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Mesoporous silica-coated magnetic nanoparticles were prepared using a modified Stöber method, followed by amino-functionalization treatment on the material surface through grafting to form NH2-MMNPs. A safe and non-toxic oxidized pullulan was used as the gated material, forming a pH-responsive imine bond between the amino groups on the surface of the nanomaterial and the aldehyde groups of oxidized pullulan, thus creating a gated switch. The loaded doxorubicin hydrochloride was encapsulated to form the intelligent drug delivery system (oMMNPs/DOX). The structure, properties, and morphology of the composite material were characterized by transmission electron microscopy (TEM), X-ray diffraction spectroscopy (XRD), fourier transform infrared spectroscopy (FT-IR), nitrogen adsorption desorption (BET) and vibrating sample magnetometry (VSM). The results showed that the composite material had good morphology, monodispersity, and superparamagnetism. Drug loading and release experiments indicated a drug loading capacity of 51. 65% for NH2-MMNPs; oMMNPs/DOX exhibited pH-responsive drug release behavior and sustained drug release during the release process. Cytotoxicity and fluorescence imaging experiments demonstrated that the composite material had good biocompatibility, successfully loaded drugs, and were uptaken by cells. [ABSTRACT FROM AUTHOR]

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