Agricultural soils are seriously polluted by heavy metals especially by cadmium (Cd) and arsenic (As), which are difficult to be degraded thus being transferred and accumulated via the food chain, posing great risk to food safety and human health. Strategies for heavy metals contaminated soils remediation include solidification and stabilization, chemical leaching, electro-based remediation, microbial remediation, and phytoremediation. Specifically, based on high resistance, mobilization and efficient uptake of hyperaccumulating plants and the roles of rhizosphere microbes in enhancing phytoremediation, microbe-plant combined remediation attracts increasing attention and shows application potentials. This review focuses on Cd and As pollution in agricultural soils and crops and the associated remediation technologies, describes the pollution status of Cd and As in soils, illustrates the research progress of microbe (arbuscular mycorrhizal fungi, endophytes and rhizosphere growth promoting bacteria)-plant (Se - dum alfredii, Solanum nigrum, Populus deltoids, Pteris vittata, Pinus sylvestris ) combined remediation of Cd/As- contaminated farmland soils, discusses the remediation mechanisms (heavy metals resistance, detoxification, mobilization, translocation and microbe-plant symbiosis). In particular, the remediation efficiency, mechanism, application condition, affecting factors and application prospects of different microbe-plant combined remediation technologies are discussed. Reasonable use of microbe-plant combined remediation technologies can amplify the independent effects of the plant and the microorganism, thereby increasing the efficiency of phytoremediation. The information provides theoretical basis and technical supports for improving remediation efficiency of Cd/As contaminated agricultural soils to ensure soil planting safety and food safety. [ABSTRACT FROM AUTHOR]