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To investigate the effect of probiotics combined with triple therapy on ( ) - related gastritis in children and its influence on inflammatory factors. 93 cases of related gastritis in our hospital from January 2017 to June 2018 were selected, and they were divided into study group (n=47) and control group (n=46) according to the method of random number table. The control group was treated with triple therapy. The study group was treated with probiotics on the basis of the control group, the clinical effect, total score of clinical symptoms, inflammatory factors, HP eradication rate, incidence and recurrence of adverse reactions were compared. After 1 month treatment, the total clinical effective rate of the study group was 87.23% (41/47), which was higher than 69.57% (32/46) of the control group (P<0.05). The total score of clinical symptoms after 2 weeks and 1 month treatment and the levels of serum tumor necrosis factor-α (TNF-α), hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6) after 1 month treatment of the two groups decreased (P<0.05), and those of the study group were lower than those of the control group (P<0.05). The eradication rate of HP of the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions and recurrence rate between the two groups (P>0.05). The curative effect of probiotics combined with triple therapy in the treatment of HP related gastritis in children is definite, which can improve the clinical symptoms and reduce the level of inflammatory factors with good drug safety in children. [ABSTRACT FROM AUTHOR]