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针对中国第一个海上风电柔性直流送出工程—江苏如东工程，从系统拓扑方案构建、过电压与绝缘配合、系统功率盈余问题与交流故障穿越技术以及控制保护技术等方面开展了深入研究，构建了轻型紧凑化的海上风电柔性直流系统拓扑方案，取消了海上换流站的启动回路与接地回路等；提出了海陆换流站的避雷器配置方案与参考电压的选取原则，形成了海陆换流站的绝缘配合方案的典型范式；提出了集中式、分布式、混合式直流侧有功功率动态平衡装置的典型拓扑方式，解决了陆上换流站交流侧故障穿越难题；提出了工程的整体控制保护方案，并研究了一种基于电压前馈环节比例谐振控制的有源谐振抑制方法，显著降低了工程的振荡风险。通过工程实际运行，全面验证了所提技术的有效性。

BACKGROUND: Osteonecrosis of the femoral head is a common and disabling disease, which is mainly characterized by microcirculation disorders and bone cell metabolism disorders. Luzhongjiangu decoction was developed by Shandong Academy of Chinese Medicine and used in the form of soup in the clinic, which has good efficacy in the treatment of osteonecrosis of the femoral head. However, its mechanism of action has not been clarified. OBJECTIVE: To study the effect mechanism of Luzhongjiangu decoction on intestinal flora in rats with osteonecrosis of the femoral head based on 16S rDNA sequencing technique. METHODS: The model of osteonecrosis of the femoral head was established in Wistar rats by intragastric administration of retinoic acid. The therapeutic effect of Luzhongjiangu decoction was evaluated by serum hormone, bone histopathology and serum hormone levels. 16s rDNA sequencing technique was used to detect the intestinal flora of rats in the blank control group, model group and middle-dose Luzhongjiangu decoction group. The corresponding library was constructed and OTU clustering and microbial community diversity and abundance analysis were carried out to determine the composition of intestinal flora and the changes of species and diversity among groups. RESULTS AND CONCLUSION: Luzhongjiangu decoction could significantly increase the expression of osteocalcin, osteopontin and other osteogenic related factors, alleviate the destruction of bone trabeculae, increase bone mineral density, and had a significant therapeutic effect on osteonecrosis of the femoral head, of which the middle dose group showed the most significant effect. The results of intestinal flora sequencing showed that Luzhongjiangu decoction improved the flora disorder of rats with osteonecrosis of the femoral head to some extent, and screened out different colonies such as Bacillus, Desulfurizans, Desulfurization, Isobacteria, Bifidobacterium and so on; it could up-regulate the abundance of beneficial bacteria such as Bifidobacterium, down-regulate the abundance of harmful bacteria such as Desulfovibrio, and improve the structure of intestinal flora. Functional prediction analysis indicated that Luzhongjiangu decoction could mainly affect amino acid metabolism and energy metabolism. Correlation analysis showed that the differential bacteria of Bifidobacterium and Intestinimonas in the middle dose group of Luzhongjiangu decoction were positively correlated with vitamin D3, estradiol and calcitonin, and negatively correlated with prostaglandin E2. In the model group, Escherichia-Shigella, Desulfovibrio, Globicatella and Streptococcus were positively correlated with prostaglandin E2 and negatively correlated with vitamin D3, estradiol and calcitonin. To conclude, Luzhongjiangu decoction may play a role in the treatment of osteonecrosis of the femoral head by regulating the structure of intestinal flora, up-regulating the abundance of beneficial bacteria and affecting the secretion of vitamin D3, estradiol, calcitonin and prostaglandin E2. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of South China Fisheries Science is the property of South China Fisheries Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Forest Products Industry is the property of China Forest Products Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Food & Machinery is the property of Food & Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Teacher Education Research is the property of Teacher Education Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas & Oil is the property of Editorial Department of Natural Gas & Oil and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the funding status of osteoporosis research projects by National Natural Science Foundation of China (NSFC) from 2012 to 2022, and to discuss the research status and direction of osteoporosis by TCM intervention. Methods The osteoporosis related research projects funded by NSFC from 2012 to 2022 were obtained using the National Natural Science Foundation of China, MedSci, the Scientific Research Z Library and MedPeer database. The project funds, Chinese (English) keywords, abstracts and project types were extracted and statistically analyzed. Results From 2012 to 2022, NSFC funded 1 290 osteoporosis-related projects (with a total amount of 573. 2 million yuan), most of which were related to the pathological mechanism and prevention measures of osteoporotic fracture, postmenopausal osteoporosis, senile osteoporosis and diabetic osteoporosis. The subjects of these project are mostly bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, etc. The common treatment method of TCM against osteoporosis include tonifying kidney and activating blood, tonifying kidney and replenishing essence, invigorating spleen and invigorating kidney, etc. The commonly used clinical TCM prescriptions and single herbs include Bushen Huoxuefang, Erxian Decoction, Erzhi Wan, Qinge Wan, etc., and Epimedium, Fructus Ligustri Lucidi, etc. The action mechanism mainly focuses on Wnt/B-catenin, OPG/RANKL/RANK, autophagy, oxidative stress, intestinal flora, etc. Conclusion Exploration of the clinical and effective treatment method and mechanisms of TCM against osteoporosis is helpful to deeply reveal the scientific connotation of TCM intervention in osteoporosis, which lays a foundation for the research and development of innovative Chinese medicine against osteoporosis. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The adoption of the Paris Agreement marks the formation of the “bottom-up” mechanism of global climate governance. As one of the most concentrated areas of population and carbon emissions in the world, how to establish and develop a regional climate governance cooperation mechanism in Northeast Asia has attracted much attention. However, Northeast Asia, where the climate change situation is grim, has not formed a highly integrated climate governance cooperation mechanism. There are problems such as insufficient coordination, low effectiveness, and greater influence by political and geographical factors. In this context, Northeast Asia can strengthen exchanges and cooperation with the international community, learn from the climate governance cooperation mechanisms in other regions, establish a practical and operational coordination mechanism under the framework of international climate governance, give full play to the role of local governments and non-governmental organizations, strengthen technological innovation and cooperation, and promote the formation of a new pattern of deep-seated and multi-channel regional climate governance in Northeast Asia. [ABSTRACT FROM AUTHOR]

