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目的 利用全脑磁共振血管壁成像（magnetic resonance vessel wall imaging，MR VWI）研究单发皮层下梗死（single subcortical infarction，SSI）患者早期神经功能恶化（early neurological deterioration，END）与豆纹动脉（lenticulostriate artery，LSA）的关系。 方法 回顾性分析邯郸市中心医院神经内二科2020年10月—2022年1月连续住院的不伴有脑大动脉狭窄的SSI患者，根据有无发生END分为END组和非END组，通过全脑MR VWI影像学方法评估LSA可视化程度，基底节区无法看到LSA记为LSA可视化差，LSA覆盖不到一半的基底节区域记为LSA部分可视化，LSA覆盖基底节区域一半以上的区域记为LSA可视化好。研究SSI患者发生END与LSA可视化程度之间的关系。 结果 本次研究共纳入77例患者，其中END组16例（20.78%），非END组61例（79.22%）。患者平均（62.21±11.03）岁，男性51例（56.7%）。END组入院时NIHSS评分[（6.13±2.09）分 vs.（5.08±1.76）分，P=0.046]、TC[（4.93±1.17）mmol/L vs.（4.34±0.76）mmol/L，P=0.018]、LDL-C[（2.92±0.69）mmol/L vs.（2.28±0.53）mmol/L，P=0.003]和LSA可视化差（50.0% vs. 18.0%，P=0.026）均高于非END组。多因素logistic回归分析显示，高LDL-C水平 (OR 5.008，95%CI 1.305～19.224，P=0.019）和LSA可视化差（OR 8.673，95%CI 1.094～68.788，P=0.041）是患者发生END的独立危险因素。 结论 高LDL-C水平和LSA可视化差是SSI且无脑大动脉狭窄患者发生END的独立危险因素。 Abstract: Objective To study the relationship between early neurological deterioration (END) and the morphology of lenticulostriate artery (LSA) in patients with single subcortical infarction (SSI) by using the whole brain magnetic resonance vessel wall imaging (MR VWI). Methods The clinical data of patients with SSI without middle cerebral artery stenosis from Department of Neurology of Handan Central Hospital from October 2020 to January 2022 were retrospectively analyzed. Patients were divided into END group and non-END group according to occurring END or not. The visualization degree of LSA was evaluated by whole brain MR VWI. The LSA not seen in the basal ganglia was marked as poor visualization of LSA; the LSA covering less than half of the basal ganglia was marked as partial visualization of LSA; the LSA covering more than half of the basal ganglia was marked as good visualization of LSA. The correlation between END and visualization degree of LSA in patients with SSI was analyzed. Results A total of 77 patients were included in this study, with an average age of 62.21±11.03 years and 51 males (56.7%). There were 16 patients (20.78%) in the END group and 61 patients (79.22%) in the non-END group. At the baseline, compared with the non-END group, the END group had a higher NIHSS score at admission (6.13±2.09 vs. 5.08±1.76, P=0.046), higher level of TC [(4.93±1.17) mmol/L vs. (4.34±0.76) mmol/L, P=0.018] and LDL-C [(2.92±0.69) mmol/L vs. (2.28±0.53) mmol/L, P=0.003] and a higher proportion of poor visualization of the LSA [8 (50.0%) vs. 11 (18.0%), P=0.026]. Multivariate logistic regression analysis showed that the high LDL-C level (OR 5.008, 95%CI 1.305-19.224, P=0.019) and poor visualization of LSA (OR 8.673, 95%CI 1.094-68.788, P=0.041) were independent risk factors for END. Conclusion High LDL-C level and poor visualization of LSA were independent risk factors for END in patients with SSI and without middle cerebral artery stenosis.

能量极小化方法已广泛用于平面曲线的构造，而在空间曲线构造方面的应用尚少。首先介绍了空间参数曲线的弯曲能和扭曲能，然后提出了一种以弯曲能和扭曲能同时极小为目标的空间参数曲线构造方法，最后以空间三次Bézier曲线为例，探讨了该方法在曲线的构造、延拓、平滑等问题中的应用。所提出的方法更符合空间参数曲线既需考虑弯曲又需考虑扭曲的特点。

