1. ADRB2、FCER2、IL-13及IL-4基因多态性与环境因素 对儿童哮喘易感性交互影响.
- Author
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杨明明, 陈又华, and 周 瑜
- Abstract
Objective To investigate ẞ2-adrenergic receptor (ADRB2) rs1042713, immunoglobulin E high affinity receptor 2 (FCER2) rs28364072, interleukin-13 (IL-13) rs20541 and interleukin-4 (IL-4) rs2243250 gene polymorphisms, environmental factors and their interactions on the incidence of childhood asthma in Chongqing, aiming to provide scientific basis for the early diagnosis and effective prevention and treatment of childhood asthma. Methods A total of 88 children with asthma who visited the pediatric asthma clinic of the hospital from November 2020 to September 2022 were selected as the case group, and 80 non- asthmatic healthy children who underwent physical examination in the children's health care department of the hospital during the same period were selected as the control group. The demographic data of the two groups were collected, and the target genes were detected by multiplex polymerase chain reaction (PCR) combined with high-throughput sequencing technology. Logistic regression was used to analyze the effect of environmental factors on childhood asthma, and generalized multifactor dimensionality reduction (GMDR) was used to deeply explore the interaction between genes and environment. Results Cockroach exposure (OR = 2.791,95%CI 1.353-5. 353-5.757,P=0.005) and pet exposure (OR=3.055,95% CI 1.453-6.423,P=0.003) were significant risk factors for asthma in children, and the differences were statistically significant. There were significant differences in the genotype distribution of rs1042713, rs28364072 and rs20541 between the two groups (P<0.05). There was no significant difference in the genotype distribution of rs2243250 between the two groups (P>0.05). There was no significant difference in the genotype distribution of rs2243250 between the two groups (P<0.05). Conclusion Cockroach and pet exposure are important factors that increase the risk of childhood asthma in Chongqing, and the rs1042713, rs2836072 and rs20541 gene polymorphisms are closely related to the susceptibility to childhood asthma. The interaction of these gene polymorphisms and environmental factors affects the risk of childhood asthma. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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