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为了从根源上解决组织管理面临的数据、信任和时效不对称问题，提出面向Web 3.0的新型组织管理模式——加密管理。它以区块链为底层技术，以联邦数据为运行基础，以去中心化自治组织为组织形态，以智能合约为实现手段，以非同质化通证为激励机制，核心目标是在数据安全与隐私保护的前提下，实现可信、可靠与可用的实时管理决策。构建了加密管理的基本框架，讨论了其核心构成与实现模式，并以面向任务的人员绩效实时管理为例，介绍了其运作流程，最后探讨了该领域潜在的研究方向。

慢光在未来全光网络通信中具有重要作用。文章提出一种基于零对比度光栅共振诱导透明效应的可实现平面外慢光滤波的设计,该设计兼具优良的透射滤波功能和慢光效应。分析了刻蚀深度和光栅周期对慢光滤波性能的影响,指出刻蚀深度影响波导层对共振诱导模式的束缚,刻蚀深度的改变将显著降低零对比度光栅的慢光滤波性能;而光栅周期主要影响入射光与波导模的相位匹配,选取不同光栅周期可在C波段实现对不同慢光滤波通道的选择。此外,研究了斜入射条件的模式劈裂效应,指出由于斜入射条件下非简并共振波导模的激发,±1级劈裂模式被激发,其虽然导致峰值透射的降低,但可以显著提高透射慢光的群折射率。该研究为慢光器件的设计提供了一种新的解决方案。

在面對十二年國民基本教育政策變革的當下，教師增能為首要策略。而精進教學計畫正是教育部近年來推動課程與教學政策的整合型計畫，藉由規劃教師專業成長，來引領地方政府有系統的提升教師教學能力，進而增進學生學習成效。本研究旨在探討精進教學計畫中教師增能之策略與作法，以提供規劃有效教師專業成長方 案及實施之參考，使用文件分析，並邀請直轄市、縣（市）政府承辦人員、學校校長及教師進行焦點團體訪談來蒐集資料。整體研究目的有四：一、了解中央輔導地方辦理教師增能之策略；二、分析地方政府規劃及實施增能活動；三、探討學校辦理教師增能作法與成效；四、綜合規劃策略的初步成效提出未來建議。研究獲致之結論，分別為：一、專業成長方案規劃能把握規劃、實踐到評鑑的整體思維；研訂政策目標，引導規劃重點，研發多元模式，支持教師專業成長。二、溝通共識、瞭解需求、運用策略及提供資源；運用組織有層次有系統，採取精緻、實務與多元作法。三、行政人員積極參與學習，發展課程領導管理能力；行政與教學合作，檢視學校脈絡，逐步改變教師文化；找出教師需求，納入教師意見，應用有效成長模式規劃研習。四、能依據評估需求，選用方式進行評估；利用專業成長方案追蹤輔導機制，持續改進成效。根據結論提出 四點建議供參考。 At the moment of facing the Twelve-year compulsory education policy changes, teacher empowerment is the principal strategy. The enhancement teaching programs are the integrated projects which the Ministry of Education promotes curriculum and teaching policies in recent years. Through planning teachers’ professional development programs, it is to guide the local government systems enhancing teachers' teaching ability and improving student learning. This study aimed to explore the strategies and practices of professional development plan and provide references with an effective teacher professional development program planning and implementation. This study utilized document analysis and focus group interviews for collecting information. The local government administrators who are in charge in school education, school principles, and representative teachers were invited to attend the focus group discussion. There are four research goals: 1) to understand the strategies for teacher empowerment used by local government encouraged by the Ministry of Education; 2) to analyze the planning and implementation by the local government; 3) to explore the practices and effectiveness of teacher empowerment conducted by schools; 4) to synthesize the primary effectiveness of planning strategies and then make further recommendations. It is concluded: 1) the professional development project can obtain the holistic thinking of planning, practice, and evaluation. It also can set policy objectives, guide the keys of develop multiple modes, and support teacher professional development. 2) The project can communicate common ideas, know needs, utilize strategies and offer sources. It is systematic, hierarchical, and organized to adopt refined, practical, and multiple approaches. 3) The administrative staffs actively participated and learned. They developed the abilities of curriculum, leadership, and management. They cooperate the administration and teaching, examine the context of schools, change the culture of teachers gradually, discover the needs of teachers, receive teachers’ comments, and apply effective development modes to plan conferences. 4) The project can utilize appropriate ways to evaluate through the basis of evaluation needs. Through the professional development project continuing to advisory mechanism, the project can continue to improve its effectiveness.

