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Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

As a severe clinical manifestation of nonalcoholic fatty liver disease， nonalcoholic steatohepatitis （NASH） is characterized by lipid deposition and inflammatory damage in the liver. At present， clinical medications for NASH are still in the exploratory phase， and it is urgent to make progress. Recent studies have shown that the pathogenesis of NASH is associated with circadian rhythm disorders in the liver， with the specific manifestation of dysregulated expression of liver clock genes such as BMAL1， which increases hepatic lipogenesis， reduces fatty acid oxidation， and activates pro-inflammatory factors. Therefore， improving circadian rhythm of the liver and regulating the expression of liver clock genes are feasible strategies for the prevention and treatment of NASH. Currently， some medications for NASH via activating the proteins encoded by clock genes have been applied in animal experiments， for example， the REVERB full-agonist SR9009 can inhibit the development of liver inflammation， which confirms the possibility of NASH treatment by targeting the proteins encoded by clock genes. This article summarizes the role of hepatic clock genes in regulating lipid metabolism and the development and progression of inflammation in the liver and elaborates on the recent advances in medications targeting clock genes and the proteins encoded by clock genes， in order to provide new targets for the treatment of NASH. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Agro-Environment Science is the property of Journal of Agro-Environment Science Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Petrochemical Universities / Shiyou Huagong Gaodeng Xuexiao Xuebao is the property of Journal Editorial Department Of Liaoning Shihua University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of International Economy & Management is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Biotechnology Bulletin is the property of Biotechnology Bulletin Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To study the effect of different masticatory pressures on alveolar bone remodeling in rats with orthodontic moving teeth. Methods Forty-five male SD rats aged 8 weeks were randomly divided into 3 groups: the baseline group (n=5), the soft diet group (n=20) and the hard diet group (n=20). Rats in the baseline group were sacrificed at the beginning of the experiment. The experimental rat models of right upper first molar movement were established in the soft diet group and the hard diet group. Left side of the maxillary was used as the control group. Each group was fed with corresponding diet. Five rats were sacrificed in each group on the day 3, day 5, day 7 and day 14 after orthodontic treatment respectively. Micro CT was used to measure the mesial movement distance of molar, bone volume/tissue volume (BV/TV), trabecular separation (Tb. Sp) and trabecular thickness (Tb. Th) of the alveolar bone on the pressure side. The number of osteoclasts in alveolar bone was counted after TRAP staining. In situ hybridization was used to detect the expression of RANKL and OPG. Results The amount of tooth movement was smaller on day 14 in the soft diet group than that of the hard diet group (P＜0.05). There were no significant differences in BV/TV, Tb.SP and Tb.Th between the soft diet group and the hard diet group. TRAP staining and in situ hybridization showed that the number of osteoclasts and the RANKL/OPG ratio on day 5 and day 7 were lower in the soft diet group than those of the hard diet group (P＜0.05). Conclusion The osteoclast activity in the alveolar bone on the pressure side of the orthodontic tooth is decreased and the tooth movement is inhibited under lower masticatory pressure. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Vibration, Measurement & Diagnosis is the property of Nanjing Hangkong Daxue and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

蛇类养殖可以缓解野外资源的开发压力,起到积极的保护作用。但是从野外非法捕捉的蛇类以人工养殖之名混入合法市场的现象也十分常见。由于缺乏有效鉴别野生和人工饲养蛇类的方法,给监管市场和打击盗猎、非法贩卖等违法犯罪行为带来困难。本研究以养殖量和盗捕量较大的王锦蛇为例,建立了肝-头指数(Ilh)和肝-体指数(Ilb)两个肝脏指数来鉴别野生和人工饲养蛇类。利用这两个指标,采用Fisher's判别将已知来源的个体进行来源回判时,两个指标的正确判别率相同,在野生组均为96.9%,饲养组均为74.1%,整体正确率为86.4%。但是两个指标在野生组和饲养组都有显著的性别差异,而且饲养组的雄性与野生组的雌性数值比较接近,当这两组同时进行判别时,Ilh和Ilb对饲养组雄性的错判风险均高达36.4%。但是,在性别明确时,Ilh对野生和饲养的雄性判别正确率在野生组为100%,饲养组为90.4%,整体达到94.1%,对于两组雌性判别正确率野生组依然达到100%,饲养组为81.3%,整体92.9%。Ilb的情形与Ilh也是一致的,同一性别的正确判别率高达90.5%(雌性)和94.1%(雄性)。因此,在实际应用中最好有性别信息。这两个指标测量方便,适用完整和不完整的死体鉴别,也可能适用于其他蛇类。

