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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of aspirin in relieving skin rashes induced by epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in mice and the possible mechanism. Methods Fifty male Balb/c mice were randomly divided into the control group, model group, and high-dose, medium-dose, and low-dose aspirin groups, with 10 mice in each group. The skin rash models were established by administering the EGFR-TKI erlotinib to the mice in all the groups except the control group. After successful modeling, the mice in the high-, medium-, and low-dose aspirin groups were given aspirin at doses of 1. 13, 0. 75, and 0. 38 mg per mouse, respectively, while the mice in the control group were given distilled water at 100 mg/kg, all by gavage, once a day, for a total of 30 days. All the mice were monitored for feeding, drinking, urination, defecation, and mental status as well as pruritus and other skin conditions. The skin moisture level was measured using a skin moisture analyzer, and skin inflammation was scored. After the mice were sacrificed, the back skin was taken for observing the pathological changes with HE staining, and serum levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were determined by ELISA. Results In the control group, the skin and general conditions were normal; the mice in the model and low-dose aspirin groups developed skin rashes, scabs, and desquamation on the back, and began to have reduced food intake, increased water intake, increased urination, and reduced defecation since the first week, accompanied by anxiety and back scratching; compared with the model group, the medium- and high-dose aspirin groups showed significant improvements in skin rashes, scabs, and desquamation, and gradually returned to normal dieting since the second week. Only the model group had mild pruritus, while the other groups did not have any pruritus. No abnormal changes were found in any epidermal layer of the skin tissues in the control group; the model group showed epidermal thickening and substantial inflammatory cell infiltration in the dermis; the high dose and medium-dose aspirin groups showed slight epidermal thickening and mild inflammatory cell infiltration in the superficial dermis, while the low-dose aspirin group had a larger number of inflammatory cells in the superficial dermis; the levels of inflammation in the three aspirin groups were all lower than that in the model group. There was no significant difference in the skin moisture level between the groups (P<0. 05). The rash site, desquamation, exudation, skin thickening score, and serum levels of TNF-α and IL-1β were as follows： the control group < the high-dose aspirin group < the medium dose aspirin group < the low-dose aspirin group and model group (all P<0. 05). Conclusion Aspirin can alleviate EGFR-TKI-induced skin rashes in mice, possibly through reducing serum TNF-α and IL-1β levels and thereby inhibiting inflammatory response. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To perform data mining on adverse drug reactions of datatumumab by using the Food and Drug Administration Adverse Event Reporting System (FAERS), so as to provide references for clinical rational and safe medication. METHODS: Data from the FAERS database for 32 consecutive quarters of daretozumab since its launch in America in 2014 were retrieved, and adverse drug reaction signal detection was performed by using the reporting odds ratio and proportional report ratio methods. RESULTS: A total of 17 757 cases of datatumumab adverse reaction events were reported, and 772 cases of target adverse reaction ( death) events were reported; the age was mainly in the range of 17-79 years old, and there were more males than females; the top 3 countries in terms of reported cases were the United States, India and France; and high frequency of adverse drug reactions were mainly focused on infusion-related reactions, pneumonia, diarrhea and neutropenia. CONCLUSIONS: The clinical application of datatumumab should not only pay attention to the common adverse reactions, but also pay attention to the adverse reactions that are not mentioned in the dispensary, and take preventive measures in time to reduce the occurrence of adverse drug reactions. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agro-Environment Science is the property of Journal of Agro-Environment Science Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【Objective】The present paper aimed to find out the distribution and ecological risk of four heavy metals Cu, Cr, Cd,Pb and As in the soil around the Ningdong Chemical Industrial Park, select representative areas and collect 24 samples in shallow topsoil(0-10 cm) and topsoil(10-20 cm). 【Method】The five-step method of Tessier was used to extract the four heavy metals in the two layers of soil. Correlation analysis and systematic cluster analysis were used to analyze the five heavy metal sources. The potential ecological risk index method and the native phase distribution ratio method(RSP method) were used to assess the ecological risk of heavy metals in the soil.【Results】The results showed that the average contents of heavy metals Cu, Cr, Cd, Pb and As were 41.13, 181.48, 0.12, 33.91 and 18.49 mg·kg-1, respectively. The results slightly exceeded the background value of local heavy metals, but met the national farmland soil quality standards. Heavy metals such as Cu, As, Pb and Cd have consistent sources and are highly likely to be disturbed by humans. Heavy metal Cr has a wider source of pollution and may be affected by multiple factors such as human disturbance and soil parent material; heavy metal Cu, Pb mainly exists in the form of a residual state, and Cr and Cd mainly exist in a carbonate-bound state. The results of potential ecological risk index evaluation showed that the risk of heavy metals from high to low was Cd>As>Cu>Pb>Cr. The results of RSP evaluation showed that Cd>Cr=As>Cu>Pb.【Conclusion】Based on the above results, it can be found that the heavy metal Cd is mainly contaminated with heavy metal elements in the sampling area and needs further repair. [ABSTRACT FROM AUTHOR]

Copyright of Theoretical Studies of Literature & Art / Wenyi Lilun Yanjiu is the property of Editorial Board of Theoretical Studies in Literature & Art and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

辅助生殖技术(ART)中控制性促排卵(COH)对促进多个卵泡同时发育及提高受孕率至关重要,而垂体降调节是COH过程中一个重要的里程碑.通过降调节,可以阻止过早的LH峰从而保证优势卵泡充分发育.经典的促性腺激素释放激素激动剂(GnRH-a)长方案是COH中应用最为广泛的抑制过早出现LH峰的方案.随着临床对促性腺激素释放激素拮抗剂(GnRH-ant)认识的不断深入及应用经验的不断积累,GnRH-ant方案已经越来越多地应用于COH.在卵巢反应正常人群中,GnRH-ant与GnRH-a方案有相似的临床结局,具有刺激周期短、Gn用量少、患者耐受性好等优点;在卵巢低反应患者中,GnRH-ant方案是否优于GnRH-a方案尚无一致的结论,但目前关于GnRH-ant方案的改良方案已表现出较好的临床效果;在卵巢高反应者中,GnRH-ant方案似乎更安全,卵巢过度刺激综合征风险更低,子宫内膜容受性更好. [ABSTRACT FROM AUTHOR]