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Objective To investigate the efficacy of sublingual immunotherapy (SLIT) in children with mite allergic rhinitis (AR) and to determine the time to efficacy. Methods Sixty-four children with mite AR were recruited and treated with sublingual corresponding dust mite drops once daily according to the treatment schedule, along with symptomatic medication as needed. The patients were divided into the ≤6 years old group and the ＞6 years old group according to school age. The TNSS, TMS and VAS scores were compared before, half a year, and one year after SLIT treatment between the two groups and within the groups. Results Compared with pre-treatment, TNSS, TMS and VAS scores were significantly reduced in 64 AR children after half a year of SLIT treatment, and scores further reduced after one year of treatment (P＜ 0.05). There were no significant differences in TNSS, TMS and VAS scores before treatment, half a year and one year after treatment between the ≤6 years old group and the ＞6 years old group (P＞0.05). All scores were significantly lower after half a year of treatment than those before treatment in the two groups, and scores were further reduced after one year treatment (P＜0.05). Conclusion Children with AR have shown good clinical results after SLIT, and should be initiated as early as possible to reduce the occurrence of long-term complications. [ABSTRACT FROM AUTHOR]