Place is a central concept and research object in cultural geography. Analyzing place components is a prerequisite for an integrated understanding of place and a core component of place theory in cultural geography. Previous studies have focused on either spatially fixed or mobile components in analytical frameworks, both of which capture different dimensions of place. However, few studies have considered both the fixed and mobile components and the interactions between them. Based on the classical framework of place components proposed by John Agnew (1987) and coupled with cultural flowscapes, this study proposes a new Analytical Framework for Place Components (AFPC) that reveals the elements of place. Taking the tourist destination of Fenghuang Ancient Town (FAT) as a case study and collecting data through observation and interviews, this study presents a preliminary empirical application of the AFPC. The results suggest that place comprises four components: location, locale, sense of place, and cultural flowscapes. Cultural flowscapes include the interrelated concepts of ethnoscapes, mediascapes, technoscapes, financescapes, and ideoscapes. The AFPC meets the scientific requirements of universality, independence, and application. It reveals the complexity of contemporary places and can be used to guide the empirical analysis of small-scale local characteristics or local specificality. The FAT case study fully reveals the multi-element features and interrelationships between the components. It was found that the location of the FAT is relatively poor, and the land-use pattern is mainly commercial. Social relationships in FAT are mainly commercial, social contact among residents is weak, and the sense of place for the different groups differed, Cultural flowscapes are dynamic and can play an active role in driving change or transformation of the locale of FAT. The locale has a mediating effect on cultural flowscapes. The location of FAT determines cultural flowscapes to some extent and partly affects the locale. Cultural flowscapes, location and locale together shape the sense of place of FAT, and the sense of place in turn gives specific meaning to the other three elements. The theoretical contributions of this study are that the AFPC considers both fixed and mobile elements of place components, and that place components are interactive, which helps enrich the theoretical perspective of place component research and expands the scope of application of place components theory. In practice, the research results can provide practical guidance for decision-makers in tourism destination development and rural revitalization, emphasizing that sustainable local development requires synergy between local and external elements. [ABSTRACT FROM AUTHOR]

Copyright of Detergent & Cosmetics is the property of Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 观察温脾补肾泄浊汤联合西医常规疗法治疗脾肾阳虚血瘀型Ⅲ、Ⅳ期糖尿病肾病(DKD)的临床 疗效, 以及患者肾脏血流动力学指标及血清炎症因子、转化生长因子β(1 TGF-β1 )、超氧化物歧化酶(SOD)水平变化。 方法 选择Ⅲ、Ⅳ期DKD患者104例, 按随机数字表法分为观察组和对照组, 每组52例。两组均以西医常规疗法治 疗, 观察组在此基础上加用温脾补肾泄浊汤, 共治疗1个月。比较两组治疗前后中医证候积分、肾功能相关指标 [肌 酐(Cr)、尿素氮(BUN)、胱抑素 C(CysC)、估算肾小球滤过率(eGFR)、β2-微球蛋白(β2-MG)、尿白蛋白排泄率 (UAER)]、肾脏血流动力学指标 [双侧肾叶间动脉的收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)、阻力指 数(RI)]、炎症指标［C反应蛋白(CRP)、肿瘤坏死因子 1型受体(TNFR1)、中性粒细胞与淋巴细胞比值(NLR)］及血 清TGF-β1、SOD水平。比较两组用药安全性及不良反应发生情况。结果 两组治疗后各项中医证候积分均低于治 疗前, 且观察组低于对照组(P 均<0. 05)。两组治疗后 UAER、尿 β2-MG、外周血 NLR、肾叶间动脉 RI 及血清 Cr、 BUN、CysC、CRP、TNFR1、TGF-β1水平低于治疗前, 且观察组低于对照组(P均<0. 05)；两组血清 SOD 水平、eGFR 及 肾叶间动脉PSV、EDV高于治疗前, 且观察组高于对照组(P均<0. 05)。观察组总有效率高于对照组(P<0. 05)。两 组不良反应发生率差异无统计学意义(P>0. 05)。结论 温脾补肾泄浊汤联合西医常规疗法治疗脾肾阳虚血瘀型 Ⅲ、Ⅳ期DKD效果明确, 可降低血清炎症因子、TGF-β1、SOD水平, 改善肾脏血流动力学和肾功能。 [ABSTRACT FROM AUTHOR]