家庭网关设备的功能和网络定位仅从运营商的基本需求出发,结合运营商网络基础,包括运营商的业务平台和管理平台,而对通过家庭网关接入的流量均统称为数据业务;同时,随着智能路由器和OTT（"过顶"）业务的兴起,家庭互联网业务和应用的入口被互联网企业持续渗透,运营商管道化趋势加剧。针对以上问题,文章从家庭网关和智能路由器在功能和定位上的异同入手,分析了二者融合的方式,提出了运营商通过智能型家庭网关进行入口竞争的可行性。

In Taiwan, Angiostrongylus cantonensis infection has been reported in foreign laborers who had consumed raw Ampullarium canaliculatus snails. This study analyzed three foreign laborers who had contracted enzyme-linked immunosorbent assay-confirmed A cantonensis infection while working in Taiwan. All three workers had consumed either roasted snails or raw snails flavored with seasoning while drinking wine. This study investigated possible risk factors for A cantonensis, including naturally occurring A cantonensis in A canaliculatus snails, viability of third-stage A cantonensis larvae in raw seasoned snails and in roasted snails, infectivity of larvae, and effects of alcohol while consuming snails. Positive infection rates in snails from five different irrigation canals in south Taiwan ranged from 12.3% to 29.4% and the average number of motile larvae per infected snail ranged from 36 to 65. The number of motile and coiled larvae in snail meat after 120 minutes seasoning was 93 (27.7%) and 233 (69.3%), respectively. After 20 minutes of roasting, most larvae in the snail meat were dead. The infectivities of motile and coiled larvae from snail meat after 60 minutes seasoning were 53.2% and 33.2%, respectively, and those from snail meat after 5 minutes roasting were 33.2% and 7.0%, respectively. Eating Taiwan A canaliculatus snails raw is extremely risky given their high infection rates and infection intensities. Even after 120 minutes seasoning or after 20 minutes roasting, snail meat should be considered unsafe for human consumption. Finally, experimental rodent studies indicated that consuming alcohol while ingesting larvae does not significantly reduced infectivity.

随着传输容量和传输距离的增加,光纤传输中信号的NLD（非线性损伤）已经成为限制光纤通信系统性能的主要因素之一。文章系统地总结了光域和电域NLC（非线性补偿）技术的最新发展动态,对各种NLC技术的机制、特点及其实用性进行了分析比较,并重点介绍了数字相干光通信系统中基于DSP（数字信号处理）的NLC技术,探讨了其未来的发展方向。

