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目的评价含泊马度胺全口服治疗方案二线治疗多发性骨髓瘤的疗效与安全性。方法回顾性分析2020年3月至2023年12月在我中心接受含泊马度胺全口服方案作为二线治疗的多发性骨髓瘤患者共22例，评价其疗效与安全性。结果22例患中位年龄为71.5岁，含泊马度胺的全口服二线治疗方案包括IPD 7例，PCD 11例， XPD 2例，PD 2例，中位治疗周期数为14，二线治疗ORR为63.64%，VGPR以上疗效为 36.36%。有来那度胺暴露史的13例患者中，ORR为53.85%， VGPR以上疗效为23.08%；无来那度胺暴露史的9例患者中， ORR为77.78%，VGPR以上疗效为55.56%；两组ORR比较，差异无统计学意义（P=0.38）。伴遗传学高危的患者12例，ORR为50%，VGPR以上疗效为16.67%。整体中位随访时间10.6（2.0，39.3）个月，10例出现疾病进展，其中6例因原发病进展死亡，中位无进展生存期（PFS）尚未达到；其中来那度胺暴露的13例患者，中位PFS为10.6个月；非来那度胺暴露的9例患者，中位PFS未达到。≥3级不良事件占18.18%，包括粒细胞缺乏、血小板减少及肺部感染。没有导致死亡的治疗相关不良事件的发生。结论含泊马度胺全口服方案二线治疗多发性骨髓瘤具有较好的疗效及安全性，对有居家治疗意愿的老年多发性骨髓瘤患者具有积极的意义。

【目的】探讨RNA干扰膜结合型前列腺素E2合酶1（mPGES-1）对阿霉素耐药的人红白血病细胞株K562/A细胞增殖、凋亡及耐药性的影响及其可能的机制。【方法】通过RNA干扰技术抑制K562/A细胞中mPGES-1表达。分组：①未处理组（K562/A），②干扰后的阴性对照组（K562/A-NC），③干扰组（K562/A-KD），④干扰后加入外源性PGE2组（K562/A-KD+PGE2）；CCK-8法检测细胞活力；流式细胞术检测细胞凋亡；ELISA法检测PGE2浓度；Western blot检测蛋白水平。【结果】RNA干扰可明显下调K562/A细胞mPGES-1表达，抑制PGE2合成（

This article used Fu tea as raw material to compare the physical properties, micro-structure, active ingredient content and in vitro antioxidant, hypoglycemic and hypolipidemic activities of Fu tea powder with different particle sizes after micro-crushing to determine the optimal grinding degree of Fu tea powder. The results showed that the particle size D50 of 200 mesh Fu tea powder was 76.45±4.32 µm, the angle of repose was 50.3°, the slip angle was 47.0°, the water holding capacity was 2. 477 g/g, the oil holding capacity was 1.934 g/g, and the polysaccharide content was 11.9%, the polyphenol content was 37.1%, the DPPH clearance rate was 80.4%, the a-glucosidase inhibition rate was 72.7%, the cholate binding rate was 71.6%, and 200 mesh is the optimal crushing size of Fu tea powder. This study will provide a theoretical reference for raw material processing of Fu tea powder hypoglycemic and hypolipidemic functional food. [ABSTRACT FROM AUTHOR]