Copyright of Natural Gas & Oil is the property of Editorial Department of Natural Gas & Oil and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Oncology is the property of Editorial Board of China Oncology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The gut microbiota (GM) is the most dense microbial community in human body, which can influence the physiological status of the host and plays an important role in maintaining physical health. The literatures from the CNKI and PubMed databases for the past 20 years reveal that GM may influence bone metabolism through the following pathways: (1) Regulating calcium absorption, immune system and central nervous system; (2) Controlling metabolites (such as short-chain fatty acids, secondary bile acid, indole derivatives and polyamines) production ; (3) Modulating estrogen, insulin-like growth factor 1, 5-hydroxytryptamine and other hormones secretion by retrieving with the keywords including GM, bone metabolism and osteoporosis. Clinical studies support that transplantation of fecal microbiota, supplementation with probiotics and prebiotics or modulation of dietary constituents can improve the GM compositions and inhibit bone loss . Therefore, GM and its metabolites may provide a novel strategy for the prevention and treatment of osteoporosis and other bone metabolic diseases. [ABSTRACT FROM AUTHOR]

The combination of standardized D2 lymph node dissection and lymph node sorting after surgery can improve the survival of patients with gastric cancer and increase the accuracy of staging. With the development of different lymphatic tracers, individualized lymphatic navigation has become a new technical breakthrough in minimally invasive surgery for gastric cancer. Lymph node tracing is an important method to improve the quality of intraoperative lymph node dissection and correct the postoperative pathological stage. This article reviews the application status and progress of lymphatic navigation technology [ABSTRACT FROM AUTHOR]