介绍光纤CATV网的网络设计和系统工程测试的关键技术,并对设计和工程中出现的具体问题给予合理解决。

Copyright of Journal of Zhengzhou University (Natural Science Edition) is the property of Journal of Zhengzhou University (Natural Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effects of long non-coding RNA (lncRNA) -AFAP1-AS1 and microRNA (miR) -195-5p on the biological behavior of hepatocellular carcinoma (HCC) cells. Methods Human HCC cell lines (HepG2, Hep3B, SMMC-7721, Bel7402, SK-hep1 cells) and normal human liver cells (HL-7702 cells) were routinely cultured. The expression levels of AFAP1-AS1 and miR-195-5p were detected by real-time fluorescence quantitative PCR to select the experimental cells. The experimental cells in logarithmic growth phase were randomly assigned to different groups： si-AFAP1-AS1 group, si-NC group, miR-195-5p mimics group, mimics-NC group, miR-195-5p inhibitor+si-NC group, miR-195-5p inhibitor+si-AFAP1-AS1 group, inhibitor-NC+si-AFAP1-AS1 group, and inhibitor-NC+si-NC group, respectively. Subsequently, the corresponding plasmids were transfected into the cells using Lipofectamine 2000 reagent based on the grouping. Cell proliferation was assessed by CCK-8 and colony formation experiments, while apoptosis and cell cycle were analyzed using flow cytometry. Cell migration and invasion capabilities were evaluated by Transwell experi­ment, and the targeted relationship between AFAP1-AS1 and miR-195-5p was confirmed via dual luciferase reporter gene assay. Results In HCC cells, AFAP1-AS1 expression was higher than that in normal liver cells (P<0. 05), while miR195-5p expression was lower than that of the normal liver cells (P<0. 05) . Given that SK-hep1 cells exhibited the highest AFAP1-AS1 expression and the lowest miR-195-5p expression, subsequent investigations were carried out using SK-hep1 cells for experimental purposes. Compared with the si-NC group, the si-AFAP1-AS1 group displayed reduced AFAP1-AS1 expression, decreased cell proliferation capacity, reduced migration and invasion cells, a higher cell population in the G0/ G1 phase, and an elevated apoptosis rate (all P<0. 05) . The Starbase v3. 0 online database predicted that there were complementary binding sites between AFAP1-AS1 and miR-195-5p. Findings from the dual-luciferase reporter gene assay indicated that there was significant difference in the relative luciferase activity between the miR-NC and miR-195-5p after cotransfection of WT-AFAP1-AS1 (P<0. 05), while no significant difference was found after co-transfection of MUT-AFAP1- AS1 (P>0. 05) . Compared with the inhibitor-NC+si-NC group, the si-NC+miR-195-5p inhibitor group demonstrated enhanced cell proliferation, increased migration and invasion, reduced cell population in the G0/G1 phase, and decreased apoptosis rate (all P<0. 05) . Conversely, the si-AFAP1-AS1+miR-195-5p inhibitor group exhibited the opposite cellular responses. Conclusion The lncRNA AFAP1-AS1 potentially plays a role in regulating various biological processes in HCC cells, including proliferation, migration, invasion, and apoptosis, through its competitive interaction with miR-195-5p. [ABSTRACT FROM AUTHOR]

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Copyright of Oilfield Chemistry is the property of Sichuan University, Oilfield Chemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Oilfield Chemistry is the property of Sichuan University, Oilfield Chemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Psoriasis is a common immune-mediated inflammatory skin disease with multiple genetic and environmental risk factors. Abnormal vascular hyperplasia, excessive proliferation of keratinocytes and infiltration of various immune cells are the main pathological features. MAPK signaling pathway is involved in the pathogenesis of psoriasis, and SPRED1 has been proved to be a major negative regulator of MAPK signaling pathway in many diseases. This article reviews the possible role of SPRED1 in the pathogenesis of psoriasis, in order to provide new insights into the pathogenesis of psoriasis and new directions for the treatment. [ABSTRACT FROM AUTHOR]

