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Objective: To investigate the effect of ademetionine 1,4-Butane Disulfonate combined with ursodeoxycholic acid on liver function and pregnancy outcome in patients with intrahepatic cholestasis during pregnancy(ICP). Methods: A total of 96 patients with ICP, who were admitted to Panyu District Central Hospital of Guangzhou from January 2016 to October 2017, were selected and randomly divided into observation group(n=48) and control group(n=48). The patients in the two groups were given routine basic treatment, on the basis of which, the control group was given ursodeoxycholic acid, and the observation group was given ademetionine 1,4-Butane Disulfonate treatment on the basis of the control group's therapy. The improvement time of itching and jaundice and the results of bile acid and liver function indexes before and after treatment in the two groups were compared. The prognosis of maternal and infant in the two groups was observed and compared. Results: The improvement time of the itching and the jaundice in the observation group was less than that in the control group(P 0.05). There were no significant differences in the levels of total bile acids(TBA),glucocholic acid(CG), alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBiL) and direct bilirubin(DBiL) between the two groups before treatment(P0.05). After treatment, the levels of TBA, CG, ALT, AST, TBiL and DBiL in the two groups were lower than those before treatment, and the observation group was lower than the control group(P0.05). The incidence of amniotic fluid pollution, fetal distress, premature delivery, cesarean section and neonatal Apgar score 7 scores of the observation group were lower than those of the control group(P 0.05). There was no significant difference in the incidence of postpartum hemorrhage and stillbirth between the two groups(P 0.05). Conclusion: Ademetionine 1,4-butanedisulfonate combined with ursodeoxycholic acid can effectively improve the symptoms and liver function of ICP and reduce the risk of poor maternal and infant prognosis, which can be used as a preferred treatment plan. [ABSTRACT FROM AUTHOR]