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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective Breast intraductal papillary tumors are clinically common diseases derived from the ducts. The aim of this study is to investigate the clinicopathological characteristics of intraductal papillary tumors and risk factors for carcinogenesis. Methods The clinicopathological data of 674 patients with breast intraductal papillary tumors， who underwent surgery in the National Cancer Center/Cancer Hospital， Chinese Academy of Medical Sciences from January 2010 to July 2015， were retrospectively analyzed. Results The median follow-up time was 4 6 months. The 674 cases were classified into 547 intraductal papilloma， 8 8 cases of intraductal papillary carcinoma， 32 cases of intracystic papillary carcinoma， and 7 cases of solid papillary carcinoma of breast. After a median follow-up time of 46 months， 13 out of 547 (2 .4 %) intraductal papillomas had local recurrence in the original dissected quadrat，another 10 cases developed breast cancer in the original dissected quadrat. The 3-year recurrence-free survival rates in intraductal papilloma and intraductal papilloma accompanied with atypical ductal hyperplasia were 97 .7 % and 93 .5 %，respectively， the recurrence-free survival curves showed a significant difference (P = 0 .011). Multivariate analysis indicated that atypical ductal hyperplasia was a major prognostic factor affecting the recurrence-free survival of intraductal papilloma (RR = 0 .183，95 % CI = 0 .054 to 0 .777，P = 0 .020). Four cases (3. 1 %) of intraductal papillary carcinoma had local recurrence. The logistic analysis showed that patient aged > 45 years, clinical manifestations of a breast lump, maximum tumor diameter greater than 2 cm are possible clinical manifestation of malignant breast intraductal papillary tumors (RR = 1 .735, 95 % CI-1 .007-2 .990，P-0 . 047； RR = 2 .849，95 % CI = 1 .207-6 .711, P - 0 .017 ；RR-3 .792, 95 % CI = 2 .162-6 .653，P < 0 .001). Conclusions Intraductal papillary tumors have a certain recurrence rate. A ge， clinical features and tumor size may be predictive factors of intraductal papillary carcinoma. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the clinical indications of MRI-guided puncture positioning or biopsy, and evaluate the clinical practical value. Methods The clinicopathological data of 30 patients who underwent MRI-guided puncture positioning or biopsy were retrospectively collected and analyzed,and the patients were followed up after operation. Results The success rate of MRI-guided puncture was 100%. After biopsy or surgical resection,the pathological diagnoses were as follows： 6 cases (20.0%) of invasive carcinoma，9 cases (30.0%) of ductal carcinoma in suit ( DCIS), and 15 cases (50.0%) of benign lesions, and the false negative rate was 0. In the 30 patients， the lesions of 22 patients were not clear and difficult to analyze qualitatively by ultrasound or mammography imaging examination. After MRI-guided puncture positioning or biopsy，the pathological examination showed that 11 cases (50.0%) of them were malignant tumors. MRI examinations indicated as malignant in 21 cases， among them， seven cases were pathologically confirmed as benign pathology， with a false positive rate of 33. 3%. MRI examination considered benign in 9 cases， in which one case was pathologically diagnosed as malignant， thus， the false negative rate was 11.1%.In the 30 patients，there were no hematoma，infection and other complications after the puncture. The median follow-up time was 7.5 months. One patient died due to breast cancer metastasis， one patient showed relapse by imaging examination and underwent surgery， one case was lost， and the remaining patients were normal in the regularly follow-up results. Conclusions MRI-guided biopsy of breast microlesions is a safe，rapid and accurate diagnostic method. When the ultrasound and mammography cannot find clear lesions or the lesions are difficult to analyze qualitatively， MRI-guided puncture positioning or biopsy can be applied to improve early diagnosis and treatment， and reduce false negative rate of breast cancer. [ABSTRACT FROM AUTHOR]