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目的 探讨基于微信平台辅助的标准化病人联合病例导入式教学法在脑血管病住院医师规范化培训中的应用效果。 方法 本研究纳入于2020年3月—2023年3月在兰州大学第二医院神经内科进行住院医师规范化培训的学员共70人，随机分为对照组和观察组，每组35人。对照组采取传统带教模式，观察组使用微信提前发送脑血管病典型病例信息，随后进行讨论总结，并对相应标准化病人进行模拟诊疗过程，4个月后对比两组学员综合理论、临床实践技能操作考核成绩以及对带教的满意度。 结果 观察组学员综合理论考核成绩为（89.74±2.53）分，临床实践技能操作考核成绩为（90.31±2.54）分，分别高于对照组的（84.26±3.94）分和（84.20±3.33）分，差异均有统计学意义（P＜0.05）。观察组学员的满意度为91.43%，高于对照组的60.00%，差异有统计学意义（P＜0.05）。 结论 在神经科住院医师规范化培训中依托微信平台应用标准化病人联合病例导入式教学法对学员进行培训，有助于学员综合理论、临床实践技能操作考核成绩提高，可推广应用。 Abstract: Objective To investigate the effect of standardized patients assisted by WeChat platform combined with case-introduction teaching method in residency training of cerebralvascular disease residents physicians. Methods A total of 70 trainees who received residents training in the Department of Neurology, Lanzhou University Second Hospital from March 2020 to March 2023 were recruited in this study. They were randomly divided into control group and observation group, with 35 in each group. While the control group adopted the traditional teaching method, the observation group used WeChat to send the information of classic cerebrovascular disease cases in advance, then discussed and summarized, and carried out the simulated diagnosis and treatment process for corresponding standardized patients. Compared comprehensive theoretical performance and practical skills of the two groups, as well as satisfaction with the teaching after four months. Results The scores of the observation group were (89.74±2.53) points in comprehensive theory assessment and (90.31±2.54) points in clinical practice skill operation assessment, which were higher than those in the control group (84.26±3.94) points in comprehensive theory assessment and (84.20±3.33) points in clinical practical skill operation assessment, respectively. The difference was statistically significant (P

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阿尔茨海默病(AD)是最常见的痴呆类型,其病因尚未明确.近年来,AD的"微生物感染假说"备受关注,多种微生物感染与AD的发生相关.单纯疱疹病毒1型的DNA存在于AD患者的大脑中,并与淀粉样斑块共定位;细胞内单纯疱疹病毒感染不仅可引起几种淀粉样蛋白前体蛋白片段的产生,还可导致糖原合成酶激酶-3的激活和淀粉样蛋白的积累.人体胃肠道含有庞大的微生物群,肠道菌群的细菌产物进入大脑后会引起炎症并促进Aβ的蓄积.慢性牙周炎患者发生AD的风险升高,牙龈卟啉单胞菌也在AD患者的大脑中被检测出,且小鼠的慢性牙周病原体感染会引起与AD一致的病理改变.幽门螺杆菌感染也与痴呆的发生有关,一些基础研究从基因和分子水平探究其致病机制,发现Hp可通过增强γ-分泌酶的活性直接促进Aβ的产生和释放,并通过中断突触功能诱导认知障碍.螺旋体感染与AD的发生相关,从AD患者的脑组织中可培养出伯氏疏螺旋体;感染螺旋体的原代细胞内出现了Aβ沉积.另在AD患者的脑脊液中发现了真菌DNA、蛋白质,并在AD患者的大脑中检测到真菌细胞. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)