BACKGROUND: There is an internal relationship between hyperhomocysteinemia and vascular calcification. However, the pathogenesis of hyperhomocysteinemia promoting vascular calcification is still unclear. OBJECTIVE: To investigate the role of bone morphogenetic protein-2 in hyperhomocysteinemia-induced vascular calcification. METHODS: Human carotid wax samples were divided into a calcified group (n=29) and a non-calcified group (n=13) according to the presence or absence of calcified plaque. Sixteen ApoE-/- mice were randomly divided into a control group and a hyperhomocysteinemia group, with 8 mice in each group. Bone morphogenetic protein-2 vector was used to transfect rat thoracic artery smooth muscle A7r5 cells, and gradient concentration of homocysteine (50, 100, 200, and 400 μmol/L) was utilized to treat A7r5 cells. Calcification was detected by alizarin red staining and hematoxylin-eosin staining. The interaction of bone morphogenetic protein 2 with Runt-related transcription factor 2 was detected by immunofluorescence, and the expressions of bone morphogenetic protein 2, Runt-related transcription factor 2, and α-smooth muscle actin were detected by immunohistochemistry and western blot assay. RESULTS AND CONCLUSION: (1) Human carotid artery tissue staining revealed that compared with the non-calcification group, inflammatory cells increased and calcification positive rate increased in the calcification group (P < 0.05). Compared with the non-calcification group, the expressions of bone morphogenetic protein-2 and Runt-related transcription factor 2 were up-regulated, and the expression of α-smooth muscle actin was decreased in the calcification group (all P < 0.05). (2) The staining of mouse arterial specimens exhibited that, the positive rate of calcified area in the hyperhomocysteinemia group was significantly higher than that in the control group (P < 0.05); serum homocysteine level in the hyperhomocysteinemia group was significantly higher than that in the control group (P < 0.05). Compared with the control group, the expressions of bone morphogenetic protein-2 and Runt-related transcription factor 2 were up-regulated, and the expression of α-smooth muscle actin was decreased in the hyperhomocysteinemia group (all P < 0.05). (3) A7r5 cell culture analysis demonstrated that with the increase of homocysteine concentration gradient, the degree of calcification, the content of bone morphogenetic protein-2 and Runt-related transcription factor 2 protein in A7r5 cells increased (P < 0.05), and the content of α-smooth muscle actin protein decreased (P < 0.05). (4) The A7r5 cell culture analysis of overexpressed bone morphogenetic protein 2 showed that the calcification degree of the overexpressed bone morphogenetic protein 2 group was increased compared with the corresponding control group, the β-sodium glycerophosphate group, and the homocysteine group. RUNtrelated transcription factor 2 expression up-regulated (P < 0.05) and α-smooth muscle actin expression down-regulated (P < 0.05). (5) The expression of bone morphogenetic protein 2 increased in A7r5 cells cultured with homocysteine in calcified medium, and the expression of Runt-related transcription factor 2 increased with the increase of bone morphogenetic protein 2 expression. (6) The results confirm that bone morphogenetic protein-2 is a key target gene in the regulation of smooth muscle cell phenotypic transformation resulting in vascular calcification by hyperhomocysteinemia. Targeted regulation of bone morphogenetic protein-2 reduces hyperhomocysteinemia-induced vascular calcification. [ABSTRACT FROM AUTHOR]

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The application of Internet technology in daily life is becoming increasingly widespread, which not only affects the way the government interacts with society, but also brings new social issues and governance challenges. Among them, the political trust issues related to social stability require particular attention. Previous studies on the political impact of Internet use in China have largely failed to distinguish between different ways of Internet use, and there is also a lack of classification and comparison of research on the intermediary mechanisms of Internet impact on political trust. This article selects rational choice and social capital as research perspectives from two major sources of political trust: institutionalism and culturalism. Using JSNET 2014 survey data, it explores the direct and intermediary effects of Internet use on political trust, and compares the differences in effects brought about by different Internet use methods. By analyzing the logical relationship between the vertical and horizontal information dissemination mechanism in the Internet era through the government performance evaluation and social capital construction; the Internet usage can be divided into four types: collective intervention-social orientation, collective intervention-entertainment orientation, individual intervention-social orientation, and individual intervention-entertainment orientation. This paper explores the characteristic orientation and political impact of each type of behavior. Overall, Internet use negatively affects political trust, but the direct impact of different Internet use methods on political trust is different. It is also found that both government performance evaluation and social capital construction are the intermediary mechanisms for the indirect impact of the Internet on political trust, but they have the opposite effect. Specifically, government performance evaluation is the main intermediary path for the negative impact of the Internet on political trust, while social capital construction has, to some extent, suppressed the negative impact of the Internet on political trust. It is speculated that the information dissemination mechanism of the internet conforms to the logic of bottom-up social capital construction. Moreover, the direct and indirect effects of different internet usage on political trust are different, which may be due to the fact that the political relevance of different types of internet use is essentially different. Social orientation is a relatively stronger influencing factor, and the weakening effect of individual intervention on trust and participation does not offset the positive impact of social orientation. This research answers the question of “how Internet use affects political trust” from the perspectives of usage patterns and intermediary mechanisms, which helps to dialectically view the positive and negative effects of information technology. The research conclusions also have certain policy implications. Political trust is the embodiment of the tension between government and society. The government needs to implement effective policy measures to gather public opinion to ensure the legitimacy of governance, which is the embodiment of national governance ability. The institutionalist research path reflects this top-down power operation logic. People need to enhance trust through spontaneous political participation to maintain their political rights, which is a demand from society. The path of cultural research reflects this bottom-up social impact process. The Internet technology can be used not only as a tool for government empowerment by improving governance capabilities and upgrading governance models, but also as a channel for public empowerment by promoting citizens' political participation and driving political and social collaboration and co-governance, which further increases the complexity and uncertainty of the relationship between the government and the public, and has an inherent logical correspondence with the two types of research paths of political trust sources. [ABSTRACT FROM AUTHOR]

