, urinary tract infection, herpes zoster, nasopharyngitis, influenza, bronchitis, tuberculosis, and phlegmonitis. Multiple infectious disease-associated PT were not documented in the drug instructions of ruxolitinib. CONCLUSIONS: When rucotinib is used clinically, attention needs to be paid to monitoring the emergence of infectious diseases to ensure the safety of medication for patients. [ABSTRACT FROM AUTHOR]

Objective To find the correlation between phosphatidylinositol kinase-3 catalytic subunit A gene (PIK3CA) mutation and pathological features as well as clinical prognosis of breast cancer. Methods The pathological data of 181 patients diagnosed with invasive breast cancer from January 2018 to January 2020 were collected. The estrogen receptor (ER), progestogen receptor (PR), human epidermal growth factor receptor-2 (HER2), Ki67 were examined by immuno-histochemistry (IHC).Mutation of exon 9 and exon 20 of PIK3CA were examined by quantitative real-time PCR (qPCR). Results Among 181 cases of invasive breast cancer, 70 cases had PIK3CA mutation with 31 cases (44.28%) showed exon 9 mutations and 39 cases (55.71%) showed exon 20 mutations. The difference between PIK3CA mutation and their distribution in molecular typing of breast cancer was statistically significant (P＜0.05). The expression of PIK3CA mutation in breast cancer with different Ki67 expression was significantly different (P＜0.05). There were 34 cases (48.57%) showed PIK3CA mutations in the HR+/HER2 group and 36 cases (51.43%) of non HR+/HER2 group mutations. There was a statistically significant difference in the distribution of PIK3CA mutations between 2 groups (P＜0.05). The death rate of PIK3CA mutation cases was higher than that of PIK3CA wild type cases (P＜0.05). Conclusions PIK3CA mutation is associated with molecular typing, Ki67 increment index and prognosis of breast cancer. Detection of PIK3CA mutation provides potential support to the development of precise treatment of breast cancer patients. [ABSTRACT FROM AUTHOR]

目的 建立接受水刀微创手术治疗的腋臭患者的标准化护理流程。方法 自 2022 年 2 月至 2023 年 3 月，海军军 医大学附属长海医院整形外科以文献回顾结合临床经验的方法确定腋臭患者水刀微创治疗的护理流程初稿，采用 Delphi 法对 院校护理系、医院护理专业、整形外科教授及手术室麻醉医护人员等共计 38 名专家实施咨询，确定最终标准化护理流程。 结果 通过分析两轮专家咨询结果，积极系数均为 100%，权威系数 Cr=0.90，最终确定一级条目 4 条，二级条目 9 条，三级条目 43 条。结论 本研究构建了腋臭患者水刀微创治疗的标准化护理流程，为优质临床护理提供理论依据。 [ABSTRACT FROM AUTHOR]

Objective To investigate the difference in intestinal flora among patients with esophageal squamous cell carcinoma and normal population and to provide a basis for the early diagnosis of esophageal squamous cell carcinoma as a marker. Methods DNA was extracted from biopsy tissue samples of 30 patients with esophageal squamous cell carcinoma (observation group) and 25 healthy people (control group) by microbial amplification sequencing. The integrity and quality of DNA were detected. The composition and abundance of intestinal flora in the samples of the two groups were determined. Results A great similarity in beta diversity was found between the two groups, but some differences were also observed. The relative abundance of Proteobacteria and Verrucomicrobia in the observation group was higher than that in the control group (P<0.05). The relative abundance of Megamonas in the observation group was lower than that in the control group (P=0.025). Conclusion Strengthening the study on the changes in intestinal flora among patients with esophageal squamous cell carcinoma may be of great significance for its prevention and treatment. [ABSTRACT FROM AUTHOR]

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