为加快张量积型Said-Ball曲面渐近迭代逼近法的收敛速度，探讨了张量积型Said-Ball曲面渐近迭代逼近法的预处理技术。首先利用对角补偿约化技术构造了预处理子，然后结合矩阵Kronecker积性质，采取预处理渐近迭代逼近法求解张量积型Said-Ball曲面。为进一步降低计算量并提高算法的稳定性，利用广义极小残差法求解预处理方程，得到预处理渐近迭代逼近法的非精确求解方法。分析了预处理渐近迭代逼近法及非精确求解方法的收敛性。最后用数值实例说明预处理子能大大减小迭代矩阵的谱半径，令预处理技术及其非精确求解方法的计算效率明显提高。此外，由于对角补偿预处理子能改善配置矩阵的谱分布，因此也可用于对广义极小残差法的预处理，以改善其收敛性。

随着配电网中新能源装机规模的扩大，会带来配网负荷峰谷差增大及新能源消纳困难等问题。储能具有“低储高发”的特性，其已经被认为是削峰填谷、提高新能源消纳能力的有效手段。但目前储能成本仍较高，故如何配置储能并对其进行经济性评估分析是重要的。为此，综合考虑储能系统参与削峰填谷、提高新能源消纳能力的两种应用场景，计及套利收益、环境效益、政府补贴、投资建设成本和年运行维护成本等多维因素，建立储能系统的经济性评估总模型，通过算例对两种场景进行经济性分析。结果表明，在削峰填谷场景中，得到了不同电价差下，储能收益最大时的最优配置。在提高新能源消纳能力场景中，确定了在所设条件下，新能源消纳比例超过66%时储能系统开始盈利。

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The leadership of the Communist Party of China (CPC) constitutes the most essential characteristics of the Chinese-style modernization. Utilizing the unique analytical paradigm of "Party-Society", it is discovered that coordinating the overall national interests with local interests in rural areas, as well as harmonizing the national governmental authority with rural autonomy, forms the logical backbone of the CPC's advancement of modern rural governance. Guided by this logic, the CPC's macro strategic agenda for modernizing rural governance has undergone a transition from "revolution" to "integration", "reform" and "revitalization", while corresponding micro-level governance approaches have evolved from mobilization-oriented model to control-oriented, responsive and collaborative models. Upholding the core leadership position of the CPC in rural governance, fully respecting the principal status of rural people, and persistently developing and perfecting the socialist rural governance system with Chinese characteristics in practice, constitute the core principles guiding the CPC's drive towards modernization of rural governance in China. [ABSTRACT FROM AUTHOR]

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Objective To examine the changes in the expression levels of Pleckstrin homology domain family A member 4（PLEKHA4) in glioma tissues and its influencing factors. Methods Fifty-two cases of glioma tissues from surgical resection and 52 cases of their corresponding paraneoplastic tissues were selected, of which 21 cases were WHO grade Ⅰ-Ⅱ and 31 cases were grade Ⅲ-Ⅳ, and 23 cases were wild-type and 29 cases were mutant type of p53 typing. Immunohistochemistry and protein immunoblotting were used to detect the expression level of PLEKHA4 in the paracancerous tissues and glioma tissues of patients with glioma. We observed the clinical characteristics and prognosis of glioma patients with different expression levels of PLEKHA4, and analyzed the factors affecting the expression level of PLEKHA4 in glioma tissues. Results PLEKHA4 was positively expressed in glioma tissues of 52 patients, and the sites of expression were mainly in the cytoplasm and cell membrane of glioma tissues； no positive expression of PLEKHA4 was seen in the paracancerous tissues. The relative expression levels of PLEKHA4 in the paracancerous tissues, grade Ⅰ-Ⅱ glioma, and grade Ⅲ-Ⅳ glioma were 0. 419 ± 0. 101，0. 968 ± 0. 061, and 1. 366 ± 0. 096, respectively. The relative expression of PLEKHA4 in the glioma tissues was higher than that in paracancerous tissues, and the relative expression of PLEKHA4 was higher in glioma tissues of grade Ⅲ-Ⅳ than that in glioma tissues of grade Ⅰ-Ⅱ, respectively (both P<0. 05) . Significant differences were found in the WHO classification and p53 typing of patients with different PLEKHA4 expression levels in glioma tissues (both P<0. 05) . Logistic regression analysis showed that WHO classification and p53 typing of gliomas were the independent influencing factors for PLEKHA4 expression (both P<0. 05) . At 2-year postoperative follow-up, the survival rate of patients with high PLEKHA4 expression was 28. 6%, the survival rate of patients with low PLEKHA4 expression was 70. 8%, and statistically significant difference was found in the survival rate between them (P<0. 05) . Conclusion PLEKHA4 was highly expressed in glioma tissues, WHO typing and p53 typing of patients were the influencing factors of PLEKHA4 expression level in glioma tissues, and the PLEKHA4 expression level was related to clinical prognosis of patients. [ABSTRACT FROM AUTHOR]

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