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目的：分析公共卫生护理在社区卫生机构中的作用。方法：选取2022年7月-2023年7月本院92例社区卫 生机构慢性病患者开展研究，随机平均分为对照组46例，行常规护理，观察组46例，联合公共卫生护理，比较两组 心理状态, 相应指标改善情况, 生活质量和治疗依从性。结果：观察组的SF-36评分, 定期检查, 规律用药, 调整饮 食, 坚持锻炼评分和HDL均明显高于对照组，SAS, SDS评分, 2hPG, 血压, HbA1c, LDL, TG, TC, BMI和FBG 均明显低于对照组（P ＜ 0.05）。结论：在社区卫生机构中实施公共卫生护理，能有效防控慢性病，提升身心健康水 平，患者依从性更高，具有推广价值。 [ABSTRACT FROM AUTHOR]

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In this paper, the effect of streptozotocin (STZ) on gonadal function in diabetic mice was studied. Seventy male Kunming mice were randomly divided into control group (10 rats) and model group (60 rats). Model group was intraperitoneally injected with STZ (75 mg./kg) for 2 days, 1 time/d,and the control group. The citrate buffer was injected intraperitoneally. Fasting blood glucose (FBG) was measured 72 hours after the last injection, and the mice in the model group with blood glucose≥11. 1 mmol/L were taken for follow-up test. Fasting blood glucose was measured at 7 d, 14 d,21 d and 28 d,and the mating experiment was carried out. The number of straddles and the number of matings were sacrificed after the 28 d mating experiment, and serum testosterone levels were determined. The results showed that compared with the control group,the blood glucose of the model group was sig-nificantly increased at 7 d,14 d.21 d and 28 d after STZ injection (P<0.05); and the number of straddles in the mating test at 7 d, 14 d,21 d and 28 d and The number of matings was significantly reduced (P<0.05,P<70.01), and serum testosterone levels were significantly decreased in 28 d mice (P<0. 01). Therefore,STZ low-dose multiple intraperitoneal injection can successfully induce hypogonadism in diabetic mice. [ABSTRACT FROM AUTHOR]

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Water- carbon nexus is one of the important research fields of regional sustainable development. Studies on industrial carbon and water footprint efficiency from the perspective of water- carbon coupling not only help reveal the impact mechanism of the resource consumption intensity and efficiency on industrial carbon emissions, but also have great significant practical meanings for reducing water and carbon emissions in regional industrial transformation under the background of globalization. By the method of input-output analysis, input- output table of Henan in 2012 and industrial water and energy consumption data were applied to discuss industrial carbon and water footprint efficiency in this paper. The conclusions are as follows: (1) Carbon and water footprints of different industries are unmatched. The agricultural water footprint is the largest, which is 2333 times of the water footprint of lumbering. The carbon footprint of extractive industry is the largest, which is 273 times of food industry. (2) There are obvious differences among industrial water and carbon footprint efficiency. In general, the water/carbon footprint efficiency is lower in the industries with higher water/carbon footprint. (3) The different water/carbon footprint efficiency among different industries were mainly influenced by industry attribute, water and carbon consumption intensity, energy structure, technological level and relationship between industries, etc. (4) In the future, Henan province should make differentiated water-saving and carbon emission reduction policies in industrial development by combining the characteristics of different industries and the water- energy nexus, strengthening institutional constraint and legal supervision, promoting water and energy efficiency of enterprises, and enhancing regional adaptation and mitigation capacity under climate change. [ABSTRACT FROM AUTHOR]