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Objective: To investigate the expressions and clinical significances of niicroRNA-221 and E-cadherin in the gastric cancer. Methods: The tumor tissues and adjacent normal tissues from 50 cases of patients with gastric cancer from the fourth affiliated hospital of Harbin medical university from 2014 to 2016 were selected as the study group and the control group respectively. The expressions of microRNA-221 and E-cadherin in both groups were examined by real-time RT-PC'R and immunohistocheniistry. Results: The expression of microRNA-221 hi the gastric cancer samples was significantly higher than that of the adjacent normal samples(P<0.05). The positive expression rate of E-cadherin hi the gastric cancer tissues was obviously lower than that of the adjacent normal tissues. The expression of microRNA-221 hi the gastric cancer was obviously associated with the TNM stage, lymph node metastasis and distant metastasis (P<0.05). E-cadherin expression was significantly associated with the lymph node metastasis and distant metastasis of gastric cancer (P<0.05). The expression of microRNA-221 hi which had negative expression of E-cadherin was obviously higher than that with positive expression of E-cadlierin hi the gastric cancer(P<0.05). Conclusions: The expression of microRNA-221 was high and expression of E-cadherin was low hi the gastric cancer which might be associated with the invasion and metastasis of gastric cancer, microRNA-221 might participate hi the invasion and metastasis of gastric cancer by Epithelial-mesenchymal transition. [ABSTRACT FROM AUTHOR]