肺大细胞神经内分泌癌（large cell neuroendocrine carcinoma of the lung，LCNEC）是一种罕见的侵袭性强、预后差 的高级别神经内分泌癌，具有独特的分子特征、基因分型。目前 LCNEC 的治疗大多借鉴小细胞肺癌（small cell lung cancer, SCLC), 非小细胞肺癌(non⁃small cell lung cancer, NSCLC) 的方案，但一直存在争议。本文结合近年来 LCNEC 的 临床研究及前沿进展，从其诊断、分子特征、治疗等方面予以综述. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To systematically evaluate the effects of Huisheng oral liquid on coagulation function, efficacy and safety of patients with non-small cell lung cancer. METHODS: CNKI, Wanfang Data, CBM, VIP, PubMed, the Cochrane Library, Embase and Web of Science were retrieved to collect the randomized controlled trial of effects of Huisheng oral liquid on coagulation function, efficacy and safety of patients with non-small cell lung cancer (the study group was treated with Huisheng oral liquid combined with other treatment or Huisheng oral liquid; while the control group received other treatment) till Sept. 2021. Quality evaluation and data extraction of the included literature were performed, and RevMan 5. 3 software was used for Meta-analysis. RESULTS: Totally 24 RCT were enrolled, including 1 783 patients (908 cases in the study group and 875 cases in the control group). Meta-analysis showed that the elevated values of D-dimer level (SMD= -1. 46,95%CI = -2. 75--0. 18,P = 0. 03), fibrinogen (Fib) level (MD= - 0. 81,95% CI = - 1. 14-- 0. 48,P < 0. 000 01) and platelet count ( PLT) ( MD = - 82.91, 95% CI = -147. 72--18. 11,P = 0. 01) in the study group were significantly lower than those in the control group, and the differences were statistically significant. There was no significant difference in prothrombin time ( MD = - 0. 71, 95%CI = -1. 71-0. 30,P = 0. 17) and activated partial prothrombin time (MD = 3. 67,95% CI = - 15. 15-22. 48,P = 0. 70) between two groups. The objective response rate (RR = 1. 28,95%CI = 1. 09-1. 51,P = 0. 003), disease control rate (RR = 1. 15,95%CI = 1. 06-1. 25,P = 0. 000 9) and improvement rate of KPS (RR = 1. 72,95%CI = 1. 39-2. 13, P<0. 000 01) in the study group were significantly better than those in the control group, the difference was statistically significant. There was no significant difference in the incidence of nausea and vomiting (RR = 0. 49, 95%CI = 0. 20-1. 20,P = 0. 12) and leukopenia ( RR = 0. 59,95% CI = 0. 29-1. 20,P = 0. 15) between two groups. CONCLUSIONS: Huisheng oral liquid may improve the coagulation function of patients with non-small cell lung cancer by reducing the levels of D-dimer, Fib and PLT. Meanwhile, it can improve the short-term clinical efficacy and quality of life of patients with non-small cell lung cancer, yet more high-quality clinical studies are needed to verify. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Information & Control is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the molecular mechanism of Notch3 reversing epithelial-mesenchymal transition (EMT) and inhibiting tumor metastasis in triple negative breast cancer (TNBC). Methods The Notch3 overexpression plasmid (pcDNA3.1-Notch3-GFP) and its negative control plasmid (pcDNA3.1-NC-GFP), the small molecule interference plasmid for Hes2 knockdown (si-Hes2-GFP) and its negative control plasmid (si-NC-GFP) were transfected into TNBC MDA-MB-231 cells. Cells were divided into the control group (no transfection was performed), the pc-NC group (transfection pcDNA3.1-NC-GFP), the Notch3 overexpression group (pc-Notch3 group, transfection pcDNA3.1-Notch3- GFP), the Notch3 overexpression+si-NC group (pc-Notch3+si-NC group, co-transfected pcDNA3.1-Notch3-GFP and si- NC-GFP), and the Notch3 overexpression+Hes2 knockdown group (pc-Notch3+si-Hes2 group, co-transfected pcDNA3.1- Notch3-GFP and si-Hes2-GFP). Real-time quantitative PCR and Western blot assay were performed to measure mRNA and protein expression levels of Notch3 and Hes2 in cells to verify the transfection efficiency. The cell counting kit-8 assay was performed to measure cell proliferation activity. Scratch healing assay and Transwell chamber assay were performed to measure cell migration and invasion abilities. Western blot assay was performed to measure EMT-related proteins (Ecadherin and Vimentin) in cells. Results Compared with the control group and the pc-NC group, the Notch3, Hes2 mRNA and protein, E-cadherin protein levels were significantly increased in the pc-Notch3 group and the pc-Notch3+si-NC MDAgroup, and the proliferation activity, mobility, number of transmembrane cells and Vimentin protein levels were significantly decreased (P＜0.05). Compared with the pc-Notch3 group and the pc-Notch3+si-NC group, the Hes2 mRNA and protein levels and E-cadherin protein were significantly decreased in the pc-Notch3+si-Hes2 group, and the proliferation activity, mobility, number of transmembrane cells and Vimentin protein levels were significantly increased (P＜0.05). Conclusion Notch3 may reverse the EMT of TNBC and inhibit tumor metastasis by up-regulating Hes2. [ABSTRACT FROM AUTHOR]

Copyright of Information & Control is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electric Power Automation Equipment / Dianli Zidonghua Shebei is the property of Electric Power Automation Equipment Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)