Objective To investigate the application status and development prospects of artificial intelligence (AI) in early diagnosis, early prevention, standardized treatment, and scientific follow-up of osteoporosis. Methods The application status of AI in medicine in the past 10 years was reviewed. The feasibility of osteoporosis AI technology development and its key technical bottlenecks were analyzed. Results An important prerequisite for the development of high-quality AI technology is the learning of a large amount of accurate knowledge. Osteoporosis screening AI technology requires many bone mineral density data and epidemiological factor survey as the data basis of the screening system. Diagnosis and follow-up AI technology requires many professional terms, imaging data, blood and urine biochemical indicator collection. Therefore, it is important in the learning and verification process to require a large amount of bone mineral density data, epidemiological investigation factors, blood and urine biochemical indicator data, bone mineral density imaging data, terminology data in osteoporosis diagnosis and treatment. The collection process of these related data can be completed through the construction of a database of osteoporosis biological samples. Conclusion The development of osteoporosis AI is inseparable from the construction of a biological sample bank for osteoporosis physical examination. The data collected during the construction of a high-quality, multi-center, and large-scale osteoporosis biological sample library for robot learning and re-learning are the key to the success of osteoporosis AI technology development. [ABSTRACT FROM AUTHOR]