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The YTH domain containing 2 (YTHDC2)protein, a methyl-binding protein of -methyladenosine (m"A), recognizes and binds mbA modifications to mediate the biological functions of mbA modifications. As mbA modifications are widely found on various RNAs, the biological functions of YTHDC2 in combination with distinct kinds of RNAs are also different. Emerging studies have shown that YTHDC2 is involved in the occurrence and development of lung, gastric, ovarian and other carcinomas through binding to mbA modifications. Binding can then yield a pro- or anti-cancer effect, which is significantly associated with the prognosis of various tumors. This paper summarizes the role and specific mechanisms of YTHDC2 in tumors to provide a reference basis for exploring the prevention, diagnosis and treatment of different tumors from the perspective of YTHDC2. [ABSTRACT FROM AUTHOR]

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目的观察长链非编码RNA-ROR(lincRNA-ROR)在乳腺癌患者血清及癌组织中的表达变化，并探讨其临床意义。方法选择行手术切除治疗的乳腺癌患者120例作为观察组，其中早期55例、中晚期65例;90例体检健康女性作为对照组。收集观察组手术前后及对照组空腹静脉血，观察组手术切除的新鲜癌组织及其配对癌旁正常组织(各24例份）。采用实时荧光定量PCR法检测两组血清及组织lmcRNA-ROR表达，电化学发光免疫分析法检测观察组早期乳腺癌患者和对照组血清糖类抗原153(CA153)、癌胚抗原（CEA)水平。采用受试者工作特征曲线分析血清lmcRNA-ROR、CA153、CEA单独或联合检测对早期乳腺癌的诊断价值。结果观察组手术前后血清lincRNA-ROR相对表达量分别为1.88±0.74、1.01±0.52，对照组为1.31±0.62，两两比较P<0.05或<0.01。乳腺癌组织lincRNA-ROR相对表达量为2.19±0.97，癌旁正常组织为0.79±0.35，二者比较P<0.01。血清lincRNA-ROR诊断早期乳腺癌的曲线下面积（AUC)大于CA153和CEA，敏感性及特异性均高于CA153和CEA;血清lincRNA-ROR、CA153、CEA联合检测诊断早期乳腺癌的AUC均大于上述指标单独检测，敏感性及特异性均高于上述指标单独检现彳。结论乳腺癌患者血清和癌组织中HncRNA-ROR表达均升高;血清UncRNA-ROR表达检测有助于乳腺癌的早期诊断及疗效判断。 [ABSTRACT FROM AUTHOR]