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Copyright of Guihaia is the property of Guihaia Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To analyze the correlation between TCM syndromes types of cervical vertigo and detection results of transcranial ultrasound cerebral artery blood flow. Methods: Patients with cervical vertigo admitted from May 2021 to May 2023 were selected as the research subjects. According to different TCM syndromes types, they were divided into phlegm-dampness retention group, liver-yang hyperactivity group, liver-kidney yin-deficiency group and qi-blood deficiency group, with 20 cases in each group. 30 patients with healthy physical examination were included in control group, and they were given Doppler ultrasound examination. The Doppler ultrasound features and cerebral artery blood flow changes [peak systolic blood flow velocity (Vs), mean blood flow velocity (Vm), peak diastolic blood flow velocity (Vd) and pulsatility index (PI) of left and right vertebral arteries, basilar artery and left and right middle cerebral arteries were analyzed among patients with different TCM syndromes types and control group. Results: Vs values of left and right vertebral arteries, basilar artery and left and right middle cerebral arteries in phlegm-dampness retention group, liver-kidney yin-deficiency group and qi-blood deficiency group were lower than those in control group(P<0.05). The Vs values of left and right vertebral arteries, basilar artery and left and right middle cerebral arteries in liver-yang hyperactivity group were higher than those in control group (P<0.05). Comparison of Vs among different TCM syndromes types groups was as follows: liver-yang hyperactivity group> phlegm-dampness retention group> liver-kidney yin-deficiency group > qi-blood deficiency group, and the Vs values of left and right vertebral arteries and basilar artery in phlegm-dampness retention group were significantly higher than those in control group (P<0.05) while the Vm values of left right middle cerebral artery were significantly lower (P<0.05). The Vm values of left and right vertebral arteries, basilar artery and left and right middle cerebral arteries were higher in liver-yang hyperactivity group than those in control group (P<0. 05), and were lower in liver-kidney yin-deficiency group than those in control group (P<0.05). The Vm values of left and right middle cerebral arteries in qi-blood deficiency group were lower compared with those in control group (P<0.05), and there were no significant differences in Vm values of left and right vertebral arteries and basilar artery compared to control group (P>0.05). Vm comparison of different TCM syndromes types groups was shown as liver-yang hyperactivity group> phlegm-dampness retention group > qi-blood deficiency group > liver-kidney yin-deficiency group. Compared with control group, the Vd values of left and right vertebral arteries and basilar artery in phlegm-dampness retention group were lower (P<0.05) while the Vd values of left and right middle cerebral arteries were higher (P<0.05). The Vd values of left and right vertebral arteries, basilar artery and left and right middle cerebral arteries were lower in liver-yang hyperactivity group than those in control group (P<0.05). The Vd values of left and right vertebral arteries and middle cerebral artery in liver-kidney yin-deficiency group were lower than those in control group (P<0.05), and there was no difference in basilar artery Vd compared to control group (P>0.05). The Vd values of left and right vertebral arteries in qi-blood deficiency group were lower than those in control group (P<0.05), and there was no significant difference in basilar artery Vd compared with that in control group (P>0.05), and the Vd values of left and right middle cerebral arteries were significantly higher than those in control group (P<0.05). Vd in different TCM syndromes types groups was as follows: qi-blood deficiency group phlegm-dampness retention group> liver-kidney yin-deficien- cy group > liver-yang hyperactivity group. The PI values of left and right vertebral arteries, basilar artery and left and right middle cerebral arteries in phlegm-dampness retention group and qi-blood deficiency groups were lower than those in control group (P<0.05). The PI values of left and right vertebral arteries, basilar artery and left and right middle cerebral arteries were higher in liver-yang hyperactivity group and liver-kidney yin-deficiency group than those in control group (P<0.05). Comparison of PI in different TCM syndromes types groups was manifested as liver-yang hyperactivity group liver-kidney yin-deficiency group phlegm-dampness retention group> qi-blood deficiency group. Conclusion: Patients with vertigo of different TCM syndromes types have different degrees of cerebral arterial hemodynamic abnormalities, and there are differences among different groups. Transcranial Doppler ultrasound examination can provide reference value for the TCM syndromes types of vertigo. [ABSTRACT FROM AUTHOR]

Objective To investigate the incidence of malignant tumors in type 2 diabetes mellitus (T2DM) patients and the effect of fasting blood glucose (FBG) on the incidence. Methods A record linkage was carried out between Cancer Registry System in Shanghai and the electronic health record (EHR) of residents in Minhang District during 2004-2020, then a retrospective cohort study was conducted for analysis. Fasting blood glucose classification was conducted with Q1 group (<7.0 mmol/L), Q2 group (7.0-7.9 mmol/L), Q3 group (8.0-9.7 mmol/L), and Q4 group (≥9.8 mmol/L). To quantify the hazard and effect on the risk of cancer incidence in diabetic patients, the Cox regression model and restricted cubic splines (RCS) were used. Results The study included 70 361 subjects in total, with a male to female ratio of 49.03% to 50.97%, an average age of (63.15±10.56) years, and an average follow-up time of (9.25±4.38) years. Malignant tumor incidence rate was 868.14/100 000 person years, while male 939.87/100 000 person years, female 801.85/100 000 person years, respectively. And the incidence of malignant tumor decreased with the duration of the disease (P<0.05). With an OR of 1.44 (95%CI: 1.33-1.56), Q3 group had the highest influence on the incidence of malignant tumors in multivariate analysis when compared to Q1 group. After adjusted the impact of age, the RCS graphs revealed a nonlinear trend in which the incidence of malignant tumors increased initially, then slowed down or decreased with an increase in mean glucose fasting, and the difference was statistically significant (Pnonlinear<0.05). Conclusion With high incidence of malignant tumors in T2DM patients, the impact of glucose fasting on the incidence of malignant tumors does not depend entirely on the concentration. [ABSTRACT FROM AUTHOR]

The molecular structure and application properties of four types of acrylamide polymers were summarized, such as anionic polymer, cationic polymer, zationic polymer of polymer and nonionic polymer, and put forward suggestions for the development of heat-resistant acid thickener. It is expected to provide a reference for the development and utilization of deep high temperature, low permeability and extremely low permeability unconventional oil and gas fields. [ABSTRACT FROM AUTHOR]

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