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目的探讨铁皮石斛多糖（DOP）对CCl4 诱导肝纤维化（HF）的影响及其作用机制。方法将56 只雄性SD 大鼠随机分为七组：正常组（NG）、模型组（MG）、秋水仙碱组（CG， 0.1mg/ kg）、扶正化瘀组（FG， 0.45g/kg）、低剂量DOP 组（LDG， 0.05 g/kg）、中剂量DOP 组（MDG， 0.1 g/kg）和高剂量DOP 组（HDG，0.2 g/kg），每组8 只。采用皮下注射40% CCl4 橄榄油混合液制备HF 大鼠模型，每3 d 注射1次，共10周。造模第6周结束后，各药物组分别给予秋水仙碱、扶正化瘀和DOP 溶液灌胃处理，NG 和MG 大鼠给予等量0.9 % 生理盐水处理，每天1次，连续4周。各组大鼠肝组织病理学采用苏木精-伊红（HE）、Masson 染色、天狼星红（Sirius red）染色检测；肝功能和肝纤四项指标采用血液生化法检测；肝组织中α-SMA、Col-I、E-cadherin、ZEB1 基因和蛋白的表达分别采用RT-qPCR 法和Western Blot 法检测。结果HE、Masson、Sirius red 染色结果显示MG 大鼠肝脏组织出现典型的HF 病理特征，LDG、MDG 和HDG 大鼠HF 均出现不同程度改善。肝功能检测结果显示，LDG、MDG、HDG 大鼠的血清AST、TBIL、AKP 水平与MG 相比均显著降低（P < 0.05或 < 0.01），血清ALT 水平除LDG 外均显著降低（P < 0.05或 < 0.01）。肝纤四项指标检测结果显示，LDG、MDG、HDG 大鼠的血清HA、LN、PC-Ⅲ、COL-Ⅳ 含量与MG 比较均明显下降（P < 0.05或 < 0.01）。基因、蛋白检测结果显示，LDG、MDG、HDG 大鼠肝组织中α-SMA、COL-I、ZEB1 的相对表达量明显降低（P < 0.05或 < 0.01），而E-cadherin 的相对表达量升高（P < 0.05或 < 0.01）。此外，HA、α-SMA、COL-I、ZEB1、E-cadherin 的表达均存在一定的DOP 剂量依赖性。结论DOP 可通过抑制大鼠肝组织的上皮-间质转化减轻CCl4 诱导的HF 程度。

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In order to investigate the influence of parameter variation and three‑dimensional effect on the interaction between conical shock wave and plate boundary layer， Menter‑SST two‑equation turbulence model is used to simulate the interaction between three‑dimensional conical shock wave and plate boundary layer in a supersonic Mach 2 flow， and the results are analyzed qualitatively and quantitatively. The influence caused by the change of shock‑wave generator’s half‑cone angle and Reynolds number on the flow in the interference region is studied， and the variation rules of flow separation caused by parameter variation are summarized. Moreover， the two‑dimensional cases which are equivalent to the incident shock wave on the central symmetry plane in corresponding three‑dimensional cases are also calculated， and the results are compared with the three‑dimensional cases. The comparison shows that the interference between conical shock wave and plate boundary layer is obviously different from that of two‑dimensional cases in terms of wall pressure coefficient， separation vortex， vorticity distribution and so on. [ABSTRACT FROM AUTHOR]