Extracorporeal membrane oxygenation (ECMO) is an advanced life support modality for patients with respiratory or cardiac failure. During ECMO, various factors impair coagulation function, resulting in an imbalance between procoagulation and anticoagulation, thus increasing the incidence of bleeding and posing a significant challenge to the development of clinical work. In this article, the epidemiology, causes, anticoagulation and monitoring of high-risk bleeding during ECMO were reviewed, aiming to provide reference for clinical practice. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Northwest A & F University - Natural Science Edition is the property of Editorial Department of Journal of Northwest A&F University (Natural Science Edition) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mining & Metallurgy (10057854) is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Geodesy & Geodynamics (1671-5942) is the property of Editorial Board Journal of Geodesy & Geodynamics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Cloud cover affects the quality of hyperspectral images (HSIs) and reduces the application value of HSIs. Therefore, cloud detection has become a main issue that need to be solved in HSIs applications. According to the characteristics of GF5 HSI, a cloud detection algorithm that combines cloud visual features and physical spectrum features was proposed. Based on the original digital number(DN) image, the cloud distribution feature in the HSV color space was used, combining with the spectral feature difference between the cloud and the typical ground objects, a cloud probability image was constructed. Then, the cloud detection threshold was dynamically set to realize the cloud detection of GF5 HSI. The overall cloud recognition accuracy of the algorithm is more than 87%, and the algorithm is less time-consuming and highly automated. It has certain adaptability to GF5 HSIs in different regions and at different times, and is convenient for engineering applications. [ABSTRACT FROM AUTHOR]

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Asthma is a common chronic respiratory disease, and as a heterogeneous disease, it is driven by a combination of immune, genetic, and environmental factors and involves multiple cells. In recent years, there has been increasing evidence that airway epithelial cells play a core role in the pathogenesis of asthma. As the first line of defense of the respiratory system against the external environment, airway epithelial cells mainly prevent harmful stimuli from entering through various intercellular connections and remove harmful foreign factors such as allergens and viruses through the mucus and cilia system and the antimicrobial peptides. The airway epithelial barrier can be disrupted when the airway mucosa is exposed to foreign harmful stimuli, and epithelial cells can release various epithelial-derived cytokines that effectively activate dendritic cells and type Ⅱ innate lymphoid cells, thereby triggering a subsequent helper T cell 2 immune cascade response that leads to the development of asthma. In view of these roles of airway epithelial cells in asthma, targeted therapeutic agents targeting the cytokines from airway epithelial cells such as thymic stromal lymphopoietin, are gradually coming into clinical use. This article reviews the role of airway epithelial cells in the pathogenesis of asthma and the future clinical applications of therapies targeting airway epithelial cells as potential targets. [ABSTRACT FROM AUTHOR]

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China / Zhongguo Yiyuan Yongyao Pingjia yu Fenxi is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Petrologica et Mineralogica / Yanshi Kuangwuxue Zazhi is the property of Acta Petrologica et Mineralogica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Medical Education Technology is the property of China Medical Education Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Chinese Institute of Food Science & Technology / Zhongguo Shipin Xuebao is the property of Journal of Chinese Institute of Food Science & Technology Periodical Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Foreign Literature Studies is the property of Foreign Literature Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The purpose of this study was to observe the killing effect of anti-mesothelin (MSLN) chimeric antigen receptor-modified T cells (CAR-T) on two types of pancreatic cancer cells in vitro, as well as porcine The effects of immune-regulating drugs such as Ling polysaccharide (PPS), ginseng polysaccharide (GPS), astragalus polysaccharide (APS), lentinan (LNT) and ganoderma polysaccharide (GLP) on the proliferation and tumor killing of CAR-T cells. The virus expression vector was transfected to prepare stably expressing anti-MSLN CAR-T cells, and then two detection methods such as real-time label-free cell analyzer (RTCA) and lactate dehydrogenase (LDH) were used to verify the effect of CAR-T cells on PANC-1 in vitro. The killing ability of two pancreatic cancer cells, ASPC-1. Finally, RTCA and CCK8 methods were used to detect the effects of PPS, GPS, APS, LNT and GLP polysaccharides on the proliferation and tumor killing effect of CAR-T cells. The results showed that the MSLN constructed in vitro CAR-T cells have a good killing effect on PANC-1 and ASPC-1 pancreatic cancer cells, and the killing rate of ASPC-1 cells with high MSLN protein expression is significantly higher than that of PANC-1 with low MSLN protein expression. cells (p<0.01); immune-modulating drugs such as PPS, GPS, APS, LNT, and GLP had little effect on CAR-T cells to kill tumors, but compared with the control group, 0.156 mg/mL Ganoderma lucidum polysaccharide and 0.625 mg/mL Ganoderma lucidum polysaccharide mL of lentinan had a certain promoting effect on the proliferation of CAR-T cells. [ABSTRACT FROM AUTHOR]