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为提高MZI（马赫-曾徳干涉仪）型交错滤波器的输出光平坦度,扩大信道带宽,提出了由1个3×3和两个2×2单模光纤耦合器组成的全光纤级联MZI型交错滤波器,用传输矩阵法推导出了模型的输出谱和相关参数之间的表达式并进行了特性分析。结果表明:当耦合器的分光比和光纤干涉臂之差为定值时,可以产生理想的交错谱图。这种滤波器信道间隔为2nm。此外应用双环光纤辅助的方法可使得输出波形的顶端更加平坦,边模抑制比贴近理论值。

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the differentially expressed genes (DEGs) related to the occurrence and development of osteoporosis (OP) and to screen the potential drug targets. Methods The microarray data concerns osteoporosis were obtained from GEO database and DEGs were identified with R statistical software. GO and KEGG enrichment analysis, protein-protein interaction (PPI) network analysis, and selection of Hub genes were conducted. Results A total of 569 DEGs were screened out. Among them, 7 genes were up-regulated and 562 genes were down-regulated. At the same time, differential gene GO analysis was mainly enriched in processes such as pre-mRNA intronic binding, nuclear body, histone modification, and mRNA 3’-end processing. KEGG analysis was mainly involved the ubiquitin mediated proteolysis signal pathway (hsa04120). PPI network analysis showed 517 nodes and 363 edges. Ten Hub genes, including TCEB1, CUL2, KBTBD6, KBTBD7, ASB8, KLHL42, ASB5, FBXO11, ANAPC10, and CDC23, were acquired using Cytoscape software. These genes were all down-regulated in mesenchymal cells of the femoral head of OP patients. Conclusion The top 10 Hub genes might help us to understand the pathophysiology of OP, and provide therapeutic targets for the development of drugs. Meanwhile, it might provide some new ideas for funding creative scientific hypotheses of OP. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of atractylone on the viability and apoptosis of hepatoma HepG2 cells and its mechanism of action. Methods Hepatoma HepG2 cells were selected and divided into low-, middle-, and high-dose atractylone groups (5, 10, and 20 μmol/L), and the cells in the control group were added with an equal volume of DMSO. MTT colorimetry was used to measure the viability of HepG2 cells after treatment with different concentrations of atractylone; flow cytometry was used to measure the apoptosis rate and mitochondrial membrane potential of HepG2 cells; the DCFH-DA fluorescent probe labeling method was used to measure the level of reactive oxygen species (ROS) in HepG2 cells; Transwell assay was used to evaluate the effect of atractylone on the migration ability of HepG2 cells; Western blot was used to measure the protein expression levels of Bcl-2, Bax, and cleaved caspase-3. A one-way analysis of variance was used for comparison of continuous data between multiple groups, and the least significant difference t-test was used for comparison between two groups. Results After 24 and 48 hours of treatment with atractylone, compared with the control group, the low-, middle-, and high-dose atractylone groups had a tendency of reduction in cell viability (all P < 0.05), with a half inhibitory concentration of 26.19 μmol/L in atractylone treatment of HepG2 cells for 72 hours. The low-, middle-, and high-dose atractylone groups had a significantly higher apoptosis rate than the control group (14.34%/29.32%/50.12% vs 0.32%, all P < 0.05). Compared with the control group, the low-, middle-, and high-dose atractylone groups had a significant increase in the fluorescence intensity of ROS in HepG2 cells (all P < 0.05). After 48 hours of treatment with atractylone, compared with the control group, the low-, middle-, and high-dose atractylone groups had a significant reduction in the number of migrated cells (132.67±18.36/57.00±9.26/31.00±2.45 vs 258.11±38.54, P < 0.05). Compared with the control group, the low-, middle-, and high-dose atractylone groups had a significant reduction in the expression of the anti-apoptotic factor Bcl-2 and significant increases in the expression of the apoptotic factors Bax and cleaved caspase-3 (all P < 0.05). Conclusion Atractylone can induce the apoptosis and inhibit the migration of HepG2 cells, which provides an experimental basis for further development and utilization of atractylone. [ABSTRACT FROM AUTHOR]

Objective To measure the changes in the length of ligaments in different positions of the wrist during throwing movement in patients with rheumatoid arthritis（RA)，and to investigate the movement characteristics of the wrist in patients with RA to guide surgical treatment. Methods Twenty-four patients with RA involving the wrist（experimental group）and 16 healthy volunteers were enrolled in the study. The subjects underwent computerized tomography of the wrist in the extreme dorsal extension-radial deviation position，neutral position，and extreme flexion-ulnar deviation position during simulated throwing movement. After three-dimensional reconstruction，the length of related ligaments［radioscaphocapitate ligament（RSC)，ulnolunate ligament（UL)，ulnocapitate ligament（UC)，ulnotriguetrum ligament （UT)，long radiolunate ligament（LRL)，dorsal radiocarpal ligament（DRC)，and dorsal intercarpal ligament（DIC)］of the wrist was measured and compared for the changes in the length of the wrist ligaments in different positions within the same group and those in the same position between the two groups. Results The normal group showed significant changes in the length of the wrist ligaments in the extreme dorsal extension-radial deviation position and the extreme flexion-ulnar deviation position compared with that in the neutral position（all P<0. 05)；during the throwing movement from the extreme dorsal extension-radial deviation position to the extreme flexion-ulnar deviation position，the length of the RSC，UC，UT， and LRL gradually decreased，while the length of the DRC and DIC continuously increased（all P<0. 05). During the throwing movement from the extreme dorsal extension-radial deviation position to the extreme flexion-ulnar deviation position，the experimental group showed gradually reduced length of the RSC，UC，and LRL（all P<0. 05)；there were no significant differences in the length of UT and DIC-1 between the extreme flexion-ulnar deviation position and the neutral position（P>0. 05）and no significant difference in the length of DIC-2 between the extreme dorsal extension-radial deviation position and the neutral position（P>0. 05). In the neutral position，there were no significant differences in the length of the wrist ligaments between the two groups；compared with the normal group，the experimental group had significantly shorter RSC，UL，UC，UT，and LRL and significantly longer DIC-2 in the extreme dorsal extension-radial deviation position as well as significantly longer RSC and LRL and significantly shorter DRC，DIC-1，and DIC-2 in the extreme flexionulnar deviation position（all P>0. 05). Conclusions In patients with RA，the changes in the length of the wrist ligaments are obviously limited during simulated throwing movement；the ligaments are less affected in the flexion position and more affected in the extension position or when the tension increases. These findings may help to guide the surgical treatment of RA of the wrist in clinical practice. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)