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Objective: To investigate relationship between serum CXC subfamily chemokine receptor 3 (CXCR3),C-X-C chemokine ligand (CXCL) 5, CXCL12 levels and the severity of coronary artery disease and prognosis in patients with coronary heart disease (CHD). Methods: A total of 189 patients with CHD (CHD group) who were admitted to the department of cardiology of our hospital from February 2018 to February 2020 were selected. According to Gensini integral, the patients were divided into mild lesion group (≤ 20 scores, 62 cases), moderate lesion group (21～40 scores, 84 cases) and severe lesion group (> 40 scores, 43 cases). According to the occurrence of major adverse cardiovascular events (MACE) during the follow-up period, the patients were divided into MACE group (45 cases) and non MACE group (144 cases), another 102 volunteers who underwent physical examination in our hospital at the same time were selected as the control group. Serum CXCR3, CXCL5, CXCL12 levels were detected, and the relationship between they and the occurrence of MACE in patients with CHD during follow-up. Results: The serum CXCR3, CXCL5 and CXCL12 levels in CHD group were higher than those in control group (P<0.05), and the serum CXCR3, CXCL5 and CXCL12 levels in severe lesion group were higher than those in moderate lesion group and mild lesion group (P<0.05). The serum CXCR3, CXCL5 and CXCL12 levels in moderate lesion group were higher than those in mild lesion group (P<0.05). The results of single factor analysis showed that left ventricular ejection fraction(LVEF), hypertension, diabetes, hyperlipemia, blood sugar, number of coronary artery lesions, length of coronary artery lesions, Gensini integral, serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), CXCR3, CXCL5, CXCL12 levels were correlated with the occurrence of MACE in patients with CHD during follow-up (P<0.05). Multivariate Logistic regression analysis showed that the number of coronary artery lesions, hypertension, CXCR3, CXCL5 and CXCL12 were the influential factors for the occurrence of MACE in patients with CHD during follow-up (P<0.05). Conclusions: The serum CXCR3, CXCL5 and CXCL12 levels in patients with CHD are increased, and they are related to the exacerbation of coronary artery disease and the occurrence of MACE. The detection of serum CXCR3, CXCL5 and CXCL12 is helpful to evaluate the condition and prognosis of CHD patients. [ABSTRACT FROM AUTHOR]