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Objective: To investigate the protective effect of ginsenoside Rg1 on cardiac injury in the rats with severe acute pancreatitis(SAP），and to elucidate the related molecular mechanisms. Methods: The SD rats were randomly divided into control group，model group and Rg1 treatment group，with 6 rats in each group. The abdominal cavity of the rats in control group was closed after laparotomy；the rats in model group were retrogradely injected with 5% sodium taurocholate (0. 15 μL·kg－1） into the biliopancreatic duct to induce SAP after laparotomy；the rats in Rg1 treatment group were injected with Rg1 (4 mg·kg－1）via the tail vein 30 min before operation of preparing the SAP model；the rats in control group and model group were injected with normal saline 30 min before operation. Enzyme linked immunosorbent assay(ELISA）method was used to detect the levels of serum tumor necrosis factor-α(TNF-α），endotoxin， endothelin 1(ET-1），interleukin-1β(IL-1β）and the activities of serum creatine kinase-MB(CK-MB）， cardiac troponin I(cTnI） and mylase of rats in various groups. Ultrasound imaging system was used to detect the heart rate(HR），left ventricular end-systolic diameter(LVDs）and left ventricular end-diastolic diameter(LVDd）of rats in various groups and calculate the fractional shortening(FS）. Western blotting method was used to detect the expression levels of NADPH oxidase(NOX）2 and NOX4，phosphorylated p38(p-p38），phosphorylated extracellular regulated protein kinase 1/2( p-ERK1/2） and phosphorylated c-Jun N-terminal kinase(p-JNK）proteins in myocardium tissue of rats in various groups. Results: Compared with control group，the levels of TNF- α，endotoxin，IL-1β and ET-1 in serum of the rats in model group were significantly increased (P<0. 05）；the activities of CK-MB，cTnI，and amylase were significantly increased(P<0. 05）. Compared with model group，the levels of TNF- α，endotoxin，IL-1β and ET-1 in serum of the rats in Rg1 treatment group were decreased(P<0. 05），and the activities of CK-MB，cTnI， and amylase were decreased(P<0. 05）. Compared with control group，the HR and LVDs of the rats in model group were significantly increased(P<0. 05），the LVDd had no significant difference(P>0. 05）， and the FS was significantly decreased(P<0. 05）；compared with model group，the LVDs of the rats in Rg1 treatment group were significantly decreased(P<0. 05），the LVDd had no significant difference(P> 0. 05），and the FS was significantly increased (P<0. 05）. The Western blotting results showed that compared with control group ，the expression levels of NOX2 ，NOX4 ，p-p38，p-ERK1/2 and p-JNK proteins in myocardium tissue of the rats in model group were significantly increased (P<0. 05 or P< 0. 01）；compared with model group，the expression levels of NOX2 ，NOX4 ，p-p38 ， p-ERK1/2 and p-JNK proteins in myocardium tissue of the rats in Rg1 treatment group were significantly decreased(P< 0. 05）. Conclusion: Rg1 has a protective effect on cardiac injury in the SAP rats，and its mechanism may be related to reducing myocardial tissue oxidative stress by inhibiring MAPK signaling pathway. [ABSTRACT FROM AUTHOR]

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本文用碳纤维制成光透电极，用电化学与紫外光谱联用技术研究了多巴胺在碳纤维电极上的电氧化，测定了式电位和反应的电子转移数，并求得了多巴胺的标准电极反应速率常数.由其紫外吸收的红移现象证明多巴胺在电极上氧化的初级产物是醌式结构.本文同时发现了其氧化产物的后继反应，用单电位阶跃计时吸收法测定了后继反应的速率常数，并提出了可能的后继反应机理.

Copyright of Tunnel Construction / Suidao Jianshe (Zhong-Yingwen Ban) is the property of Tunnel Construction Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Science & Engineering (1673-2812) is the property of Journal of Materials Science & Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observed the effects of saxagliptin and metformin monotherapy on bone metabolism and body fat distribution in patients with newly diagnosed type 2 diabetes. Method Sixty patients with newly diagnosed T2DM who visited endocrinology outpatient department of our hospital from October 2016 to June 2017 were randomly divided into the saxagliptin treatment group (Sax, n=30) and the metformin treatment group (Met, n=30) for a 24⁃week treatment. At the baseline and 24 weeks after treatment, general information, glycometabolism and lipid metabolism index, Inflammation index, bone metabolism index (25(OH)D3, β-CTx, OC, tPINP), BMD (L1-L4, FN) and Body Fat Distribution (Fat%, VAT. Area, A/G, FMI) were measured. Paired t was used to compare pre-and post treatment effect within group. Difference between groups was analyzed using independent samples t test, and the non-normal distribution data was tested with rank sum test. Results After 24 weeks of intervention, body mass index (BMI), body weight, waist circumference, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), insulin resistance index (HOMA-IR), total Cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), hypersensitive C-reactive white (hs-CRP), VAT.Area, Fat%, A/G, and FMI were all significantly decreased (Met group: t=2.1-8.3; Sax group: t=1.9-6.9; all P<0.05). Islet cell secretion index (HOMA-β), OC, 25 (OH) D3 increased significantly [Met group:HOMA-β:51.29(34.66)vs 36.16(37.20),OC:(17.27±4.86)vs (14.16±4.12) ng/ml, 25(OH)D3: (18.89±6.06)vs(14.64±5.74) ng/ml, t=-1.6,-5.6,-8.2; Sax group:HOMA-β: 54.40(29.36)vs 50.78(42.64), OC:(17.93±3.81)vs(14.30±3.77) ng/ml, 25(OH)D3: (19.01±6.17)vs(14.13±5.06) ng/ml, t=-0.5,-7.8,-8.0, all P<0.05];the left femoral neck BMD of the Sax group increased earlier [(0.81± 0.09) vs (0.79±0.09) g/cm², t=-2.7, P<0.05]. The VAT.Area and FMI of the Met group were significantly lower than those of the Sax group [VAT.Area: (81.14±19.11) vs (92.62±22.84); FMI:6.33±1.48 vs 6.78±1.34, t=-1.9,-1.2, P<0.05]. Conclusions Both metformin and saxagliptin could increase OC and 25(OH)D3 levels, promote bone formation and improve body fat distribution in patients with T2DM. Saxagliptin could increase femoral neck bone mineral density in patients with newly diagnosed T2DM. While metformin have a better effect on the improvement of visceral fat area and fat mass index. [ABSTRACT FROM AUTHOR]

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)