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BACKGROUND: Plenty of studies have already proved the effective usage of epigallocatechin gallate (EGCG) in clinical treatment. However, no current research has focused on the application of EGCG in preventing white spot lesions (WSLs) during orthodontics treatment with fixed appliances. OBJECTIVE: To study the value of EGCG in the prevention of WSLs during orthodontic treatment with fixed METHODS: In total 50 patients undergoing orthodontic treatment with fixed appliances were carefully screened and enrolled. Split-mouth design was adopted: the right side of teeth received experimental adhesive (1 g/L EGCG + Adper™ Single Bond 2); the left side of teeth acted as control. All the other clinical procedures and materials used were same. The enamel demineralization index (EDI) and the WSLs prevalence of targeted teeth (16, 11, 46, 26, 31, and 36) were detected at 3, 6, and 12 months during the treatment, and the percentage of bracket bonding failure was calculated for each group. The study protocol was implemented in line with the relevant ethical requirements of Liuzhou People’s Hospital. Patients and their guardians were fully informed of the whole trial procedures. RESULTS AND CONCLUSION: In this trial, the percentage of bracket bonding failure was significantly different between the EGCG group and control group (P > 0.05). After 3 months of treatment, the values of WSLs and EDI had no significant difference between the EGCG group and control group (P > 0.05). However, after 6 months and 12 months treatment, the EGCG group manifested significantly lower WSL and EDI values than the control group (P < 0.05). Therefore, addition of the adhesive containing 1 g/L EGCG has a considerable effect in preventing enamel demineralization and the occurrence of WSLs without influencing the enamel bonding strength, and it has a long-time effect which deserves the clinical expansion. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the role of nuclear factor-κB (NF-κB) in the development of gastric cancer mediated by He-licobacter pylori infection. Methods: From March 2016 to March 2019, a total of 110 patients with gastric diseases diagnosed and treated were enrolled. qPCR were used to detect the relative expression of NF-κB, and Helicobacter pylori (Hp) infection were detected by immunoblotting. And carry out correlation analysis. Results: In the 110 patients, there were 9 patients of gastric cancer (gastric cancer group) and 101 patients of benign gastric disease (benign group that included 52 patients of superficial gastritis, 26 patients of atrophic gastritis, and 23 patients of dysplasia). The Helicobacter pylori infection rates were 88.9%in the gastric cancer group, which were significantly higher than that in the benign group (10.9 %) (P<0.05). The positive rates of NF-κB expression in gastric cancer group were 77.8 %, which were significantly higher than that in benign group (14.9 %)(P<0.05). In the 110 patients, linear correlation analysis showed that Helicobacter pylori infection and NF-κB expression were positively correlated with gastric cancer (P<0.05). The receiver operating characteristic curve (ROC) showed that the area under the curve of Helicobacter pylori infection and NF-κB positive differential diagnosis of gastric cancer were 0.669 and 0.713, respectively. Conclusion: NF-κB are highly expressed in gastric cancer, and it are accompanied by Helicobacter pylori infection. There are significant correlation between themwhich together mediate the development of gastric cancer. [ABSTRACT FROM AUTHOR]

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Copyright of Acta Automatica Sinica is the property of Chinese Academy of Sciences, Institute of Automation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agro-Environment Science is the property of Journal of Agro-Environment Science Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To investigate the changes of interleukin-8 (IL-8)and tumor necrosis factor-a (TNF-a)levels in gingival sulcus fluid of patients with chronic periodontitis and theirs clinical significance, to provide reference for clinical diagnosis and treatment. Methods: Selected 60 cases of patients with chronic periodontitis who were collected and treated in our hospital from December 2013 to December 2015 as experiment group, and 60 cases of patients with periodontal health as control group at the same time. Collected the gingival sulcus fluid and recorded the gingival index(GI), gingival sulcus bleeding index(SBI), plaque index(PLI), probing depth(PD) and clinical attachment loss (CAL) at the times of physical examination of the control group, before and after the routine periodontal therapy of patients in the experimental group. Measured and compared the IL-8 and TNF-a levels between the patients of two groups. Results: The GI, SBI, PLI, PD and CAL periodontal clinical indexes of patients in experimental group before treatment were significantly higher than the control group, the difference was statistically significant (P<0.05); After treatment, the periodontal clinical indexes of patients in experimental group were significantly lower than before treatment, the difference was statistically significant (P<0.05), but there was no significant difference compared with the control group (P>0.05). The IL-8 and TNF-α levels in gingival sulcus fluid of patients in experimental group before treatment were significantly higher than the control group, the differences were statistically significant(P<0. 05); After treatment, the IL-8 and TNF-a levels in gingival sulcus fluid of patients in experimental group were significantly lower than before treatment, the differences were statistically significant(P<0.05). The IL-8 levels in gingival sulcus fluid of patients in experimental group before treatment have positively correlation with PD of periodontal clinical indicators (r=0.495, P=0.027), the TNF-a levels have positively correlation with SBI and PD of periodontal clinical indicators (r=0.512, 0.673; P=0.019, 0.012). Conclusion: The IL-8 and TNF-a in gingival sulcus fluid of patients with chronic periodontitis have high levels, which may be associated with the development of chronic periodontitis, and it has positive clinical significance for clinical diagnosis of chronic periodontitis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Appropriate Web content extraction technique can remove the data which is redundant, repetitive and useless from massive Web pages while extracting more meaningful and more useful data. Through the observation of Web pages, this paper proposed and implemented a Web content extraction method based on the layout similarity that the pages under the same Web site showed similar in content layout and style structure. It achieves the purpose of main content extraction by comparing the similarity of the DOM node structure data from the Web pages belong to the same topic of the same sites. It also did some tentative research and implementation on some other content relevant to this content extraction method. Experiments prove that this method is simple, practical and universal, and it can not only meet the requirement of both high accuracy but also provide support for more Internet applications of content analysis. [ABSTRACT FROM AUTHOR]