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To study the effect of puerarin and alendronate on oxidative stress, inflammatory factors, and bone metabolism in postmenopausal osteoporotic rats. Methods The experiment was divided into sham operation group, ovariectomized group, A medicine group, B medicine group, and AB medicine group. Animal models of postmenopausal osteoporosis were constructed in rats. Rats received different drug interventions . Serum levels of oxidative stress and inflammatory factors, bone metabolism indexes, and bone mineral density were detected. The morphological structure of bone ti ssue was observed. Results The levels of serum SOD and GSH-Px in the ovariectomized group were significantly lower than those in the sham operation group ( P